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Abstract: Ethnopharmacological relevance: Inspite of tremendous advances made in allopathic medical practices, herbs still play an important role in the management of various liver diseases. A large number of plants and formulations have been claimed to have hepatoprotective activity. Jaundice is a symptom, indicative of the malfunctioning of the liver. This paper provides ethnomedicinal information on the plants used to treat jaundice by three important indigenous communities, i.e., nomadic Gujjars, Tharu and Bhoxa of Sub-Himalayan region, Uttarakhand, India. Aims of the study: To record herbal preparations used by the studied indigenous communities in treatment of jaundice and discuss hepatoprotective properties of the recorded plants. Research strategy and methods: The traditional knowledge of the studied indigenous communities on herbal preparations used for treating jaundice was collected through structured questionnaire and personal interviews. The interviews were conducted with 91 traditional healers (29 Bhoxa, 35 Tharu and 27 nomadic Gujjars) in Sub-Himalayan region of Uttarakhand, India. More than 250 research papers reporting ethnomedicinal information on the hepatoprotective plants used by various communities from different parts of India were extensively reviewed. Results: A total of 40 medicinal plants belonging to 31 families and 38 genera were recorded to be used by the studied communities in 45 formulations as a remedy of jaundice. Bhoxa, nomadic Gujjars and Tharu communities used 15, 23 and 9 plants, respectively. To our knowledge eight plants reported in the present survey viz., Amaranthus spinosus L., Cissampelos pareira L., Ehretia laevis Roxb., Holarrhena pubescens Wall., Ocimum americanum L., Physalis divaricata D. Don, Solanum incanum L. and Trichosanthes cucumerina L. have not been reported earlier as remedy of jaundice in India. Literature review revealed that a total of 214 (belonging to 181 genus and 78 families), 19 (belonging to 18 genus and 12 families) and 14 (belonging to 14 genus and 11 families) plant species are used as internal, external and magico-religious remedies for jaundice, respectively by various communities in different parts of India. Most widely used hepatoprotective plant species for treatment of jaundice in India is Boerhavia diffusa L. followed by Tinospora cordifolia (Willd.) Miers, Saccharum officinarum L., Phyllanthus amarus Schumach. & Thonn., Ricinus communis L., Andrographis paniculata (Burm. f.) Nees., Oroxylum indicum (L.) Kurz, Lawsonia inermis L. and Eclipta prostrata (L.) L. Conclusions: The plants recorded in the present survey have also been discussed in relation to pharmacological studies and hepatoprotective phytoconstituents present in them. Most of the recorded plants have shown hepatoprotective effects on experimental animals in earlier studies but more studies are needed to assess hepatoprotective properties of some recorded medicinal plants viz., Averrhoa carambola L., Ehretia laevis Roxb., Holarrhena pubescens Wall., Mangifera indica L., Ocimum americanum L., Oroxylum indicum (L.) Kurz, Physalis divaricata D. Don, Solanum incanum L., Sphaeranthus senegalensis DC. and Tribulus terrestris L.. The plants enumerated in this study with high number of citations and wider distributions have given some useful leads for further biomedical research. Nevertheless more phytochemical, pharmaceutical and clinical studies are needed to evaluate hepatoprotective properties, efficacy and safety of all the claimed medicinal plants. [Copyright &y& Elsevier]

Aim of the study: We investigated the ethnomedical practices and knowledge of medicinal plant and fungus species of contemporary Yuracaré and Trinitario ethnic groups from Indigenous Territory and National Park Isiboro-Sécure (TIPNIS), located in the Bolivian Amazon region. Our aim was to identify the culturally most significant medicinal plant families, growth forms and species, as well as to assess the current state of knowledge regarding the bioactivity of the most important species, based on available literature data. Materials and methods: Medicinal plant and fungus species were inventoried during homegarden and swidden sampling, walk-in-the-woods and transect sampling. Data on medicinal uses were obtained from 12 Yuracaré and 14 Trinitario participants. Results: We commence by providing a brief overview of Yuracaré and Trinitario ethnomedical systems, highlighting the important shamanistic component of particularly Trinitario traditional medicine. The rest of the paper is dedicated to an analysis and discussion based on the 349 inventoried medicinal plant and fungus species. Contingency table and binomial analyses of medicinal plants used versus the total number of inventoried species per family showed that several plant families are significantly over (Piperaceae, Araceae, Solanaceae, Asteraceae and Siparunaceae) and underused (Chrysobalanaceae, Sapotaceae, Lauraceae, Celastraceae and Annonaceae) in traditional medicine in TIPNIS. Also herbaceous plants are significantly overrepresented in the medicinal plant inventory, which is in line with relevant literature. Our ranking of medicinal species according to cultural significance is based on the Quality Use Agreement Value (QUAV) index we developed and presented in a previous paper. Results indicate that the QUAV index's property to mainly select species that combine multiple ethnomedical uses with high informant consensus, justifies its use as a measure of cultural significance of medicinal plants in TIPNIS. Results of a literature search suggest, on the other hand, that the QUAVs score of a species could also be indicative of its bioactivity. Conclusions: In addition to the QUAV index's value as a tool for assessing the cultural significance of medicinal species, it might also be useful to identify species with a higher likeliness of being bioactive. [Copyright &y& Elsevier]

