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Wastewater treatment plants (WWTPs) play a pivotal role in natural water recycling and safeguarding the water security of approximately 42% of the world's population, yet they confront challenges posed by escalating energy consumption and regional energy constraints. In this study, we developed an evaluation framework that integrated regional energy scarcity with the operation conditions of WWTPs to quantify their energy efficiencies by applying multiregional input–output (MRIO) analysis and data envelopment analysis (DEA). A case study using this framework was conducted on 3776 WWTPs in 30 provinces in China. The results showed that the average scarcity-based energy efficiency level of WWTPs in China was low, of which those in northern provinces were higher compared to southeastern provinces. Furthermore, only 24 WWTPs in China attained the highest efficiency levels, while the rest had different degrees of input redundancy, indicating an energy-saving potential of 9.05 × 109 kWh. This paper enables the development of optimal efficiency strategies for WWTPs in different provinces considering the potential energy scarcity risks caused by trading activities. • The DEA and MRIO analyses were combined for 3776 WWTPs in China. • Efficiency evaluation index was modified considering energy scarcity levels. • Scarcity-based energy efficiency assessment framework for WWTPs was developed. [ABSTRACT FROM AUTHOR]