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Start Over Author "Abergel, A." Publisher elsevier b.v.
239 results on '"Abergel, A."'

2. Treatment with bulevirtide in HIV-infected patients with chronic hepatitis D: ANRS HD EP01 BuleDelta and compassionate cohort

Author

Raffi, François, Alric, Laurent, Miailhes, Patrick, Tran, Albert, Stern, Christiane, Causse, Xavier, Tripon, Simona, Riachi, Ghassan, Chazouillères, Olivier, Abergel, Armando, d’Alteroche, Louis, Gournay, Jérôme, Lagadic, Garance, Carrieri, Patrizia, Brichler, Ségolène, Siguier, Martin, Krause, Jessica, Foucher, Juliette, Ben Ali, Souad, Meszaros, Magdalena, Varaut, Anne, Canva, Valérie, de Lédinghen, Victor, Fougerou-Leurent, Claire, Le Pabic, Estelle, Pol, Stanislas, Alfaiate, Dulce, Lacombe, Karine, Hilleret, Marie-Noëlle, Lascoux-Combe, Caroline, Minello, Anne, Billaud, Eric, Rosa, Isabelle, Gervais, Anne, Ratziu, Vlad, Ganne, Nathalie, Pageaux, Georges-Philippe, Leroy, Vincent, Loustaud-Ratti, Véronique, Mathurin, Philippe, Chas, Julie, Jezequel, Caroline, Métivier, Sophie, Dumortier, Jérôme, Arpurt, Jean-Pierre, Asselah, Tarik, Roche, Bruno, Le Gruyer, Antonia, Valantin, Marc-Antoine, Scholtès, Caroline, Gordien, Emmanuel, Tual, Christelle, Kortebi, Amel, Coulibaly, Fatoumata, Rosenthal, Eric, Subic-Levrero, Miroslava, Roulot, Dominique, and Zoulim, Fabien

Published
2024
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4. Inevitability of disease recurrence after liver transplantation for NAFLD cirrhosis

Author

Villeret, François, Dharancy, Sébastien, Erard, Domitille, Abergel, Armand, Barbier, Louise, Besch, Camille, Boillot, Olivier, Boudjema, Karim, Coilly, Audrey, Conti, Filomena, Corpechot, Christophe, Duvoux, Christophe, Faitot, François, Faure, Stéphanie, Francoz, Claire, Giostra, Emiliano, Gugenheim, Jean, Hardwigsen, Jean, Hilleret, Marie-Noëlle, Hiriart, Jean-Baptiste, Houssel-Debry, Pauline, Kamar, Nassim, Lassailly, Guillaume, Latournerie, Marianne, Pageaux, Georges-Philippe, Samuel, Didier, Vanlemmens, Claire, Saliba, Faouzi, and Dumortier, Jérôme

Published
2023
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5. Integrating genetic variants into clinical models for hepatocellular carcinoma risk stratification in cirrhosis

Author

Nahon, Pierre, Asselah, Tarik, Guyader, Dominique, Pol, Stanislas, Fontaine, Hélène, Pageaux, Georges-Philippe, De Lédinghen, Victor, Ouzan, Denis, Zoulim, Fabien, Roulot, Dominique, Tran, Albert, Bronowicki, Jean-Pierre, Decaensi, Thomas, Riachi, Ghassan, Calès, Paul, Péron, Jean-Marie, Alric, Laurent, Bourlière, Marc, Mathurin, Philippe, Dharancy, Sebastien, Blanc, Jean-Frédéric, Abergel, Armand, Chazouillères, Olivier, Mallat, Ariane, Grangé, Jean-Didier, Attali, Pierre, Louis d’Alteroche, Wartelle, Claire, Dao, Thông, Thabut, Dominique, Pilette, Christophe, Silvain, Christine, Christidis, Christos, Nguyen-Khac, Eric, Bernard-Chabert, Brigitte, Hillaire, Sophie, Di Martino, Vincent, Ganne-Carrié, Nathalie, Chaffaut, Cendrine, Archambeaud, Isabelle, d’Alteroche, Louis, Oberti, Frédéric, Moreno, Christophe, Louvet, Alexandre, Moirand, Romain, Goria, Odile, Carbonell, Nicolas, Duclos-Vallée, Jean-Charles, de Ledinghen, Victor, Ozenne, Violaine, Henrion, Jean, Perlemuter, Gabriel, Amiot, Xavier, Zarski, Jean-Pierre, Chevret, Sylvie, Bamba-Funck, Jessica, Layese, Richard, Trépo, Eric, Zucman-Rossi, Jessica, Cagnot, Carole, Guyot, Erwan, Ziol, Marianne, Sutton, Angela, and Audureau, Etienne

Published
2023
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6. AFP score and metroticket 2.0 perform similarly and could be used in a “within-ALL” clinical decision tool

Author

Conti, Filomena, Scatton, Olivier, Bernard, Pierre Henri, Francoz, Claire, Durand, Francois, Dharancy, Sébastien, Woehl, Marie-lorraine, Laurent, Alexis, Radenne, Sylvie, Dumortier, Jérôme, Abergel, Armand, Barbier, Louise, Houssel-Debry, Pauline, Pageaux, Georges Philippe, Chiche, Laurence, Deledinghen, Victor, Hardwigsen, Jean, Gugenheim, J., altieri, M., Hilleret, Marie Noelle, Decaens, Thomas, Costa, Paulo, de Ataide, Elaine Cristina, Quiñones, Emilio, Anders, Margarita, Varón, Adriana, Zerega, Alina, Soza, Alejandro, Machaca, Martín Padilla, Arufe, Diego, Menéndez, Josemaría, Zapata, Rodrigo, Vilatoba, Mario, Muñoz, Linda, Menéndez, Ricardo Chong, Maraschio, Martín, Podestá, Luis G., McCormack, Lucas, Mattera, Juan, Gadano, Adrian, Parente García, Jose Huygens, Magini, Giulia, Miglioresi, Lucia, Gambato, Martina, D’Ambrosio, Cecilia, Vitale, Alessandro, Colledan, Michele, Pinelli, Domenico, Magistri, Paolo, Vennarecci, Giovanni, Colasanti, Marco, Giannelli, Valerio, Pellicelli, Adriano, Eduard, Callebout, Samuele, Iesari, Jeroen, Dekervel, Jonas, Schreiber, Jacques, Pirenne, Chris, Verslype, Dirk, Ysebaert, Peter, Michielsen, Valerio, Lucidi, Christophe, Moreno, Olivier, Detry, Jean, Delwaide, Roberto, Troisi, Paul, Lerut Jan, Piñero, Federico, Costentin, Charlotte, Degroote, Helena, Notarpaolo, Andrea, Boin, Ilka FSF., Boudjema, Karim, Baccaro, Cinzia, Chagas, Aline, Bachellier, Philippe, Ettorre, Giuseppe Maria, Poniachik, Jaime, Muscari, Fabrice, Dibenedetto, Fabrizio, Duque, Sergio Hoyos, Salame, Ephrem, Cillo, Umberto, Marciano, Sebastián, Vanlemmens, Claire, Fagiuoli, Stefano, Carrilho, Flair, Cherqui, Daniel, Burra, Patrizia, Van Vlierberghe, Hans, Lai, Quirino, Silva, Marcelo, Rubinstein, Fernando, and Duvoux, Christophe

Published
2023
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7. R3-AFP score is a new composite tool to refine prediction of hepatocellular carcinoma recurrence after liver transplantation

Author

Boudjema, Karim, Bachellier, Philippe, Conti, Filomena, Scatton, Olivier, Muscari, Fabrice, Salame, Ephrem, Bernard, Pierre Henri, Francoz, Claire, Durand, Francois, Dharancy, Sébastien, Woehl, Marie-lorraine, Vanlemmens, Claire, Laurent, Alexis, Radenne, Sylvie, Dumortier, Jérôme, Abergel, Armand, Cherqui, Daniel, Barbier, Louise, Houssel-Debry, Pauline, Pageaux, Georges Philippe, Chiche, Laurence, Deledinghen, Victor, Hardwigsen, Jean, Gugenheim, J., Altieri, M., Hilleret, Marie Noelle, Decaens, Thomas, Duvoux, Christophe, Piñero, Federico, Chagas, Aline, Costa, Paulo, Cristina de Ataide, Elaine, Quiñones, Emilio, Duque, Sergio Hoyos, Marciano, Sebastián, Anders, Margarita, Varón, Adriana, Zerega, Alina, Poniachik, Jaime, Soza, Alejandro, Machaca, Martín Padilla, Arufe, Diego, Menéndez, Josemaría, Zapata, Rodrigo, Vilatoba, Mario, Muñoz, Linda, Menéndez, Ricardo Chong, Maraschio, Martín, Podestá, Luis G., McCormack, Lucas, Mattera, Juan, Gadano, Adrian, Fatima Boin, Ilka S.F., Parente García, Jose Huygens, Carrilho, Flair, Silva, Marcelo, Notarpaolo, Andrea, Magini, Giulia, Miglioresi, Lucia, Gambato, Martina, Di Benedetto, Fabrizio, D’Ambrosio, Cecilia, Ettorre, Giuseppe Maria, Vitale, Alessandro, Burra, Patrizia, Fagiuoli, Stefano, Cillo, Umberto, Colledan, Michele, Pinelli, Domenico, Magistri, Paolo, Vennarecci, Giovanni, Colasanti, Marco, Giannelli, Valerio, Pellicelli, Adriano, Baccaro, Cizia, Lai, Quirino, Degroote, Helena, Van Vlierberghe, Hans, Eduard, Callebout, Samuele, Iesari, Jeroen, Dekervel, Jonas, Schreiber, Jacques, Pirenne, Chris, Verslype, Dirk, Ysebaert, Peter, Michielsen, Valerio, Lucidi, Christophe, Moreno, Olivier, Detry, Jean, Delwaide, Roberto, Troisi, Paul, Lerut Jan, Costentin, Charlotte, Boin, Ilka F., Baccaro, Cinzia, Dibenedetto, Fabrizio, Marciano, Sebastian, and Rubinstein, Fernando

Published
2022
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8. Early hepatocellular carcinoma detection using magnetic resonance imaging is cost-effective in high-risk patients with cirrhosis

