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With the advances in immunogenomics, the majority of tumor-specific antigens were found to be recognized by T helper cells (T H Cs). This observation led to the development of long epitope vaccines in various cancers. Mechanistically, we are still gaining a deeper understanding of the mode of action of T H Cs as precision antitumor agonists. Here, we discuss the specific cellular mechanisms of T H C functions in glioma immunology and contextualize current advances in anti-glioma vaccination exploiting T H Cs. [ABSTRACT FROM AUTHOR]

Relapsing-remitting multiple sclerosis (MS) 2 2 MS: multiple sclerosis. is characterized by phases of acute neuroinflammation followed by spontaneous remission. Termination of inflammation is accompanied by an influx of regulatory T cells (T regs ). 3 3 T regs : regulatory T cells. The molecular mechanisms responsible for directing T regs into the inflamed CNS tissue, however, are incompletely understood. In an MS mouse model we show that the stress kinase general control non-derepressible 2 (GCN2), 4 4 GCN2: general control non-derepressible 2. expressed in T cells, contributes to the resolution of autoimmune neuroinflammation. Failure to recover from acute inflammation was associated with reduced frequencies of CNS-infiltrating T regs . GCN2 deficient T regs displayed impaired migration to a CCL2 gradient. These data suggest an important contribution of the T cell stress response to the resolution of autoimmune neuroinflammation. [ABSTRACT FROM AUTHOR]