1. Therapeutic roles of coenzyme Q10 in peripheral nerve injury-induced neurosensory disturbances: Mechanistic insights from injury to recovery.
- Author
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Vachirarojpisan, Thanyaphorn, Srivichit, Bhumrapee, Vaseenon, Savitri, Powcharoen, Warit, and Imerb, Napatsorn
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THERAPEUTIC use of ubiquinones , *PERIPHERAL neuropathy , *NEUROPROTECTIVE agents , *SENSORY disorders , *OXIDATIVE stress , *CONVALESCENCE , *ORGANIC compounds , *INFLAMMATION , *BIOAVAILABILITY , *DISEASE complications - Abstract
• CoQ10 promotes nerve regeneration by enhancing mitochondrial biogenesis. • CoQ10 improves antioxidative mechanisms led to accelerating neural tissue healing. • CoQ10 can protect against neuroinflammation in neurosensory disturbances. • Early CoQ10 supplementation enhances neuroprotection. • CoQ10 supplementation may serve as adjunctive treatment for peripheral nerve injury. Peripheral nerve injuries (PNIs) are prevalent conditions mainly resulting from systemic causes, including autoimmune diseases and diabetes mellitus, or local causes, for example, chemical injury and perioperative nerve injury, which can cause a varying level of neurosensory disturbances (NSDs). Coenzyme Q10 (CoQ10) is an essential regulator of mitochondrial respiration and oxidative metabolism. Here, we review the pathophysiology of NSDs caused by PNIs, the current understanding of CoQ10's bioactivities, and its potential therapeutic roles in nerve regeneration, based on evidence from experimental and clinical studies involving CoQ10 supplementation. In summary, CoQ10 supplementation shows promise as a neuroprotective agent, potentially enhancing treatment efficacy for NSDs by reducing oxidative stress and inflammation. Future studies should focus on well-designed clinical trials with large sample sizes, using CoQ10 formulations with proven bioavailability and varying treatment duration, to further elucidate its neuroprotective effects and to optimize nerve regeneration in PNIs-induced NSDs. [Display omitted] Graphical abstract legend Coenzyme Q10 may serve as a potential therapeutic agent in preventing and mitigating neurosensory disturbances induced by peripheral nerve injury, primarily through enhancing mitochondrial biogenesis and bolstering antioxidant mechanisms. Additionally, its anti-inflammatory properties offer an appealing avenue for shielding against neuroinflammation, thereby augmenting its efficacy in treating neurosensory disorders. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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