Author

Nahon, Pierre, Asselah, Tarik, Guyader, Dominique, Pol, Stanislas, Fontaine, Hélène, Pageaux, Georges-Philippe, De Lédinghen, Victor, Ouzan, Denis, Zoulim, Fabien, Roulot, Dominique, Tran, Albert, Bronowicki, Jean-Pierre, Decaensi, Thomas, Riachi, Ghassan, Calès, Paul, Péron, Jean-Marie, Alric, Laurent, Bourlière, Marc, Mathurin, Philippe, Dharancy, Sebastien, Blanc, Jean-Frédéric, Abergel, Armand, Chazouillères, Olivier, Mallat, Ariane, Grangé, Jean-Didier, Attali, Pierre, d’Alteroche, Louis, Wartelle, Claire, Dao, Thông, Thabut, Dominique, Pilette, Christophe, Silvain, Christine, Christidis, Christos, Nguyen-Khac, Eric, Bernard-Chabert, Brigitte, Hillaire, Sophie, Di Martino, Vincent, Bonnet, Delphine, Payssan-Sicart, Virginie, Pomes, Chloe, Bailly, François, Beaudoin, Marjolaine, Giboz, Dominique, Hartig-Lavie, Kerstin, Maynard, Marianne, Billaud, Eric, Boutoille, David, Cavellec, Morane, Cheraud-Carpentier, Marjorie, Hubert, Isabelle, Benhida, Jaouad, Lannes, Adrien, Lunel, Françoise, Oberti, Frédéric, Boyer, Nathalie, Giuily, Nathalie, Castelnau, Corinne, Scoazec, Giovanna, Chibah, Aziza, Keser, Sylvie, Bonardi, Karim, Vallet-Pichard, Anaïs, Sogni, Philippe, Foucher, Juliette, Hiriart, Jean-Baptiste, Wilson, Amy, Shili, Sarah, Chermak, Faiza, Ansaldi, Christelle, Ben Amara, Nisserine, Chouquet, Laëtitia, De Luca, Emilie, Oules, Valérie, Anty, Rodolphe, Gelsi, Eve, Truchi, Régine, Luckina, Elena, Messaoudi, Nadia, Moussali, Joseph, De Dieuleveult, Barbara, Labarriere, Damien, Poter, Pascal, Si Ahmed, Si Nafa, Grando-Lemaire, Véronique, Bourcier, Valérie, Brulé, Séverine, Stalhberger, Thomas, Jezequel, Caroline, Brener, Audrey, Laligant, Anne, Rabot, Aline, Renard, Isabelle, Baumert, Thomas F., Dofföel, Michel, Mutter, Catherine, Simo-Noumbissie, Pauline, Razi, Esma, Barraud, Hélène, Bensenane, Mouni, Nani, Abdelbasset, Hassani-Nani, Sarah, Bernard, Marie-Albertine, Bismuth, Michael, Caillo, Ludovic, Faure, Stéphanie, Ripault, Marie Pierre, Bureau, Christophe, Peron, Jean Marie, Robic, Marie Angèle, Tarallo, Léa, Faure, Marine, Froissart, Bruno, Hilleret, Marie-Noelle, Zarski, Jean-Pierre, Goria, Odile, Grard, Victorien, Montialoux, Hélène, François, Muriel, Ouedraogo, Christian, Pauleau, Christelle, Varault, Anne, Andreani, Tony, Angoulevant, Bénédicte, Chevance, Azeline, Serfaty, Lawrence, Antonini, Teresa, Coilly, Audrey, Duclos Vallée, Jean-Charles, Tateo, Mariagrazia, Bonny, Corinne, Brigitte, Chanteranne, Lamblin, Géraldine, Muti, Léon, Babouri, Abdenour, Filipe, Virginie, Barrault, Camille, Costes, Laurent, Hagège, Hervé, Merbah, Soraya, Carrier, Paul, Debette-Gratien, Maryline, Jacques, Jérémie, Lassailly, Guillaume, Artu, Florent, Canva, Valérie, Dharancy, Sébastien, Louvet, Alexandre, Latournerie, Marianne, Bardou, Marc, Mouillot, Thomas, Bacq, Yannick, Barbereau, Didier, Nicolas, Charlotte, Chevalier, Caroline, Archambeaud, Isabelle, Habes, Sarah, Botta-Fridlund, Danièle, Saillard, Eric, Lafrance, Marie-Josée, Cacoub, Patrice, Carrat, Fabrice, Carrieri, Patrizia, Delarocque-Astagneau, Elisabeth, De Ledinghen, Victor, Dorival, Céline, Dubuisson, Jean, Housset, Chantal, Larrey, Dominique, Marcellin, Patrick, Pawlotsky, Jean-Michel, Petrov-Sanchez, Ventzislava, Vaux, Sophie, Wittkop, Linda, Yazdanpanah, Yazdan, Zucman-Rossi, Jessica, Ganne-Carrié, Nathalie, Chaffaut, Cendrine, Moreno, Christophe, Moirand, Romain, Carbonell, Nicolas, Duclos-Vallée, Jean-Charles, de Ledinghen, Victor, Ozenne, Violaine, Henrion, Jean, Perlemuter, Gabriel, Amiot, Xavier, Chevret, Sylvie, Najean, Marie, Layese, Richard, Zarca, Kevin, Segar, Laeticia Blampain, Cagnot, Carole, N’Kontchou, Gisèle, Ronot, Maxime, Audureau, Etienne, and Durand-Zaleski, Isabelle

Published
2022
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9. International study on the outcome of locoregional therapy for liver transplant in hepatocellular carcinoma beyond Milan criteria

Author

Boudjema, Karim, Bachellier, Philippe, Conti, Filomena, Scatton, Olivier, Muscari, Fabrice, Salame, Ephrem, Bernard, Pierre Henri, Francoz, Claire, Durand, Francois, Dharancy, Sébastien, Woehl, Marie-lorraine, Vanlemmens, Claire, Laurent, Alexis, Radenne, Sylvie, Dumortier, Jérôme, Abergel, Armand, Cherqui, Daniel, Barbier, Louise, Houssel-Debry, Pauline, Pageaux, Georges Philippe, Chiche, Laurence, Deledinghen, Victor, Hardwigsen, Jean, Gugenheim, J., Altieri, M., Hilleret, Marie Noelle, Decaens, Thomas, Duvoux, Christophe, Piñero, Federico, Chagas, Aline, Costa, Paulo, Cristina de Ataide, Elaine, Quiñones, Emilio, Duque, Sergio Hoyos, Marciano, Sebastián, Anders, Margarita, Varón, Adriana, Zerega, Alina, Poniachik, Jaime, Soza, Alejandro, Machaca, Martín Padilla, Arufe, Diego, Menéndez, Josemaría, Zapata, Rodrigo, Vilatoba, Mario, Muñoz, Linda, Menéndez, Ricardo Chong, Maraschio, Martín, Podestá, Luis G., Fauda, M., Campaña, A. Gonzalez, McCormack, Lucas, Mattera, Juan, Gadano, Adrian, Fatima Boin, Ilka S.F., Parente García, Jose Huygens, Carrilho, Flair, Silva, Marcelo, Notarpaolo, Andrea, Magini, Giulia, Miglioresi, Lucia, Gambato, Martina, Di Benedetto, Fabrizio, D’Ambrosio, Cecilia, Ettorre, Giuseppe Maria, Vitale, Alessandro, Burra, Patrizia, Fagiuoli, Stefano, Cillo, Umberto, Colledan, Michele, Pinelli, Domenico, Magistri, Paolo, Vennarecci, Giovanni, Colasanti, Marco, Giannelli, Valerio, Pellicelli, Adriano, Baccaro, Cizia, Degroote, Helena, Van Vlierberghe, Hans, Eduard, Callebout, Samuele, Iesari, Jeroen, Dekervel, Jonas, Schreiber, Jacques, Pirenne, Chris, Verslype, Dirk, Ysebaert, Peter, Michielsen, Valerio, Lucidi, Christophe, Moreno, Olivier, Detry, Jean, Delwaide, Roberto, Troisi, Paul, Lerut Jan, Costentin, Charlotte, Boin, Ilka F., Baccaro, Cinzia, Chagas, Aline Lopes, Di Benedetto, Fabrio, Gadano, Adrián, and Rubinstein, Fernando

Published
2021
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10. Large-scale screening of lipase acid deficiency in at risk population

Author

Tebani, Abdellah, Sudrié-Arnaud, Bénédicte, Boudabous, Hela, Brassier, Anais, Anty, Rodolphe, Snanoudj, Sarah, Abergel, Armand, Abi Warde, Marie-Thérèse, Bardou-Jacquet, Edouard, Belbouab, Reda, Blanchet, Eloi, Borderon, Corinne, Bronowicki, Jean-Pierre, Cariou, Bertrand, Carette, Claire, Dabbas, Myriam, Dranguet, Hélène, de Ledinghen, Victor, Ferrières, Jean, Guillaume, Maeva, Krempf, Michel, Lacaille, Florence, Larrey, Dominique, Leroy, Vincent, Musikas, Marietta, Nguyen-Khac, Eric, Ouzan, Denis, Perarnau, Jean-Marc, Pilon, Carine, Ratzlu, Vlad, Thebaut, Alice, Thevenot, Thierry, Tragin, Isabelle, Triolo, Valérie, Vergès, Bruno, Vergnaud, Sabrina, and Bekri, Soumeya

Published
2021
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11. Impact of cirrhosis aetiology on incidence and prognosis of hepatocellular carcinoma diagnosed during surveillance

Author

Ganne-Carrié, Nathalie, Chaffaut, Cendrine, Archambeaud, Isabelle, d’Alteroche, Louis, Oberti, Frédéric, Roulot, Dominique, Moreno, Christophe, Louvet, Alexandre, Dao, Thông, Moirand, Romain, Goria, Odile, Nguyen-Khac, Eric, Carbonell, Nicolas, Duclos-Vallée, Jean-Charles, Pol, Stanislas, de Ledinghen, Victor, Ozenne, Violaine, Henrion, Jean, Péron, Jean-Marie, Tran, Albert, Perlemuter, Gabriel, Amiot, Xavier, Zarski, Jean-Pierre, Chevret, Sylvie, Nahon, Pierre, Asselah, Tarik, Guyader, Dominique, Fontaine, Hélène, Pageaux, Georges-Philippe, De Lédinghen, Victor, Ouzan, Denis, Zoulim, Fabien, Bronowicki, Jean-Pierre, Decaens, Thomas, Riachi, Ghassan, Calès, Paul, Alric, Laurent, Bourlière, Marc, Mathurin, Philippe, Dharancy, Sebastien, Blanc, Jean-Frédéric, Abergel, Armand, Chazouillères, Olivier, Mallat, Ariane, Grangé, Jean-Didier, Attali, Pierre, Wartelle, Claire, Thabut, Dominique, Pilette, Christophe, Silvain, Christine, Christidis, Christos, Bernard-Chabert, Brigitte, Hillaire, Sophie, Di Martino, Vincent, N’Kontchou, Gisèle, Layese, Richard, and Audureau, Etienne

Published
2021
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13. Selonsertib for patients with bridging fibrosis or compensated cirrhosis due to NASH: Results from randomized phase III STELLAR trials