Ethnopharmacological relevance The rich floral and ethnic composition of eastern Nepal and the widespread utilization of locally available medicinal plants offer remarkable opportunity for ethnomedicinal research. The present paper aims to explore medicinal plant diversity and use in the remote villages of eastern Nepal. It also aims to evaluate ethnopharmacological significance of the documented use reports and identify species of high indigenous priority. Materials and methods The study was undertaken in four villages located in the Sankhuwasabha district in eastern Nepal. Ethnomedicinal information was collected through structured interviews. The homogeneity of informant's knowledge and the relative importance of documented medicinal plants were validated by informant consensus factor and use value, respectively. Species preference for treatment of particular diseases was evaluated through fidelity level. Results We reported medicinal properties of 48 species belonging to 33 families and 40 genera, for the treatment of 37 human ailments. The uses of 10 medicinal plants were previously undocumented. The informant consensus factor (F IC ) ranged between 0.38 and 1 with about 50% of values greater than 0.80 and over 75% of values greater than 0.70, indicating moderate to high consensus among the informants on the use of medicinal plants in the region. Swertia chirayita was the most preferred species with significantly high use values, followed by Paris polyphylla and Neopicrorhiza scrophulariiflora. Conclusions The remote villages in eastern Nepal possess rich floral and cultural diversity with strong consensus among informants on utilization of plants for local healthcare. The direct pharmacological evidence for medicinal properties of most species indicates high reliability of documented information. Careful and systematic screening of compounds isolated from these plants could possibly provide good opportunity for the discovery of novel medicines to treat life-threatening human diseases. We recommend prioritization of medicinal plants and reinforcement of existing cultivation practices for sustainable management of high-priority species. [ABSTRACT FROM AUTHOR]

Ethnopharmacological relevance In this paper we present a comprehensive ethnomedicinal study conducted in Mondulkiri province. Traditional knowledge about natural medicine (plants, animals, mushrooms) was investigated in Cambodia’s largest indigenous community: the Bunong people. The survey aims to document the medicinal plant use of this ethnic, by focusing on the eleven most frequent diseases encountered in the area, in order to highlight species that could be recommended in public health programs. Materials and methods During the years 2013 and 2014, 202 villagers were interviewed in 28 villages from the five districts in Mondulkiri. Two types of methodology were employed: (1) an ethnobotanical field survey (walk-in-the-wood interviews) and (2) semi-structured household interviews with a special emphasis on the treatment of 11 most common ailments encountered in the area. Medicinal plants and mushrooms were collected and identified together with medicinal animals. The factor informant consensus (F IC ) and fidelity level (FL) were calculated. Results Bunong people use a total of 214 plants belonging to 72 families, 1 mushroom and 22 animal species in their traditional healthcare practices in order to treat 51 different ailments. Among the medicinal plants, Fabaceae was the most predominant family; Chromolaena odorata (L.) R.M. King and H.Rob. (Asteraceae), Zingiber montanum (J.Koenig) Link ex A.Dietr. (Zingiberaceae) and Kalanchoe pinnata (Lam.) Pers. (Crassulaceae) were the most cited medicinal plants; and four ailments (cold/fever, diarrhea, postpartum disorders and stomachache) were described as major ailments in the community. The root was the most important part of plants used, and decoction was the most cited method of preparation. During our survey, we also discovered a “new to science” plant species called Ardisia mondulkiriensis Hul and Chassagne, and we recorded for the second time the plant species recently described, Solanum sakhanii Hul. Conclusion Most of the species reported for the treatment of the 11 most frequent ailments have already been proven to be efficient and safe. Furthermore, 10 plant species are reported for the first time as medicinal and some of them are widely used in the community. Further pharmacological and phytochemical investigations should be undergone to assess the pharmaceutical potential of these species. While undergoing considerable changes, Bunong people have maintained extensive traditional medicine knowledge. As this indigenous hill tribe depend mainly on natural remedies for their daily healthcare, environmental preservation is of high importance for the community. [ABSTRACT FROM AUTHOR]

Ethnopharmacological relevance Being one of the most common types of life threatening diseases in Southern Assam, India, the digestive system disorders (DSD) have gained much attention in recent decades. Traditional beliefs and inadequate income of mass population result in the use of alternative phytotherapies to treat the diseases. Aim of the study The present paper documents the medicinal knowledge and utilization of plants for treatment of digestive system disorders in Southern Assam, India by Disease Consensus Index (DCI). It also determines the most suitable plant species used to treat digestive system disorders in the study area. Materials and methods The study was based on ethnomedicinal field survey covering a period of 1 year from 2014–2015. The ethnomedicinal information was collected by using semi-structured questionnaires from different traditional Bengali people having knowledge on medicinal plants. Collected data were analyzed by calculating DCI. Results During the survey, 29 informants were interviewed and a total of 49 plants under 46 genera belonging to 33 families were listed. Data analysis revealed that Litsea glutinosa , Momordica charantia , Andrographis paniculata , Lawsonia inermis , Cleome viscosa , Psidium guajava , Ageratum conyzoides , Cuscuta reflexa , Cynodon dactylon and Carica papaya are the most prominent plants among the people of Southern Assam for treating DSD. Conclusion This explorative survey emphasizes the need to preserve and document the traditional healing practices for managing DSD inviting for more imminent scientific research on the plants to determine their efficacy as well as safety. With the help of statistical analysis (DCI), we propose 10 priority plants for DSD in present work. Systematic pharmacological study with these plants may contribute significant result. [ABSTRACT FROM AUTHOR]

