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The CHADS 2 and CHA 2 DS 2 -VASc scores are well-established clinical scales to estimate the risk of stroke in patients with atrial fibrillation (AF). However, the predictive power of the two scales concerning left atrial thrombus (LAT) or spontaneous echo contrast (SEC) has not been well investigated. Therefore, we investigated the predict power of CHADS 2 and CHA 2 DS 2 -VASc scores concerning LAT/SEC; identified clinical, echocardiographic and laboratory predictors of LAT/SEC in addition to the CHADS 2 and CHA 2 DS 2 -VASc scores; and derived a new scale to predict LAT/SEC accurately, it might improve thromboembolic risk stratification in patients with nonvalvular atrial fibrillation. We identified 1102 consecutive AF patients who underwent transesophageal echocardiography (TEE) for the purpose of the exclusion of LAT before catheter ablation, cardioversion or left atrial appendage occlusion. The clinical, echocardiographic and laboratory characteristics of patients were collected from the electronic medical record system. In the study, the prevalence of LAT/SEC was only 4.36%. In the multivariate logistic analysis, hypertension, left atrial enlargement, prior stroke/TIA, left ventricular dysfunction, and renal dysfunction were predictors of LAT/SEC. Receiver operating characteristic curve analysis showed that c-statistics of the CHADS 2 and CHA 2 DS 2 -VASc scores concerning LAT/SEC were 0.673 and 0.643, respectively. We derived a new scale composed of variables from the multivariate logistic analysis that showed a higher c-statistic value (0.761) than the CHADS 2 and CHA 2 DS 2 -VASc scores for the prediction of LAT/SEC. In our cohort, we found two variables not included in the CHA 2 DS 2 -VASc score (renal dysfunction, left atrial enlargement) were independent predictors of LAT/SEC. A new scale combining clinical, echocardiographic and laboratory predictors might improve thromboembolic risk stratification. And there is a great need to carry out a new prospective and multicenter study, with a population more homogenous and including all the determinants for LAT/SEC to establish the independent degree of each variable and the applicability in clinical practice, facilitating the emergence of a new score of thromboembolic risk in patients with nonvalvular atrial fibrillation. • The predictive power of CHA 2 DS 2 -VASc score concerning left atrial thrombus or spontaneous echo contrast is relatively low. • Many echocardiographic and laboratory factors may also predictors of left atrial thrombus or spontaneous echo contrast in AF patients. • A new scale combining clinical, echocardiographic and laboratory predictors might improve thromboembolic risk stratification. [ABSTRACT FROM AUTHOR]

• TRPV2 was up-regulated in pulmonary hypertension. • Insights on pulmonary hypertension-induced atrial fibrillation. • TRPV2 inhibition prevented atrial remodeling in pulmonary hypertension. Atrial fibrillation (AF) is common in pulmonary hypertension (PH), whereas the mechanisms and treatments remain to be explored. TRPV2 regulates the structure and function of the cardiovascular system; however, little attention has been given to its role in AF. This study was to determine whether TRPV2 was involved in PH-induced AF and the effects of TRPV2 inhibitor tranilast on AF in rat models of PH. Monocrotaline (MCT) and SU5416/hypoxia (SuHx)-induced PH models were performed to detect atrial electrophysiological parameters. Daily tranilast (a TRPV2 inhibitor) or saline was given starting 1 day before PH establishment. PH increased the susceptibility to AF, with TRPV2 up-regulated in the right atria. Compared to PH rats, tranilast reduced AF inducibility and the prolongations of ERP and APD; mitigated cardiopulmonary remodeling and the increases in P-wave duration and P-R interval; partially reversed the down-regulation of ion channels such as Cav1.2, Nav1.5, Kv4.3, Kv4.2, Kv1.5, Kir2.1, Kir3.1, Kir3.4 as well as connexin (Cx) 40 and Cx43; improved right atrial (RA) fibrosis, enlargement, and myocardial hypertrophy; decreased the accumulation of inflammatory cells; down-regulated inflammatory indicators such as TNF-α, IL-1β, CXCL1, and CXCL2; and inhibited the activation of the PI3K-AKT-NF-κB signaling pathway. Our results reveal that TRPV2 participates in PH-induced AF, and TRPV2 inhibitor tranilast prevents PH-induced RA remodeling. TRPV2 might be a promising target for PH-induced AF. [Display omitted] [ABSTRACT FROM AUTHOR]

Gallai's conjecture asserts that a connected graph G on n vertices can be decomposed into ⌈ n 2 ⌉ paths. In this paper, we prove that a connected graph with maximum degree 6, in which the vertices of degree 6 form an independent set, can be decomposed into n 2 paths, unless it is K 3 , K 5 and K 5 −. [ABSTRACT FROM AUTHOR]

Low nitrogen (NUE) and phosphorus (PUE) use efficiencies in food production in China result in large losses of nitrogen (N) and phosphorus (P) to the environment. The Chinese government formulated policies to increase the NUEs and PUEs. Recent policies aim for zero growth in synthetic fertilizer use after 2020 while ensuring food security. In this study we analyzed how current and improved nutrient management in China can affect future nutrient use efficiencies and nutrient losses from food production. The NUEs and PUEs of food production were quantified using the NUFER (NUtrient flows in Food chains, Environment and Resources use) model for 31 provinces and China in 2013, 2020 and 2050. Results show that national NUE (20%) and PUE (24%) in 2013 are low but vary largely among provinces (12–33% for NUE, 10–53% for PUE). The N and P losses to the air (14 Tg year − 1 of N) and waters (12 Tg year − 1 of N, 2 Tg year − 1 of P) are consequently high in 2013. Three scenarios were analyzed for 2020 and 2050 to explore future trends in NUEs and PUEs, assuming Business As Usual ( BAU ) trends, Zero Fertilizer ( ZF ) growth from 2020 , and Improved Nutrient Management ( INM ). In the BAU scenario, the NUEs and PUEs roughly remain at their low 2013 levels, while nutrient inputs to agriculture are increasing. The losses to the air therefore increase by 37% for N and to waters by 40% for N and 48% for P between 2013 and 2050. In the ZF scenario, the NUEs and PUEs are a few percent higher than in BAU . The associated N and P losses to waters are 8–16% lower than in BAU because of increased recycling of manure to cropland, but still higher than in 2013. Improved nutrient management, as assumed in our INM scenario, may increase NUEs and PUEs to 33% and 59% in 2050. Meanwhile, N and P losses to waters in 2050 are 47% and 83% lower than in 2013, and losses of N to the air 20% lower. We conclude that the policy aimed at zero growth in fertilizer use is a good start, but not very effective in reducing nutrient pollution in China. To substantially reduce N and P losses to the environment it is needed to improve nutrient management by not only reducing fertilization without yield losses, but also by improved manure management and animal production with lower nutrient excretion. [ABSTRACT FROM AUTHOR]