Author

Gadano, Adrian, Martins, Marcelo, Angus, Peter, Bate, John, Danta, Mark, George, Jacob, Hodge, Alexander, Kontorinis, Nickolas, Roberts, Stuart, Sanagapalli, Santosh, Skoien, Richard, Thompson, Alexander, Zekry, Amany, Stauber, Rudolf, Trauner, Michael, Moreno, Christophe, Reynaert, Hendrik, Verbeke, Len, Silva, Mario Reis Alvares da, Parise, Edison, Oliveira, Claudia Pinto Marques Souza de, Araujo, Roberta Chaves, Martinelli, Ana de Lourdes Candolo, Borman, Meredith, Chandok, Natasha, Elkhashab, Magdy, Fraser, Hughie, Kaita, Kelly, Ma, Mang, Marotta, Paul, Ramji, Alnoor, Tam, Edward, Yoshida, Eric, Swain, Mark, Sebastiani, Giada, Petrunia, Denis, Abergel, Armando, Anty, Rodolphe, Bourlière, Marc, Boursier, Jérôme, Bureau, Christophe, Castera, Laurent, Habersetzer, François, Hézode, Christophe, Ledinghen, Victor De, Leroy, Vincent, Loustaud-Ratti, Véronique, Mathurin, Philippe, Pol, Stanislas, Zoulim, Fabien, Hinrichsen, Holger, Ingiliz, Patrick, Lammert, Frank, Manns, Michael, Schattenberg, Jörn, Schiefke, Ingolf, Trautwein, Christian, Zeuzem, Stefan, Hui, Aric, Li, King-Kong, Wong, Vincent, Acharya, Subrat, Chowdhury, Abhijit, Duseja, Ajay, Kapoor, Dharmesh, Mukewar, Shrikant, Sarin, Shiv, Shah, Samir, Shalimar, Sood, Ajit, Tantry, BV, Ben-Ari, Ziv, Katchman, Helena, Safadi, Rifaat, Veitsman, Ella, Zuckerman, Eli, Brunetto, Maurizia, Lampertico, Pietro, Mangia, Alessandra, Akahane, Takemi, Akuta, Norio, Eguchi, Yuichiro, Fujiyama, Shigetoshi, Genda, Takuya, Hiasa, Yoichi, Ido, Akio, Ikeda, Fusao, Ikegami, Tadashi, Imajo, Kento, Itoh, Yoshito, Iwasa, Motoh, Karino, Yoshiyasu, Kato, Naoya, Kawaguchi, Takumi, Kawanaka, Miwa, Kido, Masahiro, Kobayashi, Tomoo, Kurosaki, Masayuki, Matsuzaki, Yasushi, Mita, Eiji, Mizukoshi, Eishiro, Nakahara, Takashi, Nomura, Hideyuki, Notsumata, Kazuo, Okanoue, Takeshi, Saito, Satoshi, Sakugawa, Hiroshi, Suzuki, Yoshiyuki, Takaguchi, Koichi, Takaki, Akinobu, Takashima, Tomoyuki, Tanaka, Saiyu, Tsuji, Keiji, Ueno, Yoshiyuki, Umemura, Takeji, Uto, Hirofumi, Yamashita, Nobuyuki, Yanase, Mikio, Yatsuhashi, Hiroshi, Yoneda, Masashi, Chan, Wah Kheong, Tan, Soek Siam, Garza, Laura Cisneros, Ladron De Guevara Cetina, Alma, Angeles, Rocio Guadalupe Vargas, Silva, Francisca Martinez, Van Erpecum, Karel, Orr, David, Jabłkowski, Maciej, Jaroszewicz, Jerzy, Ramos, Jose, Ahmed, Taufique, Ang, Tiing, Dan, Yock young, Goh, Boon Bee, Kaliyaperumal, Kalaiyarasi, Yip, Cherng Hann, Baik, Soon Koo, Jang, Byoung Kuk, Jun, Dae Won, Kim, Won, Kim, Hyung Joon, Kim, Ji Hoon, Lee, Kwan Sik, Lee, Chun Kyon, Lim, Young-Suk, Park, Jun Yong, Tak, Won Young, Augustin, Salvador, Perez, Salvador Benlloch, Caballeria, Juan, Luis, Jose, Panero, Calleja, Rodríguez, Jose Carrión, Garcia, Javier Crespo, Samaniego, Javier Garcia, Gibert, Pere Ginès, Prieto, Martin, Gomez, Manuel Romero, Turnes, Juan, Dufour, Jean-Francois, Moriggia, Alberto, Sheen, I-Shyan, Kao, Jia-Horng, Cheng, Pin-Nan, Huang, Jee-Fu, Yang, Sheng-Shun, Su, Wei-Wen, Chen, Chi-Yi, Chien, Rong-Nan, Lo, Gin-Ho, Chu, Chi-Jen, Wang, Horng-Yuan, Hu, Jui-Ting, Huang, Yi Wen, Agarwal, Kosh, Allison, Michael, Anstee, Quentin, Austin, Andrew, Fowell, Andrew, Ch'ng, Chin Lye, Manousou, Pinelopi, Newsome, Philip, Ryder, Stephen, Shankar, Arun, Abdelmalek, Manal, Abrams, Gary, Aguilar, Humberto, Alam, Imtiaz, Alba, Laura, Alkhouri, Naim, Allen, Alina, Aqel, Bashar, Balart, Luis, Barritt, A. Sidney, IV, Behari, Jaideep, Bennett, Michael, Bernstein, David, Bhandari, Bal Raj, Bonacini, Maurizio, Borg, Brian, Brown, Kimberly, Bzowej, Natalie, Caldwell, Stephen, Chami, Tawfik, Coates, Allan, Cueli, Adolfo, Davis, Mitchell, deLemos, Andrew, Desai, Archita, Dunn, Winston, Ferreira, Nelson, Fine, Michael, Firpi-Morell, Roberto, Freedland, Curtis, Freilich, Bradley, Fuchs, Michael, Galambos, Michael, Gallegos-Orozco, Juan, Galler, Greg, Ghali, Maged, Ghalib, Reem, Gill, Satinder, Gillis, Marcum, Gilroy, Richard, Gordon, Stuart, Gunn, Nadege, Halegoua-DeMarzio, Dina, Hassan, Mohamed, Hassanein, Tarek, Herring, Robert, Jr., Hong, John, Huang, Jonathan, Kabler, Heidi, Kayali, Zeid, Knapple, Whitfield, Kolli, Geetha, Kowdley, Kris, Krause, Richard, Lawitz, Eric, Lidofsky, Steven, Lim, Joseph, Lipkis, Donald, Loomba, Rohit, Mahgoub, Amar, Malespin, Miguel, Manch, Richard, Mannis, Steven, Manos, Paul, McDonald, Thomas, McKenzie, Mark, Mena, Edward, Merriman, Raphael, Moehlen, Martin William, Montgomery, Richard, Murphy, Robert, Natarajan, Yamini, Neff, Guy, Noureddin, Mazen, Ortiz-Lasanta, Grisell, Pagadala, Mangesh, Patel, Keyur, Patton, Heather, Peyton, Adam, Pimstone, Neville, Poulos, John, Pound, David, Pyrsopoulos, Nikolaos, Rafiq, Nila, Ravendhran, Natarajan, Ravinuthala, Ravi, Reddy, K. Rajendar, Reindollar, Robert, Reynolds, Justin, Rinella, Mary, Rizvi, Syed, Rockey, Don, Rodriguez-Perez, Federico, Ruane, Peter, Rubin, Raymond, Ryan, Michael, Saeian, Kia, Sanyal, Arun, Sarkar, Souvik, Scanga, Andrew, Schiff, Eugene, Schmidt, Warren, Schneider, Jeffrey, Sepe, Thomas, Shah, Dhiren, Shaikh, Obaid, Shankar, Uday, Sheikh, Aasim, Sheikh, Muhammad, Sherman, Kenneth, Shiffman, Mitchell, Siddique, Asma, Smith, Matthew, Suarez, Rosa, Talal, Andrew, Te, Helen, Tekola, Bezawit, Tetri, Brent, Thuluvath, Paul, Toro, Doris, Torres, Dawn, Trinh, Huy, Trotter, James, Vento, Angel, Vierling, John, Vuppalanchi, Raj, Waters, Michael, Weisberg, Ilan, Wieland, Amanda, Williams, Alonzo, Younes, Ziad, Adams, Leon, Harding, Damian, Hodge, Alex, Kontorinis, Nick, Strasser, Simone, Thompson, Alex, Horsmans, Yves, Steenkiste, Christophe Van, Bailey, Robert, Giard, Jeanne-Marie, Montano-Loza, Aldo, Puglia, Marco, Tsoi, Keith, Larrey, Dominique, Nguyen-Khac, Eric, Ratziu, Vlad, Spengler, Ulrich, Wiegand, Johannes, Hui, Aric Josun, Acharya, Subrat Kumar, Sarin, Shiv Kumar, Tantry, Vishwanath, Braun, Marius, Hazzan, Rawi, Lurie, Yoav, Colombo, Massimo, Fujii, Hideki, Hashimoto, Etsuko, Kato, Masaki, Ogawa, Koji, Takehara, Tetsuo, Tokushige, Katsutoshi, Garza, Laura Esthela Cisneros, Ladrón De Guevara, Alma Laura, Schultz, Michael, Janczewska, Ewa, Toro, Doris H., Jeong, Sook-Hyang, Kim, Yoon Jun, Lee, Jin-Woo, Ang, Tiing Leong, Bee, George Goh Boon, Benlloch, Salvador, Caballería, Juan, Calleja, José Luis, Rodríguez, Jose A. Carrión, Crespo, Javier, Diago, Moises, Fernandez-Rodriguez, Conrado, García-Samaniego, Javier, Ginès, Pere, Romero, Manuel, Dufour, Jean-François, Alazawi, William, Ch'ng, Chin-Lye, Forton, Daniel, Priest, Matthew, Sheridan, David, Ankoma-Sey, Victor, Balakrishnan, Maya, Bambha, Kiran, Barritt, A. Sidney, Bhandari, Bal, Brandman, Danielle, Chang, Charissa, Corey, Kathleen, Feldman, Michael, Gholam, Pierre, Goff, John, Marzio, Dina Halegoua-De, Harrison, Stephen, Hellstern, Paul, Jr., Herring, Robert, Iyer, Rajalakshmi, Jakiche, Antoine, Kohli, Anita, Krok, Karen, Kugelmas, Marcelo, Kumar, Sonal, Lai, Michelle, Mahmoud, Mitchell, Mantry, Parvez, Marsano, Luis, Nguyen, Tuan, Park, James, Patton, Heather M., Pockros, Paul, Reddy, Rajender, Rodriguez, Miguel, Sarles, Harry, Satapathy, Sanjaya, Sedghi, Shahriar, Shah, Nikunj, Sheikh, Muhammad Yasin, Sigal, Samuel, Stanca, Carmen, Steinbook, Michael, Szabo, Gyongyi, Terrault, Norah, Tong, Myron, Victor, David, Zervos, Xaralambos, Harrison, Stephen A., Wong, Vincent Wai-Sun, Caldwell, Stephen H., Shiffman, Mitchell L., Camargo, Marianne, Li, Georgia, Kersey, Kathryn, Jia, Catherine, Zhu, Yanni, Djedjos, C. Stephen, Subramanian, G. Mani, Myers, Robert P., Anstee, Quentin M., Romero-Gomez, Manuel, Goodman, Zachary, Lawitz, Eric J., and Younossi, Zobair

