212 results
Search Results
2. Therapeutic strategies for severe COVID-19: a position paper from the Italian Society of Infectious and Tropical Diseases (SIMIT).
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Mussini, Cristina, Falcone, Marco, Nozza, Silvia, Sagnelli, Caterina, Parrella, Roberto, Meschiari, Marianna, Petrosillo, Nicola, Mastroianni, Claudio, Cascio, Antonio, Iaria, Chiara, Galli, Massimo, Chirianni, Antonio, Sagnelli, Evangelista, Iacobello, Carmelo, Di Perri, Giovanni, Mazzotta, Francesco, Carosi, Giampiero, Tinelli, Marco, Grossi, Paolo, and Armignacco, Orlando
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COVID-19 , *COMMUNICABLE diseases , *PANDEMICS , *CORONAVIRUS disease treatment , *TROPICAL medicine , *COVID-19 treatment - Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has become pandemic, reaching almost one million death worldwide. At present standard treatment for coronavirus disease 2019 (COVID-19) is not well defined because the evidence, either from randomized or observational studies, with conflicting results, has led to rapid changes in treatment guidelines. Our aim was to narratively summarize the available literature on the management of COVID-19 in order to combine current evidence and interpretation of the data by experts who are treating patients in the frontline setting. The panel conducted a detailed review of the literature and eventual press releases from randomized clinical trials for each possible available treatment. Inductive PubMed search waws performed for publications relevant to the topic, including all clinical trials conducted. The result was a flowchart with treatment indications for patients with COVID-19. After 6 months of a pandemic situation and before a possible second coronavirus wave descends on Europe, it is important to evaluate which drugs proved to be effective while also considering that results from many randomized clinical trials are still awaited. Indeed, among treatments for COVID-19, only glucocorticoids have resulted in an association with a significant decrease in mortality in published randomized controlled trials. New therapeutic strategies are urgently needed. [ABSTRACT FROM AUTHOR]
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- 2021
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3. Why does SARS-CoV-2 survive longer on plastic than on paper?
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Corpet, Denis E.
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SARS-CoV-2 ,POROUS materials ,SURFACE stability ,COVID-19 ,PLASTICS - Abstract
The Covid-19 coronavirus, SARS-CoV-2, is inactivated much faster on paper (3 h) than on plastic (7 d). By classifying materials according to virus stability on their surface, the following list is obtained (from long to short stability): polypropylene (mask), plastic, glass, stainless steel, pig skin, cardboard, banknote, cotton, wood, paper, tissue, copper. These observations and other studies suggest that SARS-CoV-2 may be inactivated by dryness on water absorbent porous materials but sheltered by long-persisting micro-droplets of water on waterproof surfaces. If such physical phenomenons were confirmed by direct evidence, the persistence of the virus on any surface could be predicted, and new porous objects could be designed to eliminate the virus faster. [ABSTRACT FROM AUTHOR]
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- 2021
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4. Letter to editor regarding Ogen Y 2020 paper: "Assessing nitrogen dioxide (NO2) levels as a contributing factor to coronavirus (COVID-19) fatality".
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Chudnovsky, Alexandra A.
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- 2020
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5. Measuring COVID-19 related anxiety and obsession: Validation of the Coronavirus Anxiety Scale and the Obsession with COVID-19 Scale in a probability Chinese sample
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Kwok Kit Tong, Anise M. S. Wu, Xiaoyu Su, Juliet Honglei Chen, and Eilo Wing-yat Yu
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Predictive validity ,Adult ,Male ,China ,Concurrent validity ,Anxiety ,Assessment ,Obsession ,Mental distress ,medicine ,Humans ,Measurement invariance ,Pandemics ,Language ,Probability ,Pandemic ,Depression ,SARS-CoV-2 ,Reproducibility of Results ,COVID-19 ,Mental health ,Coronavirus ,Psychiatry and Mental health ,Clinical Psychology ,Distress ,Cross-Sectional Studies ,Scale (social sciences) ,Female ,medicine.symptom ,Obsessive Behavior ,Psychology ,Clinical psychology ,Research Paper - Abstract
Background With concern over the rise in mental health symptoms associated with the COVID-19 pandemic, the present study set out to address the absence of pandemic-specific screening tools for detecting those in Chinese societies who are at-risk for experiencing mental distress due to the pandemic; thus, its aim was to validate the Coronavirus Anxiety Scale (CAS) and Obsession with COVID-19 Scale (OCS) in Chinese adults. Methods With a two-stage cluster random sampling method, we surveyed 1011 Chinese community-dwelling adults (38.8% men; 41.2 years old on average with an SD of 15.8) in June and July of 2020. Results Our psychometric evaluation results showed that the Chinese version of CAS and OCS retained their original one-dimensional structure and demonstrated measurement invariance across genders. In line with validation studies of the CAS and OCS in other languages, subsequent analyses also provided support to our Chinese version with respect to their satisfactory internal consistency (α = .87 and .73, respectively), and good concurrent validity (i.e., positive associations with negative feelings, excessive time-consumption, subjective distress, and functioning impairment). Limitations Due to constraints of time and cross-sectional design, we only validated CAS and OCS among Chinese adults and did not evaluate their test-retest reliability nor predictive validity. Conclusions Considering the practical benefits of understanding the source of mental symptoms during the pandemic, we recommend the use of CAS and OCS in Chinese communities to facilitate early identification and intervention for those who require clinical attention due to their COVID-19 related anxiety and obsessive thoughts.
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- 2021
6. The mental health and lifestyle impacts of COVID-19 on bipolar disorder
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Tamsyn E Van Rheenen, Michael Berk, James A Karantonis, and Susan L. Rossell
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Bipolar Disorder ,Lifestyle factors ,Quality of life (healthcare) ,Cognition ,Medicine ,Humans ,Bipolar disorder ,Life Style ,Depression (differential diagnoses) ,business.industry ,Depression ,SARS-CoV-2 ,COVID-19 ,medicine.disease ,Mental health ,Coronavirus ,Psychiatry and Mental health ,Clinical Psychology ,Distress ,Mania ,Mood ,Mental Health ,Quality of Life ,medicine.symptom ,business ,Clinical psychology ,Research Paper - Abstract
BACKGROUND: It is unclear how those with bipolar disorder (BD) have been affected by the coronavirus (COVID-19) pandemic. This study aimed to obtain a more detailed understanding of the current mental health needs of these individuals, which is important for both the development of intervention strategies to better manage patient distress and to better prepare for similar circumstances in future. METHODS: The sample comprised 43 individuals with a verified diagnosis of BD and 24 healthy controls. Data about pandemic-related mental health support use, socio-demographics, mood, lifestyle, social rhythm and subjective cognitive dysfunction data were collected and compared between groups. Inter-relationships between scores were also examined. RESULTS: No between-group differences were found in terms of age, sex, living situation, job loss or reduced work hours due to COVID-19. Most patients with BD reported a history of ongoing formal psychological support (68.3%), with most continuing this support throughout the pandemic (82.1%). A large, statistically significant pandemic-related increase in subjective cognitive dysfunction was evident in the BD group. Subjective cognitive dysfunction was significantly associated with negative symptomology, suicidal thoughts, and quality of life ratings. LIMITATIONS: Data was collected in self-report format in an online survey and objective symptom measures were not used at this time CONCLUSION: The absenceof substantial differences between patients and controls in terms of mood symptoms, COVID-19 fear or lifestyle factors and social rhythms suggests a degree of resilience in BD patients; despite large pandemic related increases in subjective cognitive dysfunction.
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- 2020
7. In silico investigation of potential small molecule inhibitors of the SARS-CoV-2 nsp10-nsp16 methyltransferase complex
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Andrew Hung, Tom C. Karagiannis, Eleni Pitsillou, Julia Liang, and Lucy Burbury
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Methyltransferase ,In silico ,General Physics and Astronomy ,Nsp16 ,02 engineering and technology ,010402 general chemistry ,medicine.disease_cause ,01 natural sciences ,Cofactor ,Nsp10 ,medicine ,Physical and Theoretical Chemistry ,Coronavirus ,ComputingMethodologies_COMPUTERGRAPHICS ,biology ,Methyltransferase complex ,Chemistry ,SARS-CoV-2 ,RNA ,COVID-19 ,021001 nanoscience & nanotechnology ,Small molecule ,0104 chemical sciences ,Biochemistry ,Docking (molecular) ,Molecular docking ,biology.protein ,0210 nano-technology ,Research Paper - Abstract
Graphical abstract, The COVID-19 pandemic caused by SARS-CoV-2 has resulted in an international health emergency. The SARS-CoV-2 nsp16 is an S-adenosyl-L-methionine (SAM)-dependent methyltransferase, and with its cofactor nsp10, is responsible for RNA cap formation. This study aimed to identify small molecules binding to the SAM-binding site of the nsp10-nsp16 heterodimer for potential inhibition of methyltransferase activity. By screening a library of 300 compounds, 30 compounds were selected based on binding scores, side-effects, and availability. Following more advanced docking, six potential lead compounds were further investigated using molecular dynamics simulations. This revealed the dietary compound oleuropein as a potential methyltransferase inhibitor.
