Haneef, Zulfi, Yang, Kaiyuan, Sheth, Sameer A., Aloor, Fuad Z., Aazhang, Behnaam, Krishnan, Vaishnav, and Karakas, Cemal
• Sub-scalp EEG (ssEEG) is a promising next-generation technology for investigating human neurophysiology. • It enables ultra-long-term EEG recording to improve diagnostic yield in epilepsy. • Different ssEEG devices have been developed with unique strengths and limitations. Sub-scalp electroencephalography (ssEEG) is emerging as a promising technology in ultra-long-term electroencephalography (EEG) recordings. Given the diversity of devices available in this nascent field, uncertainty persists about its utility in epilepsy evaluation. This review critically dissects the many proposed utilities of ssEEG devices including (1) seizure quantification, (2) seizure characterization, (3) seizure lateralization, (4) seizure localization, (5) seizure alarms, (6) seizure forecasting, (7) biomarker discovery, (8) sleep medicine, and (9) responsive stimulation. The different ssEEG devices in development have individual design philosophies with unique strengths and limitations. There are devices offering primarily unilateral recordings (24/7 EEGTM SubQ, NeuroviewTM, Soenia ® UltimateEEG™), bilateral recordings (Minder™, Epios™), and even those with responsive stimulation capability (EASEE®). We synthesize the current knowledge of these ssEEG systems. We review the (1) ssEEG devices, (2) use case scenarios, (3) challenges and (4) suggest a roadmap for ideal ssEEG designs. [ABSTRACT FROM AUTHOR]