1. Stereotactic body radiotherapy (SBRT) in combination with drugs in metastatic kidney cancer: A systematic review.
- Author
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Ingrosso, Gianluca, Becherini, Carlotta, Francolini, Giulio, Lancia, Andrea, Alì, Emanuele, Caini, Saverio, Teriaca, Maria Ausilia, Marchionni, Alessandro, Filippi, Andrea Riccardo, Livi, Lorenzo, Sanguineti, Giuseppe, Aristei, Cynthia, and Detti, Beatrice
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STEREOTACTIC radiotherapy , *RENAL cancer , *METASTASIS , *TREATMENT effectiveness , *KINASES - Abstract
• Tyrosine Kinases Inhibitors were used in combination with SBRT in 93% of cases. • Radiotherapy schedules of single fraction doses were 10–20 Gy. • Radiotherapy schedules of hypofractionated doses were 35–60 Gy in 3–5 fractions. • Local control of irradiated lesions was achieved in 76–100% of the patients. • The 2-year overall survival was 71% after combined approach. To conduct a systematic review and meta-analysis of the role of SBRTdrug combination in patients affected by mRCC and associated oncologic outcomes and toxicity profiles. We performed a critical review of the Pubmed, Medline, and Embase databases from January 1, 2000 through April 30, 2020 according to the Preferred Reporting Items and Meta-Analyses statement. To assess the overall quality of the literature reviewed, we used a modified Delphi tool. A total of 6 studies were included, corresponding to a cohort of 216 patients. Tyrosine Kinases Inhibitors were the most widely used drugs in combination with SBRT, being administered in 93% patients. No study reported an increase of radiation-induced toxicity. SBRT resulted to be safe, without increase in terms of drugs-related adverse events in this setting. Moreover, this approach showed promising clinical outcomes in terms of LC and OS [ABSTRACT FROM AUTHOR]
- Published
- 2021
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