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- 2021
8. Topological Analysis for Sequence Variability: Case Study on more than 2K SARS-CoV-2 sequences of COVID-19 infected 54 countries in comparison with SARS-CoV-1 and MERS-CoV
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Indrajit Saha, Jnanendra Prasad Sarkar, Debasree Maity, Ujjwal Maulik, and Arijit Seal
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0301 basic medicine ,viruses ,medicine.disease_cause ,Severe Acute Respiratory Syndrome ,MERS-CoV ,Pandemic ,Global health ,Coronavirus ,Genomic sequences ,education.field_of_study ,Coronavirsus ,virus diseases ,Europe ,Infectious Diseases ,Severe acute respiratory syndrome-related coronavirus ,Host-Pathogen Interactions ,Middle East Respiratory Syndrome Coronavirus ,Coronavirus Infections ,Research Paper ,Microbiology (medical) ,Asia ,030106 microbiology ,Population ,Sequence alignment free technique ,Context (language use) ,Sequence alignment ,Genome, Viral ,Biology ,Topology ,Microbiology ,Virus ,03 medical and health sciences ,medicine ,Genetics ,Humans ,education ,Molecular Biology ,Pandemics ,Ecology, Evolution, Behavior and Systematics ,Sequence (medicine) ,Base Sequence ,SARS-CoV-2 ,fungi ,Australia ,COVID-19 ,Computational Biology ,Genetic Variation ,respiratory tract diseases ,030104 developmental biology ,Africa ,Americas ,Sequence Alignment - Abstract
The pandemic due to novel coronavirus, SARS-CoV-2 is a serious global concern now. More than thousand new COVID-19 infections are getting reported daily for this virus across the globe. Thus, the medical research communities are trying to find the remedy to restrict the spreading of this virus, while the vaccine development work is still under research in parallel. In such critical situation, not only the medical research community, but also the scientists in different fields like microbiology, pharmacy, bioinformatics and data science are also sharing effort to accelerate the process of vaccine development, virus prediction, forecasting the transmissible probability and reproduction cases of virus for social awareness. With the similar context, in this article, we have studied sequence variability of the virus primarily focusing on three aspects: (a) sequence variability among SARS-CoV-1, MERS-CoV and SARS-CoV-2 in human host, which are in the same coronavirus family, (b) sequence variability of SARS-CoV-2 in human host for 54 different countries and (c) sequence variability between coronavirus family and country specific SARS-CoV-2 sequences in human host. For this purpose, as a case study, we have performed topological analysis of 2391 global genomic sequences of SARS-CoV-2 in association with SARS-CoV-1 and MERS-CoV using an integrated semi-alignment based computational technique. The results of the semi-alignment based technique are experimentally and statistically found similar to alignment based technique and computationally faster. Moreover, the outcome of this analysis can help to identify the nations with homogeneous SARS-CoV-2 sequences, so that same vaccine can be applied to their heterogeneous human population., Highlights • Topological analysis of more than 2K SARS-CoV-2 Sequences • Sequence variability among SARS-CoV-1, MERS-CoV and SARS-CoV-2 • Sequence variability of SARS-CoV-2 in 54 countries • Development of Semi-Alignment based technique • Sequence similarity can help in decision making to apply vaccine
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- 2021
9. Immunoinformatics approach to understand molecular interaction between multi-epitopic regions of SARS-CoV-2 spike-protein with TLR4/MD-2 complex
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Garima Sharma, Ashish Ranjan Sharma, Chiranjib Chakraborty, Sang-Soo Lee, Manojit Bhattacharya, and Bidyut Mallick
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0301 basic medicine ,Microbiology (medical) ,Models, Molecular ,Antigenicity ,Protein Conformation ,030106 microbiology ,Lymphocyte Antigen 96 ,Epitopes, T-Lymphocyte ,Computational biology ,Plasma protein binding ,Biology ,Spike protein ,Adaptive Immunity ,medicine.disease_cause ,Microbiology ,Epitope ,03 medical and health sciences ,Epitopes ,Protein structure ,Immune system ,Antigen ,Genetics ,medicine ,Humans ,Molecular Biology ,Ecology, Evolution, Behavior and Systematics ,Coronavirus ,SARS-CoV-2 ,TLR4/MD-2 complex ,COVID-19 ,Computational Biology ,Acquired immune system ,Molecular Docking Simulation ,Toll-Like Receptor 4 ,030104 developmental biology ,Infectious Diseases ,Spike Glycoprotein, Coronavirus ,Epitopes, B-Lymphocyte ,Hydrophobic and Hydrophilic Interactions ,Research Paper ,Protein Binding - Abstract
Background The coronavirus (CoV) spike (S) protein is critical for receptor binding, membrane fusion and internalization of the virus into the human cells. We have tried to search the epitopic component of the S-protein that might be served as crucial targets for the vaccine development and also tried to understand the molecular mechanism of epitopes and TLR4/MD-2 complex for adaptive immunity. Material and methods Here we identified the antigenicity and the epitopic divergence of S-protein via immunoinformatics approach. The study was performed to identify the epitopes, composition of amino acids and its distribution in epitopic regions, composition of amino acid between the identified epitopes, secondary structure architecture of epitopes, physicochemical and biochemical parameters and molecular interaction between the identified epitope and TLR4/MD-2 complex. The SARS-CoV-2 can be possibly recognised by TLR4 of host immune cells that are responsible for the adaptive immune response. Results We identified four SARS-CoV-2 S-protein 9mer antigenic epitopes and observed that they bind with the TLR4/MD-2 complex by varied stable molecular bonding interactions. Molecular interaction between these characterized epitopes with TLR4/MD-2 complex might be indicated the binding affinity and downstream signalling of adaptive immune response. Different physicochemical and biochemical parameters such as O-glycosylation and N-glycosylation, Hydrophobicity, GRAVY were identified within epitopic regions of S-protein. These parameters help to understand the protein-protein interaction between epitopes and TLR4/MD-2 complex. The study also revealed different epitopic binding pockets of TLR4/MD-2 complex. Conclusions The identified epitopes impart suitable prospects for the development of novel peptide-based epitopic vaccine for the control of COVID-19 infection., Highlights • Identification and characterization of antigenic multi-epitopic region of SARS-CoV-2 Spike (S) protein. • Molecular interaction study of SARS-CoV-2 S-protein epitopes and human TLR4/MD-2 complex through molecular docking. • Binding with TLR4/MD-2 complex with four identified epitopes from SARS-CoV-2 S-protein might induce an immune response. • Identified epitopes (both B and T-cells) are promising candidates for epitope-based peptide-vaccine against COVID-19.
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- 2020
10. Gene signatures of SARS-CoV/SARS-CoV-2-infected ferret lungs in short- and long-term models
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Meng-Chi Yen, Ming Derg Lai, Chih-Yang Wang, Hui Ping Hsu, I-Jeng Yeh, Jui-Hsiang Hung, Zhengda Sun, Chien Fu Chen, Nam Nhut Phan, Hsin-Liang Liu, Jia-Zhen Jiang, Yen-Hung Wu, and Chung-Chieh Chiao
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0301 basic medicine ,Microbiology (medical) ,Bioinformatics ,viruses ,030106 microbiology ,Biology ,medicine.disease_cause ,Microbiology ,03 medical and health sciences ,Ferret (Mustela putorius furo) ,Immune system ,Gene expression ,medicine ,AXIN2 ,Genetics ,Animals ,Gene Regulatory Networks ,skin and connective tissue diseases ,Gene ,Molecular Biology ,Lung ,ACADM ,Ecology, Evolution, Behavior and Systematics ,Coronavirus ,SARS-CoV-2 ,Gene Expression Profiling ,fungi ,Ferrets ,virus diseases ,COVID-19 ,Computational Biology ,SARS-CoV ,ABHD6 ,Virology ,body regions ,Disease Models, Animal ,030104 developmental biology ,Infectious Diseases ,Gene Ontology ,Gene Expression Regulation ,NFIA ,Disease Progression ,Reactive Oxygen Species ,Research Paper - Abstract
Coronaviruses (CoVs) consist of six strains, and the severe acute respiratory syndrome coronavirus (SARS-CoV), newly found coronavirus (SARS-CoV-2) has rapidly spread leading to a global outbreak. The ferret (Mustela putorius furo) serves as a useful animal model for studying SARS-CoV/SARS-CoV-2 infection and developing therapeutic strategies. A holistic approach for distinguishing differences in gene signatures during disease progression is lacking. The present study discovered gene expression profiles of short-term (3 days) and long-term (14 days) ferret models after SARS-CoV/SARS-CoV-2 infection using a bioinformatics approach. Through Gene Ontology (GO) and MetaCore analyses, we found that the development of stemness signaling was related to short-term SARS-CoV/SARS-CoV-2 infection. In contrast, pathways involving extracellular matrix and immune responses were associated with long-term SARS-CoV/SARS-CoV-2 infection. Some highly expressed genes in both short- and long-term models played a crucial role in the progression of SARS-CoV/SARS-CoV-2 infection, including DPP4, BMP2, NFIA, AXIN2, DAAM1, ZNF608, ME1, MGLL, LGR4, ABHD6, and ACADM. Meanwhile, we revealed that metabolic, glucocorticoid, and reactive oxygen species-associated networks were enriched in both short- and long-term infection models. The present study showed alterations in gene expressions from short-term to long-term SARS-CoV/SARS-CoV-2 infection. The current result provides an explanation of the pathophysiology for post-infectious sequelae and potential targets for treatment., Highlights • The development of Wnt and stemness signaling were related to short-term SARS-CoV/SARS-CoV-2 infection. • The extracellular matrix and immune response were associated with long-term SARS-CoV/SARS-CoV-2 infection. • Metabolic, glucocorticoid, and reactive oxygen species-associated networks were enriched in both short- and long-term SARS-CoV/SARS-CoV-2 infected models.
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- 2020
11. Re-use of health masks after autoclaving
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Mi Seong Jo, Cheol Hong Kim, Il Je Yu, Jeong Suk Choi, and Hoi Pin Kim
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2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,Health professionals ,Mask ,business.industry ,Materials Science (miscellaneous) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Public Health, Environmental and Occupational Health ,02 engineering and technology ,Alcohol treatment ,010501 environmental sciences ,021001 nanoscience & nanotechnology ,01 natural sciences ,Toxicology ,Coronavirus ,Medicine ,Filtration efficiency ,0210 nano-technology ,Safety, Risk, Reliability and Quality ,business ,Re-use ,Safety Research ,Decontamination ,0105 earth and related environmental sciences ,Research Paper - Abstract
With the rapid global spread of the new coronavirus and risk of pneumonia from COVID-19 infection, wearing a mask has become an essential defense for all frontline doctors, nurses, and healthcare professionals. Plus, the rise in demand for masks from the general public means the worldwide supply of masks is insufficient, which has led to an increase in the reuse of disposable masks. Therefore, this study compared the impact of autoclaving (steaming) and 70% ethyl alcohol treatment for decontaminating masks, as both methods can easily be used at home. The autoclaved masks showed a better filtration efficiency than the 70% ethyl alcohol-treated masks. A further investigation of 8 used KF 94 masks (filtration efficiency >94%) also showed that autoclaving for decontamination was limited to two times. Moreover, a kitchen towel mask, a popular homemade alternative, did not show sufficient filtration efficiency., Highlights • New coronavirus infection pandemic requires respiratory protection such as mask. • Eight masks having filtration efficiency >94% were tested for reuse. • Masks can be decontaminated by autoclaved and reused further. • Filtration efficiency was maintained up to 2 periods of autoclaving.
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- 2020
12. Characterising public transport shifting to active and private modes in South American capitals during the COVID-19 pandemic.
