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322 results on '"Alimuddin"'

1. IHR-PVS National Bridging Workshop for Somalia: An interactive and participatory approach for operationalizing the One Health roadmap

Author

Osman, Abdinasir Yusuf, Saidouni, Asma, Wambua, Lillian Wayua, Mahrous, Heba, Malik, Sk Md Mamunur Rahman, Lubogo, Mutaawe, Van de Weerdt, Reinhilde, Adam, Ali Hadji, Mohamed, Hassan Hussien, Al Makhzoumi, Khadija, Ali, Guled Abdijalil, Nur, Mohamed Omar, Fevre, Sonia, Mucheru, Gerald, Njue, Sophycate, Mosindo, Alain Okito, Sandhaus, Kaitlin, Wigand, Rosita Claesson, Standley, Claire, Sorrell, Erin, Kock, Richard, Guitian, Javier, Zumla, Alimuddin, Dar, Osman, and Mor, Siobhan M.

Published
2024
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23. Hajj vaccination strategies: Preparedness for risk mitigation.

Author

Alshamrani, Majid, Farahat, Fayssal, Alzunitan, Mohammed, Hasan, Musallam Abu, Alsherbini, Nisreen, Albarrak, Ali, Johani, Sameera M Al, shibl, Atef, Al-Tawfiq, Jaffar A., Zumla, Alimuddin, and Memish, Ziad A.

Abstract

Millions of pilgrims travel annually to Makkah and Madinah, Saudi Arabia, for the Hajj, posing unique challenges for public health management and disease control. The large influx of pilgrims from diverse backgrounds traveling to a confined geographic area, coupled with the close proximity and interactions among them, create significant pressure on the healthcare system and heighten the potential for the spread of communicable diseases. This review examines current trends in communicable diseases and their impact, drawing insights from expert perspectives on the required (i.e., meningococcal meningitis, polio, and yellow fever) and recommended vaccinations (influenza, COVID-19) for Hajj participants. The updated COVID-19 vaccine is mandatory for local pilgrims and is strongly recommended for international visitors, with ongoing discussions on adapting protocols to address emerging variants. The timing and strain coverage of influenza vaccination, along with quadrivalent meningococcal vaccination, are also emphasized as critical preventive measures. Diseases such as cholera and yellow fever are addressed underscoring the need for rigorous surveillance and targeted vaccination strategies to mitigate the risk of transmission during the Hajj. By providing up-to-date information on mandated and recommended vaccinations, this review aims to empower pilgrims and healthcare professionals to make informed decisions regarding public health and disease prevention during this significant event. [ABSTRACT FROM AUTHOR]

Published
2024
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30. The unbalanced p53/SIRT1 axis may impact lymphocyte homeostasis in COVID-19 patients

Author

Andrea Antinori, Chiara Agrati, Emanuele Nicastri, Eleonora Cimini, Veronica Bordoni, Rita Casetti, Luisa Marchioni, Giuseppe Ippolito, Alimuddin Zumla, Germana Grassi, Eleonora Tartaglia, Stefania Notari, Michele Bibas, Franco Locatelli, Maria Rosaria Capobianchi, Alessandra Sacchi, Gian Maria Fimia, Markus Maeurer, Bordoni, V., Tartaglia, E., Sacchi, A., Fimia, G. M., Cimini, E., Casetti, R., Notari, S., Grassi, G., Marchioni, L., Bibas, M., Capobianchi, M. R., Locatelli, F., Maeurer, M., Zumla, A., Antinori, A., Nicastri, E., Ippolito, G., and Agrati, C.

Subjects
0301 basic medicine, Microbiology (medical), Male, 030106 microbiology, Inflammation, Infectious and parasitic diseases, RC109-216, CD19, Article, Proinflammatory cytokine, BLNK, Inflammation, 03 medical and health sciences, 0302 clinical medicine, Sirtuin 1, Lymphocyte homeostasis, medicine, Homeostasis, Humans, 030212 general & internal medicine, Lymphocytes, Interleukin-7 receptor, B cell, Aged, BLNK, biology, SARS-CoV-2, COVID-19, p53/SIRT1, General Medicine, IL-7R, Middle Aged, medicine.anatomical_structure, Infectious Diseases, Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, inflammation, Immunology, B-cell linker, biology.protein, Cytokines, Female, medicine.symptom, Tumor Suppressor Protein p53
Abstract

