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The Moore–Penrose inverse of a real matrix having no square submatrix with two or more diagonals is described in terms of bipartite graphs. For such a matrix, the sign of every entry of the Moore–Penrose inverse is shown to be determined uniquely by the signs of the matrix entries; i.e., the matrix has a signed generalized inverse. Necessary and sufficient conditions on an acyclic bipartite graph are given so that each nonnegative matrix with this graph has a nonnegative Moore–Penrose inverse. Nearly reducible matrices are proved to contain no submatrix having two or more diagonals, implying that a nearly reducible matrix has a signed generalized inverse. Furthermore, it is proved that the term rank and rank are equal for each submatrix of a nearly reducible matrix. [Copyright &y& Elsevier]