1. Deterioration of fine motor skills and functional disability in patients with moderate-to-advanced Parkinson disease: A longitudinal follow-up study.
- Author
-
Huang, Yin-Chia, Hong, Chien-Tai, Chi, Wen-Chou, Yen, Chia-Feng, Fang Liao, Hua-, Liou, Tsan-Hon, and Chan, Lung
- Subjects
- *
MOTOR ability , *FUNCTIONAL status , *PARKINSON'S disease , *SEVERITY of illness index , *LONGITUDINAL method , *COGNITION disorders , *DISEASE progression , *PHYSICAL mobility - Abstract
• The study examined the deterioration in FMS and its predictive value for functional disability (FD) progression in Parkinson's disease (PD). • Utilized data from the Taiwan Data Bank of Persons with Disability, assessing FMS (like pen-holding, buttoning, and knotting) and FD through the WHO Disability Assessment Schedule 2.0. • Significant correlations between the decline in FMS and FD. • Deterioration in buttoning ability was notably correlated with overall FD worsening. • Baseline FMS were indicative of future FD progression, particularly in cognition, motility, and life activity areas. Parkinson disease (PD) caused substantially disability. The impairment of fine motor skills (FMSs) is correlated with the severity of functional disability (FD) cross-sectionally in people with PD (PwP). The present study investigated the decline in FMSs and the predictive value of baseline FMSs for the progression of FD. People with moderate-to-advanced PD who received two evaluations within 1–5 years were identified from the Taiwan Data Bank of Persons with Disability database. The World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) was used to evaluate FD, and FMSs including pen-holding, buttoning, and knotting were assessed. Our study included 2,271 people with moderate-to-advanced PD. We observed annual progression of FD in each domain of the WHODAS 2.0, with no difference between the sexes. The most significant correlation between FD and FMSs was that of decline in buttoning ability and deterioration of summary WHODAS 2.0 scores. Deterioration in FD across all domains of WHODAS 2.0 was associated with at least one FMS. The extent of disability in all three types of FMS at baseline was also correlated with deterioration of motility. Additionally, baseline disability in buttoning was significantly correlated with cognitive decline, and disability in knotting was significantly associated with the progression of FD. FMSs may be reliable markers for further FD, particularly in the areas of cognition, motility, and life activity. Because of the significant FD observed in people with moderate-to-advanced PD, the availability of predictors is essential for applying precautionary measures and providing appropriate treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF