Search

Neural network models can be used to study speech segmentation. Segmentation cues are given by the way phonetic segments are distributed in conversational English. Infants are able to develop sophisticated ability in segmentation from an initial sensitivity to subsegmental primitives. They can thus develop adult abilities. The Metrical Segmentation Strategy is a helpful way of understanding this issue and helps explain how infants develop linguistic abilities.

Loot boxes are items in video games that may be bought with real-world money but contain randomised contents. Due to similarities between loot boxes and gambling, various countries are considering regulating them to reduce gambling-related harm. However, loot boxes are extremely diverse. A key problem facing regulators is determining whether specific types of loot boxes carry more potential for harm, and should be regulated accordingly. In this study, we specify seven key ways that loot boxes may differ from each other: They may involve paid or unpaid openings; give opportunities for cashing out; allow gamers to pay to win; involve the use of an in-game currency; feature crate and key mechanics; show near misses; and contain exclusive items. We then use a large-scale preregistered correlational analysis (n = 1200) to determine if any of these features strengthen the link between loot box spending and problem gambling. Our results indicate that being able to cash out, showing near-misses, and letting players use in-game currency to buy loot boxes may weakly strengthen the relationship between loot box spending and problem gambling. However, our main conclusion is that regardless of the presence or absence of specific features of loot boxes, if they are being sold to players for real-world money, then their purchase is linked to problem gambling. • Preregistered analysis replicates links between loot box spending and problem gambling (η2 = 0.092). • Loot box spending remains linked to problem gambling, regardless of presence or absence of features like cash-out. • Cash out, near-misses, and using in-game currency strengthened links between problem gambling and loot box spending. [ABSTRACT FROM AUTHOR]

Video games depict a variety of different concepts. Models of learning in games like the GLM (General Learning Model) and GAM (General Aggression Model) predict that exposing players to these in-game concepts can lead to important changes in player behaviour. Priming effects are thought to be key to determining these changes in behaviour. However, recent research has suggested problems with the priming effects that have previously been observed in the video game literature. Indeed, widespread methodological issues with this body of research make it unclear whether priming effects occur at all in video games. Two experiments (total N = 532) investigated whether priming effects still occurred in video games when known confounds in the literature were accounted for. Priming was observed in neither study. However, in both studies a novel negative priming effect was observed instead, in which exposure to a specific concept inhibited players’ reactions to things that were related to that concept. These studies support previous research which indicates there may be serious confounding in the video game literature. They also suggest that the priming-related effects of video games may be overestimated. Finally, they highlight the potential existence of negative priming as an effect of video game play. [ABSTRACT FROM AUTHOR]

Social play is an increasingly important constituent of the digital game experience. Though there is a growing understanding of how the social context influences the experience of playing, there is little known about how the experience of play influences the social experience. Specifically, it is not even known whether winning or losing affects a player's sense of social presence with their co-players. This paper provides the results of two studies aiming to explore this interaction. The first study is a lab-based study that looked at whether social presence varied in collocated teams playing team-based games depending on whether they won or lost. The second study is a user experience survey which measured how variables in the context of gameplay affected social presence across a number of team-based online games. The results of both studies show that when teams lose, the negative impact on social presence is greater within teams than between the competing teams. This has implications for how studies in this area should be analysed and also, through consideration of individual games, suggests that mechanisms in the games may lead to the reduced social presence. [ABSTRACT FROM AUTHOR]

In this cross-sectional study, we investigated the influence of personal BMI on body size estimation in 42 women who have symptoms of anorexia (referred to henceforth as anorexia spectrum disorders, ANSD), and 100 healthy controls. Low BMI control participants over-estimate their size and high BMI controls under-estimate, a pattern which is predicted by a perceptual phenomenon called contraction bias. In addition, control participants’ sensitivity to size change declines as their BMI increases as predicted by Weber's law. The responses of women with ANSD are very different. Low BMI participants who have ANSD are extremely accurate at estimating body size and are very sensitive to changes in body size in this BMI range. However, as BMI rises in the ANSD participant group, there is a rapid increase in over-estimation concurrent with a rapid decline in sensitivity to size change. We discuss the results in the context of signal detection theory. [ABSTRACT FROM AUTHOR]

