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Although endovascular therapy demonstrates robust clinical efficacy in acute ischemic stroke (AIS), not all stroke patients benefit from successful reperfusion. This study aimed to evaluate the safety, feasibility, and preliminary efficacy of intra-arterial administration of glyceryl trinitrate (GTN) after endovascular recanalization for neuroprotection. This is a prospective randomized controlled study. Eligible patients were randomized to receive 800 μg GTN or the same volume of normal saline through the catheter after recanalization. The primary outcome was symptomatic intracranial hemorrhage (ICH), while secondary outcomes included mortality, functional outcome, infarction volume, complications, and blood nitrate index (NOx). A total of 40 patients were enrolled and randomized with no participants being lost to follow-up. There was no significant difference in the proportion of sICH between GTN and control groups. Additionally, no significant difference was observed in mortality or rates of neurological deterioration and other complications. Favorable trends, while non-significant, were noted in both outcome and imaging for functional independence at 90 days and reduction in final infarct volume (75.0% vs 65.0%; 33.2 vs 38.9 ml) for the GTN group. Moreover, the concentration of blood NOx in the GTN group was significantly higher than in the control group at 2 h after GTN administration (26.2 vs 18.0 μmol/l, p < 0.05). The AGAIN study suggests intra-arterial administration of GTN post-endovascular therapy is safe and feasible and GTN successfully raised NOx levels over controls at 2 h. A multi-center randomized controlled trial with a larger sample size is warranted to determine GTN neoadjuvant efficacy. [ABSTRACT FROM AUTHOR]

In recent years, the continuous decline of marriage rate in Chinese cities has attracted significant attention. The study examined the impact of income inequality on marriage rates, and explored the mechanisms through which this relationship operates. Panel data of 35 large and medium-sized cities of mainland China from 2004 to 2019 were used to empirically test the theoretical hypothesis, finding the following results: Firstly, widening income inequality emerges as a crucial factor contributing to the decline in marriage rates within Chinese cities. Secondly, the impact of the income inequality on the marriage rate shows significant spatial and temporal differences in urban areas. Lastly, factors such as Internet penetration, urbanization and housing price are important channels for income inequality to affect the marriage rate. The objective of this study is to explain the decline of marriage rate in China's cities from the perspective of income distribution, and subsequently unveil the macro-level correlation between income inequality and marital behavior. • Widening income inequality emerges as a crucial factor contributing to the decline in marriage rates within Chinese cities. • The impact of the income inequality on the marriage rate shows significant spatial and temporal differences in urban areas. • Internet penetration, urbanization and housing price are the channels for income inequality to affect the marriage rate. [ABSTRACT FROM AUTHOR]

Mechanical system usually operates in harsh environments, and the monitored vibration signal faces substantial noise interference, which brings great challenges to the robust fault diagnosis. This paper proposes a novel attention-guided joint learning convolutional neural network (JL-CNN) for mechanical equipment condition monitoring. Fault diagnosis task (FD-Task) and signal denoising task (SD-Task) are integrated into an end-to-end CNN architecture, achieving good noise robustness through dual-task joint learning. JL-CNN mainly includes a joint feature encoding network and two attention-based encoder networks. This architecture allows FD-Task and SD-Task can achieve deep cooperation and mutual learning. The JL-CNN is evaluated on the wheelset bearing dataset and motor bearing dataset, which shows that JL-CNN has excellent fault diagnosis ability and signal denoising ability, and it has good performance under strong noise and unknown noise. • The feasibility of vibration signal denoising based on deep learning has been studied. • An excellent end-to-end CNN-based vibration signal denoising method is proposed. • A new solution to improve the noise robustness of the fault diagnosis model is proposed. • A new network framework based on joint learning is designed, which performs well under unknown noise. [ABSTRACT FROM AUTHOR]

