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In this study, we have selected the papers in the chemometric field that were published between 2001 and 2015 in the six journals (Chemometrics and Intelligent Laboratory Systems, Journal of Chemometrics, Analytica Chimica Acta , Analytical Chemistry , Talanta and Journal of Chromatography A) to investigate the collaboration patterns and network. We reveal and visualize the collaboration patterns, publication trends, and research hotspots on chemometrics based on the datasets. The central chemometricians are then determined under different indexes. Finally, we discover that the largest component of the network is clustered into the "Big Europe" and "China-Changsha" community. The rest components in the network are also identified and explained. The results show the features of the collaboration patterns and network in chemometric research and present a new way to explore the zeitgeist in the area. • This paper researches the evolving collaboration patterns and network among chemometricians quantitatively. • We discuss the results on the publication and coauthor patterns, and most central authors, hot research topics. • The major components in the network can be interpreted by their geographical distributions. • The largest component of the network could be clustered into the "Big Europe" and "China Changsha" community. [ABSTRACT FROM AUTHOR]

Abstract: Arctiin, an important lignan compound in Fructus Arctii, has been reported to possess various kinds of bioactivities. Previous studies on the pharmacokinetic of arctiin after oral administration showed that it had a rapid absorption phase followed by a sharp but lasting disappearance. To gain deep insight into the action mechanism of arctiin, the excretion and metabolism of arctiin in vivo should be further studied. In this paper, three metabolites were isolated and identified in rat feces as (−)-enterolactone (M-1), (−)-arctigenin (M-2) and [(2R,3R)-2-(3′-hydroxybenzyl)-3-(3″,4″-dimethoxybenzyl)-butyrolactone] (M-3). Based on the structures of three metabolites, possible metabolic pathways of arctiin in rats are proposed. At the same time, the cumulative excretion rate of arctiin and its metabolites in rat urine and feces were determined, indicating that arctiin was excreted 19.84% in urine and 1.80% in feces, respectively, enterolactone, the most main metabolite, was excreted 35.80% in feces. These results provide very important information for understanding the metabolism and excretion of arctiin in vivo and speculating its action mechanism, they can provide useful information and reference for further metabolic investigations on arctiin in humans. [Copyright &y& Elsevier]

Abstract: This paper describes an improved quality assessment method for Rhizoma et Radix Notopterygii (the rhizome and root of Notopterygium incisum Ting ex H.T. Chang or Notopterygium forbesii Boiss). The method was established by using fingerprinting and quantitation of marker compounds (isoimperatorin, notopterol and bergapten) in this herbal medicine. The authentication of Rhizoma et Radix Notopterygii using high performance thin-layer chromatography (HPTLC) fingerprinting was achieved by comparing the colors and R f values of the bands in TLC fingerprints with those of the marker compounds. The HPLC fingerprints of 16 batches of herbal samples from different regions of China showed similar chromatographic patterns. Five peaks were selected as characteristic peaks, and three of these were identified by using LC–MS–MS techniques. The relative retention times of these characteristic peaks in the HPLC fingerprint were established as an important parameter for identification of Rhizoma et Radix Notopterygii. Finally, the pharmacologically active marker compounds isoimperatorin, notopterol and bergapten in this herb were quantitatively determined using a validated reverse-phase HPLC method. [Copyright &y& Elsevier]