52 results on '"Dunaway, David"'
Search Results
2. Correlation between head shape and volumetric changes following spring-assisted posterior vault expansion.
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Ramdat Misier, Karan R.R., Breakey, Richard W.F., van de Lande, Lara S., Biffi, Benedetta, Knoops, Paul G.M., Schievano, Silvia, Caron, Cornelia J.J.M., Dunaway, David J., Koudstaal, Maarten J., Jeelani, N.U. Owase, and Borghi, Alessandro
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PRINCIPAL components analysis ,COMPUTED tomography ,INTRACRANIAL pressure - Abstract
The aim of the study was to investigate whether different head shapes show different volumetric changes following spring-assisted posterior vault expansion (SA-PVE) and to investigate the influence of surgical and morphological parameters on SA-PVE. Preoperative three-dimensional skull models from patients who underwent SA-PVE were extracted from computed tomography scans. Patient head shape was described using statistical shape modelling (SSM) and principal component analysis (PCA). Preoperative and postoperative intracranial volume (ICV) and cranial index (CI) were calculated. Surgical and morphological parameters included skull bone thickness, number of springs, duration of spring insertion and type of osteotomy. In the analysis, 31 patients were included. SA-PVE resulted in a significant ICV increase (284.1 ± 171.6 cm
3 , p < 0.001) and a significant CI decrease (−2.9 ± 4.3%, p < 0.001). The first principal component was significantly correlated with change in ICV (Spearman ρ = 0.68, p < 0.001). Change in ICV was significantly correlated with skull bone thickness (ρ = −0.60, p < 0.001) and age at time of surgery (ρ = −0.60, p < 0.001). No correlations were found between the change in ICV and number of springs, duration of spring insertion and type of osteotomy. SA-PVE is effective for increasing the ICV and resolving raised intracranial pressure. Younger, brachycephalic patients benefit more from surgery in terms of ICV increase. Skull bone thickness seems to be a crucial factor and should be assessed to achieve optimal ICV increase. In contrast, insertion of more than two springs, duration of spring insertion or performing a fully cut through osteotomy do not seem to impact the ICV increase. When interpreting ICV increases, normal calvarial growth should be taken into account. [ABSTRACT FROM AUTHOR]- Published
- 2022
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3. Statistical shape modelling for the analysis of head shape variations.
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Heutinck, Pam, Knoops, Paul, Florez, Naiara Rodriguez, Biffi, Benedetta, Breakey, William, James, Greg, Koudstaal, Maarten, Schievano, Silvia, Dunaway, David, Jeelani, Owase, and Borghi, Alessandro
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STATISTICAL models ,PRINCIPAL components analysis ,MODE shapes ,ANATOMICAL variation ,STEREOSCOPIC photography - Abstract
The aim of this study is, firstly, to create a population-based 3D head shape model for the 0 to 2-year-old subjects to describe head shape variability within a normal population and, secondly, to test a combined normal and sagittal craniosynostosis (SAG) population model, able to provide surgical outcome assessment. 3D head shapes of patients affected by non-cranial related pathologies and of SAG patients (pre- and post-op) were extracted either from head CTs or 3D stereophotography scans, and processed. Statistical shape modelling (SSM) was used to describe shape variability using two models – a normal population model (MODEL1) and a combined normal and SAG population model (MODEL2). Head shape variability was described via principal components analysis (PCA) which calculates shape modes describing specific shape features. MODEL1 (n = 65) mode 1 showed statistical correlation (p < 0.001) with width (125.8 ± 13.6 mm), length (151.3 ± 17.4 mm) and height (112.5 ± 11.1 mm) whilst mode 2 showed correlation with cranial index (83.5 mm ± 6.3 mm, p < 0.001). The remaining 9 modes showed more subtle head shape variability. MODEL2 (n = 159) revealed that post-operative head shape still did not achieve full shape normalization with either spring cranioplasty or total calvarial remodelling. This study proves that SSM has the potential to describe detailed anatomical variations in a paediatric population. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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4. Virtual planning in Le Fort III distraction osteogenesis: A case series.
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Vercruysse, Herman, Rubio-Palau, Josep, Van de Casteele, Elke, Nadjmi, Nasser, De Praeter, Mania, and Dunaway, David
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DISTRACTION ,BONE growth ,OPERATING rooms ,PRODUCTION planning ,CUTTING tools - Abstract
The objective of this study is to determine the value of using 3D planning tools and 3D printed cutting guides in Le Fort III osteotomies with external frame distraction osteogenesis. The process of planning and transfer of the virtual planning to the operating room is illustrated with 5 case. The virtual planning is transferred to the operating room using a 3D-printed supra-orbital reference bar with puzzle connections for the planned osteotomy guides. Different systems are presented to transfer the vector of distraction and the position of the external midface distractor. Three-dimensional planning tools and cutting guides help to design the Le Fort III osteotomy and the distraction vector, to anticipate possible difficulties, and to avoid adverse events. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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5. Junctional scotoma in moyamoya disease.
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Rodriguez, Sean Michael, Matharu, Kanwal Singh, Epner, Linda, Dunaway, David, and Foroozan, Rod
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- 2021
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6. What Are the Characteristics of the Upper Airway in Patients With Craniofacial Microsomia?
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Klazen, Yoram P., Caron, Cornelia J.J.M., Schaal, Sontje C., Borghi, Alessandro, Van der Schroeff, Marc P., Dunaway, David J., Padwa, Bonnie L., and Koudstaal, Maarten J.
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Purpose: Obstructive sleep apnea (OSA) is a common problem in patients with craniofacial microsomia (CFM); however, the exact pathophysiology in patients with CFM remains unclear. The first aim of this study was to evaluate upper airway volume and morphology in patients with CFM. The second aim was to identify risk factors for the presence of OSA.Materials and Methods: A cross-sectional study was set up and 3 study groups were identified: 1) CFM with OSA, 2) CFM without OSA, and 3) control. Computed tomographic (CT) scans of the head and neck were included and used to create 3-dimensional models. The age-matched control group consisted of patients evaluated for traumatic head injury or epilepsy. Volumetric and morphologic parameters were measured. The results of patients with CFM were compared among the 3 study groups. Descriptive statistics were computed using the Pearson χ2 test for categorical variables and nonparametric tests for continuous variables. A multiple variable regression model was used to identify risk factors for OSA.Results: In total, 79 patients with CFM were included, of which 25 patients were diagnosed with OSA. A total of 145 CT scans could be analyzed. In addition, a control population of 88 patients was identified. Oropharynx volume, mean cross-sectional area (CSA), minimal CSA, and minimal retropalatal area were found to be markedly smaller in patients with CFM compared with the control population. In contrast, in patients with CFM and OSA, minimal retroglossal area, sphericity, and uniformity markedly differed from those in patients without OSA. Sphericity was identified as the main predicting variable of OSA in patients with CFM.Conclusions: The upper airway of patients with CFM is markedly smaller and puts them at risk for developing OSA. Patients with CFM diagnosed with OSA have a markedly smaller CSA behind the base of the tongue and a difference in sphericity. [ABSTRACT FROM AUTHOR]- Published
- 2019
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7. Investigating the cause of late deformity following fronto-orbital remodelling for metopic synostosis using 3D CT imaging.
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Rodriguez-Florez, Naiara, Florez-Tapia, Aran, Jeelani, Noor U.O., Schievano, Sylvia, Dunaway, David J., and Hayward, Richard D.
