1. Anti-inflammatory, antioxidant and antifungal furanosesquiterpenoids isolated from Commiphora erythraea (Ehrenb.) Engl. resin
- Author
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Fraternale, Daniele, Sosa, Silvio, Ricci, Donata, Genovese, Salvatore, Messina, Federica, Tomasini, Sabrina, Montanari, Francesca, and Marcotullio, Maria Carla
- Subjects
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ALTERNATIVE medicine , *ANALYSIS of variance , *ANIMAL experimentation , *ANTI-inflammatory agents , *ANTIFUNGAL agents , *ANTIOXIDANTS , *BIOLOGICAL assay , *BIOLOGICAL models , *BIOPHYSICS , *ESSENTIAL oils , *GAS chromatography , *GUMS & resins , *MASS spectrometry , *RESEARCH methodology , *MEDICINAL plants , *MICE , *MICROBIAL sensitivity tests , *NUCLEAR magnetic resonance spectroscopy , *RESEARCH funding , *STATISTICS , *PLANT extracts , *DATA analysis , *PHARMACODYNAMICS - Abstract
Abstract: The topical anti-inflammatory, free radical scavenging and antifungal activities of essential oils and extracts of Commiphora erythraea (Ehrenb.) Engl. resin were investigated. The hexane extract significantly inhibited oedema when applied topically in Croton oil-induced ear oedema assay in mice. The same extract showed antioxidant activity in DPPH radical scavenging assay. A bioguided separation of the hexane extract led to the isolation of furanosesquiterpenoids 1 and 2 that showed a weak antifungal activity, while compounds 3–5 resulted to be antioxidant (EC50 4.28, 2.56 and 1.08mg/mL, respectively) and anti-inflammatory (30, 26 and 32% oedema reduction, respectively). [Copyright &y& Elsevier]
- Published
- 2011
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