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Vallejo-Borda, Jose Agustin, Giesen, Ricardo, Basnak, Paul, Reyes, José P., Mella Lira, Beatriz, Beck, Matthew J., Hensher, David A., and Ortúzar, Juan de Dios
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PUBLIC transit , *COVID-19 pandemic , *BIOLOGICAL transport , *CHOICE of transportation , *LATENT variables - Abstract
During the year 2020, the COVID-19 pandemic affected mobility around the world, significantly reducing the number of trips by public transport. In this paper, we study its impact in five South American capitals (i.e., Bogotá, Buenos Aires, Lima, Quito and Santiago). A decline in public transport patronage could be very bad news for these cities in the long term, particularly if users change to less sustainable modes, such as cars or motorbikes. Notwithstanding, it could be even beneficial if users selected more sustainable modes, such as active transport (e.g., bicycles and walking). To better understand this phenomenon in the short term, we conducted surveys in these five cities looking for the main explanation for changes from public transport to active and private modes in terms of user perceptions, activity patterns and sociodemographic information. To forecast people's mode shifts in each city, we integrated both objective and subjective information collected in this study using a SEM-MIMIC model. We found five latent variables (i.e., COVID-19 impact, Entities response , Health risk , Life related activities comfort and Subjective well-being), two COVID-19 related attributes (i.e. , new cases and deaths), two trip attributes (i.e., cost savings and time), and six socio-demographic attributes (i.e. , age, civil status, household characteristics, income level , occupation and gender) influencing the shift from public transport to other modes. Furthermore, both the number of cases and the number of deaths caused by COVID-19 increased the probability of moving from public transport to other modes but, in general, we found a smaller probability of moving to active modes than to private modes. The paper proposes a novel way for understanding geographical and contextual similarities in the pandemic scenario for these metropolises from a transportation perspective. [ABSTRACT FROM AUTHOR]
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- 2022
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13. Chest computed tomography findings of patients infected with Covid-19 and their association with disease evolution stages.
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Bomfim, L.N., de Barros, C.R.A., Veloso, F.C.S., Micheleto, J.P.C., Melo, K.A., Gonçalves, I.S., Kassar, S.B., and Oliveira, M.J.C.
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To describe CT findings in patients with confirmed Covid-19 infection and correlate them with the disease evolution stages. This is a historical cohort observational analytical study carried out with outpatients, inpatients, and emergency patients from a private hospital in Maceió/AL, Brazil. The final sample consisted of 390 patients with positive RT-PCR for Covid-19 with available laboratory tests and chest CT results. The most frequent initial symptoms were cough, fever, dyspnea and headache. The most commonly found comorbidities were hypertension, diabetes mellitus and obesity. A total of 22% of the CT scans showed no alterations; ground-glass opacity was the most frequently found one. There was a significant association between age, comorbidities, pulmonary involvement, ground-glass opacity, mosaic attenuation and percentage of pulmonary involvement with death. The analysis of the disease stages showed a significant association with laboratory data (CRP and platelet levels), ground-glass opacity and mosaic attenuation with the disease evolution stages in relation to the days since symptom onset. The disease evolution of Covid-19 occurs in stages, and this study describes tomographic findings in patients with confirmed Covid-19 infection and shows they vary depending on the disease evolution stages. This paper provides important addition to the various records that have been accumulated through the Covid-19 pandemic. [ABSTRACT FROM AUTHOR]
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- 2023
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14. Resonant frequency of coronavirus: The tensegrity approach.
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Kueh, Ahmad B.H.
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CORONAVIRUSES ,STRUCTURAL failures ,COVID-19 ,RESONANT states ,MODAL analysis ,BIOLOGICAL systems - Abstract
[Display omitted] • An alternative to vaccination to combat the attack of coronavirus. • First simple model to determine the frequency range for coronavirus inactivation. • First to use the tensegrity concept to model the coronavirus. • Coronavirus inactivation by envelope fracturing is evident in model failure mode. • First natural frequency map for coronavirus vs healthy human cells as reference. COVID-19 is a worldwide health hazard. In discovering a fully efficient vaccination for continually evolving viruses, alternatives such as the sonication treatment methods, which have seen encouraging outcomes in disinfection and medical therapies, are worth exploring. Such treatments incapacitate microbes or diseased cells by selectively invoking large deformation at the resonant frequency that initiates structural failure. Nevertheless, due to biodiversity, the precise range of resonant frequencies for different biological bodies can be widely varying, its determination of which is best achieved with the cost-effective computational simulation approach. The paper proposes, therefore, the numerical determination of the resonant frequency of the coronavirus employing the tensegrity method, due to its efficacy in modeling various biomechanical behaviors of different biological bodies and systems. Initiating from successfully verifying the resonant frequency with existing findings, the model then determines the operative sonication frequencies range for the resonant state of the virus. At these sonication frequencies, the modal analysis exhibits a large structurally destructive deformation of the coronavirus. For practical convenience, the operative range of sonication resonant frequencies of the coronavirus has been mapped alongside healthy human cells. These findings offer an alternative technological avenue in combating the COVID-19 progressive threat. [ABSTRACT FROM AUTHOR]
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- 2023
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15. COVID-19 infection risk by open and laparoscopic surgical smoke: A systematic review of the literature.
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Antunes, Diandra, Lami, Mariam, Chukwudi, Agbim, Dey, Abhishek, Patel, Mahul, Shabana, Amanda, Shams, Mohamed, Slack, Zoe, Bond-Smith, Giles, and Tebala, Giovanni
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SURGICAL smoke , *COVID-19 , *DIATHERMY , *COVID-19 pandemic , *VIRAL transmission , *INFECTION , *INHALATION injuries - Abstract
Background: The current COVID-19 pandemic has greatly changed the way surgery is delivered. In particular, current guidelines and policies have highlighted the need to use high level Personal Protective Equipment to reduce the risk of viral infection during open and laparoscopic surgical procedures. In particular, it was felt that the laparoscopic approach was at higher risk of viral transmission due to the chimney effect of the smoke escape from the trocars during and after the procedure. However, with this being a new and largely unknown viral agent, guidelines have been based on speculation and extrapolation from previous studies conducted in completely different situations, and led to anxiety amongst surgeons and theatre staff. We decided to conduct a systematic review of the Literature to try to clarify whether inhalation of surgical smoke can increase the risk of COVID-19 infection.Methods: A thorough search of the relevant Literature was performed following the PRISMA guidelines and the most relevant papers on this topic were selected for qualitative analysis. Duplicates, review, personal opinions and guidelines have been excluded. Quantitative analysis has not been performed due to the lack of homogeneous high-quality studies.Results: Literature search identified 740 papers but only 34 of them were suitable for qualitative analysis. The quality of those studies is generally quite low. We were not able to find any evidence directly linking surgical smoke with viral transmission, other than in patients with active HPV infection.Discussion: Inhalation of surgical smoke can be generally hazardous, and therefore the use of PPE during surgical operations must be recommended in any case. However, the present systematic review of the existent Literature did not identify any significant evidence of the risk of viral transmission with the surgical smoke, therefore the current guidelines restricting the use of laparoscopy and/or diathermy during the current Covid-19 pandemic may be considered excessive and non-evidence based. [ABSTRACT FROM AUTHOR]- Published
- 2021
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16. Exploring the patient experience of telehealth hand therapy services during the COVID-19 pandemic.
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Hirth, Melissa J., Hahn, Jodie, and Jamwal, Rebecca J.
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HAND injury treatment ,TIME ,MEDICAL care ,PATIENT satisfaction ,COST control ,PATIENTS' attitudes ,DESCRIPTIVE statistics ,HEALTH insurance ,METROPOLITAN areas ,TECHNOLOGY ,POLICY sciences ,COVID-19 pandemic ,TELEMEDICINE ,PSYCHOLOGICAL stress - Abstract
• Patients are satisfied with telehealth services in the context of an active pandemic. • An advantage of telehealth is more easily fitting in therapy around other commitments. • Future funding models should consider a hybrid model of face-to-face and telehealth. Electronic Survey. Internationally the COVID-19 pandemic has resulted in an unprecedented shift from face-to-face therapy to telehealth services. This paper explores the patient experience and satisfaction with telehealth hand therapy in a metropolitan setting during a period (March 1 to May 31, 2021) of 'moderate' COVID-19 risk when there was minimal community transmission of COVID-19. Patients attending telehealth services were invited to participate in an English language online survey at the conclusion of their therapy session via a pop-up invitation. During the recruitment period there were 123 survey responses (29% response rate; 98% completion rate). Half of the respondents (n = 78, 53%) reported saving between 10 and 29 minutes of travel time (each way) by attending a telehealth appointment, while 36% (n = 44) saved more than 30 minutes (each way). Almost all respondents (n = 117, 95%) noted telehealth should be used in the future. The main benefit for telehealth was more easily fitting appointments around other commitments, followed by reducing stress and costs surrounding hospital attendance. Most participants (n = 97, 79%) reported no challenges using telehealth. The most cited challenges included the therapist not being able to provide hands on treatment (n = 14, 11%) and for seven respondents getting the technology to work (6%). The elevated level of participant satisfaction of attending telehealth sessions informs us that this mode of therapy delivery could benefit patients in a post-pandemic environment. Metropolitan funding models prior to the pandemic did not allow for this mode of therapy and hence consideration for an ongoing hybrid funding model of both face-to-face and telehealth should be considered by policy makers, insurance and government funding bodies. [ABSTRACT FROM AUTHOR]
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- 2023
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17. The estimations of the COVID-19 incubation period: A scoping reviews of the literature.
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Zaki, Nazar and Mohamed, Elfadil A.
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A novel coronavirus (COVID-19) has taken the world by storm. The disease has spread very swiftly worldwide. A timely clue which includes the estimation of the incubation period among COVID-19 patients can allow governments and healthcare authorities to act accordingly. to undertake a review and critical appraisal of all published/preprint reports that offer an estimation of incubation periods for COVID-19. This research looked for all relevant published articles between the dates of December 1, 2019, and April 25, 2020, i.e. those that were related to the COVID-19 incubation period. Papers were included if they were written in English, and involved human participants. Papers were excluded if they were not original (e.g. reviews, editorials, letters, commentaries, or duplications). COVID-19 Open Research Dataset supplied by Georgetown's Centre for Security and Emerging Technology as well as PubMed and Embase via Arxiv, medRxiv, and bioRxiv. A data-charting form was jointly developed by the two reviewers (NZ and EA), to determine which variables to extract. The two reviewers independently charted the data, discussed the results, and updated the data-charting form. Screening was undertaken 44,000 articles with a final selection of 25 studies referring to 18 different experimental projects related to the estimation of the incubation period of COVID-19. The majority of extant published estimates offer empirical evidence showing that the incubation period for the virus is a mean of 7.8 days, with a median of 5.01 days, which falls into the ranges proposed by the WHO (0–14 days) and the ECDC (2–12 days). Nevertheless, a number of authors proposed that quarantine time should be a minimum of 14 days and that for estimates of mortality risks a median time delay of 13 days between illness and mortality should be under consideration. It is unclear as to whether any correlation exists between the age of patients and the length of time they incubate the virus. [ABSTRACT FROM AUTHOR]
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- 2021
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18. The global burden of trauma during the COVID-19 pandemic: A scoping review.
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Waseem, S., Nayar, S.K., Hull, P., Carrothers, A., Rawal, J., Chou, D., and Khanduja, V.