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TEMPORALIS muscle ,THREE-dimensional imaging ,BONES ,TISSUES ,HUMAN abnormalities - Abstract
Abstract Purpose Late deformity/indentation is well-recognised following fronto-orbital remodelling (FOR) for metopic synostosis. We hypothesise that if damage to temporalis muscle were a contributor, the thickness of soft tissue and bone in the affected area would be reduced. Materials and methods Soft tissues and bone were separately segmented and reconstructed three-dimensionally from computed tomograms of 8 patients 1.5–18 years post-FOR performed at 16 ± 2 months for metopic synostosis and from 8 age-matched controls. Soft tissue (taken as proxy for temporalis muscle) and bone thickness overall and in the indented areas were computed. Results Post-FOR, three-dimensional soft tissue thickness maps demonstrated temporalis extending upwards but falling short of the indented area. Overall skull thickness increased with age post-FOR (logarithmic fit R
2 = 0.71) and for controls (R2 = 0.90). Although immediately post-FOR the future indented area had a thickness of 98% of control, it decreased linearly to 64% 16 years later (Pearson's r = 0.84). Conclusion These findings suggest that late post-FOR deformity/indentation is enhanced by limited upward extension (or retraction downwards) of temporalis muscle, while bone thickness in the affected area gradually decreases. This supports the hypothesis that aberrant re-attachment of the temporalis muscle makes a material contribution to late deformity following FOR for metopic synostosis. [ABSTRACT FROM AUTHOR]- Published
- 2019
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8. Using principal component analysis to describe the midfacial deformities in patients with craniofacial microsomia.
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Maas, Britta D.P.J., Pluijmers, Britt I., Knoops, Paul G.M., Ruff, Clifford, Koudstaal, Maarten J., and Dunaway, David
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MULTIPLE correspondence analysis (Statistics) - Abstract
Abstract Purpose Craniofacial microsomia (CFM) is the result of a disturbance in embryologic development and is characterised by an asymmetric, mostly unilateral facial underdevelopment. The aim of this study is to understand the midfacial involvement in CFM using principal component analysis (PCA). Materials and methods Pre-operative data from 19 CFM and 23 control patients were collected. A set of 71 landmarks was placed on three-dimensional (3D) reconstructions of all skulls to compare both populations. PCA visualised variation within both groups and calculated the vector of change. Linear measurements were taken to compare ratios between the populations and between the affected and unaffected sides in CFM patients. Results PCA defined a vector that described shape changes between both populations. Videos showed the variation within the control and CFM group and the transformation from a mean CFM skull into a normal phenotype. Linear measurements showed a significant difference between the affected and unaffected sides in CFM patients. Conclusion PCA has not been applied on asymmetrical data before, but it has proved to be a useful method to describe CFM. The virtual normalisation of a mean CFM skull enables visualisation of the bony shape changes, which is promising to delineate and to plan surgical correction and could be used as an outcome measure. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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9. Feeding difficulties in craniofacial microsomia: A multicenter retrospective analysis of 755 patients.
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Caron, Cornelia J.J.M., Pluijmers, Britt I., Joosten, K.F.M., Dunaway, David, Padwa, Bonnie L., Wolvius, Eppo B., and Koudstaal, Maarten J.
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GOLDENHAR syndrome ,INGESTION disorders ,DISEASE prevalence ,CLEFT palate ,SLEEP apnea syndromes ,THERAPEUTICS - Abstract
Abstract A retrospective cohort study was initiated to analyse the prevalence, risk factors and treatment modalities of feeding difficulties in patients with craniofacial microsomia. This study included 755 subjects with craniofacial microsomia from three craniofacial centres. Medical charts were reviewed for severity of the deformity, documented feeding difficulties, age at which feeding difficulties first presented and treatment, presence of cleft lip/palate, extracraniofacial anomalies, and obstructive sleep apnoea. In total, 199 patients (26.4%) had documented feeding difficulties. Patients with bilateral involvement, Pruzansky-Kaban III classification, cleft lip/palate, or obstructive sleep apnoea were significantly more at risk for developing feeding difficulties and significantly more often needed additional feeding via a nasogastric tube than patients without these risk factors. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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10. Part 2: Is the maxillary canting and its surgical correction in patients with CFM correlated to the mandibular deformity?
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Pluijmers, Britt I., van de Lande, Lara S., Caron, Cornelia J.J.M., Wolvius, Eppo B., Dunaway, David J., Padwa, Bonnie L., and Koudstaal, Maarten J.
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CRANIOFACIAL dysostosis ,PEARSON correlation (Statistics) ,GOLDENHAR syndrome ,MAXILLOMANDIBULAR advancement surgery ,RADIOGRAPHIC contrast media - Abstract
Abstract Introduction Patients with Craniofacial Microsomia (CFM) mandibles Types I/IIa benefit from combined LeFort 1 osteotomy and Mandibular Distraction Osteogenesis (LeFort + MDO); Type IIb from LeFort + MDO or Bimaxillary osteotomy (BiMax); and Type III from BiMax (with 50% of cases having preceding mandibular procedures, including patient-fitted prosthesis); as seen in Part 1. This leads to the question how maxillary and mandibular hypoplasia are correlated and influence the types of maxillary correction. Material and methods A retrospective chart study was conducted including patients diagnosed with CFM from 2 large craniofacial units. Radiographic and clinical information were obtained. Unilateral affected patients with available (ConeBeam) CT-scan of the maxillary-mandibular complex, without treatment of the upper jaw prior to the CT-scan were included. A maxillary cant grading system was set up and evaluated. Pearson correlation coefficients were used to correlate the maxillary cant and the severity of the mandibular hypoplasia. Results Eighty-one patients were included, of whom 39.5% had a Pruzansky-Kaban type III mandible and 42% a mild maxillary cant. There was a significant positive correlation between severity of the mandibular hypoplasia and the categorized canting (r = 0.370; p < 0.001; n = 81). Twenty-four patients had maxillary surgery, mainly a BiMax. Conclusion There is a positive correlation between the severity of mandibular hypoplasia and maxillary cant. The severity of mandibular hypoplasia seems to dictate an intervention for both maxillary and mandibular surgery. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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11. Surgical correction of the midface in craniofacial microsomia. Part 1: A systematic review.
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van de Lande, Lara S., Pluijmers, Britt I., Caron, Cornelia J.J.M., Wolvius, Eppo B., Dunaway, David J., Koudstaal, Maarten J., and Padwa, Bonnie L.
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CRANIOFACIAL abnormalities ,OSTEOGENESIS imperfecta ,MEDLINE ,PROSTHETICS - Abstract
Abstract Introduction Mandibular reconstruction in craniofacial microsomia (CFM) has been described and reviewed at length although final results are not always (aesthetically) satisfactory due to maxillo-mandibular asymmetry, for which optimal correction techniques remain unclear. The aim of this systematic review is to provide an overview of the surgical options for maxillary correction in patients with unilateral CFM. Material and methods MEDLINE/Pubmed, Embase, Cochrane and Web of Science databases were searched up to April 15, 2017. Inclusion criteria were: studies reporting patients with unilateral CFM (n > 4) who had maxillary correction (with/without simultaneous mandibular correction) with a minimal follow-up of 6 months. The outcome measures included type of treatment (including preceding facial procedures), type and severity of mandibular deformity (by Pruzansky-Kaban system: Types I/IIa/IIb/III), asymmetry analysis method, outcome (i.e. occlusion, canting, stability, esthetic result, facial symmetry), complications and additional treatment needed. Results Nine studies met the inclusion criteria. Analysis showed that Le Fort I + mandibular distraction osteogenesis (LeFort + MDO) and BiMaxillary osteotomy (BiMax) were used for treatment, as single or multiple-stage procedures. All studies reported aesthetic and functional improvement. Conclusion Types I/IIa benefited from LeFort + MDO; Type IIb from LeFort + MDO or BiMax; and Type III from BiMax (with 50% of cases having preceding mandibular procedures, including patient-fitted prosthesis) at a mean age of 20.2 years. Four studies recommended additional (esthetic) procedures. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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12. Cranial bone structure in children with sagittal craniosynostosis: Relationship with surgical outcomes.
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Rodriguez-Florez, Naiara, Ibrahim, Amel, Hutchinson, J. Ciaran, Borghi, Alessandro, James, Greg, Arthurs, Owen J., Ferretti, Patrizia, Dunaway, David, Schievano, Silvia, and Jeelani, N. U. Owase
- Abstract
Summary Background While spring-assisted cranioplasty has become a widespread technique to correct scaphocephaly in children with sagittal synostosis, predicting head shape changes induced by the gradual opening of the springs remains challenging. This study aimed to explore the role of cranial bone structure on surgical outcomes. Methods Patients with isolated sagittal synostosis undergoing spring-assisted cranioplasty at GOSH (London, UK) were recruited (n = 18, age: 3–8 months). Surgical outcome was assessed by the change in cephalic index measured on 3D head scans acquired before spring insertion and after their removal using a 3D handheld scanner. Parietal bone samples routinely discarded during spring-assisted cranioplasty were collected and scanned using micro-computed tomography. From visual assessment of such scans, bone structure was classified into one- or three-layered, the latter indicating the existence of a diploë cavity. Bone average thickness, volume fraction and surface density were computed and correlated with changes in cephalic index. Results Cephalic index increased for all patients (p < 0.001), but individual improvement varied. Although the patient age and treatment duration were not significantly correlated with changes in cephalic index, bone structural parameters were. The increase of cephalic index was smaller with increasing bone thickness (Pearson's r = −0.79, p < 0.001) and decreasing bone surface density (r = 0.77, p < 0.001), associated with the three-layered bone structure. Conclusions Variation in parietal bone micro-structure was associated with the magnitude of head shape changes induced by spring-assisted cranioplasty. This suggests that bone structure analysis could be a valuable adjunct in designing surgical strategies that yield optimal patient-specific outcomes. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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13. Craniofacial and extracraniofacial anomalies in craniofacial macrosomia: A multicenter study of 755 patients.
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Caron, Cornelia J.J.M., Pluijmers, Britt I., Wolvius, Eppo B., Looman, Caspar .W.N., Bulstrode, Neil, Evans, Robert D., Ayliffe, Peter, Mulliken, John B., Dunaway, David, Padwa, Bonnie, and Koudstaal, Maarten J.
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DEVELOPMENTAL biology ,CRANIOFACIAL abnormalities ,PHARYNGEAL diseases ,PHENOTYPES ,RETROSPECTIVE studies ,THERAPEUTICS - Abstract
Purpose Craniofacial microsomia (CFM) is a congenital malformation of structures derived from the first and second pharyngeal arches leading to underdevelopment of the face. However, besides the craniofacial underdevelopment, extracraniofacial anomalies including cardiac, renal and skeletal malformation have been described. The aim of this study is to analyse a large population of patients with regard to demographics, typical phenotypes including craniofacial and extracraniofacial anomalies, and the correlations between the different variables of this condition. Material and methods A retrospective study was conducted in patients diagnosed with CFM with available clinical and/or radiographic images. All charts were reviewed for information on demographic, radiographic and diagnostic criteria. The presence of cleft lip/palate and extracraniofacial anomalies were noted. Pearson correlation tests and principal component analysis was performed on the phenotypic variables. Results A total of 755 patients were included. The male-to-female ratio and right-to-left ratio were both 1.2:1. A correlation was found among Pruzansky–Kaban, orbit and soft tissue. Similar correlations were found between ear and nerve. There was no strong correlation between phenotype and extracraniofacial anomalies. Nevertheless, extracraniofacial anomalies were more frequently seen than in the ‘normal’ population. Patients with bilateral involvement had a more severe phenotype and a higher incidence of extracraniofacial and cleft lip/palate. Conclusion Outcomes were similar to those of other smaller cohorts. Structures derived from the first pharyngeal arch and the second pharyngeal arch were correlated with degree of severity. Extracraniofacial anomalies were positively correlated with CFM. The findings show that bilaterally affected patients are more severely affected and should be approached more comprehensively. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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14. Three-dimensional surface scanners compared with standard anthropometric measurements for head shape.
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Beaumont, Caroline A.A., Knoops, Paul G.M., Borghi, Alessandro, Jeelani, N.U. Owase, Koudstaal, Maarten J., Schievano, Silvia, Dunaway, David J., and Rodriguez-Florez, Naiara
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THREE-dimensional imaging ,FACIAL bones ,IONIZING radiation ,COMPUTED tomography ,MAGNETIC resonance imaging - Abstract
Three-dimensional (3D) surface imaging devices designed to capture and quantify craniofacial surface morphology are becoming more common in clinical environments. Such scanners overcome the limitations of two-dimensional photographs while avoiding the ionizing radiation of computed tomography. The purpose of this study was to compare standard anthropometric cranial measurements with measurements taken from images acquired with 3D surface scanners. Two 3D scanners of different cost were used to acquire head shape data from thirteen adult volunteers: M4D scan and Structure Sensor. Head circumference and cephalic index were measured directly on the patients as well as on 3D scans acquired with the two scanners. To compare head volume measurements with a gold standard, magnetic resonance imaging scans were used. Repeatability and accuracy of both devices were evaluated. Intra-rater repeatability for both scanners was excellent (intraclass correlation coefficients > 0.99, p < 0.001). Direct and digital measures of head circumference, cephalic index and head volume were strongly correlated (0.85 < r < 0.91, p < 0.001). Compared to direct measurements, accuracy was highest for M4D scan. Both 3D scanners provide reproducible data of head circumference, cephalic index and head volume and show a strong correlation with traditional measurements. However, care must be taken when using absolute values. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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15. Comparison of three-dimensional scanner systems for craniomaxillofacial imaging.
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Knoops, Paul G.M., Beaumont, Caroline A.A., Borghi, Alessandro, Rodriguez-Florez, Naiara, Breakey, Richard W.F., Rodgers, William, Angullia, Freida, Jeelani, N.U. Owase, Schievano, Silvia, and Dunaway, David J.
- Abstract
Summary Two-dimensional photographs are the standard for assessing craniofacial surgery clinical outcomes despite lacking three-dimensional (3D) depth and shape. Therefore, 3D scanners have been gaining popularity in various fields of plastic and reconstructive surgery, including craniomaxillofacial surgery. Head shapes of eight adult volunteers were acquired using four 3D scanners: 1.5T Avanto MRI, Siemens; 3dMDface System, 3dMD Inc.; M4D Scan, Rodin4D; and Structure Sensor, Occipital Inc. Accuracy was evaluated as percentage of data within a range of 2 mm from the 3DMDface System reconstruction, by surface-to-surface root mean square (RMS) distances, and with facial distance maps. Precision was determined by RMS. Relative to the 3dMDface System, accuracy was the highest for M4D Scan (90% within 2 mm; RMS of 0.71 mm ± 0.28 mm), followed by Avanto MRI (86%; 1.11 mm ± 0.33 mm) and Structure Sensor (80%; 1.33 mm ± 0.46). M4D Scan and Structure Sensor precision were 0.50 ± 0.04 mm and 0.51 ± 0.03 mm, respectively. Clinical and technical requirements govern scanner choice; however, 3dMDface System and M4D Scan provide high-quality results. It is foreseeable that compact, handheld systems will become more popular in the near future. [ABSTRACT FROM AUTHOR]
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- 2017
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16. Quantifying the effect of corrective surgery for trigonocephaly: A non-invasive, non-ionizing method using three-dimensional handheld scanning and statistical shape modelling.
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Rodriguez-Florez, Naiara, Göktekin, Özge K., Bruse, Jan L., Borghi, Alessandro, Angullia, Freida, Knoops, Paul G.M., Tenhagen, Maik, O'Hara, Justine L., Koudstaal, Maarten J., Schievano, Silvia, Jeelani, N.U. Owase, James, Greg, and Dunaway, David J.