Published
2020
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14. R3-AFP score is a new composite tool to refine prediction of hepatocellular carcinoma recurrence after liver transplantation

Author

Charlotte Costentin, Federico Piñero, Helena Degroote, Andrea Notarpaolo, Ilka F. Boin, Karim Boudjema, Cinzia Baccaro, Luis G. Podestá, Philippe Bachellier, Giuseppe Maria Ettorre, Jaime Poniachik, Fabrice Muscari, Fabrizio Dibenedetto, Sergio Hoyos Duque, Ephrem Salame, Umberto Cillo, Sebastian Marciano, Claire Vanlemmens, Stefano Fagiuoli, Patrizia Burra, Hans Van Vlierberghe, Daniel Cherqui, Quirino Lai, Marcelo Silva, Fernando Rubinstein, Christophe Duvoux, Filomena Conti, Olivier Scatton, Pierre Henri Bernard, Claire Francoz, Francois Durand, Sébastien Dharancy, Marie-lorraine Woehl, Alexis Laurent, Sylvie Radenne, Jérôme Dumortier, Armand Abergel, Louise Barbier, Pauline Houssel-Debry, Georges Philippe Pageaux, Laurence Chiche, Victor Deledinghen, Jean Hardwigsen, J. Gugenheim, M. Altieri, Marie Noelle Hilleret, Thomas Decaens, Aline Chagas, Paulo Costa, Elaine Cristina de Ataide, Emilio Quiñones, Sebastián Marciano, Margarita Anders, Adriana Varón, Alina Zerega, Alejandro Soza, Martín Padilla Machaca, Diego Arufe, Josemaría Menéndez, Rodrigo Zapata, Mario Vilatoba, Linda Muñoz, Ricardo Chong Menéndez, Martín Maraschio, Lucas McCormack, Juan Mattera, Adrian Gadano, Ilka S.F. Fatima Boin, Jose Huygens Parente García, Flair Carrilho, Giulia Magini, Lucia Miglioresi, Martina Gambato, Fabrizio Di Benedetto, Cecilia D’Ambrosio, Alessandro Vitale, Michele Colledan, Domenico Pinelli, Paolo Magistri, Giovanni Vennarecci, Marco Colasanti, Valerio Giannelli, Adriano Pellicelli, Cizia Baccaro, Callebout Eduard, Iesari Samuele, Dekervel Jeroen, Schreiber Jonas, Pirenne Jacques, Verslype Chris, Ysebaert Dirk, Michielsen Peter, Lucidi Valerio, Moreno Christophe, Detry Olivier, Delwaide Jean, Troisi Roberto, Lerut Jan Paul, Costentin, C, Piñero, F, Degroote, H, Notarpaolo, A, Boin, I, Boudjema, K, Baccaro, C, Podestá, L, Bachellier, P, Ettorre, G, Poniachik, J, Muscari, F, Dibenedetto, F, Hoyos Duque, S, Salame, E, Cillo, U, Marciano, S, Vanlemmens, C, Fagiuoli, S, Burra, P, Van Vlierberghe, H, Cherqui, D, Lai, Q, Silva, M, Rubinstein, F, Duvoux, C, Conti, F, Scatton, O, Bernard, P, Francoz, C, Durand, F, Dharancy, S, Woehl, M, Laurent, A, Radenne, S, Dumortier, J, Abergel, A, Barbier, L, Houssel-Debry, P, Pageaux, G, Chiche, L, Deledinghen, V, Hardwigsen, J, Gugenheim, J, Altieri, M, Hilleret, M, Decaens, T, Chagas, A, Costa, P, Cristina de Ataide, E, Quiñones, E, Duque, S, Anders, M, Varón, A, Zerega, A, Soza, A, Machaca, M, Arufe, D, Menéndez, J, Zapata, R, Vilatoba, M, Muñoz, L, Menéndez, R, Maraschio, M, Mccormack, L, Mattera, J, Gadano, A, Fatima Boin, I, Parente García, J, Carrilho, F, Magini, G, Miglioresi, L, Gambato, M, Benedetto, F, D’Ambrosio, C, Vitale, A, Colledan, M, Pinelli, D, Magistri, P, Vennarecci, G, Colasanti, M, Giannelli, V, Pellicelli, A, Vlierberghe, H, Eduard, C, Samuele, I, Jeroen, D, Jonas, S, Jacques, P, Chris, V, Dirk, Y, Peter, M, Valerio, L, Christophe, M, Olivier, D, Jean, D, Roberto, T, Paul, L, Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Hôpital la Tronche, Universidad Austral de Chile, Ghent University Hospital, Arcispedale S Maria Nuova, Universidade Estadual de Campinas = University of Campinas (UNICAMP), CHU Pontchaillou [Rennes], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES), CHU Strasbourg, Universidad de Chile = University of Chile [Santiago] (UCHILE), Hôpital Universitaire de Rangueil, Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), Universidad de Antioquia = University of Antioquia [Medellín, Colombia], CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Azienda Ospedale Università di Padova = Hospital-University of Padua (AOUP), Instituto Universitario del Hospital Italiano [Buenos Aires, Argentina], Hôpital JeanMinjoz, Hospital Papa Giovanni XXIII (Hosp P Giovanni XXIII), Hôpital Paul Brousse, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), CHU Henri Mondor, Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), None, French-Italian-Belgium and Latin American collaborative group for HCC and liver transplantation: Karim Boudjema, Philippe Bachellier, Filomena Conti, Olivier Scatton, Fabrice Muscari, Ephrem Salame, Pierre Henri Bernard, Claire Francoz, Francois Durand, Sébastien Dharancy, Marie-Lorraine Woehl, Claire Vanlemmens, Alexis Laurent, Sylvie Radenne, Jérôme Dumortier, Armand Abergel, Daniel Cherqui, Louise Barbier, Pauline Houssel-Debry, Georges Philippe Pageaux, Laurence Chiche, Victor Deledinghen, Jean Hardwigsen, J Gugenheim, M Altieri, Marie Noelle Hilleret, Thomas Decaens, Christophe Duvoux, Federico Piñero, Aline Chagas, Paulo Costa, Elaine Cristina de Ataide, Emilio Quiñones, Sergio Hoyos Duque, Sebastián Marciano, Margarita Anders, Adriana Varón, Alina Zerega, Jaime Poniachik, Alejandro Soza, Martín Padilla Machaca, Diego Arufe, Josemaría Menéndez, Rodrigo Zapata, Mario Vilatoba, Linda Muñoz, Ricardo Chong Menéndez, Martín Maraschio, Luis G Podestá, Lucas McCormack, Juan Mattera, Adrian Gadano, Ilka Sf Fatima Boin, Jose Huygens Parente García, Flair Carrilho, Marcelo Silva, Andrea Notarpaolo, Giulia Magini, Lucia Miglioresi, Martina Gambato, Fabrizio Di Benedetto, Cecilia D'Ambrosio, Giuseppe Maria Ettorre, Alessandro Vitale, Patrizia Burra, Stefano Fagiuoli, Umberto Cillo, Michele Colledan, Domenico Pinelli, Paolo Magistri, Giovanni Vennarecci, Marco Colasanti, Valerio Giannelli, Adriano Pellicelli, Cizia Baccaro, Quirino Lai, Helena Degroote, Hans Van Vlierberghe, Callebout Eduard, Iesari Samuele, Dekervel Jeroen, Schreiber Jonas, Pirenne Jacques, Verslype Chris, Ysebaert Dirk, Michielsen Peter, Lucidi Valerio, Moreno Christophe, Detry Olivier, Delwaide Jean, Troisi Roberto, Lerut Jan Paul, Université de Rennes (UR), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), and CHU Henri Mondor [Créteil]

Subjects
TTR= time to recurrence, [SDV.CAN]Life Sciences [q-bio]/Cancer, Explants pathology, Liver cancer, Liver transplantation, Prediction, Recurrence, MVI= microvascular invasion, VC= validation cohort, VALIDATION, LT= liver transplantation, RETREAT SCORE, SHR= sub-distribution of hazard ratio, R3= recurrence risk reassessment, HBV= hepatitis B virus, SIROLIMUS-BASED IMMUNOSUPPRESSION, Internal Medicine, HCV= hepatitis C virus, Medicine and Health Sciences, IMPROVES, Immunology and Allergy, Hepatology, TC= test cohort, Gastroenterology, DEATH, COMPETING RISKS, MODEL, AFP= alpha-foetoprotein, SORAFENIB, SURVIVAL, HCC= hepatocellular carcinoma, RETREAT= Risk Estimation of Tumour Recurrence After Transplant
Abstract

Background & Aims: Patients with hepatocellular carcinoma (HCC) are selected for liver transplantation (LT) based on pre-LT imaging +/- alpha-foetoprotein (AFP) level, but discrepancies between pre-LT tumour assessment and explant are frequent. Our aim was to design an explant-based recurrence risk reassessment score to refine prediction of recurrence after LT and provide a framework to guide post-LT management.Methods: Adult patients who underwent transplantation between 2000 and 2018 for HCC in 47 centres were included. A prediction model for recurrence was developed using competing-risk regression analysis in a European training cohort (TC; n = 1,359) and tested in a Latin American validation cohort (VC; n=1,085).Results: In the TC, 76.4% of patients with HCC met the Milan criteria, and 89.9% had an AFP score of -4 nodules (sub-distribution of hazard ratio [SHR] = 1.88, 1 point), size of largest nodule (3-6 cm: SHR = 1.83,1 point; >6 cm: SHR = 5.82, 5 points), presence of microvascular invasion (MVI; SHR = 2.69, 2 points), nuclear grade >II (SHR = 1.20, 1 point), and last pre-LT AFP value (101-1,000 ng/ml: SHR = 1.57, 1 point; >1,000 ng/ml: SHR = 2.83, 2 points). Wolber's c-index was 0.76 (95% CI 0.72-0.80), significantly superior to an R3 model without AFP (0.75; 95% CI 0.72-0.79; p = 0.01). Four 5-year recurrence risk categories were identified: very low (score = 0; 5.5%), low (1-2 points; 15.1%), high (3-6 points; 39.1%), and very high (>6 points; 73.9%). The R3-AFP score performed well in the VC (Wolber's c-index of 0.78; 95% CI 0.73-0.83). Conclusions: The R3 score including the last pre-LT AFP value (R3-AFP score) provides a user-friendly, standardised framework to design post-LT surveillance strategies, protocols, or adjuvant therapy trials for HCC not limited to the Milan criteria.Clinical Trials Registration: NCT03775863.Lay summary: Considering discrepancies between pre-LT tumour assessment and explant are frequent, reassessing the risk of recurrence after LT is critical to further refine the management of patients with HCC. In a large and international cohort of patients who underwent transplantation for HCC, we designed and validated the R3-AFP model based on variables inde-pendently associated with recurrence post-LT (number of nodules, size of largest nodule, presence of MVI, nuclear grade, and last pre-LT AFP value). The R3-AFP model including last available pre-LT AFP value outperformed the original R3 model only based on explant features. The final R3-AFP scoring system provides a robust framework to design post-LT surveillance strategies, protocols, or adjuvant therapy trials, irrespective of criteria used to select patients with HCC for LT. (c) 2022 The Author(s). Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL).