- Abstract
Purpose; The COVID-19 pandemic has necessitated profound adaptations in the delivery of healthcare to manage a rise in critically unwell patients. In an attempt to slow the spread of the virus nationwide lockdown restrictions were introduced. This review aims to scope the literature on the impact of the pandemic and subsequent lockdown on the presentation and management of trauma globally. Methods; A scoping review was conducted in accordance with PRISMA-ScR guidelines. A systematic search was carried out on the Medline, EMBASE and Cochrane databases to identify papers investigating presentation and management of trauma during the COVID-19 pandemic. All studies based on patients admitted with orthopaedic trauma during the COVID-19 pandemic were included. Exclusion criteria were opinion-based reports, reviews, studies that did not provide quantitative data and papers not in English. Results; 665 studies were screened, with 57 meeting the eligibility criteria. Studies reported on the footfall of trauma in the UK, Europe, Asia, USA, Australia and New Zealand. A total of 29,591 patients during the pandemic were considered. Mean age was 43.7 years (range <1–103); 54.8% were male. Reported reductions in trauma footfall ranged from 20.3% to 84.6%, with a higher proportion of trauma occurring secondary to interpersonal violence, deliberate self-harm and falls from a height. A decrease was seen in road traffic collisions, sports injuries and trauma occurring outdoors. There was no significant change in the proportion of patients managed operatively, and the number of trauma patients reported to be COVID-19 positive was low. Conclusion; Whilst the worldwide COVID-19 pandemic has caused a reduction in the number of trauma patients; the services managing trauma have continued to function despite infrastructural, personnel and pathway changes in health systems. The substantial effect of the COVID-19 pandemic on elective orthopaedics is well described, however the contents of this review evidence minimal change in the delivery of effective trauma care despite resource constraints during this global COVID-19 pandemic. [ABSTRACT FROM AUTHOR]
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- 2021
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19. Insights into the impact of COVID-19 on household travel and activities in Australia – The early days of easing restrictions.
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Beck, Matthew J. and Hensher, David A.
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COVID-19 , *SARS-CoV-2 , *TELECOMMUTING , *SOCIAL distancing , *ACQUISITION of data , *BUSES - Abstract
The COVID-19 disease continues to cause unparalleled disruption to life and the economy world over. This paper is the second in what will be an ongoing series of analyses of a longitudinal travel and activity survey. In this paper we examine data collected over a period of late May to early June in Australia, following four-to-six weeks of relatively flat new cases in COVID-19 after the initial nationwide outbreak, as many state jurisdictions have begun to slowly ease restrictions designed to limit the spread of the SARS-CoV-2 virus. We find that during this period, travel activity has started to slowly return, in particular by private car, and in particular for the purposes of shopping and social or recreational activities. Respondents indicate comfort with the idea of meeting friends or returning to shops, so authorities need to be aware of potential erosion of social distancing and appropriate COVID-safe behaviour in this regard. There is still a concern about using public transport, though it has diminished noticeably since the first wave of data collection. We see that working from home continues to be an important strategy in reducing travel and pressure on constrained transport networks, and a policy measure that if carried over to a post-pandemic world, will be an important step towards a more sustainable transport future. We find that work from home has been a generally positive experience with a significant number of respondents liking to work from home moving forward, with varying degrees of employer support, at a level above those seen before COVID-19. Thus, any investment to capitalise on current levels of work from home should be viewed as an investment in transport. • Aggregate travel has increased by 50% but is still less than two-thirds of that which occurred prior to COVID-19. • Motor vehicle travel rebounding more than other modes, those planning a return to train and bus intended to do so strongly. • Large increases in activity planned for shopping and social and recreation purposes. • People feel most comfortable with meeting with friends, going to the shops and visiting restaurants. • Working from home continues, and has been largely positive for those who have been able to do so.. • Concern about the risk of COVID-19 has decreased significantly since the initial outbreak. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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20. Prediction of new active cases of coronavirus disease (COVID-19) pandemic using multiple linear regression model.
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Rath, Smita, Tripathy, Alakananda, and Tripathy, Alok Ranjan
- Abstract
The COVID-19 pandemic originated from the city of Wuhan of China has highly affected the health, socio-economic and financial matters of the different countries of the world. India is one of the countries which is affected by the disease and thousands of people on daily basis are getting infected. In this paper, an analysis of daily statistics of people affected by the disease are taken into account to predict the next days trend in the active cases in Odisha as well as India. A valid global data set is collected from the WHO daily statistics and correlation among the total confirmed, active, deceased, positive cases are stated in this paper. Regression model such as Linear and Multiple Linear Regression techniques are applied to the data set to visualize the trend of the affected cases. Here a comparison of Linear Regression and Multiple Linear Regression model is performed where the score of the model R 2 tends to be 0.99 and 1.0 which indicates a strong prediction model to forecast the next coming days active cases. Using the Multiple Linear Regression model as on July month, the forecast value of 52,290 active cases are predicted towards the next month of 15th August in India and 9,358 active cases in Odisha if situation continues like this way. These models acquired remarkable accuracy in COVID-19 recognition. A strong correlation factor determines the relationship among the dependent (active) with the independent variables (positive, deceased, recovered). • Multiple linear regression model is proposed for prediction of Active cases in COVID-19 daily data. •The model predicts a value of 52,290 active cases in India and 9358 active cases in Odisha towards the 15th of August. •The ANOVA results shows a significant P value that accepts the proposed model. •Statistical results show MLR model has fair predictive potential over the LR model. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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21. Mining text on Coronavirus.
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Beltrán-Oicatá, Cristian O., Gaitán-Angulo, Mercedes, Lis-Gutiérrez, Melissa, and Naveda, Alexa Senior
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COVID-19 ,NEWSPAPER circulation ,SARS-CoV-2 ,CORONAVIRUSES ,DATA analysis ,PERFORMING arts - Abstract
This document describes the behavior of the production of academic papers and high circulation newspapers, published under the terms "Coronavirus, Covid-19 or SARS-CoV-2". The purpose of this paper is to employ text mining techniques and qualitative data analysis for pattern identification (Dobrzyński, Dziekoński, Krzysztof, & Jurczuk, 2013; Westergaard, Staerfeldt, Tønsberg, Jensen, & Brunak, 2018). The interest of this study arises from the importance of this topic today and its relationship with the economy, business and society. As a result, the production of scientific papers has been led by the United States, China and Russia. In Latin America, Brazil is the country with the highest scientific output on this subject. The analysis of newspaper articles focusing on economic and business issues showed the work between large companies, the government and the community, as well as companies with businesses and the need to adapt to constant change in the face of the crisis of labor and production. [ABSTRACT FROM AUTHOR]
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- 2020
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22. Determinants of COVID-19 vaccine hesitancy and resistance in Russia.
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Roshchina, Yana, Roshchin, Sergey, and Rozhkova, Ksenia
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VACCINE hesitancy , *HEALTH attitudes , *ATTITUDES toward illness , *COVID-19 vaccines , *PERSONALITY - Abstract
• Russia demonstrates low vaccination intentions compared to most European countries and some emerging economies. • The paper uses a nationally representative dataset for Russia (RLMS HSE-2020) to analyze the scope of COVID-19 vaccination hesitancy and resistance prior to the start of the vaccination campaign. • 43% of the Russian adult population were resistant towards vaccination, while 13% were hesitant. • Vaccination attitudes depend on age, family composition, education, type of settlement, employment, self-rated health, previous COVID-19 experience, and self-perceived risk of being infected. • Personality traits, risk attitudes, and trust, reflect the deep-rooted causes of vaccination attitudes and strongly predict vaccination intentions. Vaccination is the main tool available to handle the COVID-19 pandemic globally. Though no vaccine is proven to be 100% effective, vaccination secures against getting seriously ill and dying from the disease. Russia announced the development of its first domestic vaccine back in August 2020 and launched the nationwide immunization campaign at the beginning of 2021. Despite these achievements, as of mid-October 2021, only 36% of the population got at least one shot of the vaccine. Massive vaccination hesitancy and refusal pose a great threat to public health and postpone social and economic recovery. Using nationally representative data from the general adult population of Russia, this study explores the scope of vaccination hesitancy and refusal as well as the determinants of vaccination attitudes. The results suggest that only 45% of the Russian population demonstrated positive attitudes towards the COVID-19 vaccination prior to the launch of a nationwide vaccination program. We analyze a wide array of demographic, socio-economic, and health-related factors in relation to vaccination intentions and explore the deep-rooted causes of vaccination reluctance by looking at personality traits, religiosity, and trust. The obtained results are vital for designing policy measures to promote vaccination. [ABSTRACT FROM AUTHOR]
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- 2022
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23. Understanding the transmission of COVID-19 news to French financial markets in early 2020.
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Thorbecke, Willem
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FINANCIAL markets ,CENTRAL banking industry ,COVID-19 ,COVID-19 pandemic ,STOCK exchanges ,BID price - Abstract
News of COVID-19 cases roiled the French stock market in 2020. Finance theory indicates that changes in returns across many assets are driven by economy-wide rather than firm-specific factors. To identify these factors, this paper investigates the time series exposure of 174 French assets to macroeconomic variables. It then uses these exposures to examine the cross-sectional pattern of asset price changes due to coronavirus news. The results indicate that investors responded to COVID-19 news by bidding down the prices of assets that do badly when oil prices fall and the euro appreciates and by bidding up the prices of assets that do well when the European Central Bank eases. Banking sector stocks were not harmed by COVID-19 news, indicating that fears of a sovereign-bank nexus were not driving the response. [ABSTRACT FROM AUTHOR]
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- 2022
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24. Myocarditis and Cardiac Complications Associated With COVID-19 and mRNA Vaccination: A Pragmatic Narrative Review to Guide Clinical Practice.
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Holland, David J., Blazak, Penni L., Martin, Joshua, Broom, Jennifer, Poulter, Rohan S., and Stanton, Tony
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Coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2 virus is likely to remain endemic globally despite widespread vaccination. There is increasing concern for myocardial involvement and ensuing cardiac complications due to COVID-19, however, the available evidence suggests these risks are low. Pandemic publishing has resulted in rapid manuscript availability though pre-print servers. Subsequent article retractions, a lack of standardised definitions, over-reliance on isolated troponin elevation and the heterogeneity of studied patient groups (i.e. severe vs. symptomatic vs all infections) resulted in early concern for high rates of myocarditis in patients with and recovering from COVID-19. The estimated incidence of myocarditis in COVID-19 infection is 11 cases per 100,000 infections compared with an estimated 2.7 cases per 100,000 persons following mRNA vaccination. For substantiated cases, the clinical course of myocarditis related to COVID-19 or mRNA vaccination appears mild and self-limiting, with reports of severe/fulminant myocarditis being rare. There is limited data available on the management of myocarditis in these settings. Clinical guidance for appropriate use of cardiac investigations and monitoring in COVID-19 is needed for effective risk stratification and efficient use of cardiac resources in Australia. An amalgamation of national and international position statements and guidelines is helpful for guiding clinical practice. This paper reviews the current available evidence and guidelines and provides a summary of the risks and potential use of cardiac investigations and monitoring for patients with COVID-19. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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25. What kinds of social networks protect older adults' health during a pandemic? The tradeoff between preventing infection and promoting mental health.
