The purpose of this study was to determine the relationship between values and psychological resilience in individuals with substance use disorder. This descriptive and correlational study was conducted with 70 individuals diagnosed with substance use disorder who had applied to the Alcohol and Drug Addiction Treatment and Research Center between February and April 2022 and volunteered to participate in the study. The data were collected using the Personal Information Form, Values Scale, and Brief Resilience Scale (BRS). All participants were male, the average age of substance use onset was 17.67 ± 5.95 years, and they had been receiving addiction treatment for 1.97 ± 2.30 years on average. The average total score of the individuals on the BRS scale was 17.18 ± 1.45. A significant positive correlation was found between the social values, intellectual values, spiritual values, materialistic values, human dignity, and freedom sub-dimensions of the Values Scale and psychological resilience (p <.001). Additionally, spiritual values were found to have the highest positive effect on the psychological resilience levels of individuals (B = 0.185; p <.05). Individuals with higher levels of social values, intellectual values, spiritual values, materialistic values, human dignity, and freedom were found to have higher psychological resilience. Nursing care provided by taking into account the values of the individual and strengthening their values may contribute to the psychological resilience of the patient. • A significant positive correlation was found between values and psychological resilience of individuals diagnosed with substance use disorder. • Spiritual values were found to have the highest and positive effect on the psychological resilience levels of individuals. [ABSTRACT FROM AUTHOR]