Background: Promoter methylation of tumor suppressor genes is a frequent and early event in breast carcinogenesis. Paired tumor tissue and serum samples from women with breast cancer show that promoter methylation is detectable in both sample types, with good concordance. This suggests the potential for these serum markers to be used for breast cancer detection.Methods: The current study was a case-control study nested within the prospective New York University Women's Health Study cohort aimed to assess the ability of promoter methylation in serum to detect pre-clinical disease. Cases were women with blood samples collected within the 6 months preceding breast cancer diagnosis (n=50). Each case was matched to 2 healthy cancer-free controls and 1 cancer-free control with a history of benign breast disease (BBD).Results: Promoter methylation analysis of four cancer-related genes: -RASSF1A, GSTP1, APC and RARβ2, - was conducted using quantitative methylation-specific PCR. Results showed that the frequency of methylation was lower than expected among cases and higher than expected among controls. Methylation was detected in the promoter region of: RASSF1A in 22.0%, 22.9% and 17.2% of cases, BBD controls and healthy controls respectively; GSTP1 in 4%, 10.4% and 7.1% respectively; APC in 2.0%, 4.4% and 4.2% respectively and RARβ2 in 6.7%, 2.3% and 1.1% respectively.Conclusion: Methylation status of the four genes included in this study was unable to distinguish between cases and either control group. This study highlights some methodological issues to be addressed in planning prospective studies to evaluate methylation markers as diagnostic biomarkers. [ABSTRACT FROM AUTHOR]

Renal oncocytosis is a rare condition characterized by the presence of numerous oncocytomas and oncocytic changes in the renal tubules. Other than oncocytomas associated with the Birt-Hogg-Dube (BDH) syndrome, the genetics of oncocytosis is not known. Whether oncocytomas and oncocytosis are similar to BDH syndrome, in which the tumors diploid (as most oncocytomas are), or show chromosomal losses may be significant regarding the observation that in oncocytosis, there frequently is morphological evidence of progression to chromophobe carcinoma. Here we report on the case of a 69-year old male who underwent a staged procedure of partial nephrectomy on the left side and right radical nephrectomy for multiple renal tumors. The tumors were studied by routine hematoxylin and eosin morphology, immunohistochemistry, cytogenetics, and loss of heterozygosity analysis. Both kidneys had numerous oncocytic neoplasms morphologically progressing from oncocytomas to hybrid tumors with chromophobe carcinoma. Genetic studies demonstrated progression from normal cytogenetics to chromosomal losses similar to those in some oncocytomas and in chromophobe carcinomas. The genetics of this apparently nonfamilial oncocytoma differs from that of BDH syndrome and is characterized by losses involving chromosomes 1, 14, 21, and Y. To our knowledge, this is the first report of the genetic and cytogenetic findings in oncocytosis not related to BDH syndrome and may suggest a possible model of progression from oncocytoma to chromophobe renal cell carcinoma. [Copyright &y& Elsevier]

Stable isotope and elemental analysis, together with statistical processing of the resultant data has been used to determine the geographical origin of poultry and hence provide a means to verify poultry labels originating from major producing countries/regions. Multivariate statistical analysis has demonstrated that 18 variables, including carbon, hydrogen and nitrogen stable isotope ratios and elemental concentrations of magnesium, thallium, rubidium and molybdenum, are important parameters in poultry origin determination. Using cross-validated discriminant analysis 88.3% of poultry geographical origins were correctly classified (n = 339). Individual correct-classification rates were as follows; China, 100% (n = 36); Brazil, 94.1% (n = 101); Europe 92% (n = 87); Chile 82.6% (n = 46); Thailand, 70.3% (n = 46) and Argentina 50% (n = 10). The main identification errors were associated with miss-classification of Argentinean samples with those originating from Chile and Thailand. Carbon stable isotope ratios of chicken meat indicate the quantity of maize in the diet and this leads to useful discrimination between a large proportion of European poultry and poultry reared in locations such as South America, Thailand and China where maize feeding predominates. The use of poultry carbon isotope values as a simple ‘screening’ parameter to differentiate European poultry meat from other major importers is not as reliable as for the differentiation of European and South American beef. However carbon isotope ratios will be useful in most instances to corroborate suspicion of mislabelling of non corn-fed European poultry. The stable isotopes of hydrogen and oxygen in chicken meat change in a similar way to surface waters around the globe. Our findings support the hypothesis that the global isotopic variation of stable isotopes in drinking water and feed are transferred into animal tissue and can be used to help establish an animal's geographic origin. This is a significant finding and mirrors our observations for beef skeletal muscle δ 2 H ‰ and δ 18 O ‰ values. These systematic variations can be exploited to give a ‘low-resolution’ indication of an animal's geographic origin (e.g. Northern Europe versus the tropics). [ABSTRACT FROM AUTHOR]

Presents research data showing that LOT1, a zinc-finger nuclear transcription factor and the candidate tumor suppressor gene at chromosome 6q24-25, is epigeneticallty regulated in cancer. Cloning of the full-length LOT1 cDNA and 5' RACE; Analysis of the LOT1 splice variants; Characterization of the human LOT1 promoter; Inhibition of histone deactylase activates the transcription of LOT1.