• A new multi-target domain fault diagnostic method is proposed. • An attention mechanism adaptively assigns weights to data from multiple sensors. • Classification feature augmentation is combined with subdomain adaptation for aligning feature distributions. • Domain invariant feature augmentation is combined with domain adversarial for finding real domain invariant features. Intelligent diagnostic methods for identifying faults in rotating machinery, based on domain adaptation, have garnered significant attention. However, most current domain adaptation approaches are primarily designed for single-source domain and single-target domain (SSST) applications. There is a dearth of domain adaptation approaches tailored for single-source to multi-target domains (SSMT). In contrast to SSST, SSMT takes a more comprehensive approach by considering relationships across multiple target domains. This approach offers increased versatility and a broader range of potential applications. To address this, an end-to-end multi-target adversarial subdomain adaptation method is proposed that leverages attention mechanism data fusion and mixup feature augmentation. Firstly, the attention mechanism is used to fuse data from different sensors in both channel and spatial dimensions. Subsequently, a mixup-based feature augmentation method is proposed for multi-target domain adaptation. The method is combined with subdomain adaptation and domain discrimination to further reduce the distributional differences between the source and various target domains while relieving the overfitting problem during domain adaptation. Finally, with the above approach, a robust and stable model for multiple target domain fault diagnosis can be trained. Our experimental results illustrate that our approach has higher accuracy and robustness compared to several popular domain adaptation methods. [ABSTRACT FROM AUTHOR]

Portulacae Herba and Granati Pericarpium pair (PGP) is a traditional Chinese herbal medicine treatment for colitis, clinically demonstrating a relatively favorable effect on relieving diarrhea and abnormal stools. However, the underlying mechanism remain uncertain. The present study intends to evaluate the efficacy of PGP in treating colitis in mice and investigate its underlying mechanism. The protective effect of PGP against colitis was determined by monitoring body weight, colon length, colon weight, and survival rate in mice. Colonic inflammation was assessed by serum cytokine levels, colonic H&E staining, and local neutrophil infiltration. The reversal of intestinal epithelial barrier damage by PGP was subsequently analyzed with Western blot and histological staining. Furthermore, RNA-seq analysis and molecular docking were performed to identify potential pathways recruited by PGP. Following the hints of the transcriptomic results, the role of PGP through the IL-6/STAT3/SOCS3 pathway in DSS-induced colitis mice was verified by Western blot. DSS-induced colitis in mice was significantly curbed by PGP treatment. PGP treatment significantly mitigated DSS-induced colitis in mice, as evidenced by improvements in body weight, DAI severity, survival rate, and inflammatory cytokines levels in serum and colon. Moreover, PGP treatment up-regulated the level of Slc26a3, thereby increasing the expressions of the tight junction/adherens junction proteins ZO-1, occludin and E-cadherin in the colon. RNA-seq analysis revealed that PGP inhibits the IL-6/STAT3/SOCS3 pathway at the transcriptional level. Molecular docking indicated that the major components of PGP could bind tightly to the proteins of IL-6 and SOCS3. Meanwhile, the result of Western blot revealed that the IL-6/STAT3/SOCS3 pathway was inhibited at the protein level after PGP administration. PGP could alleviate colonic inflammation and reverse damage to the intestinal epithelial barrier in DSS-induced colitis mice. The underlying mechanism involves the inhibition of the IL-6/STAT3/SOCS3 pathway. [Display omitted] [ABSTRACT FROM AUTHOR]

Adjuvant neuroprotective therapies for acute ischemic stroke (AIS) have demonstrated benefit in animal studies, albeit without human translation. We investigated the safety and efficacy of high-flow normobaric oxygen (NBO) after endovascular recanalization in anterior circulation stroke. This is a prospective randomized controlled study. Eligible patients were randomized to receive high-flow NBO by a Venturi mask (FiO2 50%, flow 15 L/min) or routine low-flow oxygen supplementation by nasal cannula (flow 3 L/min) after vessel recanalization for 6 h. Patient demographics, procedural metrics, complications, functional outcomes, symptomatic intracranial hemorrhage (sICH), and infarct volume were assessed. A total of 91 patients were treated with high-flow NBO. NBO treatment revealed a common odds ratio of 2.2 (95% CI, 1.26 to 3.87) favoring the distribution of global disability scores on the mRS at 90 days. The mortality at 90 days was significantly lower in the NBO group than in the control group, with an absolute difference of 13.86% (rate ratio, 0.35; 95% CI, 0.13–0.93). A significant reduction of infarct volume as determined by MRI was noted in the NBO group. The median infarct volume was 9.4 ml versus 20.5 ml in the control group (beta coefficient, − 20.24; 95% CI, − 35.93 to − 4.55). No significant differences were seen in the rate of sICH, pneumonia, urinary infection, and seizures between the 2 groups. This study suggests that high-flow NBO therapy after endovascular recanalization is safe and effective in improving functional outcomes, decreasing mortality, and reducing infarct volumes in anterior circulation stroke patients within 6 h from stroke onset. [ABSTRACT FROM AUTHOR]