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Coleman, Max E., Manchella, Mohit K., Roth, Adam R., Peng, Siyun, and Perry, Brea L.
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LONELINESS ,SOCIAL networks ,OLDER people ,MENTAL health ,HEALTH behavior ,PANDEMICS - Abstract
When the coronavirus emerged in early 2020, older adults were at heightened risk of contracting the virus, and of suffering mental health consequences from the pandemic and from the precautions designed to mitigate it. In this paper, we examine how social networks prior to the pandemic helped to shape health beliefs, behaviors, and outcomes among older adults during its onset, focusing on (1) perceived risk of COVID-19, (2) preventative health behaviors, and (3) mental health, including loneliness, perceived stress, depression, and anxiety. Drawing on the longitudinal Social Networks in Alzheimer Disease study, we find that networks high in bridging social capital predict greater perceived risk and more precautions taken, but worse mental health. In contrast, networks high in bonding social capital predict less perceived risk and fewer precautions taken, but better mental health. We discuss this apparent tradeoff between physical and mental health. • We examined how the networks of older adults influenced their health beliefs, behaviors, and mental health outcomes during the pandemic. • We divided social network characteristics into two broad categories: bonding social capital and bridging social capital. • Findings suggest an apparent tradeoff between preventing infection and promoting mental health depending on one's network. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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26. Coronavirus disease 2019 and the global economy.
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Yilmazkuday, Hakan
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COVID-19 , *VECTOR autoregression model , *COVID-19 pandemic , *PETROLEUM sales & prices , *ECONOMIC activity - Abstract
Using daily data on the coronavirus disease 2019 (COVID-19) cases from China and the rest of the world, this paper investigates the corresponding effects on the global economic activity. The empirical results based on a structural vector autoregression model using crude oil prices (COP) and the Baltic Exchange Dry Index (BDI) are consistent with increases in COVID-19 cases acting as negative demand shocks in the global economic activity (reflected as reductions in COP) and negative supply shocks in the global transportation of commodities (reflected as increases in BDI). The historical decomposition results further suggest that the effects of COVID-19 cases on COP and BDI have been mostly observed in the early COVID-19 period. [ABSTRACT FROM AUTHOR]
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- 2022
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27. Hydroxychloroquine as antiviral prophylaxis for exposed caregivers to Covid-19: An urgent appraisal is needed.
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Tahiri Joutei Hassani, Rachid and Bennis, Ahmed
- Abstract
Since the onset of the new coronavirus pandemic, the world is facing a public health emergency. Repositioning hydroxychloroquine (HQ) seems to be a promising option. Many emerging evidences have converged on the effectiveness of HQ in the treatment of Covid-19 infection. In a recent paper, Gautret et al. suggested that further works are needed to determine if HQ antiviral prophylaxis is useful, especially for healthcare workers. The purpose of this paper is to assess the Covid-19 exposure and risks level among caregivers. For this, we performed research on internet and PubMed by crossing the following keywords: healthcare givers, healthcare workers, doctors, nurses, coronavirus, Covid-19, mortality, infection rate, chloroquine, hydroxychloroquine. Data on healthcare worker's infection and mortality by Covid-19 are partial and are not systematically published. However, it seems that the infection rate varies between 3.8% and 9% depending on the country. Moreover, the mean age of this population is relatively old, especially in the OECD area. Anti-Covid-19 HQ prophylaxis should be urgently accessed, especially for healthcare workers. It is to be hoped that HQ prophylaxis reduces the morbidity and mortality from Covid-19 infection among this population which is particularly exposed and relatively old. [ABSTRACT FROM AUTHOR]
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- 2020
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28. The global prevalence of depression and anxiety among doctors during the covid-19 pandemic: Systematic review and meta-analysis.
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Johns, G., Samuel, V., Freemantle, L., Lewis, J., and Waddington, L.
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COVID-19 pandemic , *MENTAL depression , *ANXIETY , *PHYSICIANS , *OBJECTIVITY in journalism - Abstract
Background: This review provides an estimate of the global prevalence of depression and anxiety symptoms among doctors, based on analysis of evidence from the first year of the COVID-19 pandemic.Methods: A systematic review was conducted to identify suitable studies. Final searches were conducted on 3rd March 2021. Papers were initially screened by title and abstract, based on pre-agreed inclusion criteria, followed by full-text review of eligible studies. Risk of bias was assessed using the Joanna Briggs Checklist for Prevalence Studies. Data from studies rated as low or medium risk of bias were pooled using a random-effects meta-analysis. Sensitivity and subgroup analyses were conducted to explore heterogeneity.Results: Fifty-five studies were included after full-text review. Of these, thirty studies were assessed as low or medium risk of bias and were included in primary analyses. These comprised twenty-six studies of depression (31,447 participants) and thirty studies of anxiety (33,281 participants). Pooled prevalence of depression and anxiety was 20.5% (95% CI 16.0%-25.3%) and 25.8% (95% CI 20.4%-31.5%) respectively.Interpretation: Evidence from the first year of the pandemic suggests that a significant proportion of doctors are experiencing high levels of symptoms of depression and anxiety, although not conclusively more so than pre-pandemic levels. Differences in study methodology and variation in job demands may account for some of the observed heterogeneity.Limitations: Findings must be interpreted with caution due to the high heterogeneity and moderate risk of bias evident in the majority of included studies. [ABSTRACT FROM AUTHOR]- Published
- 2022
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29. Gender inequality and health disparity amid COVID-19.
- Author
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Su, Zhaohui, Cheshmehzangi, Ali, McDonnell, Dean, Šegalo, Sabina, Ahmad, Junaid, and Bennett, Bindi
- Abstract
Gender inequalities could lead to grave human and economic consequences, especially amid global health crises of the coronavirus 2019′s (COVID-19) scale. The COVID-19 pandemic exacerbated gender inequalities women face and introduced new challenges that are unprecedented to society at large. Adverse effects of COVID-19, compounded by unintended consequences caused by public health policies such as lockdowns (e.g., delayed or canceled health services), have forced women to face issues ranging from COVID-19 infections and deaths, prolonged unemployment, to unparalleled scale and severity of domestic violence. However, though women face a canopy of debilitating challenges, there is a shortage of research that examines health solutions that can mitigate, if not offset, challenges women experience amid COVID-19. In this paper, we aim to shed light on why timely solutions are needed to mitigate gender inequalities and health disparities women face amid COVID-19 promptly. Furthermore, we underscore the imperative for cost-effective interventions that could shed light on the current health crisis and future pandemics. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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30. Can povidone iodine gargle/mouthrinse inactivate SARS-CoV-2 and decrease the risk of nosocomial and community transmission during the COVID-19 pandemic? An evidence-based update.
- Author
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Chopra, Aditi, Sivaraman, Karthik, Radhakrishnan, Raghu, Balakrishnan, Dhanasekar, and Narayana, Aparna
- Subjects
INFECTIOUS disease transmission ,POVIDONE-iodine ,COVID-19 ,COVID-19 pandemic ,SARS-CoV-2 - Abstract
The Coronavirus disease in 2019 (COVID-19), also referred to as the novel 'CoV19 (nCov19)' is caused by a new coronavirus strain similar to Severe Acute Respiratory Syndrome (SARS-CoV-2). SARS-CoV-2 spreads via respiratory droplets, saliva, or direct contact. Therefore it is important to control the viral load in the saliva and respiratory secretions. One of the most simple and cost-effective measures that can be adopted by the public and healthcare professionals to prevent cross-contamination and community transmission, is the implementation of effective oral and throat hygiene. Recent evidence has confirmed that 0.5% povidone iodine (PVP-I) mouthrinse/gargle for 30 s can reduce SARS-CoV-2 virus infectivity to below detectable levels. PVP-I can even interrupt SARS-CoV-2 attachment to oral and nasopharyngeal tissues and lower the viral particles in the saliva and respiratory droplets. Thus, the use of PVP-I mouthrinse as a prophylactic measure has been advocated across the globe to reduce disease transmission. Although the efficacy of PVP-I against SARS-CoV-2 is proven, no review articles have yet discussed the evidence and mechanisms of PVP-I against the SARS-CoV-2. Thus, this paper highlights the rationale, safety, recommendations, and dosage of PVP-I gargle/mouthrinse as an effective method to decrease the viral loads during the pressing times of COVID-19. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
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31. Interim recommendations for the management of forensic investigation during the COVID-19 pandemic: An Italian perspective.
- Author
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Di Luise, Enrico and Magni, Paola A.
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COVID-19 pandemic ,COVID-19 ,FORENSIC sciences ,CRIME scene searches ,SARS-CoV-2 ,CRIME laboratories - Abstract
• During the COVID-19 pandemic the activity of the law enforcement never stopped. • Adjustments to the existing CSI SOP are crucial for safeguarding forensic technicians. • Main measures to make the operations possible during the pandemic are provided. The Coronavirus disease 2019 (COVID-19) is spreading around the world, representing a global pandemic. In this context, governments from around the world suspended almost all education, industry and business activities, alongside restricting the movement of people. Nevertheless, during this period, the activity of the law enforcement and forensic investigators never stopped. At present, guidelines regarding forensic autopsies of SARS-CoV-2 virus-positive cases and the handling of potentially infected biological samples are available in literature. However, less attention has been given to the development of specific adjustments to the existing crime scene investigation protocols and procedures for this exceptional time. This manuscript aims to share the methods and strategies adopted for the investigation of high priority criminal cases during the pandemic. Furthermore, other pandemic-related processes are critically explored, in order to propose adjustments for any forensic services to be prepared to face similar challenges in the future. The overall goal of this manuscript is to provide a summary of the main measures and the procedures developed to make the operations possible, while safeguarding the technicians in the field and the activity in the forensic laboratory. In order to minimize the risk of infection for personnel, adjustments to the standard practice have been proposed for each of the different phases of crime scene management, i.e. CSI call policy, equipment preparation, working groups, procedure at the scene, chain of custody and analyses of the evidence at the forensic lab. As this is a current study, based on limited cases and limited sources in the literature, changes and updates to the indications provided in this paper may be needed in the near future, according to new virological data epidemiological trends. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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- View/download PDF
32. Oil price volatility in the context of Covid-19.
- Author
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Bourghelle, David, Jawadi, Fredj, and Rozin, Philippe
- Subjects
PETROLEUM sales & prices ,COVID-19 ,COVID-19 pandemic ,PETROLEUM ,PETROLEUM industry ,MARKET volatility - Abstract
The recent coronavirus pandemic (COVID-19) has negatively impacted the whole economy, especially the oil industry, in at least two ways. First, it created a demand shock as COVID-19 reduced global demand for crude oil, increased uncertainty, and triggered a serious economic recession in most developed and emerging countries. Second, it led to a supply shock as the pandemic resulted in an oil trade war between the major oil-producing nations (Saudi Arabia and Russia). Both shocks led to very high levels of oil price volatility. Our paper explores the dynamics of this volatility and explains the effects of these two shocks (induced by an adjustment of oil demand and supply) on West Texas Intermediate (WTI) crude oil price volatility. Accordingly, we show that oil price volatility reacted substantially to the pandemic-induced oil shocks. In particular, we document the impact of uncertainty caused by these shocks and investor anxiety on oil price volatility. We show that greater uncertainty leads to more oil price volatility. Our findings remained unchanged even after controlling for modeling robustness. • We analyze the dynamics of oil price volatility in the context of the COVID-19. • We show that pandemic shock affected oil price volatility significantly. • We point to supply and demand oil shocks. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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33. Mega-disruptions and policy change: Lessons from the mobility sector in response to the Covid-19 pandemic in the UK.
