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Start Over Author "De Nicola S." Publisher elsevier b.v.
73 results on '"De Nicola S."'

6. Performance of the model for end-stage liver disease score for mortality prediction and the potential role of etiology

Author

D'Amico, G, Maruzzelli, L, Airoldi, A, Petridis, I, Tosetti, G, Rampoldi, A, D'Amico, M, Miraglia, R, De Nicola, S, La Mura, V, Solcia, M, Volpes, R, Perricone, G, Sgrazzutti, C, Vanzulli, A, Primignani, M, Luca, A, Malizia, G, Federico, A, Dallio, M, Andriulli, A, Iacobellis, A, Addario, L, Garcovich, M, Gasbarrini, A, Chessa, L, Salerno, F, Gobbo, G, Merli, M, Ridola, L, Baroni, G, Tarantino, G, Caporaso, N, Morisco, F, Pozzoni, P, Colli, A, Belli, L, D'Amico, Gennaro, Maruzzelli, Luigi, Airoldi, Aldo, Petridis, Ioannis, Tosetti, Giulia, Rampoldi, Antonio, D'Amico, Mario, Miraglia, Roberto, De Nicola, Stella, La Mura, Vincenzo, Solcia, Marco, Volpes, Riccardo, Perricone, Giovanni, Sgrazzutti, Cristiano, Vanzulli, Angelo, Primignani, Massimo, Luca, Angelo, Malizia, Giuseppe, Federico, Alessandro, Dallio, Marcello, Andriulli, Angelo, Iacobellis, Angelo, Addario, Luigi, Garcovich, Matteo, Gasbarrini, Antonio, Chessa, Luchino, Salerno, Francesco, Gobbo, Giulia, Merli, Manuela, Ridola, Lorenzo, Baroni, Gianluca Svegliati, Tarantino, Giuseppe, Caporaso, Nicola, Morisco, Filomena, Pozzoni, Pietro, Colli, Agostino, Belli, Luca Saverio, D'Amico, G, Maruzzelli, L, Airoldi, A, Petridis, I, Tosetti, G, Rampoldi, A, D'Amico, M, Miraglia, R, De Nicola, S, La Mura, V, Solcia, M, Volpes, R, Perricone, G, Sgrazzutti, C, Vanzulli, A, Primignani, M, Luca, A, Malizia, G, Federico, A, Dallio, M, Andriulli, A, Iacobellis, A, Addario, L, Garcovich, M, Gasbarrini, A, Chessa, L, Salerno, F, Gobbo, G, Merli, M, Ridola, L, Baroni, G, Tarantino, G, Caporaso, N, Morisco, F, Pozzoni, P, Colli, A, Belli, L, D'Amico, Gennaro, Maruzzelli, Luigi, Airoldi, Aldo, Petridis, Ioannis, Tosetti, Giulia, Rampoldi, Antonio, D'Amico, Mario, Miraglia, Roberto, De Nicola, Stella, La Mura, Vincenzo, Solcia, Marco, Volpes, Riccardo, Perricone, Giovanni, Sgrazzutti, Cristiano, Vanzulli, Angelo, Primignani, Massimo, Luca, Angelo, Malizia, Giuseppe, Federico, Alessandro, Dallio, Marcello, Andriulli, Angelo, Iacobellis, Angelo, Addario, Luigi, Garcovich, Matteo, Gasbarrini, Antonio, Chessa, Luchino, Salerno, Francesco, Gobbo, Giulia, Merli, Manuela, Ridola, Lorenzo, Baroni, Gianluca Svegliati, Tarantino, Giuseppe, Caporaso, Nicola, Morisco, Filomena, Pozzoni, Pietro, Colli, Agostino, and Belli, Luca Saverio

Abstract

Although discrimination of the model for end stage liver disease (MELD) is generally considered acceptable, its calibration is still unclear. In a validation study, we assessed the discrimination and calibration performance of 3 versions of the model: original MELD-TIPS, used to predict survival after transjugular intra-hepatic portosystemic shunt (TIPS); classic MELD-Mayo; MELD-UNOS, used by United Network for Organ Sharing (UNOS). Recalibration and model updating were also explored.

Published
2021

15. Myosteatosis is not associated with complications or survival in HCC patients undergoing transarterial embolization.

Author

Masetti, C., Pugliese, N., Lofino, L., Colapietro, F., Ceriani, R., Lleo, A., Poretti, D., Pedicini, V., De Nicola, S., Torzilli, G., Rimassa, L., Aghemo, A., and Lanza, E.