Ethnopharmacological relevance Sokoto is known for its diverse traditional medicinal wealth and international market of traditional medicines in Africa. However, information of the folk knowledge, especially for the treatment of diabetes, is not documented. Aim of the study This survey identified and documented the information on traditional medicinal plants used by Hausa–Fulani community of Sokoto for the treatment of diabetes. Materials and method Demographic data and information about the medicinal plants were collected via administration of semi-structured oral questionnaires. Willing herbal medical practitioners/traditional healers were interviewed. The medicinal plants mentioned by herbalists were collected and authenticated by a taxonomist and the voucher specimens were preserved. Results Fifty one informants across the state divulged information on traditional medicinal plants and practices used in diabetes and revealed 54 species, belonging to 33 families, with Cassia sieberiana being cited the most (19 times) and ranked first (39%). Azadirachta indica , Ficus exasperata and Schwenckia americana ranked second (15%), each cited 8 times. Conclusion The survey documented the rich wealth of knowledge and usage of plants for the treatment of diabetes in Sokoto. The paper will not only serve as a source of information but will also help to make the knowledge accessible for further drug screening and development, and at the same time underlines the need for biodiversity conservation of this traditional wealth. [ABSTRACT FROM AUTHOR]

Ethnopharmacological relevance During the last few decades there has been an increasing interest in the study of medicinal plants with their traditional use and related pharmacological research all over the World. This paper enumerated folk medicinal plants used by Malayali tribal people in an unexplored and biodiversity rich region of Eastern Ghats in southern India. Aim of study The aim of this study is to collect and identify the plants used in medicinal therapy by the local people and professional traditional healers with quantitative analysis. Materials and methods An ethnobotanical survey was carried out during January to December 2014 among the Malayali tribal people in four villages of Palamalai region in Eastern Ghats, India. The information was obtained through open and semi-structured face-to-face interviews with the local knowledgeable people and professional traditional healers. The statistical analysis, use value, family use value, informants’ consensus factor, fidelity level, frequency of citation, relative frequency citation and informants’ agreements ratio were calculated for the quantitative study of ethnomedicinal data. Results A total of 118 plant species belonging to 95 genera and 55 families dominated by the families like Leguminosae, Asteraceae and Lamiaceae were enumerated with detailed information on parts used, method of preparation, mode of administration and ailments treated. Leaves were mostly used plant part and predominantly used herbal preparations were decoction and paste. Moringa oleifera Lam. was reported by all the interviewed informants and gives the highest UV of 3.9 with 78 use reports due to its diverse medicinal uses. Conclusion The present study demonstrated the need for importance of documenting the traditional knowledge of forest dwelling people. As a result of the study, Abutilon indicum (L.) Sweet., Andrographis echioides (L.f.) Nees., Bacopa monnieri (L.) Wettst., Canarium strictum Roxb., Centella asiatica (L.) Urban., Senna auriculata (L.) Roxb. and Tribulus terrestris (L.) were recommended for further ethnopharmacological studies since these plants were recorded with high UV, IAR, RFC and FL values. [ABSTRACT FROM AUTHOR]

Ethnopharmacological relevance This paper provides new and significant ethnopharmacological information on medicinal plants used by native people who live in Sarigöl and its surroundings in Turkey. Aim of the study To compile herbal remedies from the area of Sarigöl with their traditional uses, parts of the plant used and form of administration as well as to calculate ethnobotanical indices and validate its therapeutic use. Materials and methods Plant samples that have been collected by herbalists or informants from Sarigöl and its surroundings for medical purposes were studied by visiting the villages during the study period, and then brought to the laboratory to identify the species. The relative frequency citation (RFC), use value (UV), informant consensus factor (ICF) and fidelity level (FL) were computed for the plants included in the study as well as a pharmacological validation from International Official sources by using WHO, ESCOP and EMA monographs. Results In this research conducted between 2010 and 2013, 141 taxa affiliated with 55 families, including 3 Gymnosperms, were determined as they used for medical purposes. The study was carried out by visiting 15 villages and 4 herbalist shops identified in Sarigöl and its surroundings. Asteraceae, Lamiaceae, Fabaceae, Rosaceae and Apiaceae have been detected as the most consumed families for medical purposes. The research showed that most of the informants agreed on the use of Vitis vinifera fruits to cure gastrointestinal diseases that demonstrated the highest fidelity level (0.62). Only 31, out of 141, of the species recorded in this study, currently have a monograph with a validated use. Conclusion During the survey, it was observed that local people consumed plants in the form of the infusion, whereas when using hard organs such as bark or branches, decoctions were preferred. It was identified that most of the medicinal plants have been used for gastrointestinal and respiratory disorders, and they are mainly utilized in the form of infusion or decoction. Vitis vinifera has a different traditional use compared to therapeutic indication proposed by monographs from Official sources like ESCOP or EMA. [ABSTRACT FROM AUTHOR]