- Author
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Marsden, Greg and Docherty, Iain
- Subjects
- *
COVID-19 pandemic , *PANDEMICS , *COVID-19 , *TIME pressure , *OLDER people , *URBAN planning - Abstract
There has been widespread interest in the potential for the significant behavioural and policy adaptations rendered necessary by Coronavirus to act as a catalyst for radical longer term policy change in transport. However, this body of work to date has been limited in its consideration of how such policy change might be brought about. Translating the lessons from the Coronavirus response to other ongoing strategic challenges such as decarbonisation requires analysis of what the pandemic has revealed about processes of policy formulation and how institutions responsible for policy implementation actually work. This paper explores the extent to which rapid policy change has actually been possible in the transport sector in England and Scotland during the pandemic, and key examples of how such change has been both achieved and blocked. Two rounds of interviews with senior stakeholders from across the transport sector were undertaken in June and November 2020 to inform the analysis. We find that the pandemic has accelerated some policy commitments that were already planned, but at a time of huge stress on the whole of government and its partner delivery organisations, the potential to deliver radical policy adaptation was limited. However, Coronavirus is recognised as being a potentially path-changing disruption to existing trajectories in terms of the adaptations to business practices, industry structures, ways of working and the public finances. Paradoxically, whilst recognising these uncertainties, decision-makers are yet to deviate from pre-pandemic planning assumptions and policy plans and this risks missing the opportunities to steer how those changes unfold. • Addresses research gap in the study of governance responses during disruptions. • Identifies transport as a distant policy sub-sector in a crisis that affected all parts of government. • Finds that the response to the pandemic has accelerated already planned policies but generated few new policies. • Long-term impacts on the future structure of cities, use of public transport and uptake of active travel could still emerge. • The leading strategic thinkers on transport policy are still unsure what kinds of future demand to plan for. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
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34. Effect of Fall 2020 K-12 instruction types on COVID-19 cases, hospital admissions, and deaths in Illinois counties.
- Author
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Reinbold, Gary W.
- Abstract
• Illinois counties with more online or hybrid K-12 pupils had fewer new COVID-19 cases. • Illinois counties with more in-person K-12 pupils had more new COVID-19 cases. • New county COVID-19 cases were similar for online and hybrid K-12 instruction types. • New county COVID-19 hospital admissions were similar for all K-12 instruction types. • New county COVID-19 deaths were similar for all K-12 instruction types. One of the most difficult public policy decisions associated with the COVID-19 pandemic has been about how to offer K-12 instruction. We sought to determine whether differences in instruction types at the beginning of the 2020-2021 school year were related to differences in COVID-19 cases, hospitalizations, and deaths in Illinois counties during the first 3 weeks of the school year. We divided Illinois counties into 3 groups based on the instruction type used for a majority of K-12 students at the start of the school year: in-person, hybrid, or online-only. We used synthetic control analysis to match counties between the 3 groups. Both majority hybrid and majority online-only counties had significantly fewer new cases than majority in-person counties. There were no significant differences in new cases between majority hybrid counties and majority online-only counties or in new hospital admissions or deaths between any of the 3 county groups. This paper adds to the growing scientific consensus that at least some forms of in-person K-12 instruction have not contributed significantly to the spread of the pandemic. However, our results suggest that there may be an important difference between fully in-person instruction and hybrid instruction. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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35. Outcomes of major head and neck reconstruction during the COVID-19 pandemic: The St. Andrew's centre experience.
- Author
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Thacoor, Amitabh, Sofos, Stratos S., Miranda, Benjamin H., Thiruchelvam, Janaviculam, Perera, Esther H.K., Randive, Nilesh, Tzafetta, Kallirroi, and Ahmad, Fateh
- Abstract
The coronavirus disease-2019 (COVID-19) pandemic has generated enormous pressure on healthcare establishments, prompting the restructuring of services to rationalise resources. Complex head and neck reconstructive surgery in this setting may carry substantial risk to patients and staff. This paper outlines the management strategy and outcomes of major head and neck oncological cases at a single regional tertiary referral centre. A database review was undertaken of consecutive patients undergoing major head and neck surgery and reconstruction during the COVID-19 pandemic at St Andrew's Centre for Plastic Surgery & Burns, Chelmsford UK. Patient demographics, tumour and reconstruction characteristics as well as peri‑operative information were determined. Patients were prospectively contacted with regard to COVID-related symptoms and investigations. Twenty-two patients (15 males and 7 females) with a mean age of 67 years (range: 36–92 years) were included between March 1 and June 13, 2020. Patients underwent pre-operative throat swabs at 72 h and 24 h as well as chest CT scanning as part of a robust protocol. Twelve free flaps, four loco-regional flaps, four parotidectomies and 23 cervical lymphadenectomies were performed. Two patients required a return to theatre. No post-operative deaths occurred and flap survival rate was 100%. A single patient tested positive for COVID-19 pre-operatively and no post-operative COVID-19 infections occurred. Although head and neck surgery represents a high-risk procedure to patients and healthcare professionals, our institutional experience suggests that in the presence of a robust peri‑operative protocol and judicious patient selection, major head and neck surgery, including free tissue transfer reconstruction, may be performed safely. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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36. The efficacy of ultraviolet light-emitting technology against coronaviruses: a systematic review.
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Chiappa, F., Frascella, B., Vigezzi, G.P., Moro, M., Diamanti, L., Gentile, L., Lago, P., Clementi, N., Signorelli, C., Mancini, N., Odone, A., Chiappa, Federica, Frascella, Beatrice, Vigezzi, Giacomo Pietro, Moro, Matteo, Diamanti, Luca, Gentile, Leandro, Lago, Paolo, Clementi, Nicola, and Signorelli, Carlo
- Abstract
The ongoing pandemic of COVID-19 has underlined the importance of adopting effective infection prevention and control (IPC) measures in hospital and community settings. Ultraviolet (UV)-based technologies represent promising IPC tools: their effective application for sanitation has been extensively evaluated in the past but scant, heterogeneous and inconclusive evidence is available on their effect on SARS-CoV-2 transmission. With the aim of pooling the available evidence on the efficacy of UV technologies against coronaviruses, we conducted a systematic review following PRISMA guidelines, searching Medline, Embase and the Cochrane Library, and the main clinical trials' registries (WHO ICTRP, ClinicalTrials.gov, Cochrane and EU Clinical Trial Register). Quantitative data on studies' interventions were summarized in tables, pooled by different coronavirus species and strain, UV source, characteristics of UV light exposure and outcomes. Eighteen papers met our inclusion criteria, published between 1972 and 2020. Six focused on SARS-CoV-2, four on SARS-CoV-1, one on MERS-CoV, three on seasonal coronaviruses, and four on animal coronaviruses. All were experimental studies. Overall, despite wide heterogenicity within included studies, complete inactivation of coronaviruses on surfaces or aerosolized, including SARS-CoV-2, was reported to take a maximum exposure time of 15 min and to need a maximum distance from the UV emitter of up to 1 m. Advances in UV-based technologies in the field of sanitation and their proved high virucidal potential against SARS-CoV-2 support their use for IPC in hospital and community settings and their contribution towards ending the COVID-19 pandemic. National and international guidelines are to be updated and parameters and conditions of use need to be identified to ensure both efficacy and safety of UV technology application for effective infection prevention and control in both healthcare and non-healthcare settings. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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37. Impact of IoT devices in E-Health: A Review on IoT in the context of COVID-19 and its variants.
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Fagroud, Fatima Zahra, Toumi, Hicham, Ben Lahmar, El Habib, Talhaoui, Mohamed Amine, Achtaich, Khadija, and Filali, Sanaa El
- Subjects
COVID-19 ,INTERNET of things ,TELEMEDICINE ,TECHNOLOGICAL revolution ,COST effectiveness ,SYMPTOMS - Abstract
Actually, COVID-19 and its variants present a big challenge for the public health security. COVID-19 is a new form of the coronaviruses characterized by a set of symptoms like laboratory and radiological symptoms, when the first case has confirmed in December 2019 in Wuhan City, as well as a new variant of this form has appeared in December 2020 in the United Kingdom. Internet of things (IoT) is a technological revolution employed in different areas in the aim to serve the asked purposes. The implementation of IoT solutions in healthcare area has several benefits such as reducing the cost of services and improving treatment results. In this paper, we present a review on the impact of IoT on this new health challenge (COVID-19 and its variants), we will focus this study on the impact of the use of IoT devices to reduce transmissions of COVID-19 and its variants. [ABSTRACT FROM AUTHOR]
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- 2021
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38. Recovery scenario and immunity in COVID-19 disease: A new strategy to predict the potential of reinfection.
