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310 results on '"Böcker, A."'

10. Clinical characteristics and outcome of biopsy-proven myocarditis in children – Results of the German prospective multicentre registry “MYKKE”

Author

Seidel, Franziska, Opgen-Rhein, Bernd, Rentzsch, Axel, Boehne, Martin, Wannenmacher, Bardo, Boecker, Dorotheé, Reineker, Katja, Grafmann, Maria, Wiegand, Gesa, Hecht, Tobias, Kiski, Daniela, Fischer, Marcus, Papakostas, Konstantin, Ruf, Bettina, Kramp, Jennifer, Khalil, Marcus, Kaestner, Michael, Steinmetz, Michael, Fischer, Gunther, Özcan, Sevinc, Freudenthal, Noa, Schweigmann, Ulrich, Hellwig, Regina, Pickardt, Thomas, Klingel, Karin, Messroghli, Daniel, and Schubert, Stephan

Published
2022
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20. Structural and functional MRI of altered brain development in a novel adolescent rat model of quinpirole-induced compulsive checking behavior

Author

Buitelaar, Jan, de Ruiter, Saskia, Naaijen, Jilly, Akkermans, Sophie, Mennes, Maarten, Zwiers, Marcel, Ilbegi, Shahrzad, Hennissen, Leonie, Glennon, Jeffrey, van de Vondervoort, Ilse, Kapusta, Katarzyna, Bielczyk, NaAAtalia, Amiri, Houshang, Havenith, Martha, Franke, Barbara, Poelmans, Geert, Bralten, Janita, Heskes, Tom, Sokolova, Elena, Groot, Perry, Williams, Steven, Murphy, DeAAclan, Lythgoe, David, Bruchhage, Muriel, Dud, Iulia, Voinescu, Bogdan, Dittmann, Ralf, Banaschewski, Tobias, Brandeis, Daniel, Mechler, Konstantin, Berg, Ruth, Wolf, Isabella, Häge, Alexander, Landauer, Michael, Hohmann, Sarah, Schlier, Regina Boecker, Ruff, Matthias, Mandl, René, Dijkhuizen, Rick, Blezer, Erwin, Straathof, Milou, van der Marel, Kajo, Pullens, Pim, Mol, Wouter, van der Toorn, Annette, Otte, Willem, van Heijningen, Caroline, Durston, Sarah, Mensen, VinAAcent, Oranje, Bob, Joel, Daphna, Cryan, John, Petryshen, Tracey, Pauls, David, Saito, Mai, Heckman, Angelique, Bahn, Sabine, Schwalber, Ameli, Florea, Ioana, Blezer, Erwin L.A., Smeele, Christel E., Buitelaar, Jan K., Glennon, Jeffrey C., Otte, Willem M., and Dijkhuizen, Rick M.

Published
2020
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24. Inflammatory tissue response in human soft tissue is caused by a higher particle load near carbon fiber-reinforced PEEK compared to titanium plates.

Author

Fleischhacker, E, Sprecher, CM, Milz, S, Saller, MM, Wirz, R, Zboray, R, Parrilli, A, Gleich, J, Siebenbürger, G, Böcker, W, Ockert, B, and Helfen, T

Subjects
CARBON fiber-reinforced plastics, TITANIUM, INFLAMMATION, HUMERAL fractures, SURFACE plates
Abstract

Titanium as the leading implant material in locked plating is challenged by polymers such as carbon fiber-reinforced polyetheretherketone (CFR-PEEK), which became the focus of interest of researchers and manufacturers in recent years. However, data on human tissue response to these new implant materials are rare. Osteosynthesis plates and peri‑implant soft tissue samples of 16 healed proximal humerus fractures were examined (n = 8 CFR-PEEK, n = 8 titanium). Soft tissue was analyzed by immunohistochemistry and µCT. The entrapped foreign bodies were further examined for their material composition by FTIR. To gain insight into their origin and formation mechanism, explanted and new plates were evaluated by SEM, EDX, profilometry and HR-CT. In the peri‑implant soft tissue of the CFR-PEEK plates, an inflammatory tissue reaction was detected. Tissues contained foreign bodies, which could be identified as tantalum wires, carbon fiber fragments and PEEK particles. Titanium particles were also found in the peri‑implant soft tissue of the titanium plates but showed a less intense surrounding tissue inflammation in immunohistochemistry. The surface of explanted CFR-PEEK plates was rougher and showed exposed and broken carbon fibers as well as protruding and deformed tantalum wires, especially in used screw holes, whereas scratches were identified on the titanium plate surfaces. Particles were present in the peri‑implant soft tissue neighboring both implant materials and could be clearly assigned to the plate material. Particles from both plate materials caused detectable tissue inflammation, with more inflammatory cells found in soft tissue over CFR-PEEK plates than over titanium plates. Osteosynthesis plates are ubiquitously used in various medical specialties for the reconstruction of bone fractures and defects and are therefore indispensable for trauma surgeons, ENT specialists and many others. The leading implant material are metals such as titanium, but recently implants made of polymers such as carbon fiber-reinforced polyetheretherketone (CFR-PEEK) have become increasingly popular. However, little is known about human tissue reaction and particle generation related to these new implant types. To clarify this question, 16 osteosynthesis plates (n = 8 titanium and n = 8 CFR-PEEK) and the overlying soft tissue were analyzed regarding particle occurrence and tissue inflammation. Tissue inflammation is clinically relevant for the development of scar tissue, which is discussed to cause movement restrictions and thus contributes significantly to patient outcome. [Display omitted] [ABSTRACT FROM AUTHOR]

Published
2024
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46. Impact of the future liver remnant volume before major hepatectomy.

Author

Reese, Tim, Gilg, Stefan, Böcker, Jörg, Wagner, Kim C., Vali, Marjan, Engstrand, Jennie, Kern, Anna, Sturesson, Christian, Oldhafer, Karl J., and Sparrelid, Ernesto

Subjects
DISEASE risk factors, GALLBLADDER cancer, LIVER failure, HEPATECTOMY, PATIENTS' rights
Abstract

Following major liver resection, posthepatectomy liver failure (PHLF) is associated with a high mortality rate. As there is no therapy for PHLF available, avoidance remains the main goal. A sufficient future liver remnant (FLR) is one of the most important factors to reduce the risk for PHLF; however, it is not known which patients benefit of volumetric assessment prior to major surgery. A retrospective, bi-institutional cohort study was conducted including all patients who underwent major hepatectomy (extended right hepatectomy, right hepatectomy, extended left hepatectomy and left hepatectomy) between 2010 and 2023. A total of 1511 major hepatectomies were included, with 29.4 % of patients undergoing FLR volume assessment preoperatively. Overall, PHLF B/C occurred in 9.8 % of cases. Multivariate analysis identified diabetes mellitus, extended right hepatectomy, perihilar cholangiocarcinoma (pCCA), gallbladder cancer (GBC) and cirrhosis as significant risk factors for PHLF B/C. High-risk patients (with one or more risk factors) had a 15 % overall incidence of PHLF, increasing to 32 % with a FLR <30 %, and 13 % with an FLR of 30–40 %. Low-risk patients with a FLR <30 % had a PHLF rate of 21 %, which decreased to 8 % and 5 % for FLRs of 30–40 % and >40 %, respectively. For right hepatectomy, the PHLF rate was 23 % in low-risk and 38 % in high-risk patients with FLR <30 %. Patients scheduled for right hepatectomy and extended right hepatectomy should undergo volumetric assessment of the FLR. Volumetry should always be considered before major hepatectomy in patients with risk factors such as diabetes, cirrhosis, GBC and pCCA. In high-risk patients, a FLR cut-off of 30 % may be insufficient to prevent PHLF, and additional liver function assessment should be considered. [ABSTRACT FROM AUTHOR]

Published
2024
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