Ethnopharmacological relevance This paper provides significant ethnobotanical information on medicinal plants in the villages of Çatak in the Eastern Anatolia Region. Recording such data calls for urgency. This is the first ethnobotanical study in which statistical calculations about plants are carried out by means of FIC method in Eastern (Van) part of Turkey. Aim of the study This study aims to identify the wild plants collected for medicinal purposes by locals of Çatak which is located in the Eastern Anatolia Region of Turkey, and to identify the uses and local names of these wild plants. Materials and methods A field study had been carried out for a period of approximately 2 years (2010–2012). During this period, 78 plants taxa were collected. Demographic characteristics of participants, names of the local plants, their utilized parts and preparation methods were investigated and recorded. The plant taxa were collected within the scope of the study; and herbarium materials were prepared. In addition, the relative significance value of the taxa was determined, and informant consensus factor (FIC) was calculated for the medicinal plants included in the study. Results We have found out in the literature review of the plants included in our study that 78 plant taxa are already used for medicinal purposes while 19 plants are not available among the records in the literature. The most common families are Asteraceae, Apiaceae, Lamiaceae, Rosaceae, Euphorbiaceae, Fabaceae, and Malvaceae. We include in our study and report for the first time the medicinal uses of Alchemilla buseriana Rothm., Astragalus longifolius Lam., Cephalaria microcephala Boiss., Euphorbia grisophylla M.S. Khan, Fritillaria crassifolia Boiss. & Huet. subsp. kurdica (Boiss. & Noe) Rix, Fritillaria pinardii Boiss., Malabaila lasiocarpa Boiss., Nepeta betonicifolia C.A. Mey., Onobrychis altissima Grossh., Onobrychis carduchorum C.C. Townsend, Papaver bracteatum Lindl., Phlomis tuberosa L., Psephellus karduchorum (Boiss.) Wagenitz, Scutellaria orientalis L. subsp. pichleri (Stapf.) Edmondson, Stachys kurdica Boiss. & Hohen var. kurdica, Tanacetum kotschyi (Boiss.) Grierson, Tanacetum zahlbruckneri (Nâb.) Grierson, Turanecio eriospermus (DC.) Hamzaoğlu, Verbascum pyramidatum M.Bieb. Names of local plants in Turkey vary especially due to vernaculars. The plants that the locals of Çatak use are called with the same or different local names in various parts of Anatolia. Conclusion We found out that locals living in the research area use for therapeutic purpose 78 plants taxa which belong to 22 families. Turkish citizens with different ethnic backgrounds took the questionnaire. These people use these wild plants in treatment of several diseases. Comparison of the data obtained in this study with the experimental data obtained in the previous laboratory studies on the wild plants which grow in Çatak proved ethnobotanical usages to a great extent. Literature review indicated that the therapeutic plants that grow in Çatak are used in different parts of the world for the treatment of similar diseases. [ABSTRACT FROM AUTHOR]

Ethnopharmacological relevance With this study, we aimed to document traditional uses of medicinal plants in the western part of Aladaglar/Nigde. Materials and methods This study was conducted between 2003 and 2005. The research area was in the western part of the Aladaglar mountains. The settlements in Aladaglar (5 towns and 10 villages) were visited during the field work. The plants collected by the help of medicinal plant users. The plants were identified and voucher specimens prepared. These voucher specimens were kept at the Herbarium of Istanbul University Faculty of Pharmacy (ISTE). We collected the information by means of semi-structured interviews with 170 informants (90 men and 80 women). In addition, the relative importance value of the species was determined and the informant consensus factor (FIC) was calculated for the medicinal plants researched in the study. Results According to the results of the identification, among 126 plants were used by the inhabitants and 110 species belonging to 40 families were used for medicinal purposes. Most of the medicinal plants used in Aladaglar/Nigde belong to the families Lamiaceae (25 species), Asteraceae (16 species), Apiaceae (7 species), Fabaceae (6 species) and Brassicaceae (5 species). The most commonly used plant species were Hypericum perforatum Thymus sipyleus var. sipyleus , Rosa canina , Urtica dioica , Malva neglecta, Thymus leucotrichus, Salix alba, Mentha longifolia , Berberis crataegina, Juniperus oxycedrus , Viscum album subsp. abietis , Allium rotundum and Taraxacum stevenii . The most common preparations were infusion and decoction. The traditional medicinal plants have been mostly used for the treatment of cardiovascular diseases (86%), hemorrhoids (79%), urinary diseases (69%), diabetes (68%) and respiratory diseases (61%). Conclusion The use of traditional medicine was still widespread among the inhabitants of Aladaglar mountains/Nigde region. Due to the lack of medical facilities in the villages of Aladaglar mountains, local people prefer herbal treatment rather than medical treatment. This study identified not only the wild plants collected for medical purposes by local people of Aladaglar/Nigde, but also the uses and local names of these plants. This paper helps to preserve valuable information that may otherwise be lost to future generations. [ABSTRACT FROM AUTHOR]

Aim of the Study and Ethnopharmacological relevance This paper presents the first ethnobotanical survey conducted among the Achuar (Jivaro), indigenous people living in Amazonian Ecuador and Peru. The aims of this study are: (a) to present and discuss Achuar medicinal plant knowledge in the context of the epidemiology of this population (b) to compare the use of Achuar medicinal plants with the uses reported among the Shuar Jivaro and other Amazonian peoples. Materials and methods The author conducted field research in 9 indigenous villages in the region of Morona Santiago and Pastaza in Ecuador. Semi-structured interviews on local illnesses and herbal remedies were carried out with 82 informants and plant specimens were collected and later identified in Quito. A literature research was conducted on the medicinal species reported by Achuar people during this study. Results The most reported medicinal plants are species used by the Achuar to treat diarrhoea, parasites infection, fractures, wounds, and snakebites. Informants reported the use of 134 medicinal species for a total of 733 recorded use-reports. Of these 134 species, 44 are reported at least 3 times for one or more specific disease condition for a total of 56 uses. These species are considered a core kit of medicinal plants of the Achuar of Ecuador. Most of these medicinal species are widely used in the Amazon rainforest and in many other parts of Latin America. Conclusion The author documented a core kit of 44 medicinal plants used among the Achuar of Ecuador and found that this core set of medicinal plants reflects local epidemiological concerns and the pharmacopoeias of the Shuar and other Amazonian groups. These findings suggest that inter-group diffusion of medicinal plant knowledge had a prominent role in the acquisition of current Achuar knowledge of medicinal plants. [ABSTRACT FROM AUTHOR]