Published
2022

20. SAT-048 Long-term mortality and risk factors associated with mortality after liver transplantation in the modern era

Author

Meszaros, Magdalena, Coilly, Audrey, Francoz, Claire, Conti, Filomena, Duvoux, Christophe, Dumortier, Jérôme, Antonini, Teresa, Dharancy, Sébastien, Hilleret, Marie-Noëlle, Del Bello, Arnaud, Anty, Rodolphe, Weil-Verhoeven, Delphine, Latournerie, Marianne, Houssel-Debry, Pauline, Dassetto, Clara, Chermak, Faiza, Faitot, François, Elkrief, Laure, Perignon, Claire, Abergel, Armand, Charpy, Flora, Molinari, Nicolas, and Pageaux, Georges-Philippe

Published
2024
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21. SAT-010 Elaboration of a one-year mortality score for first elective liver transplantation recipients over 60 years based on the results of the french national cohort between 2007 and 2017

Author

Labruyere, Marie, Sow, Amadou-Khalilou, Antoine, Corinne, Dharancy, Sebastien, Dumortier, Jérôme, Turco, Celia, Di Martino, Vincent, Weil-Verhoeven, Delphine, Houssel-Debry, Pauline, Conti, Filomena, Francoz, Claire, Pageaux, Georges-Philippe, Mabrut, Jean-Yves, Salamé, Ephrem, Faitot, François, Coilly, Audrey, Hardwigsen, Jean, Decaens, Thomas, Chermak, Faiza, Muscari, Fabrice, Anty, Rodolphe, Duvoux, Christophe, Abergel, Armand, Franza, Anne Minello, Binquet, Christine, and Latournerie, Marianne

Published
2024
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22. THU-079 Pre-transplant work-up for acute-on-chronic liver failure patients in intensive care units, a nationwide french survey

Author

Bellec, Claire, Moirand, Romain, Abergel, Armand, Antonini, Teresa, Anty, Rodolphe, Mabile-Archambeaud, Isabelle, Baron, Aurore, Bureau, Christophe, Cadranel, Jean-Francois, Carbonell, Nicolas, Carrier, Paul, Coilly, Audrey, Conti, Filomena, Costentin, Charlotte, de Lédinghen, Victor, Dharancy, Sebastien, Francoz, Claire, Garioud, Armand, Gerolami, René, Gigante, Elia, Lannes, Adrien, Latournerie, Marianne, Nault, Jean Charles, Pageaux, Georges-Philippe, Perignon, Claire, Reboux, Noemi, Rolle, Valentin, Rosa, Isabelle, Weil-Verhoeven, Delphine, Wartel, Faustine, Elkrief, Laure, and Artru, Florent

Published
2024
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23. OS-060 Hepatocellular carcinoma development despite histological regression of liver fibrosis following HCV cure (ANRS CirVir, Hepather, LICAVIR)

Author

Nahon, Pierre, lusivka-Nzinga, Clovis, Merle, Philippe, Zoulim, Fabien, Decaens, Thomas, Ganne-Carrié, Nathalie, Pageaux, Georges-Philippe, Leroy, Vincent, Alric, Laurent, Bronowicki, Jean-Pierre, Bourliere, Marc, Gournay, Jérôme, Tran, Albert, Pol, Stanislas, Mathurin, Philippe, Loustaud-Ratti, Veronique, Metivier, Sophie, de Lédinghen, Victor, Abergel, Armand, Thabut, Dominique, Dalteroche, Louis, Bouattour, Mohamed, Asselah, Tarik, Ouzan, Denis, Cales, Paul, Chazouillères, Olivier, Gelu-Simeon, Moana, Roulot, Dominique, Boursier, Jerome, Carole, Cagnot, Tamazirt, Sonia, Pascale, Alina, Nilusmas, Samuel, Lewin, Maite, Ziol, Marianne, Carrat, Fabrice, and Duclos-Vallée, Jean-Charles

Published
2024
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26. FRI-286 - Phenotypic characteristics of primary liver cancer in a large French cohort of patients with viral chronic liver disease followed-up before and after viral eradication: an ANRS study

Author

Pascale, Alina, Tamazirt, Sonia, Lusivka-Nzinga, Clovis, Nilusmas, Samuel, Djebbar, Meriem, Zoulim, Fabien, Decaens, Thomas, Ganne-Carrié, Nathalie, Pageaux, Georges-Philippe, Leroy, Vincent, Alric, Laurent, Bronowicki, Jean-Pierre, Bourliere, Marc, Tran, Albert, Pol, Stanislas, Mathurin, Philippe, Loustaud-Ratti, Veronique, Metivier, Sophie, Abergel, Armand, de Lédinghen, Victor, Thabut, Dominique, Dalteroche, Louis, Asselah, Tarik, Chazouillères, Olivier, Cales, Paul, Gelu-Simeon, Moana, Roulot, Dominique, Ziol, Marianne, Lewin, Maite, Carrat, Fabrice, Nahon, Pierre, and Duclos-Vallée, Jean-Charles

Published
2023
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27. THU-511 - Long-term outcome following liver transplantation for chronic liver disease in intensive care unit: the French nationwide experience

Author

Meszaros, Magdalena, Saliba, Faouzi, Francoz, Claire, Duvoux, Christophe, Conti, Filomena, Faitot, François, Houssel-Debry, Pauline, Hardwigsen, Jean, Hilleret, Marie-Noëlle, Vanlemmens, Claire, Salamé, Ephrem, Kamar, Nassim, Gugenheim, Jean, Abergel, Armand, Perignon, Claire, Chiche, Laurence, Gratien, Maryline Debette, Mabrut, Jean-Yves, Dharancy, Sebastien, Dumortier, Jérôme, Pageaux, Georges-Philippe, and Artru, Florent

Published
2023
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28. THU-498 - Evaluation of a delayed liver transplant strategy for patients listed for hepatocellular carcinoma treated with resection or thermo-ablation as a bridge to liver transplantation; the DELTAS-HCC study

Author

Lamarque, Catherine, Segaux, Lauriane, Abergel, Armand, Bachellier, Philippe, Chermak, Faiza, Coilly, Audrey, Conti, Filomena, Decaens, Thomas, Dharancy, Sebastien, Di Martino, Vincent, Dumortier, Jérôme, Francoz, Claire, Gugenheim, Jean, Hardwigsen, Jean, Muscari, Fabrice, Radenne, Sylvie, Salamé, Ephrem, Uguen, Thomas, Bedoya, José Ursic, Antoine, Corinne, Leroy, Vincent, Oubaya, Nadia, and Duvoux, Christophe

Published
2023
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30. Hepatitis B virus reactivation in transplant patients treated for hepatitis C recurrence: Prophylaxis makes the difference

Author

Mouna, Lina, Rossignol, Emilie, Tateo, Mariagrazia, Coilly, Audrey, Duclos-Vallée, Jean-Charles, Duvoux, Christophe, Durand, François, Tran, Albert, Radenne, Sylvie, Canva-Delcambre, Valerie, Houssel-Debry, Pauline, Dumortier, Jérôme, Conti, Filomena, de Ledinghen, Victor, Leroy, Vincent, Kamar, Nassim, Di Martino, Vincent, Moreno, Christophe, Botta Fridlund, Danielle, d'Alteroche, Louis, Lebray, Pascal, Perre, Philippe, Besch, Camille, Silvain, Christine, Habersetzer, François, Debette-Gratien, Maryline, Abergel, Armando, Diallo, Alpha, Samuel, Didier, Roque-Afonso, Anne-Marie, and Pageaux, Georges-Philippe

Published
2019
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31. Vascular and cardiac remodeling in world class professional cyclists

Author

Abergel, Eric, Linhart, Ales, Chatellier, Gilles, Gariepy, Jerome, Ducardonnet, Alain, Diebold, Benoit, and Menard, Joel

Subjects
Cyclists -- Physiological aspects, Heart ventricle, Left -- Physiological aspects, Carotid artery -- Physiological aspects, Health
Published
1998

32. Doxorubicin-loaded nanoparticles for patients with advanced hepatocellular carcinoma after sorafenib treatment failure (RELIVE): a phase 3 randomised controlled trial.

