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Your search keyword '"Cell-mediated cytotoxicity -- Physiological aspects"' showing total 14 results
Start Over Descriptor "Cell-mediated cytotoxicity -- Physiological aspects" Publisher elsevier b.v.
14 results on '"Cell-mediated cytotoxicity -- Physiological aspects"'

1. Immunity to K1 killer toxin: internal TOK1 blockade

Author

Sesti, Federico, Shih, Theodore M., Nikolaeva, Natalia, and Goldstein, Steve A.N.

Subjects
Saccharomyces -- Research, Potassium channels -- Physiological aspects, Bacterial toxins -- Physiological aspects, Cell-mediated cytotoxicity -- Physiological aspects, Biological sciences
Abstract

Research demonstrates that the K1 killer cells of Saccharomyces cerevisiae avoid cell death by in vivo produced K1 toxin by the inhibition of TOK1 potassium channels. Further, TOK1 blockade also prevents cell death by external toxin.

Published
2001

3. Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system

Author

Steinman, Lawrence

Subjects
Multiple sclerosis -- Research, Demyelination -- Analysis, Cell-mediated cytotoxicity -- Physiological aspects, Immunologic diseases -- Physiological aspects, Biological sciences
Abstract

Multiple sclerosis (MS) is caused by a bacterial agent that triggers a T cell to activate the immune system to destroy the myelin sheath. Analysis of the immune response in MS subjects has shown that the anti-myelin T cells are activated by invading bacteria. Subsequent reactions will then lead to lymphocyte penetration of the myelin sheath by utilizing the matrix metalloproteases enzyme. This enzyme is found in all MS patients and the inhibition of its activity in animals reverses the disease. The prevention of myelin damage by the immune system is a promising cure for MS.

Published
1996

4. Double signal stimulation was required for full recovery of the autologous tumor-killing effect of effusion-associated lymphocytes *. (laboratory and animal investigations)

Author

Chen, Yuh-Min, Tsai, Chun-Ming, Whang-Peng, Jacqueline, and Perng, Reury-Perng

Subjects
T cells -- Physiological aspects, Mortality -- Taiwan, Cell-mediated cytotoxicity -- Physiological aspects, Interleukins -- Physiological aspects, Pleural effusions -- Patient outcomes, Health, Physiological aspects, Patient outcomes
Abstract

Study objectives: To determine the different effects of interleukin (IL)-2, IL-4, IL-7, IL-10, IL-12, and/or T-cell receptor (TCR)-CD3 engagement in recovering the functions of cytotoxic T lymphocytes (CTL) from malignant [...]

Published
2002

5. Neopterin concentrations in fetal and maternal blood: a marker of cell-mediated immune activation

Author

Radunovic, Nebojsa, Kuczynski, Edward, Rebarber, Andrei, Nastic, Danica, and Lockwood, Charles J.

Subjects
Immune response -- Physiological aspects, Fetus -- Growth, Cell-mediated cytotoxicity -- Physiological aspects, Health
Abstract

Fetal blood levels of neopterin increase as the baby grows, indicating a functioning immune system. Neopterin is produced by immune cells called macrophages and monocytes.

Published
1999

6. Awake epidural anesthesia is associated with improved natural killer cell cytotoxicity and a reduced stress response

Author

Koltun, Walter A., Bloomer, Michele M., Tilberg, Anna F., Seaton, John F., Ilahi, Obeid, Rung, George, Gifford, Robert M., and Kauffman, Gordon L., Jr.