Ethnopharmacological relevance The area of the Nebrodi Regional Park (North-Eastern Sicily, Italy) has been quantitatively investigated in an ethnobotanical study for the first time. A total of 90 wild species are used for medicinal purposes and the uses of 5 species have not previously been reported in ethnobotanical studies in Italy (e.g., the use of Arisarum vulgare O. Targ. Tozz. for the treatment of rheumatic pains, the use of Silene vulgaris (Moench) Garcke for the treatment of liver diseases). The aim of this paper was to understand to what extent current knowledge on the medicinal use of plants is still an element of the culture within the rural populations of the Nebrodi Park. Materials and methods Semi-structured interviews were carried out in the local communities within the Nebrodi Regional Park with local people retained experts in rural traditions. A total of 226 people over the age of 60 were interviewed. Local plant uses were evaluated using ethnobotanical indices (e.g., cultural importance index, index of ethnobotanical diversity, informant consensus factor) and then compared with uses in other localities in Sicily, Italy and the Mediterranean area. Results Local communities use a total number of 90 wild species belonging to 44 plant families as medicinal remedies. The majority of the species are used as treatments against gastrointestinal system. The cultural importance index showed that Malva sylvestris (1.31) and Clinopodium nepeta (0.86) are the most important species to the Nebrodi area in terms of medicinal use. The use of Brassica rupestris Raf. for therapeutic purposes is limited to Sicily and it is an innovative finding of this study. Conclusions The research shows an ongoing process of cultural erosion in an advanced stage, but quantitative indices still highlight only for those species was a natural remedy deemed highly effective. [ABSTRACT FROM AUTHOR]

Ethnopharmacological relevance The present paper documents the utilization of medicinal plants for the treatment of various human ailments in two village development committees in the Rasuwa district of central Nepal. It also evaluates the ethnopharmacological significance of the documented reports and identifies species of high indigenous priority in local therapeutics. Materials and methods The ethnobotanical information was collected by interviews and group discussions using standard ethnobotanical procedures. The homogeneity of informant׳s knowledge was validated by Informant consensus factor ( F IC ) and the relative importance of a plant species used as medicine in the study area was calculated with the help of use value (UV). Results The present study identified a total of 46 medicinal plants belonging to 26 families used for the treatment of 38 human ailments. Besides medicinal uses, the study has also documented the culinary and cultural use of 13 species of medicinal plants. The most commonly used part was root constituting about 42% of the total utilized plants. The most commonly used form of preparation was paste (31.91%). We found new usage reports for 9 medicinal plants. The F IC value in the present study ranged from 0.66 to 1 with 84.6% values greater than 0.8 indicating high consensus among the informants. The most preferred species was Neopicrorhiza scrophulariflora (UV=0.96) and the lowest used value was found for Lyonia ovalifolia (UV=0.32). Conclusions People of Rasuwa possess rich traditional knowledge in medicinal plants utilization with strong consensus among local people on the utilization of species evident by higher F IC values in different ailment categories. Strong pharmacological evidence for a majority of species being currently used as medicines shows that the plants used in local therapeutics are likely to be more effective in treating different medical ailments. The bioactive compounds extracted from these medicinal plants could subsequently be used in the creation of novel drugs to treat life threatening human diseases. The species with high use values are the ones likely to be more vulnerable because of high demand and high collection pressure. Therefore, it is imperative to prioritize such species for cultivation and sustainable management in order to ensure their long term availability. [ABSTRACT FROM AUTHOR]

Abstract: Background: Ethnopharmacological relevance: Indigenous communities have often served as rich repositories of empirical knowledge on medicinal plants used for anemia. Use of these plants need to be validated with respect to their efficacy and safety so as to provide scientific basis of their use. Quantifying presence of medicinal plants used for anemia treatment, validating indigenous knowledge and extent of its use in rural Mkuranga district, Tanzania is the main focus of this paper. Methods: A cross sectional study conducted in May and December 2013 at Mkuranga District of Coastal region of Tanzania. Forty key informants including traditional healers, religious leaders, community members and healthcare workers were interviewed using semi structured questionnaire. Eight focus group discussions were also conducted. Both interviews and focus group discussion gathered data on socio-demographics, general knowledge of anemia and plants used to correct anemia. In a brief field visit, all plants mentioned during the interview were collected and later identified. Both NVivo 10 and STATA softwares were employed for statistical analysis. Results: Out of 40 participants, 31 were traditional healers, majority were male (77.4%). Mean age of the participants was 55.7±15 years. About 45% had no any formal education and majority (80%) were married. Twenty eight plant species are used to treat anemia. Hibiscus sabdariffa was the most mentioned species. The species belongs to 24 families, with Euphorbiaceae (14.3%) having the largest number. Lawsonia inermis, Aloe sp, Uvaria acuminata, Parinari curatellifolia, Ozoroa reticulata, Manihot esculenta, Canthium sp and Afzelia quanzensis were the plant species in which their claimed use for anemia were novel. Conclusions: People in rural areas of Mkuranga district possess a rich traditional knowledge of medicinal plants species for anemia treatment. Researches on these plants showed promising anti-anemic activity. Analysis and documentation of this knowledge has not only helped the analysis and recognition of novel information, it also contributed to conserving it for future generations. [Copyright &y& Elsevier]

