5 results on '"Cirtiu, Ciprian Mihai"'
Search Results
2. Whole blood metal ion measurement reproducibility between different laboratories.
- Author
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Rahmé, Michel, Lavigne, Martin, Barry, Janie, Cirtiu, Ciprian Mihai, Bélanger, Patrick, and Vendittoli, Pascal-André
- Abstract
Monitoring patients' metal ion blood concentrations can be useful in cases of problematic metal on metal hip implants. Our objective was to evaluate the reproducibility of metal ion level values measured by two different laboratories. Whole blood samples were collected in 46 patients with metal on metal hip arthroplasty. For each patients, two whole blood samples were collected and analyzed by two laboratories. Laboratory 1 had higher results than laboratory 2. There was a clinically significant absolute difference between the two laboratories, above the predetermined threshold, 35% of Cr samples and 38% of Co samples. All laboratories do not use the same technologies for their measurements. Therefore, decision to revise a metal on metal hip arthroplasty should rely on metal ion trends and have to be done in the same laboratory. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
3. Biological monitoring of exposure to rare earth elements and selected metals in the Inuit population of Nunavik, Canada.
- Author
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Cirtiu, Ciprian Mihai, Valcke, Mathieu, Gagné, Michelle, Bourgault, Marie-Hélène, Narame, Céline, Gadio, Souleymane, Poulin, Patrick, and Ayotte, Pierre
- Subjects
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RARE earth metals , *CANADIAN Inuit , *BIOLOGICAL monitoring , *URANIUM , *METALS , *LANTHANUM - Abstract
In Nunavik (Northern Quebec, Canada), some mining projects are envisioned, that could increase the contamination of the environment by various chemicals, including rare earth elements (REEs), and implicitly Inuit population exposure. The objective of this study was to determine the baseline biological exposure of the population to these elements, before the potential mining development occurs. In the framework of the 2017 Qanuilirpitaa ? Inuit health survey, urine samples were obtained from a representative sample of the adult Nunavik population, which were used to constitute 30 pooled samples according to age, sex and Nunavik subregions. Pooled samples were analyzed using sensitive and accurate methods involving ICP-MS platforms to quantify urinary concentrations of 17 REEs and 7 elements of interest in Nunavik (arsenic, antimony, chromium, cobalt, nickel, thallium and uranium). REEs were mostly not detected in pooled samples from this population. Detectable concentrations were found in some samples for cerium (range: 0.5–0.7 nmol/L; 27% > method detection limit (MDL) and lanthanum (range: 0.2–0.4 nmol/L; 33% > MDL). As for the other elements of interest, antimony, arsenic, cobalt and thallium were detected in 100% of the samples, whereas chromium and nickel were detected in 83% and 80% of the samples, respectively. Concentrations of arsenic (geometric mean (GM) = 0.5 μmol/L) and cobalt (GM = 5.2 nmol/L) were greater than in the general Canadian population; the opposite was observed for nickel (GM = 8.9 nmol/L). Arsenic concentrations increased significantly with age, whereas the opposite trend was observed for nickel and thallium. In this first biomonitoring study focusing on REEs and carried out in a representative sample of the Nunavik population, we found no evidence of significant exposure from pooled samples analysis. These results could eventually be used as baseline values in future studies aiming to assess temporal trends of exposure to REEs. • Urine samples from the Inuit population of Nunavik were pooled according to subregion, sex and age. • Rare earth elements were measured using our newly-developed ICP-MS/MS method. • Cerium and lanthanum were detected in ≈30% of the pooled samples, mostly from the Ungava Bay region. • As, Co, Cr, Ni, Sb and Tl were measured in most pooled samples (≥80%). [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
4. Maternal and fetal exposure to cadmium, lead, manganese and mercury: The MIREC study.
- Author
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Arbuckle, Tye E., Liang, Chun Lei, Morisset, Anne-Sophie, Fisher, Mandy, Weiler, Hope, Cirtiu, Ciprian Mihai, Legrand, Melissa, Davis, Karelyn, Ettinger, Adrienne S., and Fraser, William D.
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EXPOSURE therapy , *PHYSIOLOGICAL effects of cadmium , *PHYSIOLOGICAL effects of lead , *PHYSIOLOGICAL effects of manganese , *PHYSIOLOGICAL effects of mercury , *FETUS , *TOXINS , *CORD blood - Abstract
Given the susceptibility of the fetus to toxicants, it is important to estimate their exposure. Approximately 2000 pregnant women were recruited in 2008–2011 from 10 cities across Canada. Cd, Pb, Mn and total Hg were measured in maternal blood from the 1st and 3rd trimesters, umbilical cord blood, and infant meconium. Nutrient intakes of vitamin D, iron, and calcium (Ca) were assessed using a food frequency questionnaire and a dietary supplement questionnaire. Median concentrations in 1st trimester maternal blood (n = 1938) were 0.20, 8.79 and 0.70 μg/L for Cd, Mn and Hg, respectively, and 0.60 μg/dL for Pb. While the median difference between the paired 1st and 3rd trimester concentrations of Cd was 0, there was a significant decrease in Pb (0.04 μg/dL) and Hg (0.12 μg/L) and an increase in Mn (3.30 μg/L) concentrations over the course of the pregnancy. While Cd was rarely detected in cord blood (19%) or meconium (3%), median Pb (0.77 μg/dL), Mn (31.87 μg/L) and Hg (0.80 μg/L) concentrations in cord blood were significantly higher than in maternal blood. Significant negative associations were observed between estimated Ca intake and maternal Cd, Pb, Mn and Hg, as well as cord blood Pb. Vitamin D intake was associated with lower maternal Cd, Pb, and Mn as well as Pb in cord blood. Even at current metal exposure levels, increasing dietary Ca and vitamin D intake during pregnancy may be associated with lower maternal blood Pb and Cd concentrations and lower Pb in cord blood. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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5. Nanoparticles in electrochemical sensors for environmental monitoring
- Author
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Rassaei, Liza, Marken, Frank, Sillanpää, Mika, Amiri, Mandana, Cirtiu, Ciprian Mihai, and Sillanpää, Markus
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NANOPARTICLES , *ELECTROCHEMICAL sensors , *ENVIRONMENTAL monitoring , *ANALYTICAL chemistry , *POLLUTANTS , *MICROFABRICATION , *SUSTAINABLE chemistry - Abstract
Abstract: We review the state-of-the-art application of nanoparticles (NPs) in electrochemical analysis of environmental pollutants. We summarize methods for preparing NPs and modifying electrode surfaces with NPs. We describe several examples of applications in environmental electrochemical sensors and performance in terms of sensitivity and selectivity for both metal and metal-oxide NPs. We present recent trends in the beneficial use of NPs in constructing electrochemical sensors for environmental monitoring and discuss future challenges. NPs have promising potential to increase competitiveness of electrochemical sensors in environmental monitoring, though research has focused mainly on development of methodology for fabricating new sensors, and the number of studies for optimizing the performance of sensors and the applicability to real samples is still limited. [Copyright &y& Elsevier]
- Published
- 2011
- Full Text
- View/download PDF
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