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Your search keyword '"Parrotta E"' showing total 2 results
Start Over Author "Parrotta E" Publisher elsevier b. v
2 results on '"Parrotta E"'

1. It's not always an infection: Pyoderma gangrenosum of the urogenital tract in two patients with multiple sclerosis treated with rituximab.

Author

Parrotta E, Kopinsky H, Abate J, Ryerson LZ, and Krupp LB

Subjects
Humans, Male, Female, Rituximab therapeutic use, Immunoglobulins, Intravenous therapeutic use, Multiple Sclerosis drug therapy, Pyoderma Gangrenosum diagnosis, Pyoderma Gangrenosum drug therapy, Pyoderma Gangrenosum etiology, Multiple Sclerosis, Relapsing-Remitting drug therapy
Abstract

B-cell depleting therapies such as rituximab and ocrelizumab are widely used for the treatment of Multiple Sclerosis but have increased risks of adverse reactions compared to earlier MS therapies. One rarely reported reaction is pyoderma gangrenosum (PG), an inflammatory, ulcerative, skin disease of unclear etiology. Here we describe a male and female patient, each with Relapsing-Remitting Multiple Sclerosis, and both of whom developed PG while on rituximab. Both PG diagnoses were supported by persistent fever, biopsy reports of sterile neutrophilia, and leukocytosis in the absence of an identifiable infectious agent. The diagnoses were further confirmed by dramatic clinical improvement following initiation of high dose steroids and intravenous immunoglobulins, and discontinuation of rituximab., Competing Interests: Declaration of Competing Interest None., (Copyright © 2023 Elsevier B.V. All rights reserved.)

Published
2023
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2. Multiple sclerosis risk factors contribute to onset heterogeneity.

Author

Briggs FBS, Yu JC, Davis MF, Jiangyang J, Fu S, Parrotta E, Gunzler DD, and Ontaneda D

Subjects
Age of Onset, Cross-Sectional Studies, Disease Progression, Female, HLA-DRB1 Chains genetics, Humans, Machine Learning, Male, Middle Aged, Multiple Sclerosis genetics, Obesity epidemiology, Obesity genetics, Retrospective Studies, Risk Factors, Smoking epidemiology, Smoking genetics, Multiple Sclerosis epidemiology
Abstract

Background: The phenotypic presentation of multiple sclerosis (MS) may predict long-term outcomes and little is known about factors contributing to heterogeneity at MS onset. Given temporality, it is likely MS risk factors also influence presentation of the disease near onset., Methods: Using a retrospective cross-sectional study of MS cases, we investigated: age of onset (AOO), number of impaired functional domains (NIFDs), time to second relapse (TT2R), and early relapse activity (ERA). Machine learning variable selection was applied to epidemiologic data for each outcome, followed by multivariable regression models. The models were further adjusted for HLA-DRB1*15:01 carrier status and a MS genetic risk score (GRS). The TT2R and ERA analyses were restricted to relapsing remitting MS cases., Results: HLA-DRB1*15:01, GRS, and smoking were associated with earlier AOO. Cases who were male, obese, had lower education, or had primary progressive MS were older at onset. For NIFDs, those with relapsing remitting MS and of lower SES had increased NIFDs. Among relapsing remitting cases, those who were older at onset, obese, and had polyfocal presentation had shorter TT2R, while ERA was greater among those younger at onset and who were obese., Conclusion: Individual characteristics including age, genetic profiles, obesity, and smoking status contribute to heterogeneity in disease presentation and modulate early disease course evolution., (Copyright © 2018 Elsevier B.V. All rights reserved.)

Published
2019
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