Abstract: Ethnopharmacological relevance: The area of the “Monte Sicani Regional Park” (Central Western Sicily, southern Italy) has been quantitatively and extensively investigated in an ethnobotanical study for the first time. A total of 108 wild species are used for medicinal purposes, while, according to our study, the uses of 9 species have not previously been reported in ethnobotanical studies in Italy (e.g., the use of Kickxia elatine (L.) Dumort. for the treatment of hyperhydrosis of the feet, the use of Lavatera agrigentina Tineo for cough and bronchitis). Aim of the study: The aim of this paper is to analyze, through quantitative indicators, the extent of the current knowledge on medicinal uses of plants in the area, evaluating also the features of uniqueness and commonality of this knowledge in comparison with other Italian and Mediterranean areas. Methodology: Semi-structured interviews were carried out in the local communities between 2009 and 2010 within the Monti Sicani Regional Park with local people retained experts in rural traditions. A total of 230 people were interviewed about their knowledge on medicinal plant uses. Local plant uses were evaluated using ethnobotanical indices (e.g., cultural importance index, ethnobotanicity index, informant consensus factor) and then compared with uses in other localities in Sicily, Italy and the Mediterranean basin. Results: Local communities currently use a total number of 108 wild species (43 families) as remedies for human and livestock ailments. The majority of plants are used in the treatment of articular, skin and gastrointestinal problems. The use of some species is limited to Sicily (e.g., Rhus coriaria L., Athamanta sicula L., Senecio delphinifolius Vahl). Conclusions: The research shows an ongoing process of cultural erosion in an advanced stage, but results still highlight an interesting cultural identity as regards the local folk medicine. [Copyright &y& Elsevier]

Abstract: Ethnopharmacological relevance: Boophone disticha is the most common member of the South African Amaryllidaceae used extensively in traditional medicine of the various indigenous population groups, including the Sotho, Xhosa and Zulu as well as the San. This survey was carried out to identify and highlight areas relevant to the traditional usage of Boophone disticha. Pharmacological aspects were examined with the purpose of reconciling these with the traditional usage of the plant. In relation to phytochemical make-up, particular attention was paid on how its alkaloid constitution might corroborate the various biological effects manifested by the plant. Materials and methods: Information gathering involved the use of four different database platforms, including Google Scholar, ScienceDirect, SciFinder® and Scopus. Arrangement and detailing of this information is as reflected in the various sections of the paper. Results: Sixteen categories were identified under which Boophone disticha finds use in traditional medicine. These were shown to include general usage purposes, such as ‘cultural and dietary’, ‘well-being’, ‘personal injury’, ‘divinatory purposes’, ‘psychoactive properties’ and ‘veterinary uses’. Furthermore, traditional usage was seen to involve six body systems, including functions pertaining to the circulatory, gastrointestinal, muscular, neurological, respiratory and urinary systems. The four remaining categories relate to use for inflammatory conditions, cancer, malaria and tuberculosis. Overall, three areas were discernible in which Boophone disticha finds most usage, which are (i) ailments pertaining to the CNS, (ii) wounds and infections, and (iii) inflammatory conditions. In addition, several aspects pertaining to the toxic properties of the plant are discussed, including genotoxicity, mutagenicity and neurotoxicity. Conclusion: The widespread ethnic usage of Boophone disticha has justified its standing as a flagship for the Amaryllidaceae and its relevance to South African traditional medicine. Furthermore, its promising pharmacological and phytochemical profiles have stimulated significant interest in the clinical realm, especially in the areas of cancer and motor neuron disease chemotherapy. These collective properties should prove useful in steering the progress of the plant towards a wider audience. [ABSTRACT FROM AUTHOR]

Abstract: Ethnopharmacological relevance: Dysentery and diarrhoea are major causes of morbidity and mortality in rural communities of developing world. The Bhoxa community is an important primitive indigenous community of Uttarakhand, India. In this paper we have tried to scientifically enumerate ethnomedicinal plants and herbal preparations used by Bhoxa community to treat dysentery and diarrhoea, and discuss their antidiarrhoeal properties in the light of previous ethnomedicinal, pharmacological, microbiological and phytochemical studies. To record plants and herbal preparations used by Bhoxa community of district Dehradun, Uttarakhand, India in treatment of dysentery and diarrhoea, and to discuss antidiarrhoeal and antimicrobial properties of the recorded plants. Materials and methods: Ethnomedicinal survey was conducted in different villages of Bhoxa community located in district Dehradun, Uttarakhand, India. Thirty Bhoxa traditional healers were interviewed to collect information on plants used by them for treating dysentery and diarrhoea. For each of the recorded plant species the use value (UV) and fidelity level (FL) was calculated. Detailed literature survey was conducted to summarize ethnomedicinal, pharmacological, microbiological and phytochemical information on the medicinal plants listed in the present study. Results: Fifty medicinal plants (45 genera and 30 families) were used by Bhoxa community to treat dysentery and diarrhoea, among which 27 species were used for dysentery, 41 for diarrhoea and 18 for both dysentery and diarrhoea. Three plants viz., Dioscorea bulbifera L., Euphorbia thymifolia L. and Prunus persica (L.) Stokes, recorded in the present survey have been reported for the first time in treatment of dysentery and diarrhoea by any indigenous communities in India. FL and UV values revealed that most preferred species for the treatment of dysentery and diarrhoea by Bhoxa community are Euphorbia hirta L. followed by Holarrhena pubescens Wall., Helicteres isora L. and Cassia fistula L. Earlier pharmacological studies confirmed that 27 of the recorded plants have some proven antidiarrhoeal properties and remaining 23 plants have to be pharmacologically evaluated for their antidiarrhoeal properties. Except 6 plants all the other recorded plants have shown antimicrobial properties in previous microbiological studies. Previous studies have corroborated the ethnomedicinal claims made by the traditional healers of the Bhoxa community. Conclusions: Present study has provided new information on many medicinal plants and their uses. All the three newly reported plants for treatment of dysentery and diarrhoea have not been pharmacologically evaluated yet for their possible antidiarrhoeal properties. Twenty-three and six plants have not been evaluated pharmacologically and microbiologically, respectively. The present information may serve as a baseline data to initiate further research for discovery of new compounds and biological activities of these potential plants. Further research on these plants may provide some important clues for development of new drugs for dysentery and diarrhoea or other related diseases. [Copyright &y& Elsevier]