- Author
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Khoshkam, Zahra, Aftabi, Younes, Stenvinkel, Peter, Paige Lawrence, B., Rezaei, Mehran Habibi, Ichihara, Gaku, and Fereidouni, Sasan
- Subjects
- *
COVID-19 , *REINFECTION , *SARS-CoV-2 , *COVID-19 pandemic , *ANGIOTENSIN converting enzyme , *CELLULAR immunity - Abstract
[Display omitted] The recent ongoing outbreak of coronavirus disease 2019 (COVID-19), still is an unsolved problem with a growing rate of infected cases and mortality worldwide. The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is targeting the angiotensin-converting enzyme 2 (ACE2) receptor and mostly causes a respiratory illness. Although acquired and resistance immunity is one of the most important aspects of alleviating the trend of the current pandemic; however, there is still a big gap of knowledge regarding the infection process, immunopathogenesis, recovery, and reinfection. To answer the questions regarding "the potential and probability of reinfection in COVID-19 infected cases" or "the efficiency and duration of SARS-CoV-2 infection-induced immunity against reinfection" we critically evaluated the current reports on SARS-CoV-2 immunity and reinfection with special emphasis on comparative studies using animal models that generalize their finding about protection and reinfection. Also, the contribution of humoral immunity in the process of COVID-19 recovery and the role of ACE2 in virus infectivity and pathogenesis has been discussed. Furthermore, innate and cellular immunity and inflammatory responses in the disease and recovery conditions are reviewed and an overall outline of immunologic aspects of COVID-19 progression and recovery in three different stages are presented. Finally, we categorized the infected cases into four different groups based on the acquired immunity and the potential for reinfection. In this review paper, we proposed a new strategy to predict the potential of reinfection in each identified category. This classification may help to distribute resources more meticulously to determine: who needs to be serologically tested for SARS-CoV-2 neutralizing antibodies, what percentage of the population is immune to the virus, and who needs to be vaccinated. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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- View/download PDF
39. Working from home and its implications for strategic transport modelling based on the early days of the COVID-19 pandemic.
- Author
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Hensher, David A., Beck, Matthew J., and Wei, Edward
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COVID-19 pandemic , *TELECOMMUTING , *LOGISTIC regression analysis , *COMMUTING , *COVID-19 , *REGRESSION analysis - Abstract
The COVID-19 pandemic has changed the way we go about our daily lives in ways that are unlikely to return to the pre-COVID-19 levels. A key feature of the COVID-19 era is likely to be a rethink of the way we work and the implications this may have on commuting activity. Working from home (WFH) has been the 'new normal' during the period of lockdown, except for essential services that require commuting. In recognition of the new normal as represented by an increasing amount of WFH, this paper develops a model to identify the incidence of WFH and what impact this could have on the amount of weekly one-way commuting trips by car and public transport. Using Wave 1 of an ongoing data collection effort done at the height of the restrictions in March and April 2020 in Australia, we develop a number of days WFH ordered logit model and link it to a zero-inflated Poisson (ZIP) regression model for the number of weekly one-way commuting trips by car and public transport. Scenario analysis is undertaken to highlight the way in which WFH might change the amount of commuting activity when restrictions are relaxed to enable changing patterns of WFH and commuting. The findings will provide one reference point as we continue to undertake similar analysis at different points through time during the pandemic and after when restrictions are effectively removed. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
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40. Global orthopaedic trauma surgeons highlight telenomics during the COVID-19 era: A case for advancing telemedicine in orthopaedics.
- Author
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Cole, Peter A., Lezak, Bradley A., and Schroder, Lisa K.
- Abstract
The Coronavirus (COVID-19) pandemic sparked rapid widespread adoption of telemedicine throughout specialties, including orthopaedics. A succession of factors, starting with payers, followed by provider adoption, and reciprocated by patient approval, created newly accepted telehealth practices that have moved from trial to norm in a short time span. Orthopaedic surgeons believe telehealth will endure as a permanent change to their practice beyond the COVID-19 era, however, many permanent changes must take place by payers, providers, and patients to sustain telehealth into the future. The goal of this paper is to highlight the indelibility of telemedicine adoption in orthopaedic practices globally, characterize the chain of events that led to its large-scale adoption, and catalyze discussion around actionable next steps to sustain its benefits. [ABSTRACT FROM AUTHOR]
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- 2021
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41. Effects of strong and weak non-pharmaceutical interventions on stock market returns: A comparative analysis of Norway and Sweden during the initial phase of the COVID-19 pandemic.
- Author
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Størdal, Ståle, Lien, Gudbrand, Mydland, Ørjan, and Haugom, Erik
- Subjects
RATE of return on stocks ,COVID-19 pandemic ,STOCK exchanges ,SCHOOL administration ,COMPARATIVE studies ,SCHOOL closings - Abstract
In this paper, we examine the behaviour of stock market returns in Norway and Sweden during the early days of the COVID-19 pandemic. We test how the different government interventions chosen in Norway and Sweden, including restrictions such as school closures and travel prohibitions along with economic support, affected equity markets in both countries. Our dataset comprises a panel of data for Norway and Sweden over 221 trading days during the period 1 January to 5 November 2020. The result show that while non-pharmaceutical interventions had few or no effects on Norwegian stock market returns, they positively affected the stock market in Sweden, although the strength of this effect weakened with the increasing number of confirmed COVID-19 cases. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
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42. COVID-19 vaccine rollout—scale and speed carry different implications for corruption.
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Goel, Rajeev K., Nelson, Michael A., and Goel, Viraat Y.
- Subjects
- *
COVID-19 vaccines , *CORRUPTION , *SPEED , *PANDEMICS , *COVID-19 , *CIVIL service - Abstract
The sanctioning of different coronavirus vaccines (with some approved by regulators for public delivery, and others in the pipeline) has met with relief by many sections of the public and the government. However, partly due to the damages associated with the pandemic and the ensuing euphoria over vaccines' arrival, some of the challenges are mostly being ignored or are not recognized. This paper identifies some pitfalls and drawbacks in vaccine delivery. We argue that the somewhat unique tension between the speed of vaccine delivery and its scale can create opportunities for corrupt behavior that are often at odds with effective means to check abuse. While data on instances of abuse will emerge over time, it is useful to point out different avenues of abuse so that some preventive government actions can be undertaken. Specifically, we argue that the potential for out of turn delivery of vaccines and the stockpiling by unauthorized agents creates incentives for corruption, with the public or bureaucrats initiating corrupt transactions. An understanding of the potential avenues for corruption should guide the formulation of appropriate corruption-control policies and similar challenges that will be faced by policy makers in addressing future pandemics. [ABSTRACT FROM AUTHOR]
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- 2021
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43. The asymmetric impact of the pandemic crisis on interest rates on public debt in the Eurozone.
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Carnazza, Giovanni and Liberati, Paolo
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INTEREST rates , *RATINGS & rankings of public debts , *GOVERNMENT securities , *CREDIT default swaps , *ECONOMIC impact , *COUNTERPARTY risk , *EUROZONE - Abstract
The outbreak of Covid-19 has played the role of a 'game changer' in the way countries of the Eurozone have faced the economic consequences of the pandemic crisis. This paper investigates what has happened to the interest rates of the sovereign bond in selected countries of the Eurozone during 2020. While the pandemic crisis can be interpreted as a symmetric shock, we found some important asymmetric consequences both in the sovereign bond market and the credit default swap market. Even though the European Central Bank (ECB) has played a fundamental role in easening tensions, especially with the announce of the Pandemic Emergency Purchase Programme (PEPP), countries with a higher pre-Covid level of the debt-to-GDP ratio have been found to undergo a significant jump in interest rates and a greater perceived risks of default. Important policies implications emerge in relation to the future role of the ECB. [ABSTRACT FROM AUTHOR]
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- 2021
- Full Text
- View/download PDF
44. Mental health outcomes of coronavirus infection survivors: A rapid meta-analysis.
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Liu, Dong, Baumeister, Roy F., and Zhou, Yong
- Subjects
- *
COVID-19 , *MENTAL health , *COVID-19 pandemic , *HOSPITAL admission & discharge - Abstract
The current COVID pandemic is happening while the long-term effects of coronavirus infection remain poorly understood. The present article meta-analyzed mental health outcomes (anxiety, depression, etc.) from a previous coronavirus outbreak in China (2002). CNKI, Wanfang, PubMed/Medline, Scopus, Web of Science, Baidu Scholar, and Google Scholar were searched up to early June 2020 for articles in English or Chinese reporting mental illness symptoms of SARS patients. Main outcome measures include SCL-90, SAS, SDS, and IES-R scales. 29 papers met the inclusion criteria. The longest follow-up time included in the analysis was 46 months. The systematic meta-analysis indicated that mental health problems were most serious before or at hospital discharge and declined significantly during the first 12 months after hospital discharge. Nevertheless, average symptom levels remained above healthy norms even at 12 months and continued to improve, albeit slowly, thereafter. The adverse mental health impact of being hospitalized with coronavirus infection long outlasts the physical illness. Mental health issues were the most serious for coronavirus infected patients before (including) hospital discharge and improved continuously during the first 12 months after hospital discharge. If COVID-19 infected patients follow a similar course of mental health development, most patients should recover to normal after 12 months of hospital discharge. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
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45. Coronavirus disease-19: The multi-level, multi-faceted vasculopathy.
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Quinaglia, Thiago, Shabani, Mahsima, Breder, Ikaro, Silber, Harry A., Lima, João A.C., and Sposito, Andrei C.
- Subjects
- *
SARS-CoV-2 , *COVID-19 , *ENDOTHELIAL cells , *SYMPTOMS , *ENDOTHELIUM diseases , *THROMBOTIC thrombocytopenic purpura - Abstract
The new coronavirus disease (COVID-19) is a systemic disease. Mounting evidence depict signs and symptoms involving multiple organs, most of which supported by pathological data. A plausible link to these manifestations is vascular and endothelial dysfunction/damage. However, much of the current knowledge relies on opinion and incipient evidence. We aim to objectively appraise current evidence on the association between COVID-19 and vascular disease, specifically endotheliitis and vasculitis. Two researchers independently entered the search terms COVID-19 OR SARS-CoV-2 AND vasculitis, endotheliitis OR endothelium in the following online platforms: MedRxiv and LitCovid (PubMed). The search period was set from November 1, 2019 to August 28, 2020. Manuscripts with unavailable full texts, not in English, mainly on pre-clinical data, presenting only study designs or not directly related to the topics of this review were excluded. Retrospective and prospective studies, especially longitudinal ones, were given priority to the purpose of this review. Since there was paucity of prospective controlled evidence, case reports/series were also considered. A total of 318 manuscripts were initially found. Sixty-seven (21%) were excluded: 59 (18.5%) met exclusion criteria and 8 (2.5%) were duplicates. One hundred and forty-two manuscripts (44,6%) did not provide original data and were also excluded: 35 (11%) were comments, 108 (33.9%) reviews; 1 (0.3%) position paper. One hundred and seven (33.6%) studies were considered for the present scoping review: 81 (25,5%) case reports/series; 18 (5.7%) prospective; 8 (2.5%) retrospective. Viral inclusions in endothelial cells, mononuclear cell infiltrates in the intima of small vessels and markers of endothelial cell apoptosis were demonstrated. Specificities of COVID-19 may lead to diverse vascular manifestations in different levels of the vascular bed. Evidence indicates that COVID-19 targets vasculature and endothelium. However, high quality data is still lacking and studies with prospective designs and appropriately matched controls are needed. [Display omitted] • The new coronavirus disease (Covid-19) is a systemic disease. • Vascular and endothelial dysfunction/damage at different levels is a plausible link through which the disease can occur. • Endothelial cell damage and apoptosis could lead to basal membrane exposure and a thrombotic macro- and/or microangiopathy. • Endothelial cell dysfunction due to unbalanced angiotensin II could drive vasoconstriction in virtually any affected organ. • Endothelial cells are recognized as part of the innate immune system and could play a role in an exacerbated inflammation. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
