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Your search keyword '"Criscuolo, Elena"' showing total 6 results
Start Over Author "Criscuolo, Elena" Publisher elsevier b.v.
6 results on '"Criscuolo, Elena"'

2. A spatial multi-scale fluorescence microscopy toolbox discloses entry checkpoints of SARS-CoV-2 variants in Vero E6 cells

Author

Storti, Barbara, Quaranta, Paola, Di Primio, Cristina, Clementi, Nicola, Mancini, Nicasio, Criscuolo, Elena, Spezia, Pietro Giorgio, Carnicelli, Vittoria, Lottini, Giulia, Paolini, Emanuele, Freer, Giulia, Lai, Michele, Costa, Mario, Beltram, Fabio, Diaspro, Alberto, Pistello, Mauro, Zucchi, Riccardo, Bianchini, Paolo, Signore, Giovanni, and Bizzarri, Ranieri

Published
2021
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6. Novel therapeutic investigational strategies to treat severe and disseminated HSV infections suggested by a deeper understanding of in vitro virus entry processes.

Author

Clementi, Nicola, Criscuolo, Elena, Cappelletti, Francesca, Burioni, Roberto, Clementi, Massimo, and Mancini, Nicasio

Subjects
*HERPES simplex treatment, *SEVERITY of illness index, *VIRUS reactivation, *ANTIVIRAL agents, *VIROLOGY, *DRUG development
Abstract

The global burden of herpes simplex virus (HSV) legitimates the critical need to develop new prevention strategies, such as drugs and vaccines that are able to fight either primary HSV infections or reactivations. Moreover, the ever-growing number of patients receiving transplants increases the number of severe HSV infections that are unresponsive to current therapies. Finally, the high global incidence of genital HSV-2 infection increases the risk of perinatal transmission to newborns, in which disseminated infection or central nervous system (CNS) involvement is frequent, with associated high morbidity and mortality rates. There are several key features shared by novel anti-HSV drugs, from currently available optimized drugs to small molecules able to interfere with various virus replication steps. However, several virological aspects of the disease and associated clinical needs highlight why an ideal anti-HSV drug has yet to be developed. [ABSTRACT FROM AUTHOR]

Published
2016
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