Abstract: Ethnopharmacological relevance: This paper represents the first large-scale ethnobotanical study in the Alaşehir and its surrounding (Manisa/Turkey). There are scarcely any studies for using plants. There is urgency in recording such data. This is the first ethnobotanical study in which statistical calculations about plants are done by ICF (Informant Consensus Factor) method. This study aimed to identify plants collected for medicinal purposes by the local people of Alaşehir, located in the Aegean Region of Turkey, and to document the traditional names, preparation and uses of these plants. Materials and methods: Field study was carried out over a period of approximately 2 years (2010–2012) in Alaşehir. During this period, 137 vascular plant specimens were collected. Demographic characteristics of participants, local plant names, utilized parts and preparation methods of the plants were investigated and recorded. In the scope of the study, medicinal plant species and related information were collected; herbarium materials were prepared; and the specimens were entitled. Field research was conducted by collecting ethnobotanical information during structured and semi-structured interviews with native knowledgeable people in territory. In addition, the relative importance value of species was determined and ICF was calculated for the medicinal plants included in the study. Results: A total of 137 medicinal plants belonging to 58 families were identified in the region. Among them, 105 species are wild and 32 species are cultivated plant. The most dominant medicinal plant families were Asteraceae (>13%), Lamiaceae (>11%), Rosaceae (>7%), and Fabaceae (>4%), again; the most common preparations were infusion and decoction. It was found that Origanum onites L., Urtica urens, Thymus zygioides Griseb., Matricaria chamomilla L., Salvia tomentosa Mill., Cerasus avium (L.), Tilia argentea Desf. ex DC., Hyoscyamus niger L., Urtica pilulifera L., Anethum graveolens L., Euphorbia rigida Bieb., Hypericum perforatum L., Paliurus spina-christi Mill., Rosa canina L., Viscum album L. subsp. austriacum (Wiesb.) Vollman, Silybum marianum (L.) Gaertn., Elymus repens (L.) Gould and Juglans regia L. were the most commonly used species. The traditional medicinal plants have been mostly used for the treatment respiratory tract diseases (14.1%), gastro-intestinal diseases (10%), kidney problems (7.3%), diabetes (7.1%), cholesterol (5%), rheumatism (4%), cancer various (4%), cardiovascular problems (3.1%) and burn (3%). Conclusion: Gathering, processing and consuming wild edible plants are still practiced in all the studied Alaşehir areas. These plants, used in the treatment of many different diseases, are freely harvested in this region at abundant amounts. Due to the increasing health service facilities in the area, herbal medicine, seemed to be more related to health care and disease prevention than cure. [Copyright &y& Elsevier]

Abstract: Ethnopharmacological relevance: A comprehensive ethnobotanical study was made in Turgutlu. This paper contains folk medicinal plants and ethnopharmacological information of this ethnobotanical study. Aim of study: The aim of this study is to collect and identify the plants used in therapy by the local people and to reveal information on traditional herbal medicine. Materials and methods: This study was made between 2010 and 2011 and its materials were the plants collected during the field work. The information was obtained through open and semi-structured interviews with the local people. In addition, informant consensus factor (FIC) and use value (UV) were calculated. Results: 76 Folk medicinal plants belonging to 44 families were identified in this study. Among them, 68 species are wild and eight species are cultivated plants. The most common families are Asteraceae (11.8%), Rosaceae (9.2%), Lamiaceae (7.9%), Apiaceae (3.9%) and Malvaceae (3.9%); the most common preparations were infusion (37%) and decoction (18.5%). A total of 177 medicinal uses (remedies) was recorded. Digestive system disorders have the highest FIC (0.73). According to use value (UV) the most important plants were Rosa canina (0.75), Ficus carica subsp. carica (0.74), Tilia platyphyllos (0.71) and Vitex agnus-castus (0.70). Conclusion: In the research area the use of traditional folk medicine is still prevalent in the community especially in the villages. [Copyright &y& Elsevier]

