1. Long non-coding RNAs regulation in adipogenesis and lipid metabolism: Emerging insights in obesity.
- Author
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Chen, Chen, Cui, Qingming, Zhang, Xing, Luo, Xuan, Liu, Yingying, Zuo, Jianbo, and Peng, Yinglin
- Subjects
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NON-coding RNA , *ADIPOGENESIS , *LIPID metabolism , *OBESITY , *CALORIC expenditure - Abstract
Abstract Obesity is a widespread health problem that brings about various adipose tissue dysfunctions. The balance of energy storage and energy expenditure is critical for normal fat accumulation and lipid metabolism. Therefore, understanding the molecular basis of adipogenesis and thermogenesis is essential to maintain adipose development and lipid homeostasis. Increasing evidence demonstrated that lncRNAs (long non-coding RNAs), a class of non-protein coding RNAs of >200 nucleotides in length, are identified as key regulators in obesity-related biological processes through diverse regulatory mechanisms. In this review, we concentrate on recent and relevant studies on the roles of lncRNAs in regulation of white adipogenesis, brown adipocyte differentiation and lipid metabolism. In addition, the diagnostic and therapeutic potential of lncRNAs is highlighted, and that will make recommendations for the future application of lncRNAs in the treatment of obesity. Highlights • The transcriptional and regulatory mechanisms of lncRNAs are illustrated by figure. • Roles of lncRNAs in regulation of white/brown adipogenesis and lipid metabolism are summarized. • The potential lncRNAs involved in adipogenesis and lipid metabolism are represented. • The diagnostic and therapeutic potential of lncRNAs is highlighted. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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