Author

UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, UCL - (SLuc) Service de gastro-entérologie, Merle, Philippe, Blanc, Jean-Frederic, Phelip, Jean-Marc, Pelletier, Gilles, Bronowicki, Jean-Pierre, Touchefeu, Yann, Pageaux, Georges, Gerolami, René, Habersetzer, François, Nguyen-Khac, Eric, Casadei-Gardini, Andrea, Borbath, Ivan, Tran, Albert, Wege, Henning, Saad, Amr Shafik, Colombo, Massimo, Abergel, Armand, Richou, Carine, Waked, Imam, Yee, Nelson S, Molé, Audrey, Attali, Pierre, Le Boulicaut, Julie, Vasseur, Bérangère, RELIVE Investigators, UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, UCL - (SLuc) Service de gastro-entérologie, Merle, Philippe, Blanc, Jean-Frederic, Phelip, Jean-Marc, Pelletier, Gilles, Bronowicki, Jean-Pierre, Touchefeu, Yann, Pageaux, Georges, Gerolami, René, Habersetzer, François, Nguyen-Khac, Eric, Casadei-Gardini, Andrea, Borbath, Ivan, Tran, Albert, Wege, Henning, Saad, Amr Shafik, Colombo, Massimo, Abergel, Armand, Richou, Carine, Waked, Imam, Yee, Nelson S, Molé, Audrey, Attali, Pierre, Le Boulicaut, Julie, Vasseur, Bérangère, and RELIVE Investigators

Abstract

BACKGROUND: Cytotoxic chemotherapy is generally ineffective in patients with hepatocellular carcinoma. We assessed the intravenous perfusion of doxorubicin-loaded nanoparticles in patients with hepatocellular carcinoma in whom previous sorafenib therapy had failed. METHODS: We did a multicentre, open-label, randomised, controlled phase 3 trial at 70 sites in 11 countries. Patients with hepatocellular carcinoma with one or more previous systemic therapies, including sorafenib, were randomly assigned to receive 30 mg/m2 doxorubicin-loaded nanoparticles (30 mg/m2 group), 20 mg/m2 doxorubicin-loaded nanoparticles (20 mg/m2 group), or standard care using a computer-generated randomisation list prepared by the funder and stratified by geographic region. Patients in the experimental groups received perfusion of the drug every 4 weeks and those in the control group received any systemic anticancer therapy (except sorafenib) as per investigator decision. The primary endpoint was overall survival in the intention-to-treat population. Safety was assessed in the population of patients who received at least one dose of their assigned treatment. This trial is registered with ClinicalTrials.gov, number NCT01655693. FINDINGS: Between June 15, 2012, and Jan 27, 2017, 541 patients were screened, of whom 144 were excluded and 397 were randomly assigned to one of the groups (133 to the 30 mg/m2 group; 130 to the 20 mg/m2 group; and 134 to the control group). Median follow-up was 22·7 months (IQR 11·2-34·9). After pooling the doxorubicin groups for the efficacy analysis, median overall survival was 9·1 months (95% CI 8·1-10·4) in the pooled doxorubicin-loaded nanoparticles group and 9·0 months (7·1-11·8) in the control group (HR 1·00 [95% CI 0·78-1·28], two-sided p=0·99). 227 (94%) of 242 patients who received doxorubicin-loaded nanoparticles and 100 (75%) of 134 patients in the control group had at least one treatment-emergent adverse event. The most common drug-related grade 3 or 4 tr

Published
2019

35. Endoscopic transsphenoidal surgery reduces the need for re-operation compared to the microscopic approach in pituitary macroadenomas.

Author

Shimony, Nir, Popovits, Nataly, Shofty, Ben, Abergel, Avraham, Ram, Zvi, and Grossman, Rachel

Subjects
TUMOR surgery, REOPERATION, ENDOSCOPIC surgery, SURGICAL complications, ADENOMA, MULTIVARIATE analysis
Abstract

Pituitary surgery has shifted in recent years from microscopic surgery(MS) to endoscopic endonasal surgery (EES). However, the comparative long-term outcome of these surgical approaches, including the need for subsequent re-operation has never been reported. We present our experience in a high-volume referral center experienced in both endoscopic and microscopic approaches to compare the need for re-operation after initial resection of non-functioning pituitary macroadenomas using these surgical approaches. 684 patients (398 with NF adenomas) underwent trans-sphenoidal pituitary surgery in our institution between 2006 and 2017. Complete follow-up (mean 72 months, minimum two years) was available in 87 newly diagnosed patients with non-functioning pituitary macroadenomas (NFPMA; 48-microscopic and 39-endoscopic). The EES approach has been used almost exclusively since 2012. The need for repeat operation for tumor resection during the follow-up period was assessed as the primary end-point of the study. Extracted data included various demographic and clinical parameters, radiographic findings as well as the extent of resection (EOR). The EOR was similar for both groups, with a trend towards better EOR in the EES group. The rate of surgical complications was also similar for both groups. There was a strong trend towards lower need for re-operation in the EES group compared to the MS group (12.8% vs. 29.2%, p = 0.056). In a multivariate analysis, only EOR and Knosp grade were independently associated with the need for re-operation surgery. Our data indicate that EES in NFPMA tends to be associated with a lower need for re-operation compared to the MS approach, with a similar rate of EOR and complications. [ABSTRACT FROM AUTHOR]

Published
2021
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36. Watchful waiting care or early intervention in asymptomatic severe aortic stenosis: Where we are.

Author

Ennezat, Pierre Vladimir, Malergue, Marie Christine, Le Jemtel, Thierry H., and Abergel, Eric

Abstract

Copyright of Archives of Cardiovascular Diseases is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2021
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37. Accuracy and reproducibility of left ventricular mass measurement by subcostal M-mode echocardiography in hypertensive patients and professional bicyclists

Author

Abergel, Eric, Cohen, Ariel, Vaur, Laurent, Khellaf, Fadia, Menard, Joel, and Chatellier, Gilles

Subjects
Hypertension -- Prognosis, Heart enlargement -- Physiological aspects, Echocardiography -- Methods, Heart ventricle, Left -- Measurement, Health
Abstract