Subjects
Colectomy -- Methods, Peridural anesthesia -- Physiological aspects, Cell-mediated cytotoxicity -- Physiological aspects, General anesthesia -- Physiological aspects, Killer cells -- Measurement, Health
Abstract

BACKGROUND: Laparotomy under general anesthesia is associated with depressed natural killer cell cytotoxicity (NKCC) and compromised clearance of tumor cells. We tested the hypothesis that awake epidural anesthesia (AEA) improves NKCC compared to conventional general endotracheal anesthesia (GEA). PATIENTS AND METHODS: Preoperative, perioperative, and postoperative (day 3) NKCC, plasma epinephrine, norepinephrine, cortisol levels, and 24-hour urinary cortisol levels were measured in 20 patients undergoing open colectomy under either AEA or GEA. RESULTS: Preoperative and postoperative measurements were not significantly different in the two groups. Patients receiving GEA had a significant reduction in NKCC from 36% [+ or -] 4% preoperatively to 22% [+ or -] 4% perioperatively (P = 0.02). Patients receiving AEA had no significant change in NKCC. Perioperative plasma epinephrine and cortisol levels were higher with GEA than AEA. The perioperative 24-hour urinary cortisol excretion values were significantly higher in the group receiving GEA, suggesting a greater stress hormone response in this group compared to AEA patients. CONCLUSIONS: Compared to GEA,AEA appears to preserve perioperative NKCC. This effect may be related to an attenuated stress hormone response associated with AEA. Cancer patients may have improved killing of embolized tumor cells during surgery performed under AEA. Am J Surg. 1996;171:68-73.

Published
1996

8. Lysis of human alveolar macrophages by lymphokine-activated killer cells

Author

Maruyama, Muneharu, Kawasaki, Akira, Suzuki, Hidehiko, Yamashita, Naohiro, and Yano, Saburo

Subjects
Interleukin-2 -- Physiological aspects, Cell-mediated cytotoxicity -- Physiological aspects, Killer cells -- Physiological aspects, Cancer -- Physiological aspects, Health, Physiological aspects
Abstract

In order to determine if human LAK cells were cytotoxic against autologous AMφ, we studied the ability of human peripheral blood MNCs, stimulated in vitro with recombinant human IL-2, to [...]

Published
1990

9. DOES HIGHLY ACTIVE ANTIRETROVIRAL THERAPY IMPROVE THE LYMPHOPROLIFERATIVE RESPONSE TO MICROBIAL ANTIGENS AND PHYTOHEMOAGGLUTININ?

Author

D'Alfonso-Laghi, Nausica, Ghassemi, M, Koirala, J, Sagha, H, Pitrak, D L., and Novak, R M.

Subjects
Opportunistic infections -- Prevention -- Drug therapy, Antiviral agents -- Physiological aspects, Anti-HIV agents -- Physiological aspects, Cell-mediated cytotoxicity -- Physiological aspects, Infection -- Prevention -- Drug therapy, Lungs -- Physiological aspects, HIV infection -- Drug therapy -- Prevention, Health, Drug therapy, Prevention, Physiological aspects
Abstract

Nausica D'Alfonso-Laghi, MD(*); M Ghassemi, PhD; J Koirala, MD; H Sagha, MD; D L Pitrak, MD and R M Novak, MD. Infectious Diseases, University of Illinois, Chicago, IL. PURPOSE: We [...]

Published
2000

12. A cytotoxic response against AIDS

Author

Thompson, Clare

Subjects
AIDS (Disease) -- Development and progression, Cell-mediated cytotoxicity -- Physiological aspects, Cytokines -- Physiological aspects
Published
1994

13. HIV-specific cytotoxic T-cell activity in an HIV-exposed but uninfected infant

Author

Rowland-Jones, Sarah L., Nixon, Douglas F., Aldhous, Marian C., Gotch, Frances, Ariyoshi, Koya, Hallam, Nicholas, Kroll, J. Simon, Froebel, Karin, and McMichael, Andrew

Subjects
T cells -- Physiological aspects, Infants -- Physiological aspects, HIV infection -- Physiological aspects, Cell-mediated cytotoxicity -- Physiological aspects
Published
1993

14. Bispecific antibodies: the new magic bullets

Author

Featherstone, Carol

Subjects
Antibodies -- Health aspects, Cell-mediated cytotoxicity -- Physiological aspects, Tumors -- Growth, Cancer -- Cytopathology, Monocytes -- Health aspects
Published
1996

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