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Start Over Author "Bisogno T" Publisher elsevier b.v.
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3. Metabolically labile cannabinoid esters: A ‘soft drug’ approach for the development of cannabinoid-based therapeutic drugs

Author

Minutolo, F., Cascio, M.G., Carboni, I., Bisogno, T., Prota, G., Bertini, S., Digiacomo, M., Bifulco, M., Di Marzo, V., and Macchia, M.

Subjects
*DRUG receptors, *CANNABINOIDS, *HALLUCINOGENIC drugs, *SIDE effects of psychiatric drugs
Abstract

Abstract: Biphenylic ester derivatives, designed by using a ‘soft-drug’ approach, proved to possess good binding properties toward cannabinoid CB1 and CB2 receptors and, at the same time, their metabolically labile ester portion would promote a rapid systemic inactivation. This may constitute a possible solution to the psychotropic side effects encountered when cannabinoids are therapeutically employed as local analgesic or antiglaucoma agents. [Copyright &y& Elsevier]

Published
2007
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