Background/objectives A dysregulated inflammatory profile plays an important role in coronavirus disease-2019 (COVID-19) pathogenesis. Moreover, the depletion of lymphocytes is typically associated with an unfavourable disease course. We studied the role and impact of p53 and deacetylase Sirtuin 1 (SIRT1) on lymph-monocyte homeostasis and their possible effect on T and B cell signalling. Methods Gene expression analysis and flow cytometry were performed on peripheral blood mononuclear cells (PBMC) of 35 COVID-19 patients and 10 healthy donors (HD). Inflammatory cytokines, the frequency of Annexin+ cells among CD3+ T cells and CD19+ B cell subsets were quantified. Results PBMC from COVID-19 patients had a higher p53 expression, and higher concentrations of plasma proinflammatory cytokines (IL1β, TNF-α, IL8, and IL6) than HD. Deacetylase Sirtuin 1 (SIRT1) expression was significantly decreased in COVID-19 patients and was negatively correlated with p53 (p = 0.003 and r = −0.48). A lower expression of IL-7R and B Cell linker (BLNK), key genes for lymphocyte homeostasis and function, was observed in COVID-19 than in HD. The reduction of IgK and IgL chains was seen in lymphopenic COVID-19 patients. A significant increase in both apoptotic B and T cells were observed. Inflammatory cytokines correlated positively with p53 (IL-1β: r = 0.5 and p = 0.05; IL-8: r = 0.5 and p = 0.05) and negatively with SIRT1 (IL1-β: r = −0.5 and p = 0.04; TNF-α: r = −0.4 and p = 0.04). Conclusions Collectively, our data indicate that the inflammatory environment, the dysregulated p53/SIRT1 axis and low expression of IL7R and BLNK may impact cell survival, B cell signalling and antibody production in COVID-19 patients. Further studies are required to define the functional impact of low BLNK/IL7R expression during severe acute respiratory syndrome coronavirus-2 infection.

Published
2021

38. The immune system of children: the key to understanding SARS-CoV-2 susceptibility?

Author

Alimuddin Zumla, Isabella Quinti, Giuseppe Ippolito, Eva Piano Mortari, Concetta Quintarelli, Franco Locatelli, Rita Carsetti, Carsetti, R., Quintarelli, C., Quinti, I., Piano Mortari, E., Zumla, A., Ippolito, G., and Locatelli, F.

Subjects
Cellular immunity, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Pneumonia, Viral, Article, Child health, Immune system, Disease severity, Developmental and Educational Psychology, Humans, Medicine, Pediatrics, Perinatology, and Child Health, Child, Pandemics, B-Lymphocytes, Innate immune system, biology, business.industry, SARS-CoV-2, COVID-19, Severe acute respiratory syndrome-related coronavirus, Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, Immune System, Pediatrics, Perinatology and Child Health, Immunology, biology.protein, Disease Susceptibility, Antibody, Coronavirus Infections, business, Immunologic Memory, Immunologic memory, CD27 Ligand
Published
2020

40. Detection of seco-macrotetrolides caused by regiospecific hydrolysis in Indonesian Streptomyces strains isolated at the karst area in Sulawesi Island.

Author

Muslimin, Rukman, Ali, Alimuddin, Ogaki, Sho, Nurjannah, Alam, Ummu Kalsum, Choi, Sisun, Kim, Eung-Soo, and Arakawa, Kenji

Subjects
*KARST, *STREPTOMYCES, *NORMAL-phase chromatography, *HYDROLYSIS, *ISLANDS, *ANTI-infective agents, *MACROCYCLIC compounds
Abstract

Among a total of 30 endophytic Streptomyces strains collected at the karst area in Sulawesi Island, Indonesia, four strains showed antimicrobial activity together with distinct purple-colored spot(s) on TLC after anisaldehyde staining and baking. Four endophytic strains AA004, AA010, AA034, and AA035 accumulated ionophore macrotetrolides (cyclic tetraesters) including nonactin, monactin, dinactin, trinactin, and tetranactin. Occasionally, strains AA034 and AA035 accumulated considerable amount of seco -macrotetrolides (ring-opened, linear macrotetrolides) including seco -dinactin, seco -monactin, and seco -trinactin, together with macrotetrolides as above mentioned. Time-course increase of seco -macrotetrolides indicates the subsequent hydrolysis of macrotetrolides. Seco -macrotetrolides in strain AA034 were separated from macrotetrolides and other metabolites through Sephadex LH20 and silica gel chromatographies, although seco -macrotetrolides contain inseparable five analogs. We here investigated the hydrolyzed positions in seco -macrotetrolides. ESI-CID-MS/MS analysis of seco -dinactin (m / z 805 as [M+Na]+) and its derivatives, methyl ester (m / z 819 as [M+Na]+) and O -acetyl methyl ester (m / z 861 as [M+Na]+), revealed that seco -dinactin obtained in strains AA034/AA035 is a single regioisomer with a cleavage at an ester bond between the alcohol of (−)-homononactate and the carboxylate of (+)-nonactate, suggesting the regioselective hydrolysis on the occurrence of seco -dinactin. Further ESI-CID-MS/MS analysis revealed that seco -monactin (m / z 791 as [M+Na]+) is also single regioisomer with the ester-bond cleavage between the alcohol of (−)-homononactate and the carboxylate of (+)-nonactate. In the case of seco -trinactin (m / z 819 as [M+Na]+), additional regioisomer with the ester-bond cleavage between the alcohol of (−)-homononactate and the carboxylate of (+)-homononactate was detected, together with the regioisomer with the ester-bond cleavage between the alcohol of (−)-homononactate and the carboxylate of (+)-nonactate. A mixture of seco -macrotetrolides exhibited no antimicrobial activity, indicating the importance of macrocyclic structure for antimicrobial activity. [Display omitted] [ABSTRACT FROM AUTHOR]