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CRANIOSYNOSTOSES ,FRONTAL bone ,THREE-dimensional imaging ,PRINCIPAL components analysis ,HOSPITAL care ,NUMERICAL analysis ,DIAGNOSIS - Abstract
Trigonocephaly in patients with metopic synostosis is corrected by fronto-orbital remodelling (FOR). The aim of this study was to quantitatively assess aesthetic outcomes of FOR by capturing 3D forehead scans of metopic patients pre- and post-operatively and comparing them with controls. Ten single-suture metopic patients undergoing FOR and 15 age-matched non-craniosynostotic controls were recruited at Great Ormond Street Hospital for Children (UK). Scans were acquired with a three-dimensional (3D) handheld camera and post-processed combining 3D imaging software. 3D scans were first used for cephalometric measurements. Statistical shape modelling was then used to compute the 3D mean head shapes of the three groups (FOR pre-op, post-op and controls). Head shape variations were described via principal component analysis (PCA). Cephalometric measurements showed that FOR significantly increased the forehead volume and improved trigonocephaly. This improvement was supported visually by pre- and post-operative computed mean 3D shapes and numerically by PCA (p < 0.001). Compared with controls, post-operative scans showed flatter foreheads (p < 0.001). In conclusion, 3D scanning followed by 3D statistical shape modelling enabled the 3D comparison of forehead shapes of metopic patients and non-craniosynostotic controls, and demonstrated that the adopted FOR technique was successful in correcting bitemporal narrowing but overcorrected the rounding of the forehead. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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17. Combined soft and skeletal tissue modelling of normal and dysmorphic midface postnatal development.
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Ibrahim, Amel, Suttie, Michael, Bulstrode, Neil W., Britto, Jonathan A., Dunaway, David, Hammond, Peter, and Ferretti, Patrizia
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BODY dysmorphic disorder ,MANDIBULOFACIAL dysostosis ,SOFT tissue injuries ,PREOPERATIVE care ,QUANTITATIVE research - Abstract
Background Midface hypoplasia as exemplified by Treacher Collins Syndrome (TCS) can impair appearance and function. Reconstruction involves multiple invasive surgeries with variable long-term outcomes. This study aims to describe normal and dysmorphic midface postnatal development through combined modelling of skeletal and soft tissues and to develop a surgical evaluation tool. Materials and methods Midface skeletal and soft tissue surfaces were extracted from computed tomography scans of 52 control and 14 TCS children, then analysed using dense surface modelling. The model was used to describe midface growth, morphology, and asymmetry, then evaluate postoperative outcomes. Results Parameters responsible for the greatest variation in midface size and shape showed differences between TCS and controls with close alignment between skeletal and soft tissue models. TCS children exhibited midface dysmorphology and hypoplasia when compared with controls. Asymmetry was also significantly higher in TCS midfaces. Combined modelling was used to evaluate the impact of surgery in one TCS individual who showed normalisation immediately after surgery but reversion towards TCS dysmorphology after 1 year. Conclusion This is the first quantitative analysis of postnatal midface development using combined modelling of skeletal and soft tissues. We also provide an approach for evaluation of surgical outcomes, laying the foundations for future development of a preoperative planning tool. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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18. Fronto-facial advancement and bipartition in Crouzon–Pfeiffer and Apert syndromes: Impact of fronto-facial surgery upon orbital and airway parameters in FGFR2 syndromes.
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Khonsari, Roman H., Way, Benjamin, Nysjö, Johan, Odri, Guillaume A., Olszewski, Raphaël, Evans, Robert D., Dunaway, David J., Nyström, Ingela, and Britto, Jonathan A.
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CRANIOFACIAL dysostosis ,MAXILLOFACIAL surgery ,OSTEOTOMY ,COMPUTED tomography ,TREATMENT effectiveness ,THERAPEUTICS - Abstract
A major concern in FGFR2 craniofaciosynostosis is oculo-orbital disproportion, such that orbital malformation provides poor accommodation and support for the orbital contents and peri-orbita, leading to insufficient eyelid closure, corneal exposure and eventually to functional visual impairment. Fronto-facial monobloc osteotomy followed by distraction osteogenesis aims to correct midfacial growth deficiencies in Crouzon–Pfeiffer syndrome patients. Fronto-facial bipartition osteotomy followed by distraction is a procedure of choice in Apert syndrome patients. These procedures modify the shape and volume of the orbit and tend to correct oculo-orbital disproportion. Little is known about the detailed 3D shape of the orbital phenotype in CPS and AS, and about how this is modified by fronto-facial surgery. Twenty-eight patients with CMS, 13 patients with AS and 40 control patients were included. CT scans were performed before and after fronto-facial surgery. Late post-operative scans were available for the Crouzon–Pfeiffer syndrome group. Orbital morphology was investigated using conventional three-dimensional cephalometry and shape analysis after mesh-based segmentation of the orbital contents. We characterized the 3D morphology of CPS and AS orbits and showed how orbital shape is modified by surgery. We showed that monobloc-distraction in CPS and bipartition-distraction in AS specifically address the morphological characteristics of the two syndromes. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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19. 10. Comparison of Internal and External Distraction in Frontofacial Monobloc Advancement: A Three-Dimensional Quantification.
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Rickart, Alexander, van de Lande, Lara, O' Sullivan, Eimear, Bloch, Kevin, Arnaud, Eric, Schievano, Silvia, ul Owase Jeelani, Noor, Paternoster, Giovanna, Khonsari, Roman, and Dunaway, David
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DISTRACTION - Published
- 2022
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20. Staged separation of craniopagus twins.
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Dunaway, David and Jeelani, N.U. Owase
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Craniopagus twins are rare and account for up to 6% of all conjoined twins. No hospital will encounter many such twins and the opportunity to develop expertise is limited. We have dealt with 2 such sets and illustrate our approach by reference to our most recent set. We believe that detailed imaging allows precise delineation of the anatomy and facilitates detailed planning of the surgery. When venous drainage from the 2 brains is connected, we believe that staged separation is preferable as gradual alteration of hemodynamics may be safer than a single-stage procedure. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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21. Aberrant facial flushing following monobloc fronto-facial distraction.
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Cobb, Alistair R.M., Vourvachis, Michael, Ahmed, Jahangir, Wyatt, Michelle, Dunaway, David, and Hayward, Richard
- Subjects
FACIAL abnormalities ,CRANIOSYNOSTOSES ,EXOPHTHALMOS ,POSTOPERATIVE care ,PTERYGOPALATINE ganglion ,PATIENTS - Abstract
Background Patients with syndromic forms of craniosynostosis may experience functional problems such as raised intracranial pressure, proptosis, obstructive sleep apnoea and failure to thrive. The monobloc fronto-facial advancement with osteogenic distraction is increasingly used to correct these functional problems in one procedure as well as improve appearance. The authors report the phenomenon of post operative aberrant facial flushing – an unusual and previously unreported complication of the procedure. Methods The case notes of 80 consecutive patients undergoing fronto-facial advancement by distraction using the rigid external distraction device (RED) were reviewed for features of aberrant facial flushing. Results Four out of eighty individuals developed facial flushing after monobloc fronto-facial distraction using the rigid external distractor (RED) frame. All were female with Crouzon or Pfeiffer syndromes causing the severe functional problems for which they underwent the surgery. They were aged 6–8 years. Following removal of the frame, they developed intermittent but severe facial flushing. The flushing spontaneously settled in three patients after up to four years but persists in the other child seven years after her surgery. Conclusion Aberrant facial flushing is a rare but significant complication of monobloc fronto-facial surgery. It occurred in 4 of our 80 (5%) patients. The skull base osteotomies essential for the procedure are made anterior to the pterygopalatine ganglion and it is our contention that damage from these was responsible for a neuropraxia of its efferent nerve branches. A review of the autonomic control of the facial vascular system suggests that the phenomenon is due to an unequal process of recovery that leaves the cutaneous vasodilating parasympathetic or beta-adrenergic innervation relatively unopposed – a situation that persists until with time a normal balance of autonomic input is achieved. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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- View/download PDF
22. Monitoring of intestinal transplant rejection
- Author
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Teitelbaum, Daniel H., Wise, William E., Sonnino, Roberta E., Dunaway, David J., Powers, Priscilla, McClung, H. Juhling, and Harmel, Richard P., Jr.
