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Several nonmodifiable factors are associated with worse postoperative renal function in patients that have undergone nephron sparing surgery. Also, a positive correlation between renal disease and the calcification of renal arteries has been shown. This study aimed to investigate whether the calcification of renal arteries and aorta may be risk factors for developing chronic kidney disease after nephron sparing surgery. Introduction: This study aims to investigate whether the calcification of renal arteries and aorta may be risk factors for developing chronic kidney disease (CKD) after Nephron sparing surgery (NSS). Materials and Methods: The patients that underwent either open or laparoscopic NSS from 2000 to 2019 in 4 different centers were retrospectively assessed. Of these patients, 328 had a non-contrast-enhanced computer tomography. Calcium scores of the renal arteries and abdominal aorta were measured in the non-contrast-enhanced images with the calcium score plugin (version 2.0) of Horos TM. Univariate and multivariate logistic regression analysis was performed to determine significant risk factors for developing CKD at the last check-up. Roc curve analysis was performed to determine the optimal cut-off values of age and abdominal aorta calcium scores. Results: A total of 302 patients, of which 52 (16,6%) with CKD and 252 (83,4%) without CKD at the last check-up, were included in the analysis. The mean warm ischemia duration was significantly higher in patients with CKD (18,79 ±6,72 vs 16,38 ±5,57 minutes, p = 0,016). The mean size of the tumor diameter and the number of the patients with =stage T1b were higher in the group with CKD (p = 0,024 and 0,005, respectively). The median calcium scores of the aorta and renal arteries were higher in the group with CKD (p < 0,001 and p < 0,001, respectively). In multivariate analysis, age > 60 years (OR:3,65, p = 0,022), calcium score of the aorta (OR:4,07, p = 0,029), tumor diameter (OR:1,03, p = 0,026) and pre-operative CKD stage (OR:10,13, p < 0,001) found the be significant factors for predicting last check-up CKD. Conclusion: The calcium score of the aorta may be used as an additional risk factor to predict post-operative CKD risk after NSS with sensitivity over 80%. [ABSTRACT FROM AUTHOR]

TROP-2, a novel marker of trophoblastic cells, is being widely analyzed for its possible role in carcinogenesis and clinical behavior of various carcinomas. In this study, we aimed to evaluate the relationship between clinicopathologic parameters and TROP2 expression in prostatic adenocarcinomas. 101 prostatic adenocarcinomas treated by radical prostatectomy in our hospital between 2013 and 2018 were reviewed retrospectively for histopathological features, and one representative block of each case was stained with TROP2 antibody. Histopathologic prognostic features were assessed for their relationship with TROP2 expression. The mean age was found as 64.11 year. TROP2 was stained in over 10% of the tumoral cells in 64 (63.4.%) cases. Gleason grade group, perineural invasion, lymphovascular invasion, ganglionic and seminal vesicle involvement, lateral and basal surgical margin positivity showed a significant relationship with TROP2 staining. TROP2 is overexpressed in various human cancers and TROP2 overexpression appears to correlate with poor prognosis leading to the suggestion that TROP2 could be a therapeutic target for various carcinomas. Our results suggest that TROP2 expression is higher in advanced tumors and these results need to be supported by larger studies. • Trophoblast cell surface antigen 2 (TROP2), which is defined on trophoblastic cells, is a transmembrane glycoprotein. • TROP2 expression is reported to be higher in solid tumors with aggressiveness, invasiveness, and metastasis. • Our results show that high TROP2 expression was mostly seen in prostatic carcinomas with poor prognostic histologic features. • These results lead us think that TROP2 could be a therapeutic target for prostatic carcinomas. [ABSTRACT FROM AUTHOR]