Search

• Highly accurate and efficient analytical instability boundaries are derived and validated. • The parametric resonances of difference type do not exist. • The effects of anisotropy in bearing supports on rotor instability are determined. • Anisotropy leads to interactions within a single whirl mode or between two whirl modes. Ensuring rotor stability is a major concern in engineering, as instabilities can lead to catastrophic failures. Existing literature shows that anisotropic boundary conditions significantly affect the parametric instability characteristics of rotors under periodical axial loads. However, there is little literature systematically analyzing the formation mechanism of parametric resonance under these boundary conditions or providing a detailed classification of the parametric instability regions. Therefore, this paper presents a comprehensive parametric instability analysis of a rotor subjected to periodic axial loads under anisotropic boundary conditions. A novel approach based on the multiple scales method is proposed to address anisotropy in the boundary conditions. Using this approach, the analytical boundaries of the parametric instability regions are derived, and a proof regarding the absence of certain parametric resonances is presented. These analytical solutions are validated by numerical results obtained from the discrete transition matrix method, which form the basis for systematically investigating the effects of anisotropy in direct or cross-coupling stiffness/damping coefficients on the rotor instability. The key scientific contributions of this work include: Deriving analytical instability boundaries, providing a more efficient alternative to purely numerical methods while maintaining high accuracy; Demonstrating the absence of parametric resonance of difference type under both isotropic or anisotropic boundary conditions; Discovering that anisotropy in stiffness coefficients can induce self-interaction within a given forward or backward whirl mode, as well as interaction between two forward or two backward whirl modes, leading to additional instability regions; Reducing anisotropy in direct damping coefficients may increase critical dynamic load coefficients, potentially enhancing rotor safety; If the cross-coupling stiffness coefficients exceed the threshold for triggering intrinsic instability, the rotor may become unstable in all operating conditions. All these findings offer insights into the stability management of rotors under various operating conditions and provide valuable guidance for designing and operating safer, more efficient rotor systems. [Display omitted] [ABSTRACT FROM AUTHOR]

Abstract Aims Ovarian cancer is the most leading cause of deaths among gynecologic malignancies, and Neuron-restrictive silencer factor (NRSF) can be upregulated or downregulated according to the type of tumor. However, the expression and function of NRSF in ovarian cancer is still unknown. Main methods Expression of NRSF in normal ovary and ovarian cancer cells were evaluated by quantitative PCR (qPCR). NRSF expression in normal ovary and ovarian cancer tissue samples were examined by qPCR, western blotting and immunohistochemistry (IHC). MTT, colony formation, anchorage-independent growth assay were applied to examine the effect of NRSF on ovarian cancer cell proliferation. Bromodeoxyuridine (BrdUrd) labeling and flow cytometry assay were carried out to investigate the role of NRSF on cell cycle of ovarian cancer cells. Luciferase reporter assay and western blotting, immunofluorescence labeling were devoted to explore the mechanism by which NRSF contributes to proliferation of ovarian cancer cells. Key findings The results demonstrated that NRSF is significantly upregulated in ovarian cancer cells and tissues and negatively related with the survival of patients with ovarian cancer, and knockout of NRSF inhibit proliferation of ovarian cancer cells. Further analysis showed that NRSF can influence G1/S transition of cell cycle via regulating the transcription of Hippo pathway. Significance Herein, our study suggest that NRSF is associated with the progression of ovarian cancer, and NRSF may be a valuable early detection marker of ovarian cancer and inhibiting NRSF expression may be an effective method to treat ovarian cancer. [ABSTRACT FROM AUTHOR]