1. Regions in beta-chemokine receptors CCR5 and CCR2b that determine HIV-1 cofactor specificity
- Author
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Rucker, Joseph, Samson, Michel, Doranz, Benjamin J., Libert, Frederick, Berson, Joanne F., Yi, Yanjie, Smyth, Robert J., Collman, Ronald G., Broder, Christopher C., Vassart, Gilbert, Doms, Robert W., and Parmentier, Marc
- Subjects
HIV infection -- Genetic aspects ,Viruses -- Receptors ,Membrane fusion -- Genetic aspects ,Biological sciences - Abstract
The beta-chemokine receptors CCR5 and CCR2b are the cofactors for entry of M-tropic viruses into cells. Previous studies have reported that M-tropic trains are more sensitive to substitutions in the regions of CCR5 than CCR2b. To understand the molecular basis of CCR5 usage in viral tropism, chimeric molecules of both CCR5 and CCR2b were constructed and regions involved in cofactor utilization by HIV-1 strains were mapped. The chimeras showed that the amino terminus and the first extracellular loop of CCR5 contribute to enhancing the entry of HIV-1 cofactors into the cell.
- Published
- 1996