1. Nucleation, reorganization and disassembly of an active network from lactose-modified chitosan mimicking biological matrices.
- Author
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Furlani, Franco, Sacco, Pasquale, Scognamiglio, Francesca, Asaro, Fioretta, Travan, Andrea, Borgogna, Massimiliano, Marsich, Eleonora, Cok, Michela, Paoletti, Sergio, and Donati, Ivan
- Subjects
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BORIC acid , *CHITOSAN , *MATERIALS science , *LACTITOL , *CYTOSKELETON , *TISSUE engineering - Abstract
Graphical abstract Highlights • Boric acid causes the formation of transient network in lactose-modified chitosan. • The active network shows strain-hardening features resembling ECM components. • The super-soft material can reorganize and undergo disassembly. Abstract Developing synthetic materials able to mimic micro- and macrorheological properties of natural networks opens up to novel applications and concepts in materials science. The present contribution describes an active network based on a semi-synthetic polymer, a lactitol-bearing chitosan derivative (Chitlac), and a transient inorganic cross-linker, boric acid. Due to the many and diverse anchoring points for boric acid on the flanking groups of Chitlac, the cross-links constantly break and reform in a highly dynamic fashion. The consequence is a network with unusual non-equilibrium and mechanical properties closely resembling the rheological behavior of natural three-dimensional arrangements and of cytoskeleton. Concepts like network nucleation, reorganization and disassembly are declined in terms of amount of the cross-linker, which acts as a putative motor for remodeling of the network upon application of energy. The out-of-equilibrium and non-linear behavior render the semi-synthetic system of great interest for tissue engineering and for developing in-vitro mimics of natural active matrices. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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