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Background Repigmentation at previous biopsy sites pose a significant diagnostic dilemma given clinical and histologic similarities between recurrent nevi and locally recurrent melanoma. Though common in melanoma, the role of TERT promoter mutations (TPMs) in recurrent nevi is unknown. Objective We investigated the role of TPMs in recurrent nevi and whether the presence of hotspot TPM distinguishes recurrent nevi from locally recurrent melanoma. We also characterized clinical and histologic features differentiating these lesions. Methods We analyzed 11 locally recurrent melanomas, 17 recurrent nevi, and melanoma and nevus controls to determine TPM status. We also assessed clinical and histologic features of the recurrent groups. Results Hotspot TPMs were more common in recurrent melanomas than recurrent nevi (P =.008). Recurrent melanomas were more likely to have solar elastosis (P =.0047), multilayering of melanocytes in the epidermis (P =.0221), adnexal involvement (P =.0069), and epidermal consumption (P =.0204). Recurrent nevi had intra-epidermal atypia limited to the area above the scar (P <.0001) and occurred earlier after the original biopsy (P <.0008). Solar elastosis, months to recurrence, and hotspot TPMs were independently associated with recurrent melanoma in multivariate analysis. Limitations This was a retrospective study. Conclusion Hotspot TPMs are significantly more frequent in recurrent melanomas and could serve as a diagnostic clue in histologically ambiguous cases. [ABSTRACT FROM AUTHOR]

A radial scar or complex sclerosing lesion is a benign hyperplastic lesion that ranks among the risk lesions, (histologically B3a, B3b) as it is not sparse associated with cell atoms or malignancy. In addition, it exhibits high morphological similarity to breast cancer in the imaging methods. USG diagnostics is a very useful way. The goal of the presentation: In a retrospective study at the Department of Radiology in Trencin and St. Elisabeth Institute of Oncology, he discovered the benefit and accuracy of sonography compared to mammography and magnetic resonance, and biopsy. In the period from December 2018 to January 2022, we retrospectively evaluated the results of 386 patients with histologically diagnosed radial scars. We performed examination by age sonographically, mammographically, with magnetic resonance, but always verified histologically. The core biopsy under USG control was realized by freehand methods. The patients were surgically treated. We compared the results of sonographic conclusions, biopsies, and final histology, and compared the accuracy and correctness of the conclusion of sonography and histopathology. We evaluated the data using Mc Nemar's test. We have tested the relationship with Spearman's correlation coefficient The results are in the tables. The following resulted from the comparison: sonography was consistent with the correct assumption of radial lesion of benign characteristics in 251 cases, in 40 cases it was fundamentally different and the other 95 suspected. USG shows better results in women under the age of 40, women between ages 40 and 50 are less reliable when comparing lesions by age. At the age of 50, MG and DBT are more accurate than the USG. The low correlation of correspondence is also in the field of architectural changes. More precisely, it is the elderly patient's mammography a digital breast tomography. Sonography has a benefit in examining women aged up to 40 years of age and with dense breast tissue, women over 50 years of age have a more accurate X-ray, MR is not very beneficial, and has low specificity. Sonography is important in the differential diagnosis of radial scar lesions. [ABSTRACT FROM AUTHOR]

Abstract: Purpose: To elucidate the incidence of signal intensity patterns of borderline lesions of hepatocellular carcinoma (HCC) on hepatobiliary phase Gd-EOB-DTPA (EOB) enhanced MRI and clarify the natural histories of these lesions. Materials and methods: Total 99 borderline lesions of HCC were identified by angiography-assisted CT. The signal intensity of borderline lesions on hepatobiliary phase of EOB-enhanced MRI was analyzed. Progress rate from borderline lesions to hypervascular HCC was calculated with the Kaplan–Meier method among each signal intensity groups of nodules. Results: On hepatobiliary phase of EOB-enhanced MRI, 41.4% of the borderline lesions showed hypo-, 42.4% showed iso-, and 16.2% showed hyperintense, compared to background liver. Overall progress rates from borderline lesions to HCC were 10% in 1-year, 14% in 2-year and 20% in 3-year follow-up period. Progress rates to HCC in hypointense borderline lesions were 17% in 1-year, 28% in 2-year and 41% in 3-year follow-up period, and in isointense borderline lesions were 7% in 1-year, 7% in 2-year and 7% in 3-year follow-up period. No hyperintense borderline lesions progressed to HCC in follow-up period. Conclusion: Although borderline lesions of HCC may show hypo-, iso- and hyperintensity on hepatobiliary phase of EOB-enhanced MRI, hypointense borderline lesions are high risk to progress HCC. [Copyright &y& Elsevier]

Abstract: The purpose of this study is to assess whether magnetic resonance mammography (MRM) can exclude associated malignancy in case of diagnosis of borderline breast lesions (B3) at core needle biopsy (CNB). Retrospective analysis of MRM findings of 79 borderline breast lesions (26 benign papillomas, 29 radial sclerosing lesions, 6 atypical ductal hyperplasias, 18 lobular neoplasias) diagnosed at CNB was performed. Lesions were classified as “non-suspicious” or “suspicious” according to Fischer score. These findings were compared to the results of histological analysis of the excisional specimens. Sensitivity, specificity, positive (PPV) and negative (NPV) predictive values of MRM in predicting the presence of malignancy were calculated. Out of 24 (30.4%) lesions classified as “suspicious”, 8 (33.3%) proved to be malignant and 16 (66.7%) benign. Among the 55 (69.6%) “non-suspicious” lesions, only 1 (1.8%) was malignant (low-grade ductal carcinoma in situ), while the remaining 54 (98.2%) proved to be benign. MRM sensitivity, specificity, PPV, and NPV were 88.9%, 77.1%, 33.3%, and 98.2%, respectively. When a borderline lesion is diagnosed on CNB, in case of mild or no enhancement at MRM, follow-up rather than excisional biopsy might be prompted. [Copyright &y& Elsevier]