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Background: Since 2021, international guidelines for cardiopulmonary resuscitation recommend the implementation of so-called "life-saving systems". These systems include smartphone alerting systems (SAS), which enable dispatch centres to alert first responders via smartphone applications, who are in proximity of a suspected out-of-hospital cardiac arrest (OHCA). However, the effect of SAS on survival remains unknown., Aim: The aim is to assess the rate of survival to hospital discharge in adult patients with OHCA not witnessed by emergency medical services (EMS): before and after SAS implementation., Design: Multicentre, prospective, observational, intention-to-treat, pre-post design clinical trial., Population: Adults (aged ≥ 18 years), OHCA not witnessed by EMS, no traumatic cause for cardiac arrest, cardiopulmonary resuscitation initiated or continued by EMS., Setting: Dispatch-centre-based., Outcomes: Primary: survival to hospital discharge. Secondary: time to first compression, rate of basic life support measures before EMS arrival, rate of patients with shockable rhythm at EMS arrival, Cerebral Performance Category at hospital discharge, and duration of hospital stay., Sample Size: Assuming an absolute difference in survival rates to hospital discharge of 4% in the two groups (11% before implementation of the SAS versus 15% after) and 80% power, and a type 1 error rate of 0.05, the required sample size is N  = 1,109 patients per group (at least N  = 2,218 evaluated patients in total)., Conclusions: The HEROES trial will investigate the effects of a SAS on the survival rate after OHCA., Trial Registration: German Clinical Trials Register (DRKS, ID: DRKS00032920)., Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: ‘MPM is chair of Region der Lebensretter e.V. (non-profit organisation), member of the executive committee of the German Resuscitation Council (GRC), shareholder of SmartResQ ApS, Denmark, and received speaker honoraria by Stryker. JG is board member of Region der Lebensretter e.V. HJB is vice chair of Region der Lebensretter e.V. GT is board member of Region der Lebensretter e.V., secretary of the GRC, and shareholder of Resuscitec GmbH, Freiburg, Germany. JSP is member of Region der Lebensretter e.V. and member of the executive committee of the GRC. All other authors have no conflicts of interest to declare’., (© 2024 The Author(s).)

Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: ‘DF is co-founder and operations manager of the Heartrunner Citizen Responder System, Sweden and member of the tech&ops committee of EENA (European Emergency Number Association). CM is Guest Editor special issue “Impact of First Responders in Resuscitation” in Resuscitation Plus. MPM is chair of Region of Lifesavers, shareholder of SmartResQ ApS, and received speaker honoraria from Stryker. TS is the Social Media Editor of Resuscitation and Resuscitation Plus journals. All other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper’.