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Intestines ,Transplantation immunology -- Research ,Graft rejection -- Physiological aspects ,Health - Abstract
This paper showed that in a successful gut transplant, the level of enzymes which break down various sugars is of normal value. The reduction of these levels in transplanted bowel was correlated with a microscopic confirmation of transplant rejection. These results suggest that monitoring specific enzymes involved in the breakdown of specific (disaccharide) sugars may be useful in monitoring bowel transplant rejections.
- Published
- 1989
23. Describing Crouzon and Pfeiffer syndrome based on principal component analysis.
- Author
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Staal, Femke C.R., Ponniah, Allan J.T., Angullia, Freida, Ruff, Clifford, Koudstaal, Maarten J., and Dunaway, David
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CRANIOFACIAL dysostosis ,APERT syndrome ,CRANIOSYNOSTOSES ,GENETIC mutation ,FIBROBLAST growth factor receptors ,PRINCIPAL components analysis - Abstract
Crouzon and Pfeiffer syndrome are syndromic craniosynostosis caused by specific mutations in the FGFR genes. Patients share the characteristics of a tall, flattened forehead, exorbitism, hypertelorism, maxillary hypoplasia and mandibular prognathism. Geometric morphometrics allows the identification of the global shape changes within and between the normal and syndromic population. Methods Data from 27 Crouzon-Pfeiffer and 33 normal subjects were landmarked in order to compare both populations. With principal component analysis the variation within both groups was visualized and the vector of change was calculated. This model normalized a Crouzon-Pfeiffer skull and was compared to age-matched normative control data. Results PCA defined a vector that described the shape changes between both populations. Movies showed how the normal skull transformed into a Crouzon-Pfeiffer phenotype and vice versa. Comparing these results to established age-matched normal control data confirmed that our model could normalize a Crouzon-Pfeiffer skull. Conclusions PCA was able to describe deformities associated with Crouzon-Pfeiffer syndrome and is a promising method to analyse variability in syndromic craniosynostosis. The virtual normalization of a Crouzon-Pfeiffer skull is useful to delineate the phenotypic changes required for correction, can help surgeons plan reconstructive surgery and is a potentially promising surgical outcome measure. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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- View/download PDF
24. The surgical management of Treacher Collins syndrome.
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Cobb, Alistair R. M., Green, Ben, Gill, Daljit, Ayliffe, Peter, Lloyd, Timothy W., Bulstrode, Neil, and Dunaway, David J.
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MANDIBULOFACIAL dysostosis ,GENETIC disorders ,DYSGENESIS ,NEURODEVELOPMENTAL treatment ,CHRONOLOGY ,MAXILLOFACIAL surgery ,THERAPEUTICS - Abstract
Treacher Collins syndrome (TCS), mandibulofacial dysostosis, or Franceschetti-Zwahlen-Klein syndrome, is a rare genetic disorder characterised by dysgenesis of the hard and soft tissues of the first and second branchial arches. Early operations focus on maintaining the airway, protecting the eyes, and supporting auditory neurological development. Later operations include staged reconstruction of the mouth, face, and external ear. Bimaxillary surgery can improve the maxillomandibular facial projection, but correction of malar, orbital rim, and temporal defects may be more difficult. We present a clinical review of the syndrome with a chronological approach to the operations. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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25. Ocular and adnexal anomalies in Treacher Collins syndrome: a retrospective multicenter study.
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Rooijers, Wietse, Schreuder, Marloes J., Loudon, Sjoukje E., Wan, Michael J., Dunaway, David J., Padwa, Bonnie L., Forrest, Christopher R., Koudstaal, Maarten J., and Caron, Cornelia J.J. M.
- Subjects
ADNEXAL diseases ,REFRACTIVE errors ,VISION disorders ,VISUAL acuity ,SYNDROMES ,MEDICAL records - Abstract
Treacher Collins syndrome (TCS) is a rare craniofacial disorder characterized by bilateral hypoplasia of facial structures and periorbital, ocular, and adnexal anomalies. The purpose of this multicenter study was to report the prevalence of ocular and adnexal anomalies in TCS and to identify patients at risk for visual impairment. The medical records of patients seen at four craniofacial centers were reviewed retrospectively. The following data were reported: primary and secondary ocular and adnexal anomalies, orthoptic and ophthalmological findings, and severity of TCS based on the facial deformity. A total of 194 patients were included, of whom 49.5% were examined by an ophthalmologist or optometrist. The mean age at the first visual acuity measurement was 6.96 ± 6.83 years (range, 1.50-47.08); at final measurement, 11.55 ± 10.64 years (range, 1.75-62.58). Primary ocular anomalies were reported in 98.5% of cases, secondary anomalies in 34.5%, strabismus in 27.3%, refractive errors in 49.5%, and visual impairment in 4.6%. We found no association between ocular anomalies and visual impairment or between the severity of TCS and ocular anomalies or visual impairment, except for an increased prevalence of secondary ocular anomalies in patients with more severe manifestations of TCS. Ocular anomalies were present in nearly all patients with TCS, even in mild cases. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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- View/download PDF
26. Mechanical and morphological properties of parietal bone in patients with sagittal craniosynostosis.
- Author
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Ajami, Sara, Rodriguez-Florez, Naiara, Ong, Juling, Jeelani, Noor ul Owase, Dunaway, David, James, Greg, Angullia, Freida, Budden, Curtis, Bozkurt, Selim, Ibrahim, Amel, Ferretti, Patrizia, Schievano, Silvia, and Borghi, Alessandro
- Subjects
FINITE element method ,BONE mechanics ,SANDWICH construction (Materials) ,BONE density ,CRANIOSYNOSTOSES ,ELASTIC modulus - Abstract
Limited information is available on the effect of sagittal craniosynostosis (CS) on morphological and material properties of the parietal bone. Understanding these properties would not only provide an insight into bone response to surgical procedures but also improve the accuracy of computational models simulating these surgeries. The aim of the present study was to characterise the mechanical and microstructural properties of the cortical table and diploe in parietal bone of patients affected by sagittal CS. Twelve samples were collected from pediatric patients (11 males, and 1 female; age 5.2 ± 1.3 months) surgically treated for sagittal CS. Samples were imaged using micro-computed tomography (micro-CT); and mechanical properties were extracted by means of micro-CT based finite element modelling (micro-FE) of three-point bending test, calibrated using sample-specific experimental data. Reference point indentation (RPI) was used to validate the micro-FE output. Bone samples were classified based on their macrostructure as unilaminar or trilaminar (sandwich) structure. The elastic moduli obtained using RPI and micro-FE approaches for cortical tables (E RPI 3973.33 ± 268.45 MPa and E micro-FE 3438.11 ± 387.38 MPa) in the sandwich structure and diploe (E RPI 1958.17 ± 563.79 MPa and E micro-FE 1960.66 ± 492.44 MPa) in unilaminar samples were in strong agreement (r = 0.86, p <.01). We found that the elastic modulus of cortical tables and diploe were correlated with bone mineral density. Changes in the microstructure and mechanical properties of bone specimens were found to be irrespective of patients' age. Although younger patients are reported to benefit more from surgical intervention as skull is more malleable, understanding the material properties is critical to better predict the surgical outcome in patients <1 year old since age-related changes were minimal. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
27. Free groin flap in hemifacial volume reconstruction.
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Cobb, Alistair R.M., Koudstaal, Maarten J., Bulstrode, Neil W., Lloyd, Timothy W., and Dunaway, David J.
