1. Calprotectin levels in the cerebrospinal fluid reflect disease activity in multiple sclerosis
- Author
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Berg-Hansen, Pål, Vandvik, Bodvar, Fagerhol, Magne, and Holmøy, Trygve
- Subjects
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CEREBROSPINAL fluid examination , *MULTIPLE sclerosis , *MONOCYTES , *MICROGLIA , *SYMPTOMS , *INFLAMMATION , *CALCIUM-binding proteins , *PATIENTS - Abstract
Abstract: Calprotectin is produced by activated monocytes and microglia, and cerebrospinal fluid (CSF) levels could be a marker of neuroinflammation. Calprotectin was detectable in CSF from 13.8% of normal controls, compared to 90.5% of patients with neurological infections (p <0.001). In CSF from patients with multiple sclerosis (MS) and clinically isolated demyelinating syndrome, calprotectin was detected in 64.7% within 2weeks after symptom debut compared to 30.8% between 2 and 4weeks and 17.0% thereafter (p <0.001). We conclude that CSF calprotectin reflects the disease activity in MS but does not discriminate between MS and other inflammatory or infectious conditions. [Copyright &y& Elsevier]
- Published
- 2009
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