Abstract: Ethnopharmacological relevance: Vapour-based medicines are an aspect of traditional medicine in North East India. However, no collective studies on this therapy in the region have been attempted. With the changing perception of traditional knowledge, documenting these herbal preparations and the subsequent development of baseline data for applications in further ethnopharmacological research are needed. Aims of the study: To survey and document the plant species associated with vapour therapy in Manipur, North East India, and to evaluate these traditional practices. Materials and methods: Semi-structured questionnaires were used to collect information from the Meitei community in the Imphal valley and the Jiribam area in Manipur. Traditional disease concepts were studied along with their corresponding medical terminologies. Plant samples collected from fields, healers' private collections and home gardens were identified. Evaluation of the ethnobotanical data was performed with a modified fidelity level index. Results: In the study, 41 traditional disease complexes were treated by 13 different routes of administration using 48 mono-ingredient and 17 multi-ingredient compositions. Preparation methods included boiling in water (28%), burning the materials (48%), crushing the materials to release the aroma (21%) and slight heating of the materials (3%). Some of the mono-ingredient recipes reported in the study were observed to have similar uses in other parts of the world, whereas polyherbal remedies were found to be unique without any similar report. Conclusion: Many compositions mentioned in the paper are still used by the Meitei community. Traditional healers follow their own criteria for selecting medicinal plants. Plants recorded in this ethnobotanical study can suggest methods for selecting and identifying potentially effective plants for future drug candidates. Scientific characterisation of the herbal remedies can contribute to the endorsement of traditional vapour-based therapies in the modern health care systems. Findings from these “new usage” reports of plants and unique combinations of polyherbal compositions indicate the importance of such documentation efforts. [Copyright &y& Elsevier]

Abstract: Ethnopharmacological relevance: This paper provides significant ethnobotanical information on medicinal plant uses in the Zlatibor district, South-Western Serbia. Materials and methods: A survey was performed using questionnaires with 220 informants (mean age 47, 79% female, 21% male). In addition, the use value and the relative importance of species were determined and the informant consensus factor was calculated for the medicinal plants included in the study. Intended plants usage was compared with previous ethnobotanical literature, with reference to the neighboring areas of Zlatibor district. Results: The informants provided data for 69 medicinal plants belonging to 36 families. Rosaceae, Lamiaceae and Asteraceae were the predominant locally used families. The species with the highest use value were Mentha piperita, Matricaria chamomilla, Hypericum perforatum and Achillea millefolium. The most frequently reported medicinal uses were ones for treating gastrointestinal ailments, respiratory problems and skin diseases. Usually, the administration was primarily oral followed by topical applications. All different plant parts were utilized, however leaves were the most exploited parts of the plants. Conclusions: Folk medicine in South-Western Serbia, Zlatibor district is intended mainly as a mode of primary health care in healing of minor illnesses. The results indicate a slight reduction in the ethnobotanical and medical knowledge in this area, when compared with neighboring regions. [Copyright &y& Elsevier]

Abstract: Ethnopharmacological relevance: This paper provides significant ethnobotanical information on medical plants in the Western Region of Turkey. There is urgency in recording such data. This is the first ethnobotanical study in which statistical calculations about plants are done by FIC method in western part of Turkey. Aim of study: This study aimed to identify plants collected for medical purposes by the local people of Edremit Gulf, located in the Western Region of Turkey, and to document the uses and local names of these plants. Materials and methods: This study, conducted between 2007 and 2010, gathered information on the medicinal plant species traditionally used in Edremit Bay, Turkey and the local names of these plants. In the scope of the study, medicinals plant species and related information were collected; herbarium materials were prepared; and the specimens were entitled. Field research was conducted by collecting ethnobotanical information during structured and semi-structured interviews with native knowledgeable people in territory. In addition, the relative importance value of species was determined and informant consensus factor (FIC) was calculated for the medicinal plants included in the study. Results: A total of 118 medical plants belonging to 50 families were identified in the region. Among them, 99 species are wild and 19 species are cultivated plant. The most common medicinal plant families were Lamiaceae (>18%), Asteraceae (>11%), Rosaceae (>7%); the most common preparations were infusion and decoction. It was found that Hypericum perforatum, Lavandula stoechas, Salviatomentosa, Origanum onites, Origanum vulgare, and Teucrium polium were the most commonly used species. A total of 218 medicinal uses (remedies) were recorded. The traditional medicinal plants have been mostly used for the treatment of abdominal and stomach pain (17%), cough and cold (12%), diabetes (6%), kidney ailments (5%), wounds (4%). Conclusion: The use of traditional medicine was still widespread among the people interviewed during this study. Due to the increasing health service facilities in the area, herbal medicine, seemed to be more related to health care and disease prevention than cure. [Copyright &y& Elsevier]

Aim of the study: To collect, analyze and evaluate the ethnopharmacologic knowledge in Nor-Yauyos in order to protect it. This paper reports the results of an ethnopharmacological survey on the uses of medicinal plants by inhabitants of the Andean region Nor-Yauyos, Peru. In this region one surviving ethnic group, the Jaqaru-Quichuas, has been identified. Methodology: Field work was concluded between October 1999 and March 2000, using semi-structured questionnaire and participant observation as well as transects walks in wild herbal plant collection. Interviews with 68 informants (mean age: 54; 100% men, 0% women) were performed in 12 farmers’ communities: Huancaya, Vilca, Vitis, Miraflores, Piños, Carania, San Lorenzo De Alis, Santa Rosa De Tinco, Tomás, Huancachi, Laraos and Huantán. Results: 63 species of plants belonging to 29 families were reported. More than a half of reported plants were native, endemic of the studied area. Leaves and their mixtures were the most (67.26%) commonly used plant part. Most of the remedies were prepared in infusion, and 90.08% were administered orally. Most treated disorders were the gastrointestinal (18.59%) and respiratory ones (18.22%). Conclusions: 6 species (9.52%) without pharmacological references in international scientific literature, 21 species (33.33%) with 1–2 references, 16 species (25.40%) with 3–6 references, and 20 species (31.75%) that have been already widely studied were found. [Copyright &y& Elsevier]