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1. A replication-incompetent influenza virus bearing the HN glycoprotein of human parainfluenza virus as a bivalent vaccine.

Author

Kobayashi, Hirofumi, Iwatsuki-Horimoto, Kiyoko, Kiso, Maki, Uraki, Ryuta, Ichiko, Yurie, Takimoto, Toru, and Kawaoka, Yoshihiro

Subjects
*INFLUENZA viruses, *GLYCOPROTEINS, *PARAINFLUENZA viruses, *MENINGOCOCCAL vaccines, *INFLUENZA prevention, *VIRAL replication
Abstract

Highlights: [•] PB2-KO virus bearing HN of HPIV3 did not replicate in normal cells. [•] PB2-KO virus bearing HN of HPIV3 elicited mucosal and systemic immunity. [•] Hamsters immunized with PB2-KO virus bearing HN of HPIV3 were protected from both influenza virus and parainfluenza virus challenge. [ABSTRACT FROM AUTHOR]

Published
2013
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