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Estimating wastewater treatment plants' (WWTPs) influent parameters such as 5-day biological oxygen demand (BOD 5) and chemical oxygen demand (COD) is vital for optimizing electricity and energy consumption. Against this backdrop, the existing body of knowledge is bereft of a study employing Artificial Intelligence-based techniques for the prediction of BOD 5 and COD. Thus, in this study, Gene expression programming (GEP), multilayer perception neural networks, multi-linear regression, k-nearest neighbors, gradient boosting, and regression trees -based models were trained for predicting BOD 5 and COD, using monthly data collected from the inflow of 7 WWTPs over a three-year period in Hong Kong. Based on different statistical parameters, GEP provides more accurate estimations, with R2 values of 0.784 and 0.861 for BOD 5 and COD respectively. Furthermore, results of sensitivity analysis undertaken by monte Carlo simulation revealed that both BOD 5 and COD were mostly affected by concentrations of total suspended solids, and a 10% increase in the value of TSS resulted in a 7.94% and 7.92% increase in the values of BOD 5 and COD, respectively. It is seen that the GEP modeling results complied with the fundamental chemistry of the wastewater quality parameters and can be further applied on other sewage sources such as industrial sewage and leachate. The promising results obtained pave the way for forecasting the operational parameters during sludge processing, leading to an extensive energy savings during the wastewater treatment processes. • Different machine learning techniques for predicting BOD 5 and COD were employed. • GEP showed superior performance against other machine learning-based techniques. • BOD 5 and COD were correlated with TSS, NH 3 , OrgN, InorgP and OrgP. • The sensitivity analysis was undertaken through Monte Carlo simulation. [ABSTRACT FROM AUTHOR]