Published
2024
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43. World Tuberculosis Day 2021 Theme — 'The Clock is Ticking' — and the world is running out of time to deliver the United Nations General Assembly commitments to End TB due to the COVID-19 pandemic.

Author

Zumla, Alimuddin, Chakaya, Jeremiah, Khan, Mishal, Fatima, Razia, Wejse, Christian, Al-Abri, Seif, Fox, Greg J., Nachega, Jean, Kapata, Nathan, Knipper, Michael, Orcutt, Miriam, Goscé, Lara, Abubakar, Ibrahim, Nagu, Tumaini Joseph, Mugusi, Ferdinand, Gordon, Alice Kizny, Shanmugam, Sivakumar, Bachmann, Nathan Lloyd, Lam, Connie, and Sintchenko, Vitali

Subjects
*COVID-19 pandemic, *TUBERCULOSIS
Published
2021
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46. BCG: the story continues

Author

Lienhardt, Christian and Zumla, Alimuddin

Subjects
BCG vaccination -- Evaluation, Mycobacterium tuberculosis -- Risk factors, Mycobacterium tuberculosis -- Prevention
Published
2005

47. Reducing mortality and morbidity in patients with severe COVID-19 disease by advancing ongoing trials of Mesenchymal Stromal (stem) Cell (MSC) therapy — Achieving global consensus and visibility for cellular host-directed therapies.

Author

Zumla, Alimuddin, Wang, Fu-Sheng, Ippolito, Giuseppe, Petrosillo, Nicola, Agrati, Chiara, Azhar, Esam I., Chang, Chao, El-Kafrawy, Sherif A., Osman, Mohamed, Zitvogel, Laurence, Galle, Peter R., Locatelli, Franco, Gorman, Ellen, Cordon-Cardo, Carlos, O'Kane, Cecilia, McAuley, Danny, and Maeurer, Markus

Subjects
*COVID-19, *SARS-CoV-2, *CELLULAR therapy, *PATHOLOGY, *CLINICAL trial registries
Abstract

As of May 17th 2020, the novel coronavirus disease 2019 (COVID-19) pandemic has caused 307,395 deaths worldwide, out of 3,917,366 cases reported to the World Health Organization. No specific treatments for reducing mortality or morbidity are yet available. Deaths from COVID-19 will continue to rise globally until effective and appropriate treatments and/or vaccines are found. In search of effective treatments, the global medical, scientific, pharma and funding communities have rapidly initiated over 500 COVID-19 clinical trials on a range of antiviral drug regimens and repurposed drugs in various combinations. A paradigm shift is underway from the current focus of drug development targeting the pathogen, to advancing cellular Host-Directed Therapies (HDTs) for tackling the aberrant host immune and inflammatory responses which underlie the pathogenesis of SARS-CoV-2 and high COVID-19 mortality rates. We focus this editorial specifically on the background to, and the rationale for, the use and evaluation of mesenchymal stromal (Stem) cells (MSCs) in treatment trials of patients with severe COVID-19 disease. Currently, the ClinicalTrials.gov and the WHO Clinical Trials Registry Platform (WHO ICTRP) report a combined 28 trials exploring the potential of MSCs or their products for treatment of COVID-19. MSCs should also be trialed for treatment of other circulating WHO priority Blueprint pathogens such as MERS-CoV which causes upto 34% mortality rates. It's about time funding agencies invested more into development MSCs per se, and also for a range of other HDTs, in combination with other therapeutic interventions. MSC therapy could turn out to be an important contribution to bringing an end to the high COVID-19 death rates and preventing long-term functional disability in those who survive disease. [ABSTRACT FROM AUTHOR]

Published
2020
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50. Crohn's disease and MAP

Author

Huggett, Jim, Dheda, Keertan, Zumla, Alimuddin, Rook, Graham, Naser, Saleh A., Valentine, John F., Gaya, Daniel R., Black, Richard A., and MacKenzie, John F.

Published
2004

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