Search

Nuclear power plants should be capable of contributing safely and flexibly to the electrical grid stability. This research deliberates the feasibility of a new innovative concept of a passive and autonomous frequency control operation (PAFO) in soluble-boron-free (SBF) pressurized water reactors (PWRs). The new concept eliminates any required active control in the reactor core for attaining primary and secondary frequency control operational modes in PWRs. In particular, control rods and soluble-boron are not utilized in a PAFO. Meanwhile, the reactor power maneuvering is achieved entirely by the passive reactor feedback to the coolant temperature change. This approach is motivated by the strongly negative coolant temperature coefficient available in an SBF coolant system. In order to ascertain judiciously the practical viability of the proposed concept, numerical simulations of passive primary and secondary frequency operations are performed using a lumped PWR system model solved by an in-house FORTRAN-95 computer code. The various simulation parameters are obtained from 3D Monte Carlo simulations of an SBF 450 MWt PWR by using Serpent-2 code with ENDF/B-7.1 data library. The numerical simulations are carried out at the beginning, middle and end of the fuel cycle to emphasize the effect of fuel burnup on the proposed PAFO. Moreover, sensitivity analyses on xenon worth and nominal fuel temperature are performed to deliberate their impacts in tailoring the reactor performance. Because the reactor power matches well with the power demand with a small variation in coolant temperature during the frequency control, we conclude that there is promising potential for the proposed PAFO concept. [ABSTRACT FROM AUTHOR]

Cyanine compounds have previously shown excellent in vitro and promising in vivo antileishmanial efficacy, but the potential toxicity of these agents is a concern. A series of 22 analogs of thiazole orange ((Z)-1-methyl-4-((3-methylbenzo[ d ]thiazol-2(3 H)-ylidene)methyl)quinolin-1-ium salt), a commercial cyanine dye with antileishmanial activity, were synthesized in an effort to increase the selectivity of such compounds while maintaining efficacy. Cyanines possessing substitutions on the quinolinium ring system displayed potency against Leishmania donovani axenic amastigotes that differed little from the parent compound (IC 50 12–42 nM), while ring disjunction analogs were both less potent and less toxic. Changes in DNA melting temperature were modest when synthetic oligonucleotides were incubated with selected analogs (ΔTm ≤ 5 °C), with ring disjunction analogs showing the least effect on this parameter. Despite the high antileishmanial potency of the target compounds, their toxicity and relatively flat SAR suggests that further information regarding the target(s) of these molecules is needed to aid their development as antileishmanials. [ABSTRACT FROM AUTHOR]

The non-base load operation of nuclear power plants is expected to be unavoidable in future due to the increasing shares of the intermittent renewables. In this paper, the physics conditions required for a passively autonomous frequency control operation (PAFO) in a 3400 MWt conventional pressurized water reactor (PWR) design is investigated. The PAFO scheme allows a PWR to passively achieve the requested power maneuverability for primary and secondary frequency regulations on the electrical grid. This study is carried out for a conventional coolant system with a typical critical boron concentration, which yields a less negative coolant temperature coefficient (CTC) than that in a soluble-boron-free (SBF) core. The PAFO scheme is expected to be more challenging in the conventional PWRs than in an SBF small modular reactor, particularly for the secondary frequency regulation. This is mainly due to the weaker coolant reactivity feedback and the higher fuel temperature, which yields a stronger Doppler reactivity feedback during the passive power transients. Numerical simulations of PAFO are performed, for typical power ranges and power ramping rates required for frequency regulations, using a lumped PWR model that is solved by an in-house Fortran-95 computer code. In conventional PWRs, the progressive dilution of the soluble-boron throughout the cycle and the fuel depletion vary the reactivity coefficients. Therefore, we perform sensitivity analyses on CTC, FTC, and Xe worth to assess the feasibility of PAFO throughout the fuel cycle. In addition, sensitivity analysis on the fuel temperature is done to study its role in altering the reactor performance during PAFO. [ABSTRACT FROM AUTHOR]