1. Aspercitrininone A, novel antibacterial polyketide featuring unusual spiral skeleton from Aspergillus cristatus.
- Author
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Li, Tian-Xiao, Dong, Hong-Hui, Xing, Lei, He, Li, Zhang, Rong-Ya, Shao, Deng-Yin, Dai, Yu-Xiang, Li, Dong-Liang, and Xu, Chun-Ping
- Subjects
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ANTIBIOTICS , *ANTIFUNGAL agents , *IN vitro studies , *MEDICINAL plants , *BIOLOGICAL products , *TETRACYCLINE , *FUNGI , *ANTI-infective agents , *POLYKETIDES , *PHYTOCHEMICALS , *PLANT extracts , *ASPERGILLUS , *SPECTRUM analysis - Abstract
Aspercitrininone A (1), a novel polyketide featuring an unprecedented tetracyclic 6/6/6/5 spiral skeleton, was obtained from the rice fermentation cultures of the fungus Aspergillus cristatus together with five known compounds (2 – 6). Their structures were determined by HRESIMS data, 1D and 2D NMR spectroscopic analysis, and electronic circular dichroism (ECD) calculations. Aspercitrininone A was revealed as a new type of C/D cycle spiral structure and an unusual addition product of o-quinoid form citrinin with 2-methylterrefuranone. Compounds 1 , 4 , and 5 exhibited potent antibacterial activities with minimal inhibitory concentration (MIC) values from 13.2 to 67.3 μg/mL against four strains of human pathogenic bacteria in vitro. [Display omitted] • A novel polyketide aspercitrininone A was isolated from rice cultures of Aspergillus cristatus. • Aspercitrininone A possessed an unprecedented tetracyclic 6/6/6/5 spiral skeleton. • It could be formed by o-quinoid form citrinin with 2-methylterrefuranone through Michael addition reaction. • Aspercitrininone A exhibited antibacterial activities. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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