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MAXILLOFACIAL surgery ,FREE flaps ,MICROCIRCULATION ,GROIN surgery ,PEDICLE flaps (Surgery) ,SURGICAL anastomosis ,RETROSPECTIVE studies - Abstract
Abstract: Use of the free groin flap, one of the first microvascular free flaps described, has been neglected recently because it has a short pedicle and varies anatomically. However, we have found its anatomical features and type of tissue ideal for volumetric enhancement in severe hemifacial asymmetry. We present a retrospective review of a consecutive series of 14 patients who had hemifacial augmentation with a free groin flap (mean age at operation 17 years, range 10–42) since 2001, and discuss the surgical technique. The most common cause of asymmetry was hemifacial microsomia (n =6). Anatomical variation of the vessels in the groin did not cause problems. Arterial anastomosis was to the facial artery in 13 patients; 12 patients had simultaneous hard tissue procedures. No flaps failed. The free groin flap is a useful adjunct in the management of hemifacial deficits in volume when free fat grafts will not provide enough bulk. Although the operation can take longer than non-vascularised grafts, little tissue is lost so long-term results may be more predictable. We have found the anatomy fairly consistent and the short pedicle caused no problems. [Copyright &y& Elsevier]
- Published
- 2013
- Full Text
- View/download PDF
28. Juvenile nasopharyngeal angiofibroma involving the cavernous sinus: Does surgery have a role?
- Author
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Singh, Arvind, Gunny, Roxana, Dunaway, David, and Hartley, Ben
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CAVERNOUS sinus ,RADIOTHERAPY ,SURGICAL excision ,OPERATIVE surgery - Abstract
Summary: Juvenile nasopharyngeal angiofibroma involving the cavernous sinus poses a difficult dilemma. In the UKJ practice, radiotherapy is often recommended but has significant implications due to tumour volume and patient age. We present two cases of JNA involving the cavernous sinus treated by surgical excision. The surgical approaches and literature are discussed. In these cases, it was possible to separate the disease from the cavernous sinus without neurological sequelae. In advanced juvenile nasopharyngeal angiofibroma involving the cavernous sinus, surgical treatment remains an important option. [Copyright &y& Elsevier]
- Published
- 2008
- Full Text
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29. Monobloc distraction in an infant, using the rigid external distractor: Problems and solutions—A case report.
- Author
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Witherow, Helen, Dunaway, David, Ponniah, Allan, and Hayward, Richard
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CRANIOFACIAL dysostosis ,SKULL abnormalities ,INFANTS ,MONONUCLEOSIS ,BLOOD diseases ,OSTEOTOMY ,ORTHOPEDIC surgery - Abstract
Summary: Introduction: Patients with craniofacial dysostosis frequently develop functional problems including raised intracranial pressure, ocular dysfunction, obstructive sleep apnoeas and failure to thrive. These functional problems can be treated by a number of different techniques. The monobloc frontofacial advancement has the ability to correct all of these functional problems in one procedure, but can be associated with high morbidity particularly in the young infant. Aim: A case report of a 4-month-old infant with Pfeiffers syndrome and severe functional problems treated by monobloc osteotomy and distraction using the rigid external distractor is reported. The management, problems and complications encountered with this patient are discussed together with the role of monobloc distraction in the infant. Adaptation of the rigid external distraction (RED) technique using two titanium mesh sheets to prevent penetration of the skull by the cranial pins is described. Conclusions: Monobloc frontofacial advancement in the very young can be successfully achieved using the RED frame, thus treating exophthalmus, raised intracranial pressure and upper airway problems in one operation. However, it may be associated with significant complications and should only be used for those extreme cases where the severity of the functional problems prevent treatment being delayed. [Copyright &y& Elsevier]
- Published
- 2008
- Full Text
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30. Endothelin-1 in Human Intestine Resected for Necrotizing Enterocolitis.
- Author
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Nowicki, Philip T., Dunaway, David J., Nankervis, Craig A., Giannnone, Peter J., Reber, Kristina M., Hammond, Susan B., Besner, Gail E., and Caniano, Donna A.
- Abstract
Objectives: We asked if the tissue concentration of the potent vasoconstrictor endothelin-1 (ET-1) is greater in areas of human preterm intestine that demonstrate histologic evidence of necrotizing enterocolitis (NEC) when compared with relatively healthy areas within the same resection specimen. We then evaluated if ET-1 participates in hemodynamic regulation within intestinal subserosal arterioles harvested from portions of human preterm intestine that demonstrate NEC. Study design: Human preterm intestine resected for NEC was divided into three zones based on proximity to the perforation (zone 1 most proximal, zone 3 most distal). Histologic evidence of NEC was determined in each zone (normal=0, advanced necrosis=6). The tissue concentration of ET-1 was determined by enzyme-linked immunosorbent assay within intestinal homogenates prepared from each zone. Arteriolar hemodynamics were determined in vitro on subserosal arterioles harvested from different zones. Arteriolar flow rate, diameter, and resistance were determined at pressure gradients (ΔP) of 20 and 40 mmHg under control conditions and again after blockade of endothelin ET
A receptors with BQ610 (10−9 mol/L). Results: The tissue concentration of ET-1 (pg/mg protein) and histologic score in the three zones were: zone 1: 84 ± 14, 5.5 ± 0.3; zone 2: 99 ± 12, 4.7 ± 0.4, and zone 3: 33 ± 9, 0.8 ± 0.6, respectively (M ± SD, n =10 resection specimens, P <.05, zone 3 vs zones 1 and 2). Zone 2 arterioles demonstrated significantly lower flow rate and diameter and increased resistance under control conditions than zone 3 arterioles when ΔP was either 20 or 40 mmHg (n =7, P <.05). Treatment with BQ610 had no effect on zone 3 arterioles but significantly vasodilated zone 2 arterioles, increasing flow rate and vessel diameter, and decreasing vascular resistance (n =7, P <.05). Conclusions: The tissue concentration of ET-1 is greater in human preterm intestine that demonstrates histologic evidence of NEC. Arterioles harvested from intestine exhibiting histologic evidence of NEC demonstrate vasoconstriction when compared with arterioles from relatively healthy intestine in the same resection specimen. This vasoconstriction was reversed by blockade of endothelin ETA receptors. [Copyright &y& Elsevier]- Published
- 2005
- Full Text
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31. Advancing the Mandibular Distractor.
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Rodgers, Will, Borghi, Alessandro, Jeelani, Owase, Schievano, Silvia, and Dunaway, David
- Published
- 2018
- Full Text
- View/download PDF
32. A classification system to guide orbitozygomatic reconstruction in Treacher-Collins syndrome.
- Author
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Nikkhah, Dariush, Ponniah, Allan, Ruff, Cliff, and Dunaway, David
- Published
- 2013
- Full Text
- View/download PDF
33. Using principal component analysis to describe the Apert skull deformity and simulate its correction.
- Author
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Pluijmers, Britt I., Ponniah, Allan J.T., Ruff, Clifford, and Dunaway, David
- Published
- 2012
- Full Text
- View/download PDF
34. Erratum to “Craniofacial and extracraniofacial anomalies in craniofacial macrosomia: A multicenter study of 755 patients” [J Craniomaxillofac Surg vol. 45(8) (August 2017), 1302–1310].
- Author
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Caron, Cornelia J.J.M., Pluijmers, Britt I., Wolvius, Eppo B., Looman, Caspar W.N., Bulstrode, Neil, Evans, Robert D., Ayliffe, Peter, Mulliken, John B., Dunaway, David, Padwa, Bonnie, and Koudstaal, Maarten J.
