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• Carbohydrate-restricted dietary patterns may improve cardiometabolic risk factors. • Severe carbohydrate restriction limits intake of foods with putative health benefits. • Recommended healthy dietary patterns can be modified to be lower in carbohydrate. • The quality of foods consumed is as important as quantity of macronutrients. • High-quality carbohydrates promote benefits within a carbohydrate-restricted diet. [ABSTRACT FROM AUTHOR]

As ongoing research continues to reveal the links between metabolism, cancer, and aging it is good to see non-toxic interventions such as caloric restriction (CR) coming into focus. Recently, Meynet and Ricci provided a timely review summarizing the current state of research on the possible role of CR in cancer treatment. In discussing ways to implement clinically the beneficial effects of CR without a need for overall reduced food intake these authors focused on CR-mimicking drugs that have several limitations. I propose carbohydrate restriction as probably the best way to mimic CR in humans without the need to restrict energy intake. [ABSTRACT FROM AUTHOR]