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Your search keyword '"Golebiowski, Jérôme"' showing total 1 results
Start Over Author "Golebiowski, Jérôme" Topic azt Publisher elsevier b.v.
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1. Design, synthesis and studies of triphosphate analogues for the production of anti AZT-TP antibodies

Author

Roucairol, Camille, Azoulay, Stéphane, Nevers, Marie-Claire, Golebiowski, Jérôme, Créminon, Christophe, Grassi, Jacques, Burger, Alain, and Duval, Danièle

Subjects
*DRUG design, *ORGANIC synthesis, *IMMUNOGLOBULINS, *REVERSE transcriptase, *ENZYME inhibitors, *DRUG monitoring, *AZIDOTHYMIDINE, *THERAPEUTICS, *HIV infections
Abstract

Abstract: Triphosphates anabolites are the active chemical species of nucleosidic reverse transcriptase inhibitors in HIV-therapy. Herein, we describe (i) the design of stable triphosphate analogues of AZT using molecular modelling, (ii) their synthesis and (iii) their use for producing anti AZT-TP antibodies in the aim of developing an immunoassay for therapeutic drug monitoring. [Copyright &y& Elsevier]

Published
2010
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