1. t(3;21)(q22;q22) leading to truncation of the RYK gene in atypical chronic myeloid leukemia
- Author
-
Micci, Francesca, Panagopoulos, Ioannis, Haugom, Lisbeth, Andersen, Hege Kilen, Tjønnfjord, Geir E., Beiske, Klaus, and Heim, Sverre
- Subjects
- *
CHRONIC myeloid leukemia , *CHROMOSOMAL translocation , *PROTEIN-tyrosine kinases , *LEUKEMIA etiology , *NUCLEOTIDE sequence ,LEUKEMIA genetics - Abstract
Abstract: The analysis of a small number of patients with atypical chronic myeloid leukemia showing balanced chromosomal translocations has revealed diverse tyrosine kinase fusion genes, most commonly involving FGFR1, PDGFRA, PDGFRB, JAK2, and ABL. We present a case of aCML with a 3q22;21q22-translocation that led to truncation of the receptor-like tyrosine kinase (RYK) gene and its juxtaposition with sequences from chromosome 21 including the ATP5O gene coding for a mitochondrial ATP synthase. The resulting fusion was not in frame, however, which is why we speculate that an abrogated RYK gene product rather than a chimeric protein might be the leukemogenic result. [Copyright &y& Elsevier]
- Published
- 2009
- Full Text
- View/download PDF