- Subjects
CRANIOFACIAL abnormalities ,MAXILLOFACIAL surgery ,THERAPEUTICS - Published
- 2017
- Full Text
- View/download PDF
35. Quantitative analysis of fetal facial morphology using 3D ultrasound and statistical shape modeling: a feasibility study.
- Author
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Dall’Asta, Andrea, Schievano, Silvia, Bruse, Jan L., Paramasivam, Gowrishankar, Kaihura, Christine Tita, Dunaway, David, Lees, Christoph C., and Dall'Asta, Andrea
- Subjects
DIAGNOSIS of facial abnormalities ,FETAL development ,ULTRASONIC imaging ,THREE-dimensional imaging ,PRENATAL diagnosis ,PRINCIPAL components analysis ,FACIAL abnormalities ,FACE ,FETAL ultrasonic imaging ,GESTATIONAL age ,PILOT projects ,CRANIOFACIAL abnormalities ,STATISTICAL models ,DIAGNOSIS - Abstract
Background: The antenatal detection of facial dysmorphism using 3-dimensional ultrasound may raise the suspicion of an underlying genetic condition but infrequently leads to a definitive antenatal diagnosis. Despite advances in array and noninvasive prenatal testing, not all genetic conditions can be ascertained from such testing.Objectives: The aim of this study was to investigate the feasibility of quantitative assessment of fetal face features using prenatal 3-dimensional ultrasound volumes and statistical shape modeling. STUDY DESIGN: Thirteen normal and 7 abnormal stored 3-dimensional ultrasound fetal face volumes were analyzed, at a median gestation of 29+4 weeks (25+0 to 36+1). The 20 3-dimensional surface meshes generated were aligned and served as input for a statistical shape model, which computed the mean 3-dimensional face shape and 3-dimensional shape variations using principal component analysis.Results: Ten shape modes explained more than 90% of the total shape variability in the population. While the first mode accounted for overall size differences, the second highlighted shape feature changes from an overall proportionate toward a more asymmetric face shape with a wide prominent forehead and an undersized, posteriorly positioned chin. Analysis of the Mahalanobis distance in principal component analysis shape space suggested differences between normal and abnormal fetuses (median and interquartile range distance values, 7.31 ± 5.54 for the normal group vs 13.27 ± 9.82 for the abnormal group) (P = .056).Conclusion: This feasibility study demonstrates that objective characterization and quantification of fetal facial morphology is possible from 3-dimensional ultrasound. This technique has the potential to assist in utero diagnosis, particularly of rare conditions in which facial dysmorphology is a feature. [ABSTRACT FROM AUTHOR]- Published
- 2017
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- View/download PDF
36. Microvascular reconstruction of facial defects in settings where resources are limited.
- Author
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Rodgers, Will, Lloyd, Timothy, Mizen, Kelvin, Fourie, Leroux, Nishikawa, Hiroshi, Rakhorst, Hinne, Schmidt, Andreas, Kuoraite, Dalia, Bulstrode, Neil, and Dunaway, David
- Subjects
MICROCIRCULATION disorders ,FACIAL abnormalities ,CEREBRAL revascularization ,SURGICAL flaps ,TISSUE culture - Published
- 2016
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37. A Comparison of Geometric Morphometrics to Linear Morphometrics in Craniofacial Surgical Planning for Apert Syndrome.
- Author
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Farooq, Saadia, Ponniah, Allan, Anguilla, Frieda, Booth, James, and Dunaway, David
- Subjects
MORPHOMETRICS ,ONTOGENY ,FACIAL abnormalities ,APERT syndrome ,CRANIOSYNOSTOSES - Published
- 2016
- Full Text
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38. Spring Assisted Cranioplasty for the Correction of Non-Syndromic Scaphocephaly: A Quantitative Analysis of 100 consecutive cases.
- Author
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Rodgers, Will, Glass, Graeme, Tahim, Arpan, Ponniah, Allan, Schievano, Silvia, Borghi, Alessandro, James, Gregory, O’Hara, Justine, Dunaway, David, and Jeelani, Owase
- Subjects
QUANTITATIVE research ,CRANIOSYNOSTOSES ,MEDICAL care ,RETROSPECTIVE studies ,SURGICAL complications - Published
- 2016
- Full Text
- View/download PDF
39. Transcutaneous reconstructive lateral canthal anchoring for craniofacial surgery.
- Author
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Potgieter, Anton, Marucci, Damian D., and Dunaway, David J.
- Published
- 2011
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40. Assessing the corrective effects of facial bipartition distraction in Apert syndrome using geometric morphometrics.
- Author
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Crombag, Genevieve A.J.C., Verdoorn, Melanie H.A.S., Nikkhah, Dariush, Ponniah, Allan J.T., Ruff, Clifford, and Dunaway, David
- Abstract
Summary: Apert syndrome is a congenital disorder characterized by craniosynostosis and midface hypoplasia. This study looks to identify to what extent bipartition distraction corrects the morphological abnormalities of this condition. Preoperative and postoperative three-dimensional computed tomography (3DCT) scans of 10 patients with Apert syndrome (12–21 years) were identified from the Great Ormond Street Hospital database. To analyse preoperative and postoperative scans, 98 landmarks and 13 normal skulls were used. Principal component analysis (PCA) was used to analyse patterns in the datasets. Within each group, eigenvectors were identified that demonstrated the aspects of the skull where most variations were found. The analysis allowed both global shape measurement and local proportions. Postoperative and normal scans both showed the same first three principal components. Warping from preoperative to postoperative illustrates midface advancement and inward rotation of the orbits. Postoperative to normal warps demonstrate some remaining differences. The reliability of the used land marks varied between 77% and 95% for the highly reproducible landmarks between the two observers. 95% versus 100% were at least acceptable reproducible landmarks. This study allows us to understand the way bipartition distraction corrects the abnormalities of the Apert skull. Analysing the surgical outcome of facial bipartition with geometric morphometrics shows that some major Apert characteristics are corrected. Using the data and the output of further studies, surgical procedures can be adapted in order to achieve a postoperative result closer to the normal population. Level of evidence: Therapeutic clinical question Level IV. [Copyright &y& Elsevier]
- Published
- 2014
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41. Craniofacial disorders that have phenotypic overlap with Treacher Collins syndrome.
- Author
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Green, Ben, Nikkhah, Dariush, Cobb, Alistair R.M., and Dunaway, David J.
- Published
- 2013
- Full Text
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42. The surgical management of severe macroglossia in systemic AL amyloidosis.
- Author
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Cobb, Alistair R.M., Boyapati, Raghu, Walker, Donald Murray, Dunaway, David J., and Lloyd, Timothy W.
- Subjects
AMYLOIDOSIS treatment ,ABNORMAL proteins ,AMYLOID ,TISSUES ,TONGUE surgery ,MAXILLOFACIAL surgery ,SURGERY - Abstract
Abstract: Amyloidosis is a disease characterised by the deposition in body tissues of amyloid: abnormal protein in a beta pleated sheet formation. It is a systemic disorder and macroglossia may be seen in all forms. Changes to the normal architecture of the tissues and systemic features of the disease and its underlying cause can complicate the surgical management of the enlarged tongue. [Copyright &y& Elsevier]
- Published
- 2013
- Full Text
- View/download PDF
43. Re: Craniofacial development: current concepts in the molecular basis of Treacher Collins syndrome.
- Author
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Green, Ben, Nikkhah, Dariush, Cobb, Alistair R.M., and Dunaway, David J.
