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Your search keyword '"Choi, Kyung Hyun"' showing total 111 results
Start Over Author "Choi, Kyung Hyun" Publisher elsevier b.v.
111 results on '"Choi, Kyung Hyun"'

20. Artificial intelligence-assisted repurposing of lubiprostone alleviates tubulointerstitial fibrosis.

Author

Samantasinghar, Anupama, Ahmed, Faheem, Rahim, Chethikkattuveli Salih Abdul, Kim, Kyung Hwan, Kim, Sejoong, and Choi, Kyung Hyun

Abstract

Tubulointerstitial fibrosis (TIF) is the most prominent cause which leads to chronic kidney disease (CKD) and end-stage renal failure. Despite extensive research, there have been many clinical trial failures, and there is currently no effective treatment to cure renal fibrosis. This demonstrates the necessity of more effective therapies and better preclinical models to screen potential drugs for TIF. In this study, we investigated the antifibrotic effect of the machine learning-based repurposed drug, lubiprostone, validated through an advanced proximal tubule on a chip system and in vivo UUO mice model. Lubiprostone significantly downregulated TIF biomarkers including connective tissue growth factor (CTGF), extracellular matrix deposition (Fibronectin and collagen), transforming growth factor (TGF-β) downstream signaling markers especially, Smad-2/3, matrix metalloproteinase (MMP2/9), plasminogen activator inhibitor-1 (PAI-1), EMT and JAK/STAT-3 pathway expression in the proximal tubule on a chip model and UUO model compared to the conventional 2D culture. These findings suggest that the proximal tubule on a chip model is a more physiologically relevant model for studying and identifying potential biomarkers for fibrosis compared to conventional in vitro 2D culture and alternative of an animal model. In conclusion, the high throughput Proximal tubule-on-chip system shows improved in vivo-like function and indicates the potential utility for renal fibrosis drug screening. Additionally, repurposed Lubiprostone shows an effective potency to treat TIF via inhibiting 3 major profibrotic signaling pathways such as TGFβ/Smad, JAK/STAT, and epithelial-mesenchymal transition (EMT), and restores kidney function. [ABSTRACT FROM AUTHOR]

Published
2023
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43. Microphysiological system with continuous analysis of albumin for hepatotoxicity modeling and drug screening.

Author

Asif, Arun, Park, Sung Hyuk, Manzoor Soomro, Afaque, Khalid, Muhammad Asad Ullah, Salih, Abdul Rahim Chattikatikatuveli, Kang, Bohye, Ahmed, Faheem, Kim, Kyung Hwan, and Choi, Kyung Hyun

Subjects
SERUM albumin, HEPATOTOXICOLOGY, VETERINARY drugs, DRUG metabolism, ALBUMINS
Abstract

In microfluidics, the emerging field of microphysiological systems (MPS) is overcoming the challenge of physiological irrelevancy by animal models for drug discovery and development. Liver function is critically influenced by drugs owing to its role in drug metabolism and detoxification. Human serum albumin (HSA) is one of the most important secreted biomarkers which indicate normal liver function. A microfluidic albumin immunosensor was developed to be integrated with liver-on-a-chip MPS for continuous feedback over disease modeling and treatment. A gold-electrode based electrochemical immunosensor was established by anti-HSA antibody immobilization. The liver MPS was found to be efficient for live monitoring of disease modelling and drug treatment over the period of 6 days. The system emulated and analyzed real-time toxicity modeling with HSA sensing. The detection limit of integrated sensor was 1 μg/ml with successive reproducibility. The proposed sensor was also validated with metabolic biomarkers' assays. Molecular assays supported the sensor monitoring and depicted liver injury and recovery. The liver MPS with combined albumin sensor chip may be a promising platform to mimic real-time drug assessment. [ABSTRACT FROM AUTHOR]

Published
2021
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50. Hydrophobicity enhancement of Al2O3 thin films deposited on polymeric substrates by atomic layer deposition with perfluoropropane plasma treatment.

Author

Ali, Kamran, Choi, Kyung-Hyun, Kim, Chang Young, Doh, Yang Hoi, and Jo, Jeongdai

Subjects
*ALUMINUM oxide films, *HYDROPHOBIC compounds, *METALLIC thin films, *POLYMERS, *SUBSTRATES (Materials science), *ATOMIC layer deposition, *PROPANE, *PLASMA chemistry
Abstract

Highlights: [•] Good quality Al2O3 thin films are fabricated on PEN substrates through ALD. [•] Hydrophobicity of Al2O3 films has been enhanced greatly by C3F8 plasma treatment. [•] C3F8 plasma treated films have retained good surface morphology. [•] C3F8 plasma treated films have shown high optical transmittance of more than 90%. [Copyright &y& Elsevier]

Published
2014
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