46. Implementing the National Incident Management System at schools of nursing in response to COVID-19.
- Author
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de Tantillo, Lila and Christopher, Roberta
- Abstract
Unprecedented financial and logistical barriers in educating nurses during COVID-19 have threatened nursing education. The purpose of this article is to provide a template to facilitate the maintenance and stability of teaching and learning in a pandemic environment for nursing school administration and faculty leaders. The National Incident Management System (NIMS), previously used in training nurses for emergency preparation and response, has been applied as a guiding framework. The framework consists of five elements: Preparedness, Communication/Information Management, Resource Management, Command and Ongoing Management/Maintenance. This paper addresses how schools of nursing may apply each of these elements to address both the needs of the institution and community. The Comprehensive Vulnerability Management paradigm is further offered as a lens for professional development. Free preparedness education is showcased from leading nursing and healthcare professional and government organizations. Finally, the Quality and Safety Education for Nurses competencies are used for integrating NIMS and social dimensions of disaster. Such tools may equip academic leaders at schools of nursing to surmount challenges posed by the pandemic, and to ensure educational readiness to respond to global health crisis through use of the NIMS framework. • The COVID-19 pandemic has produced unprecedented barriers to nursing education. • Supporting nursing education to respond to the current global emergency and future health needs is an ongoing priority. • Implementing the National Incident Management System can help address challenges faced by nursing schools during COVID-19. • Academic nursing leaders may consider professional development to advance emergency management skills during the pandemic. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
47. The educational and psychosocial needs of students with additional provisions during COVID-19 in Greece: Parents' perspectives against schools' crisis management.
- Author
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Vlachou, Anastasia, Fyssa, Aristea, Papazis, Filippos, Toulia, Anastasia, Papazoglou, Theodora, Tsermidou, Lia, and Kalaitzi, Stavroula
- Subjects
- *
PARENT attitudes , *COVID-19 pandemic , *SPECIAL education schools , *CRISIS management , *SCHOOL absenteeism , *SOCIAL systems , *SCHOOL attendance , *SCHOOL nursing - Abstract
The sudden breakdown of educational and care services following the COVID-19 outbreak caused severe implications to the educational and psychosocial well-being of students with additional needs. The present study investigates the perspectives of parents of students requiring additional provisions in relation to the schools' responsiveness against their children's educational and psychosocial needs during the COVID-19 pandemic, with a focus on (non-) applied inclusive and empowerment practices of parenthood. A sample of 125 parents in Greece filled out a self-reported questionnaire providing information on four main themes: school organisation in accordance with the COVID-19 measures; distance education; support on transition from quarantine and remote education back to school; and parental empowerment. The data revealed that most of the participating parents felt poorly supported during the pandemic. The feeling of being left alone in supporting their children and in fully meeting their personal needs and emotions was also identified. The demographics of the participating parents with children with additional needs revealed an experiences mosaic in relation to the parents' level of education, the number of children who were present in their households, the children's gender as well as their level of school education (preschool- and primary school-aged or secondary school-aged pupils) and attendance of the school programme in regular or special schools. Data suggest that regular and special schools in Greece, as orchestrated by the Ministry of Education, deployed practices that left students requiring additional provisions unsupported in relation to their educational and psychosocial needs while their parents felt disempowered during the whole period of the COVID-19 pandemic. A range of implications on a more effective support for families and their children with additional needs in alignment with the principles of inclusive education is detailed and discussed. The focus of research on the schools' responsiveness to the needs of students requiring additional provisions from the perspective of their parents is of critical importance as it may offer valuable insights pertaining to the school's inclusive policy practices and the promotion of empowering parent partnerships during crisis times. The knowledge gained by exploring parents' experiences will contribute significantly to inform modifications and changes in education delivery in crisis times so as school, as a social system, become more inclusive, supportive, and effective for pupils with additional needs. So far, little attention has been paid to the above-mentioned issues. In the current paper, the parents perspectives were explored through a self-reported questionnaire to reflect on the way schools responded to theirs and their children's educational and psychosocial needs during the COVID-19 pandemic. Most of the participating parents felt poorly supported. The feeling of being left alone in supporting their children and in fully meeting their personal needs and emotions was also identified. The demographics of the participating parents with children requiring additional provisions revealed an experiences mosaic in relation to the parents' level of education, the number of children who were present in their households, the children's gender as well as their level of school education (preschool and primary school or secondary school education) and attendance of the school programme in regular or special schools. A range of implications on a more effective support for families and their children with additional needs in alignment with the principles of inclusive education is detailed and discussed. • Greek schools' responsiveness towards students with additional needs during COVID-19 is questioned. • Parents report uncovered educational-psychosocial needs for their children. • Parents also felt disempowered through the school system. • Guidance should address inclusive school response and parent partnership in crisis. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
48. Scientometric assessment of scientific documents published in 2020 on herbal medicines used for COVID-19.
- Author
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Atlasi, Rasha, Ramezani, Aboozar, Tabatabaei-Malazy, Ozra, Alatab, Sudabeh, Oveissi, Vahideh, and Larijani, Bagher
- Subjects
HERBAL medicine ,COVID-19 ,SCIENCE publishing ,CHINESE medicine ,COVID-19 treatment - Abstract
Many studies have suggested herbal medicines as alternatives or adjuvants to modern drugs for COVID-19. Their scientometric analyses can provide a scientific overview of this topic. Web of Science (WOS) and Scopus were searched for articles on the use of herbal medicines in COVID-19 published until 26 October 2020. Collected data were analyzed for document type, subject area, top journal, citation number, and authors' collaboration network using VOSviewer 1.6.15, ScientoPy 2.0.3, Gephi 0.9.2, and SPSS 15 statistical tools. After screening the 3185 retrieved records, 378 and 849 records, respectively from WOS and Scopus, remained for quantity analysis. Original and review articles were the two main types of papers in both databases. Top subject areas were drug and medicine, respectively in the WOS and Scopus databases. The top three productive countries in the field were China, the US, and India. The most cited article was a practice guideline in both databases. "Journal of Biomolecular Structure Dynamics" in WOS and "Chinese Traditional and Herbal Drugs" in Scopus were the top journals. Top keywords included "COVID-19″ and "Traditional Chinese Medicine". US authors had the highest collaboration with other authors. The current study provides a snapshot of the quantity and characteristics of published scholarly documents in recent months in the intersection of herbal medicines and COVID-19. Our findings help scientists to find the existing gaps, identify the active authors and scientific institutes to collaborate with and use their experience to produce new knowledge in the future. [Display omitted] • This scientometrics was propsed to show an overview of the published documents on herbal medicine therapy for COVID-19 in WOS and Scopus databases and compare their characteristics. • Quantity analysis showed original and review articles as the main types of papers, drug and medicine as top subject areas, and China as top productive country. • A practice guideline was the highest cited article "Journal of Biomolecular Structure Dynamics" and "Chinese Traditional and Herbal Drugs" were the toppest journals in WOS, and Scopus, respectively. • US authors had the highest collaboration with other authors. • The topic modeling could give an overview of issues that publications have been focused on whether it is clinical care, management, public heath, and pathogenesis. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
49. Psychological impact of infectious disease outbreaks on pregnant women: rapid evidence review.
- Author
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Brooks, S.K., Weston, D., and Greenberg, N.
- Subjects
- *
COMMUNICABLE diseases , *PSYCHOLOGICAL distress , *DISEASE outbreaks , *FEAR , *HEALTH , *MENTAL health , *PREGNANCY & psychology , *INFORMATION resources , *SYSTEMATIC reviews , *SOCIAL support , *COVID-19 pandemic , *PREGNANCY - Abstract
Infectious disease outbreaks can be distressing for everyone, especially those deemed to be particularly vulnerable such as pregnant women, who have been named a high-risk group in the current COVID-19 pandemic. This paper aimed to summarise existing literature on the psychological impact of infectious disease outbreaks on women who were pregnant at the time of the outbreak. The design of this study is a rapid review. Five databases were searched for relevant literature, and main findings were extracted. Thirteen articles were included in the review. The following themes were identified: negative emotional states; living with uncertainty; concerns about infection; concerns about and uptake of prophylaxis or treatment; disrupted routines; non-pharmaceutical protective behaviours; social support; financial and occupational concerns; disrupted expectations of birth, prenatal care and postnatal care and sources of information. Pregnant women have unique needs during infectious disease outbreaks and could benefit from up-to-date, consistent information and guidance; appropriate support and advice from healthcare professionals, particularly with regards to the risks and benefits of prophylaxis and treatment; virtual support groups and designating locations or staff specifically for pregnant women. • Pregnant women may be particularly susceptible to distress during pandemics. • Infection fears and prophylaxis concerns may exacerbate distress. • Disrupted routines, financial concerns and uncertainty are also stressors. • Disrupted expectations of birth and related healthcare may be distressing. • Pregnant women may benefit from clear information/guidance and support groups. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
50. COVID-19 pandemic in the United States.
- Author
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Bergquist, Savannah, Otten, Thomas, and Sarich, Nick
- Abstract
• COVID-19 data collection, reporting, and infection has varied widely across states. • US policy response has been decentralized with state-specific containment and exit measures. • Testing and surveillance have been limited and impeded by unclear federal policies. The paper highlights US health policy and technology responses to the COVID-19 pandemic from January 1, 2020 – August 9, 2020. A review of primary data sources in the US was conducted. The data were summarized to describe national and state-level trends in the spread of COVID-19 and in policy and technology solutions. COVID-19 cases and deaths initially peaked in late March and April, but after a brief reduction in June cases and deaths began rising again during July and continued to climb into early August. The US policy response is best characterized by its federalist, decentralized nature. The national government has led in terms of economic and fiscal response, increasing funding for scientific research into testing, treatment, and vaccines, and in creating more favorable regulations for the use of telemedicine. State governments have been responsible for many of the containment, testing, and treatment responses, often with little federal government support. Policies that favor economic re-opening are often followed by increases in state-level case numbers, which are then followed by stricter containment measures, such as mask wearing or pausing re-opening plans. While all US states have begun to "re-open" economic activities, this trend appears to be largely driven by social tensions and economic motivations rather than an ability to effectively test and surveil populations. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
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