Abstract

Alterations in nutritional and metabolic status, in particular sarcopenia, have been extensively associated with a poor prognosis in cirrhotic patients regardless of the etiology of liver disease. Less is known about predictive value of myosteatosis, defined as pathological fat infiltration into the skeletal muscle, in this context. We retrospectively analyzed a cohort of 151 cirrhotic patients with unresectable hepatocellular carcinoma (HCC) who underwent their 1st trans-arterial embolization (TAE) between March 1st 2011 and July 1st 2019 in our Institution. Demographic, clinical and biochemical data were collected. Sarcopenia was assessed using the L3-SMI method. We calculated myosteatosis with a dedicated segmentation suite (3D Slicer), using a single slice at an axial plane located at L3 and calculating the IMAC (Intramuscular Adipose Tissue Content Index). The sex-specific cut-off values for defining myosteatosis were IMAC > -0.44 in male and > -0.31 in female. In our cohort of 151 patients, 115 (76%) patients were included in the myosteatosis group; 128 (85%) patients had a coexistent diagnosis of sarcopenia. Patients with myosteatosis were significantly older and showed higher BMI than patients without myosteatosis: male gender and alcoholic or metabolic-related cirrhosis were most represented in the myosteatosis group. Myosteatosis was not associated with different HCC burden, length of hospitalization, complication rates and readmission in the first 30 days after discharge. Overall survival was not influenced by the presence of myosteatosis. Myosteatosis didn't significantly affect the main outcomes of cirrhotic patients with HCC undergoing locoregional treatments. [ABSTRACT FROM AUTHOR]

Published
2023
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20. High Incidence of sepsis caused by MDR bacteria in patients undergoing Percutaneous biliary drainage for the treatment of biliary obstruction.

Author

De Nicola, S., Cento, V., Fortunato, M., Masetti, C., Colapietro, F., Pugliese, N., Ceriani, R., Bianchi, I., Pedicini, V., Lanza, E., Torzilli, G., Lleo, A., and Aghemo, A.

Abstract

Percutaneous biliary drainage (PTBD) is indicated in the management of jaundice and cholangitis caused by biliary obstructions. In an era of increasing prevalence of multidrug resistant (MDR) bacteria the risk of post-PTBD infection is not well established. The aim of our study was to assess the prevalence of post PTBD sepsis driven by MDR bacteria and to identify clinical and epidemiological variables associated with MDR Bacteria. We retrospectively collected data of all consecutive patients who underwent PTBD in our Hospital from January 2015 to January 2020.We recorded the overall incidence of post-procedural sepsis and analyzed various clinical features for their contribution to MDR-sepsis incidence using multivariate linear regression analysis. A total of 99 PTBD were performed in 73 patients during the selected period. The most frequent etiology of biliary obstruction was malignant: Cholangiocarcinoma in 40(54%), Hepatocellular Carcinoma(HCC) in 10(13%) and biliary involvement from other neoplasms in 15 (20%). The median age was 68(range 31-86), male sex was predominant (61%) with 23% of patients having a concomitant chronic liver disease. The majority of patients received cancer treatment prior to PTBD (surgery in 36%, chemotherapy 27%, locoregional treatment in 19%, radiotherapy 19%). Twenty-nine patients (39%) had at baseline a bacterial cholangitis, with only 1 patient infected by a MDR micro-organism prior to PTBD. After PTBD 34/73 (46%) patients developed sepsis, in 9 cases (9/34,26%) was caused by MDR bacteria(5 ESBL, 2 Amp-C, 2 VRE). At multivariate analysis the only risk factors associated with MDR sepsis were previous local radiotherapy (p=0.01) and baseline AST value (p=0.009). Post PTBD sepsis is frequent in patients undergoing treatment of biliary obstruction. MDR sepsis was found mostly in patients who underwent radiotherapy and had high AST values. Further studies to assess the need for pre PTBD screening for MDR colonization are warranted [ABSTRACT FROM AUTHOR]

Published
2023
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22. Profile measurement of a one-dimensional phase boundary sample using a single shot phase-step method

Author

de Angelis, M., De Nicola, S., Ferraro, P., Finizio, A., Grilli, S., and Pierattini, G.

Subjects
*OPTICAL measurements, *PHASE shift (Nuclear physics), *SCATTERING (Physics), *INTERFEROMETRY
Abstract

Abstract: Phase shifting interferometry is a preferred technique for high-resolution phase profile measurement, but the difficulty in generating the requested shifted pattern has limited the use of the technique to low-noise environment and in case accurate calibration of the phase shifting device is available. In the present experiment, a sample having one-dimensional straight phase boundary is mounted in one arm of an interferometer. One single image of the fringe pattern is recorded, a simple image process is applied generating phase shifted patterns from the original image. Using the appropriate phase shift algorithms, a phase map of the sample is obtained which gives a quantitative measurement of the topographical structure with the resolution of the phase shift method but a single shot recorded pattern. [Copyright &y& Elsevier]

Published
2005
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