In some patients, left ventricular (LV) mass cannot be evaluated by M-mode echocardiography because the parasternal long-axis view is not available. The aim of this study was to determine whether the subcostal view obtained by N-mode echocardiography under 2-dimensional guidance allows accurate and reproducible LV mass determination. Using the cube formula, LV mass was calculated, from parasternal and subcostal views in 96 subjects: 73 hypertensives and 23 professional bicyclists, covering a wide range of LV dimensions. M-mode tracings were read by 2 experienced echocardiographers and the interobserver variability was evaluated. With use of the subcostal view, the interobserver reproducibility, expressed as observer 1-observer 2, was excellent: -0.3 [+ or -] 1.3 mm for LV diastolic diameter, -0.1 [+ or -] 1.0 mm for ventricular diastolic septal thickness, 0.2 [+ or -] 0.6 mm for diastolic free wall thickness and 0.03 [+ or -] 16.7 g for LV mass. In 96% of cages, the difference in LV mass between the 2 observers did not exceed 30 g, With use of the parasternal and subcostal approaches, LV mass was not statistically different (202.6 [+ or -] 2.2 g and 206.5 [+ or -] 2.0 g, respectively) and the difference was Left ventricular (LV) hypertrophy has a recognized prognostic value in patients with systemic hypertension, and is an independent predictor of increased morbidity and mortality.[1-5] LV hypertrophy can be easily characterized and quantified by M-mode echocardiography under 2-dimensional guidance using a left parasternal view of the left ventricle.[6,7] LV mass determination, derived from an elliptical model of the left ventricle incorporating the cavity diameter and wall thickness, is reliable and reproducible,[8-10] providing that certain patients are excluded.[11] Patients with obesity, respiratory insufficiency or unaligned septum offer a poor quality parasternal view. hi such cases, the subcostal view may be useful since the M-mode ultrasonic beam can also be aimed perpendicularly to the long axis of the left ventricle.[12] Although some studies have compared LV dimensions using both approaches,[12-15] no study comparing the evaluation of LV mass by these 2 methods has been published. Therefore, the aim of the present study was to assess the accuracy and reproducibility of LV dimension and mass measurements obtained from a subcostal view compared with those obtained from the parasternal view. METHODS Enchocardiography: All examinations were performed using a Hewlett Packard Sonos 100 machine with a 2.5 MHz transducer. M-mode tracings of the left ventricle using parasternal and subcostal views were obtained from each patient during the same examination. We used the recommendations of Devereux regarding M-mode echocardiographic technique, using the parasternal window for measurement of the left ventricle.[11] For the subcostal view, special attention was paid to the following procedures: (1) accurate 2-dimensional imaging of LV long axis; this was achieved with patients in the left lateral position in the majority of cases, or in the supine position; (2) directing the ultrasonic M-mode beam perpendicularly to the walls, just below the tip of the mitral leaflet (using the same 'operator dependent' criteria as for the parasternal window); the M-mode echocardiographic recording was obtained during apnea at the moment in the respiratory cycle giving the optimal echo beam position (most often found to be at half to full inspiration); and (3) the maintenance of apnea, allowing the recording of [greater than or equal to] 3 cardiac cycles. Both the examination procedure and image interpretation were performed by 2 fully trained echocardiographers, who had previously achieved good interobserver reproducibility with this technique before the present study. Figure 1 shows the LV wall segments explored by both parasternal and subcostal M-mode examination. The following ventricular parameters were recorded on the parasternal and subcostal M-mode echocardiograms: LV diastolic and systolic internal dimensions, ventricular septal thickness, and free wall thickness. Inclusion design: Subjects were selected from 2 different populations: (1) hypertensive patients referred to our outpatient hypertension clinic, and (2) normotensive professional bicyclists participating in the 1991 Tour de France. We used the following inclusion criteria based on echographic data from a complete preliminary scan: (1) availability of an accurate M-mode echocardiogram of the left ventricle with both parasternal and subcostal views; (2) absence of LV distortion; and (3) absence of excessive variability in wall thickness (e.g., localized ventricular septal hypertrophy). Study design: No M-mode scans were interpreted until the completion of the study. Subjects' identification labels were masked and each echocardiogram interpreted independently. Each parameter was measured using the conventions of the American Society of Echocardiography[11] and averaged over 3 cardiac cycles by each of the 2 observers. Tracings were then unmasked, and the results of the 2 observers compared. The following rules were observed before any data analysis: (1) When the difference between the 2 observers' readings was Statistical analysis: Results are shown as mean [+ or -] 1 SD. Between-group comparisons were performed using the unpaired Student's t test. A p value RESULTS Study subjects: Table I summarizes the main characteristics of the 96 subjects included in this study. Only 4 subjects were excluded before data analysis, all due to poor quality paper tracings despite a satisfactory screen image during the on-line examination. [TABULAR DATA I OMITTED] Reproducibility of subcostal readings: The values of the different parameters measured by each observer are listed in Table II. For ventricular septal readings, significant discrepancies (difference >1 mm) were observed in 11 cases, the difference exceeding 2 mm in 5 cases (5.2%). For free wall thickness, the difference never exceeded 2 mm. For LV diastolic internal diameter, 3 readings differed by >2 mm, and 2 by >3 mm. The between-observer difference in LV mass did not exceed 30 g in 96% of cases, the greatest discrepancy being 65 g (Figure 2). LV mass difference did not depend on LV mass value. [TABULAR DATA II OMITTED] Comparison of left ventricular dimensions using parasternal and subcostal views: The main results are listed in Table III. Of 96 cases, the difference between parasternal and subcostal views for ventricular septal thickness was 2 mm in 12. For free wall thickness, the difference was >1 mm in 33 cases and >2 mm in 4 (4.2%). For LV diastolic internal diameter measurements, the difference was >2 mm, >3 mm or >5 mm in 58, 41 and 16%, respectively. The differences in the latter parameter ranged from -10 to +8 mm, with no over- or underestimation by the subcostal measurements compared with parasternal measurements (Figure 3). LV mass measurements exhibited a difference [TABULAR DATA III OMITTED] DISCUSSION Concerning the application of the same mathematic model to calculate mass using parastemal and subcostal view: LV mass can be accurately estimated by M-mode echocardiography, using the cube formula based on a prolate ellipsoid model (Figure 1) of a regularly configurated left ventricle (major to minor axis ratio approximately 2 to 1).[8,9] Myocardial volume is calculated as the difference between the external (external ellipsoid) and the internal (internal ellipsoid) volume of the left ventricle. LV volume may be approximated using only the minor axis measurement. Determination of the minor axis of the internal (LV diastolic internal diameter) and the external (LV diastolic internal diameter + wall segments) ellipsoids is derived from an M-mode echocardiogram of the left ventricle using the left parasternal window. The base of the ellipsoid is circular, which, in theory, allows an infinite number of identical measurements passing through the center. However, the number of echocardiographic views is limited and only the subcostal view allows the measurement of another minor axis of the left ventricle more or less perpendicular to that obtained using the parasternal view (Figure 1). Therefore, the subcostal view should allow the calculation of LV mass in nondeformed hearts. Reproducibility of readings: A measurement difference in reading of 1 mm for walls and 2 mm for the diameter is usually technically acceptable.[16,17] However, this can lead to variations in LV mass of up to 30 g for the same subject. In our clinic, we had previously evaluated the reproducibility of parasternal M-mode tracing interpretations in our daily practice. The mean between-observer difference in LV mass was 2 [+ or -] 8 g, a value comparable to that found in the present study using subcostal M-mode tracings. Finally, at the group level, the mean difference in LV mass between subcostal and parasternal views is not clinically relevant ( Comparison of the results obtained by each approach: Chang et al[12] and Starling et al[15] found comparable LV diastolic internal diameter values with both parasternal and subcostal views in ideal conditions. Bruntz et al[13] reported an overestimation using the parasternal approach (mean 53.4 vs 52.4 mm), whereas Rein et al[14] reported an overestimation using the subcostal view (51.4 [+ or -] 6.4 mm vs 50.0 [+ or -] 5.2 mm). The difference was statistically significant in Bruntz's study only; in none of these studies was the difference clinically relevant. Our results in the nondilated (hypertensive subjects) and in slightly dilated (bicyclists) left ventricle are in agreement with published data. To our knowledge, there is no reported data comparing LV mass calculation using parasternal and subcostal views. The present study shows similar results with both methods. This is corroborated by the fact that our SDs for each view are of the same order of magnitude as those obtained during reproducibility testing of repeated LV mass measurements using the parasternal view.[19] A case by case study shows a between-method difference of Study limitations: Only the reproducibility of readings was tested. We have no data on the inter- and intraexamination reproducibility of LV dimensions. In normal subjects, Brenner and Waugh[20] found a 2.9 mm inspiratory decrease of LV diastolic dimension; in this study, the phase of the respiratory cycle used for M-mode LV imaging was generally different for the 2 views but usually constant for each--mild to full expiration for the parasternal view and mild to full inspiration for the subcostal view. Clinical implications: The parasternal view remains the reference method for LV mass determination because it has been both anatomically validated and shown to be more reproducible than the subcostal view. However, in population studies, an M-mode parasternal view of the left ventricle is not achievable in 10 to 25% of cases,[11,15] especially in elderly and obese patients. Therefore, reliable LV assessment using another method is required. In this study concerning selected patients, the subcostal approach was a valuable alternative. In individual patients, this method allows the determination of LV mass for clinical purposes. In a research setting, recourse to the subcostal view may prevent patient exclusion because of a poor parasternal window. A prospective study in an unselected population would be justified to estimate the proportion of subjects in whom subcostal LV mass measurement can be performed accurately when the parasternal view is not reliable. Acknowledgment: We warmly thank Anne and Nick Berendt for their contribution in preparing the manuscript. [1.] Casale PN, Devereux RB, Milner M, Zullo G, Harshfield GA, Pickering TG, Laragh JH. Value of echocardiographic measurement of left ventricular mass in predicting cardiovascular morbid events in hypertensive men. Ann Intern Med 1986; 105:173-178. [2.] Levy D, Garrison RJ, Savage DD, Kannel WB, Castelli WP. Left ventricular mass and incidence of coronary heart disease in an elderly cohort. Ann Intern Med 1989;110:101-107. [3.] Levy D, Garrison RJ, Savage DD, Kannel WB, Castelli WP. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med 1990;322:1561-1566, [4.] Koren MJ, Devereux RB, Casale PN, Savage DD, Laragh JH. Relation of left ventricular mass and geometry to morbidity and mortality in uncomplicated essential hypertension. Ann Intern Med 1991;114:345-352. [5.] Ghali JK, Liao Y, Simmons B, Castaner A, Cao G, Cooper RS. The prognostic role of left ventricular hypertrophy in patients with or without coronary artery disease. Ann Intern Med 1992;117:831-836. [6.] Pearson AC, Gudipati CV, Nagelhout D, Sear J, Cohen JD, Labovitz AJ. Echocardiographic evaluation of cardiac structure and function in elderly subjects with isolated systolic hypertension. J Am Coll Cardiol 1991;17:422-430. [7.] Geva B, Elkayam U, Frishman WH. Determination of left ventricular wall thickening in patients with chronic systemic hypertension. Chest 1979;76:557-562. [8.] Devereux RB, Alonso DR, Lutas EM, Gottlieb GJ, Campo E, Sachs I, Reichek N. Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings. Am J Cardiol 1986;57:450-458. [9.] Devereux RB, Reichek N. Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. Circulation 1977;55:613-618. [10.] Collins HW, Kronenberg MW, Byrd BF. Reproducibility of left ventricular mass measurements by two-dimensional and M-mode echocardiography. J Am Coll Cardiol 1989;14:672-676. [11.] Devereux RB, Liebson PR, Horan MJ. Recommendations concerning the use of echocardiography in hypertension and general population research. Hypertension 1987;9(suppl II):II-97-11-104. [12.] Chang S, Feigenbaum H, Dillon J. Subxiphoid echocardiography. Chest 1975; 68:233-235. [13.] Bruntz JF, Chivoret G, Bourdon JL, Ethevenot G, Aliot E, Gilgenkrantz JM. Comparaison des principaux parametres echocardiographiques (mode TM) obtenus par voie parasternale et sous-costale. Arch Mal Coeur 1982;10:1159-1166. [14.] Rein AJJ, Azancot I, N'Gyen AVC, Adda JL, Georgiopoulos G, Piekarski A, Slama R. Subcostal M-mode computerised echocardiography, an alternative or complementary approach to parasternal echocardiography. Br Heart J 1983;50: 21-26. [15.] Starling MR, Crawford MH, O'Rourke RA, Groves BM, Amon KW. Accuracy of subxiphoid echocardiography for assessing left ventricular size and performance. Circulation 1980;61:367-373. [16.] Wallerson DC, Devereux RB. Reproducibility of echocardiographic left ventricular measurements. Hypertension 1987;9(suppl II):II-6-II-18. [17.] Lapido GOA, Dunn FG, Pringle TH, Bastian B, Lawrie TDV. Serial measurements of left ventricular dimensions by echocardiography. Assessment of week-to-week, inter- and intraobserver variability in normal subjects and patients with valvular heart disease. Br Heart J 1980;44:284-289. [18.] Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986;1:307-310. [19.] Devereux RB. Detection of left ventricular hypertrophy by M-mode echocardiography. Anatomic validation, standardization, and comparison to other methods. Hypertension 1987;9(suppl II):II-19-II-26. [20.] Brenner JI, Waugh RA. Effect of phasic respiration on left ventricular dimension and performance in a normal population. An echographic study. Circulation 1978;57:122-127. From the Centre de Medecine Preventive Cardio-Vasculaire and the Departement de Biostatistiques et d'Informatique Medicale, Hopital Broussais, and the Service de Cardiologie, Hopital Saint Antoine, Paris, France. Manuscript received January 8, 1993; revised manuscript received and accepted March 18, 1993. Address for reprints: Eric Abergel, MD, Centre de Medecine Preventive Cardio-Vasculaire, Hopital Broussais, 96 rue Didot, 75674 Paris Cedex 14, France.

Published
1993

38. Surgical management of odontogenic cysts involving the maxillary sinus- a retrospective study.

Author

Safadi, Ahmad, Kleinman, Shlomi, Gigi, Dana, Wengier, Anat, Oz, Itay, Abergel, Avraham, Koren, Ilan, and Ungar, Omer J.

Subjects
ODONTOGENIC cysts, MAXILLARY sinus surgery, DENTIGEROUS cyst, RADICULAR cyst, MAXILLARY sinus, ENDOSCOPIC surgery
Abstract

To describe our strategy for the management of odontogenic cysts involving the maxillary sinus, and to define the role of transnasal endoscopic sinus surgery in the treatment algorithm. A retrospective study was conducted. Included were all consecutive patients with odontogenic cysts involving the maxillary sinus who were treated in a single medical center between 2011 and 2019. Their medical records were reviewed for demographic data, preoperative presentation, surgical approach, final pathology, and postoperative course. Odontogenic cysts were classified as small or large according to maxillary sinus extension within or beyond the alveolar recess, respectively. A total of 30 patients with odontogenic cysts involving the maxillary sinus were treated by a team of maxillofacial and endoscopic sinus surgeons during the study period. There were 11 cases of dentigerous cysts, 11 radicular cysts, seven odontogenic keratocysts (OKCs), and one glandular cyst. Sixteen cases were managed by transnasal endoscopic sinus surgery alone and 14 were managed by a combined intraoral and endoscopic sinus surgery approach. A total of 22 patients had large cysts and total resection was achieved in 20 of them. There was one case of OKC recurrence during an average follow-up of 31 months. No major complications were recorded. The endoscopic approach can serve as an alternative to the transalveolar or lateral window approach. The endoscopic approach is associated with low morbidity and low recurrence rates. [ABSTRACT FROM AUTHOR]

Published
2020
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39. Endoscopic sinus surgery for dental implant displacement into the maxillary sinus—a retrospective clinical study.

Author

Safadi, A., Ungar, O.J., Oz, I., Koren, I., Abergel, A., and Kleinman, S.

Abstract

The aims of this retrospective clinical study were to present our management protocol for the retrieval of impacted dental implants that have become displaced into the maxillary sinus cavity and to define the role of endoscopic sinus surgery in this setting. All 24 patients (25 implants) who underwent surgical retrieval of dental implants displaced into the maxillary sinus between 2012 and 2019 were included. Data on surgical interventions and complications were collected retrospectively. Eleven patients (46%) had chronic sinusitis associated with the migrated implant. All implants were successfully retrieved via transnasal endoscopic approach alone: 80% via a middle meatal antrostomy and 20% via a combined middle and inferior meatal antrostomy. Five patients required a concomitant transoral approach for oro-antral fistula repair. None required a transoral approach for displaced implant retrieval. All patients healed uneventfully without complications. Transnasal endoscopic sinus surgery via a middle meatal antrostomy or a combined middle and inferior antrostomy is recommended as the primary choice for dental implant retrieval from the maxillary sinus. A transoral approach should be performed simultaneously only for oro-antral fistula repair. This surgical protocol proved to be safe and efficient, and it obviated the need for osteotomies of the anterolateral maxillary wall. [ABSTRACT FROM AUTHOR]

Published
2020
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40. The Clinical SYNTAX score predicts survival better than the SYNTAX score in coronary revascularization.