- Published
- 2013
- Full Text
- View/download PDF
44. Congenital malignant rhabdoid tumor of the scalp.
- Author
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Cobb, Alistair R.M., Sebire, Neil J., Anderson, John, and Dunaway, David
- Subjects
SCALP tumors ,CENTRAL nervous system ,HISTOPATHOLOGY ,SURGICAL excision ,DIFFERENTIAL diagnosis ,CANCER chemotherapy - Abstract
Abstract: Background: Malignant rhabdoid tumors (MRT) are rare but aggressive tumors presenting in the pediatric population. First thought a variant of Wilms’ tumor in the kidney, it is recognized as presenting at renal, central nervous system and other extra-renal primary sites. It is uniformly of very poor prognosis, however. Case report and discussion: We present a case of congenital MRT of the scalp, which we believe to be the first described at this site. The clinical and histopathological features of the tumor are discussed in light of the current literature on MRT at other sites. The bleak prognosis at this site appears to be no different from others – the child succumbed at 10months old despite surgical resection and initial excellent response to chemotherapy. Conclusion: Malignant rhabdoid tumor has a very poor prognosis and needs to be considered in the differential diagnosis of similar lesions by clinicians involved in pediatric head and neck care. [Copyright &y& Elsevier]
- Published
- 2012
- Full Text
- View/download PDF
45. Bone sutures—prevention of vertical height gain in midface distraction during callus formation.
- Author
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Cobb, Alistair R.M., Lloyd, Timothy E., and Dunaway, David J.
- Published
- 2012
- Full Text
- View/download PDF
46. Butterfly reconstruction of the anterior scalp hairline using bilaterally apposing STA island flaps.
- Author
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Cobb, Alistair R.M., Ghali, Shadi, and Dunaway, David J.
- Subjects
SCALP ,SURGICAL flaps ,CHILDHOOD cancer ,SCALP tumors ,TUMOR surgery ,HAIR physiology ,SURGICAL excision ,ARTERIAL surgery ,SURGERY - Abstract
Summary: Traditional methods of reconstruction of the hair-bearing scalp can provide incorrect directional hair growth and may require secondary procedures to complete. We present a case of reconstruction of the anterior hairline after tumour resection in an infant. Lessons learned from the case have led to a novel method for a single stage reconstruction of the anterior hairline using pedicled superficial artery flaps. [Copyright &y& Elsevier]
- Published
- 2012
- Full Text
- View/download PDF
47. Unilateral isolated frontosphenoidal craniosynostosis causing frontal plagiocephaly.
- Author
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Marucci, Damian D., Jones, Barry M., Dunaway, David J., and Hayward, Richard D.
- Subjects
CRANIOSYNOSTOSES ,CASE studies ,CHILDREN ,MEDICAL radiology ,SKULL abnormalities ,CRANIOLOGY ,DIAGNOSIS ,ANTHROPOMETRY - Abstract
Summary: Synostotic frontal plagiocephaly is most commonly caused by frontoparietal (unicoronal) synostosis, but may be caused by other fusions along the coronal hemiring. Frontosphenoidal synostosis is a rare cause of frontal plagiocephaly, with only five previously reported cases. We present the case of an 8-month-old male infant with frontal plagiocephaly caused by unilateral isolated frontosphenoidal synostosis mimicking frontoparietal (unicoronal) synostosis. The clinical and radiological features included flattened ipsilateral forehead, retruded ipsilateral maxilla, a midline chin, contralateral deviation of the nasal root and endocranial base, and anomalies of the bony orbit. Unilateral isolated frontosphenoidal synostosis may be misdiagnosed as unicoronal synostosis. Careful physical and radiological assessment is necessary to recognise this synostotic disorder of the coronal hemiring. [Copyright &y& Elsevier]
- Published
- 2009
- Full Text
- View/download PDF
48. Long-term experience with methylmethacrylate cranioplasty in craniofacial surgery.
- Author
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Dunaway, David J.
- Published
- 2008
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49. Spring assisted cranioplasty: A patient specific computational model.
- Author
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Borghi, Alessandro, Rodriguez-Florez, Naiara, Rodgers, Will, James, Gregory, Hayward, Richard, Dunaway, David, Jeelani, Owase, and Schievano, Silvia
- Subjects
- *
FINITE element method , *BIOMECHANICS , *MEDICAL imaging systems , *THREE-dimensional imaging , *COMPUTED tomography , *COMPUTER-assisted image analysis (Medicine) - Abstract
Implantation of spring-like distractors in the treatment of sagittal craniosynostosis is a novel technique that has proven functionally and aesthetically effective in correcting skull deformities; however, final shape outcomes remain moderately unpredictable due to an incomplete understanding of the skull-distractor interaction. The aim of this study was to create a patient specific computational model of spring assisted cranioplasty (SAC) that can help predict the individual overall final head shape. Pre-operative computed tomography images of a SAC patient were processed to extract a 3D model of the infant skull anatomy and simulate spring implantation. The distractors were modeled based on mechanical experimental data. Viscoelastic bone properties from the literature were tuned using the specific patient procedural information recorded during surgery and from x-ray measurements at follow-up. The model accurately captured spring expansion on-table (within 9% of the measured values), as well as at first and second follow-ups (within 8% of the measured values). Comparison between immediate post-operative 3D head scanning and numerical results for this patient proved that the model could successfully predict the final overall head shape. This preliminary work showed the potential application of computational modeling to study SAC, to support pre-operative planning and guide novel distractor design. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
50. Adverse events of local treatment in long-term head and neck rhabdomyosarcoma survivors after external beam radiotherapy or AMORE treatment.
- Author
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Schoot, Reineke A., Slater, Olga, Ronckers, Cécile M., Zwinderman, Aeilko H., Balm, Alfons J.M., Hartley, Benjamin, van den Brekel, Michiel W., Gupta, Sanjeev, Saeed, Peerooz, Gajdosova, Eva, Pieters, Bradley R., Gaze, Mark N., Mandeville, Henry C., Fajardo, Raquel Davila, Chang, Yen Ch’ing, Gains, Jennifer E., Strackee, Simon D., Dunaway, David, Abela, Christopher, and Mason, Carol
- Subjects
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HEAD tumors , *NECK tumors , *AGE distribution , *CANCER patients , *DIFFUSION of innovations , *HEALTH care teams , *PATIENT aftercare , *RADIOISOTOPE brachytherapy , *RADIOTHERAPY , *RHABDOMYOSARCOMA , *OPERATIVE surgery , *PLASTIC surgery , *SURVIVAL , *PATIENT selection , *ADVERSE health care events , *TUMOR treatment - Abstract
Background Radiotherapy is a well-known cause of adverse events (AEs). To reduce AEs, an innovative local treatment was developed in Amsterdam: A blative surgery, MO uld brachytherapy and surgical RE construction (AMORE). Aims: (1) to determine the prevalence of AEs in HNRMS survivors and (2) to compare AEs between survivors treated with the international standard: external beam radiotherapy (EBRT-based: London) and survivors treated with AMORE if feasible, otherwise EBRT (AMORE-based: Amsterdam). Methods All HNRMS survivors, treated in London or Amsterdam between January 1990 and December 2010 ( n = 153), and alive ⩾2 years post-treatment were eligible ( n = 113). A predefined list of AEs was assessed in a multidisciplinary clinic and graded according to the Common Terminology Criteria for Adverse Events. Results Eighty HNRMS survivors attended the clinic (median follow-up 10.5 years); 63% experienced ⩾1 severe or disabling event, and 76% had ⩾5 AEs (any grade). Survivors with EBRT-based treatment were, after adjustment for site, age at diagnosis, and follow-up duration, at increased risk to develop any grade 3/4 event or ⩾5 AEs (any grade) compared with survivors with AMORE-based treatments ( p = 0.032 and 0.01, respectively). Five year overall survival (source population) after EBRT-based treatment was 75.0%, after AMORE-based treatment 76.9%, p = 0.56. Conclusion This study may serve as a baseline inventory and can be used in future studies for prospective assessments of AEs following the introduction of novel local treatment modalities. AMORE-based local treatment resulted in similar overall survival and a reduction of AEs secondary to local treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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