Author

Barac, Yaron D., Witberg, Guy, Assali, Abid, Klempfner, Robert, Krutzwald-Josefson, Efrat, Rubchevsky, Victor, Abergel, Eytan, Kornowski, Ran, and Aravot, Dan

Abstract

The Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery (SYNTAX) trial showed that the SYNTAX score (SS) is a useful tool for customizing revascularization treatment for patients with multivessel coronary disease. In the past decade, the Clinical SS (CSS) has emerged as a comprehensive tool. This novel tool considers the SS as well as patient clinical parameters such as age, creatinine clearance, and ejection fraction, which were shown to be relevant for patient prognosis. Thus, in the current work we set out to compare the survival predictive values of the SS versus the CSS and their future application in real-world implementation of the revascularization guidelines. This study was a subanalysis of data collected in a prospective national registry in Israel that enrolled consecutive patients with left main and/or 2- to 3-vessel coronary artery disease involving the proximal or mid-left anterior descending artery; the MULTI-vessel Coronary Artery Disease (MULTICAD). The revascularization method was chosen by the physicians taking care of the patients at each hospital and the patients were followed for 5 years. Patients were categorized according to their SS, the CSS, and their revascularization method (primary coronary intervention [PCI] vs coronary artery bypass grafting [CABG]) and patient survival were compared. A total of 585 patients were enrolled in the study and were followed for 5 years. The median CSS was 27, with 288 patients showing a CSS ≥27, with a mean CSS of 47.85 and a mean SS of 29.05. At 3 and 5 years post-treatment, the CSS ≥27 group had a lower survival probability, CSS ≥27 was associated with a lower survival probability among patients who underwent PCI compared with those who underwent CABG. More specifically, the high-CSS CABG group had a 5-year mortality rate of 16.8%, whereas the high-CSS PCI group had a 5-year mortality rate of 32.2%. In a comparison of SS with CSS for the 5-year mortality outcome prediction, CSS was superior to SS with a higher area under the curve. This prospective registry of real-world revascularization strategies in patients with multivessel disease showed that CSS is a better predictive tool of postrevascularization survival than SS. Moreover, it showed that surgical revascularization in patients with CSS ≥27 is associated with better all-cause mortality outcome after CABG as compared with after PCI. This attests to the need for a score that considers clinical parameters in a real-world scenario. [Display omitted] [ABSTRACT FROM AUTHOR]

Published
2024
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41. Right Ventricular-Pulmonary arterial (RV-PA) coupling is load independent and accurately predicts right ventricular function.

Author

Chong Fah Shen, V.C.F.S., Venner, C.V., and Abergel, E.A.

Abstract

RV-PA coupling can be evaluated, using non-invasive surrogates such as Tricuspid annular plane systolic excursion/Systolic pulmonary artery pressure (TAPSE/SPAP) or RV free wall longitudinal strain/SPAP (RVFWLS/SPAP) emerged. The aim of the present study was: 1) Population 1: in Hemodialysis population (HD), to evaluate RV parameters during important load variations, immediately before and after HD. 2) Population 2: in routine cardiologic population, to evaluate the diagnostic value of RV-PA coupling for RV dysfunction Population 1: 85 patients (53 men), 64 ± 16 years old, had an echocardiography with RV analysis (s', TAPSE, RVFWLS)immediately before starting HD(Pre-HD)and at the end of HD(Post-HD). Population 2: 96 patients (60 men), 64 ± 14 years old with various disease in the Department of cardiology had an echocardiography including RVFWLS,RV fractional area change(RVFAC), TAPSE,S', Tei index, Isovolumic acceleration(IVA),and 3D RVEF. Patients were split in normal RV function (defined by 6 concordant normal indices) and RV dysfunction (defined by the presence of at least 3 abnormal indices) Population 1: TAPSE, s', RVFWLS were significantly decreased in post-HD as compared to pre-HD; when indexing these parameters by SPAP (s'/SPAP, TAPSE/SPAP, RVFWLS/SPAP), they remain unchanged. Population 2: RVFWLS/SPAP and TAPSE/SPAP were significantly higher in normal RV function compared to dysfunction (1.02 ± 0.31 vs 0.57 ± 0.34 and 0.83 ± 0.20 vs 0.47 ± 0.21); diagnostic thresholds for RV dysfunction were 0.67 for RVFWLS/SPAP(sensitivity:95%, specificity:78%)and 0.63 for TAPSE/SPAP (sensitivity:86%, specificity:80%) Surrogates of RV-PA coupling, such as TAPSE/SPAP or RVFWLS/SPAP are load independent in a HD population. Moreover, these parameters may contribute to precisely evaluate RV function. [ABSTRACT FROM AUTHOR]

Published
2023
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43. Characterization of gene expression associated with the adaptation of the nematode C. elegans to hypoxia and reoxygenation stress reveals an unexpected function of the neuroglobin GLB-5 in innate immunity.

Author

Zuckerman‎, Binyamin, Abergel, Zohar, Zelmanovich, Veronica, Romero, Leonor, Abergel, Rachel, Livshits, Leonid, Gross, Einav, and Smith, Yoav

Subjects
*GLOBIN genes, *CAENORHABDITIS elegans, *HYPOXEMIA, *GENE expression, *EFFECT of stress on natural immunity, *ACTIVE oxygen in the body, *PHYSIOLOGY, *DISEASE risk factors, *MICROORGANISMS
Abstract

Oxygen (O 2 ) is a double-edged sword to cells, for while it is vital for energy production in all aerobic animals and insufficient O 2 (hypoxia) can lead to cell death, the reoxygenation of hypoxic tissues may trigger the generation of reactive oxygen species (ROS) that can destroy any biological molecule. Indeed, both hypoxia and hypoxia-reoxygenation (H/R) stress are harmful, and may play a critical role in the pathophysiology of many human diseases, such as myocardial ischemia and stroke. Therefore, understanding how animals adapt to hypoxia and H/R stress is critical for developing better treatments for these diseases. Previous studies showed that the neuroglobin GLB-5( Haw ) is essential for the fast recovery of the nematode Caenorhabditis elegans ( C. elegans ) from H/R stress. Here, we characterize the changes in neuronal gene expression during the adaptation of worms to hypoxia and recovery from H/R stress. Our analysis shows that innate immunity genes are differentially expressed during both adaptation to hypoxia and recovery from H/R stress. Moreover, we reveal that the prolyl hydroxylase EGL-9, a known regulator of both adaptation to hypoxia and the innate immune response, inhibits the fast recovery from H/R stress through its activity in the O 2 -sensing neurons AQR, PQR, and URX. Finally, we show that GLB-5( Haw ) acts in AQR, PQR, and URX to increase the tolerance of worms to Pseudomonas aeruginosa pathogenesis. Together, our studies suggest that innate immunity and recovery from H/R stress are regulated by overlapping signaling pathways. [ABSTRACT FROM AUTHOR]

Published
2017
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44. Quantification of steatosis in alcoholic and nonalcoholic fatty liver disease: Evaluation of four MR techniques versus biopsy.

Author

Boudinaud, Claire, Abergel, Armand, Joubert-Zakeyh, Juliette, Fontarensky, Mikael, Pereira, Bruno, Chauveau, Benoit, Garcier, Jean Marc, Chabrot, Pascal, Boyer, Louis, and Magnin, Benoît

Subjects
*FATTY liver, *RUBELLA, *HISTOLOGICAL techniques, *LIVER biopsy, *DISEASE complications, *ALCOHOL drinking
Abstract

Purpose: Given the growing prevalence of obesity and metabolic syndrome, the management of hepatic steatosis, especially its quantification, is a major issue. We assessed the quantification of liver steatosis using four different MR methods, in order to determine the one that is best correlated with the reference method which consists of histological measurement by liver biopsy.Method: Seventy-one successive patients requiring liver biopsy for acute or chronic liver disease were enrolled prospectively between March 2017 and March 2018, 11 were excluded and 60 were reported. Liver MR (1.5 T) was organised in order to be performed the same day, using four different steatosis quantification techniques (3-echo MRI, 6-echo MRI, 11-echo MRI and MR Spectroscopy). Quantitative histological and imaging data were compared. In a secondary analysis, we studied the possible influence of alcohol drinking, hepatic iron overload, and the presence of liver fibrosis.Results: All four MR techniques were found to have excellent correlations with the histological measurements: 3-echo MRI (r = 0.852, p < 0.001), 6-echo MRI (r = 0.819, p < 0.001), 11-echo MRI (r = 0.818, p < 0.001) and MR Spectroscopy (r = 0,812, p < 0,001). Interestingly, we also found that the presence of alcohol consumption, iron overload and fibrosis did not interfere with measurements, whichever technique was used.Conclusion: In the evaluation of hepatic steatosis, our study showed very good correlations of all four MR techniques with the histological standard. There was no confounding factor in a representative group of patients with associated liver conditions such as alcohol consumption, fibrosis and iron overload, for each technique. All four MR techniques may be used in daily practice. [ABSTRACT FROM AUTHOR]

Published
2019
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46. THU-123-No effect of alcohol consumption or dependence on treatment outcome in chronic hepatitis C patients treated with Elbasvir/Grazoprevir in a real-world setting

Author

Bronowicki, Jean-Pierre, Miailhes, Patrick, Hanslik, Bertrand, Abergel, Armand, Larrey, Dominique, Pospait, Dr. Dan, Truchi, Régine, Ouzan, Denis, Jouannaud, Vincent, Perot, Ms. Stéphanie, Skrzypski, Jérémy, Liautard, Ms. Camille, Estrabaud, Ms. Emilie, SpampinatoMs, Axelle, Guidoum, Dr. Amir, and Sogni, Philippe

Published
2019
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47. THU-111-High efficacy and safety of the combination HCV regimen elbasvir and grazoprevir for 8 weeks in treatment-naive non-severe fibrosis HCVGT1b-infected patients: Final results of the STREAGER study

Author

Abergel, Armand, Hezode, Christophe, Asselah, Tarik, Larrey, Dominique, Gournay, Jérôme, Loustaud-Ratti, Veronique, martino, vincent di, Hubert, Isabelle Fouchard, Stanislas, Pol, Bailly, Francois, Samuel, Didier, Albert, Tran, Chanteranne, Brigitte, Dodel, Marie, Faure, Frederic, Pereira, Bruno, Lamblin, Géraldine, Muti, Leon, Campos, Cecile, Reymond, Maud, Teilhet, Camille, and Buchard, Benjamin

Published
2019
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