7 results on '"Climie, RE"'
Search Results
2. Youth Vascular Consortium (YVC) Protocol: Establishing Reference Intervals for Vascular Ageing in Children, Adolescents and Young Adults.
- Author
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Fong TS, Urbina EM, Howden EJ, Wallace I, Park C, Gall S, Salim A, Boutouyrie P, Bruno RM, and Climie RE
- Subjects
- Adolescent, Child, Humans, Life Style, Multicenter Studies as Topic, Reference Values, Retrospective Studies, Risk Factors, Young Adult, Aging, Cardiovascular Diseases
- Abstract
Background: In the last two decades, the global prevalence of paediatric hypertension increased by approximately 75%. Nearly 25% of children are now classified as obese or overweight. Substantial evidence suggests that risk factors for cardiovascular disease (CVD) begin to develop in childhood, thus warranting the need for tools to better screen for early CVD risk in youth. Vascular ageing, the deterioration of vascular structure and function, may be a potentially useful tool for detecting the early and asymptomatic signs of CVD burden. However, it is currently unclear what differentiates normal from pathological ageing in youth as existing reference values for vascular ageing in youth are limited by small sample size or homogenous populations. The international Youth Vascular Consortium (YVC) has been established to address these issues., Aims: The primary aim of the YVC is to develop reference intervals of normal vascular ageing in children, adolescents, and young adults. The secondary, exploratory, aim is to perform head-to-head comparisons of vascular ageing biomarkers to determine which biomarker is most strongly related to cardiometabolic health., Study Design: The YVC is a retrospective, multicentre study and will collate data on vascular ageing in children (5-12 years), adolescents (13-18 years) and young adults (19-40 years), as well as routine clinical biochemistry, lifestyle, sociodemographic factors and parental health., Conclusion: To date, 31 research groups from 19 countries have joined the YVC. To our knowledge, this will be the largest study of its kind to investigate vascular ageing in youth., (Copyright © 2021 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
3. Vascular Ageing: A Key Frontier in the Fight Against Cardiovascular Disease.
- Author
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Climie RE, Gregory AT, Denniss AR, Mynard JP, and Pepe S
- Subjects
- Aging, Humans, Cardiovascular Diseases prevention & control, Vascular Stiffness
- Published
- 2021
- Full Text
- View/download PDF
4. Vascular Ageing in Youth: A Call to Action.
- Author
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Climie RE, Park C, Avolio A, Mynard JP, Kruger R, and Bruno RM
- Subjects
- Adolescent, Adult, Aging, Blood Pressure, Child, Humans, Risk Factors, Cardiovascular Diseases epidemiology, Cardiovascular Diseases prevention & control, Hypertension, Pediatric Obesity, Vascular Stiffness
- Abstract
Extensive evidence shows that risk factors for cardiovascular disease (CVD) begin to develop early in life. Childhood obesity and elevated blood pressure (BP) have become overwhelmingly challenging, with 57% of today's children predicted to be obese by the age of 35 years, and global rates of hypertension in children and adolescents increasing by 75% from 2000 to 2015. Thus, there is an urgent need for tools that can assess early CVD risk in youth, which may lead to better risk stratification, preventative intervention, and personalised medicine. Vascular ageing (the deterioration in vascular structure and function) is a pivotal progenitor of health degeneration associated with elevated BP. Exposure to adverse environmental and genetic factors from fetal life promotes the development and accumulation of subclinical vascular changes that direct an individual towards a trajectory of early vascular ageing (EVA)-an independent predictor of target organ damage in the heart, brain, and kidneys. Therefore, characterising vascular ageing from youth may provide a window into cardiovascular risk later in life. However, vascular ageing measurements only have value when techniques are accurate/validated and when reliable thresholds are available for defining normal ranges and ranges that signal increased risk of disease. The aim of this paper is to summarise current evidence on the importance of vascular ageing assessment in youth and the impact of interventions to prevent or delay EVA, to highlight the need for standardisation and validation of measurement techniques in children and adolescents, and the importance of establishing reference values for vascular ageing measures in this population., (Copyright © 2021 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
5. Exercise blood pressure and cardiac structure: A systematic review and meta-analysis of cross-sectional studies.
- Author
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Moore MN, Climie RE, Otahal P, Sharman JE, and Schultz MG
- Subjects
- Adult, Aged, Cardiovascular Diseases physiopathology, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Regression Analysis, Risk, Systole physiology, Ventricular Remodeling physiology, Ventricular Septum physiology, Young Adult, Blood Pressure physiology, Exercise physiology, Hypertension physiopathology, Hypertrophy, Left Ventricular pathology, Hypertrophy, Right Ventricular pathology
- Abstract
Objectives: A hypertensive response to exercise (HRE) is associated with cardiovascular disease and high blood pressure (BP). Sub-clinical changes to cardiac structure may underlie these associations, although this has not been systematically determined. Via systematic review and meta-analysis, we aimed to (1) assess the relationship between exercise BP and cardiac structure, and (2) determine if cardiac structure is altered in those with an HRE, across various study populations (including those with/without high BP at rest)., Design and Methods: Three online databases were searched for cross-sectional studies reporting exercise BP, HRE and cardiac structural variables. Random-effects meta-analyses and meta-regressions were used to calculate pooled correlations between exercise BP and cardiac structure, and pooled mean differences and relative risk between those with/without an HRE., Results: Forty-nine studies, (n=23,707 total; aged 44±4 years; 63% male) were included. Exercise systolic BP was associated with increased left ventricular (LV) mass, LV mass index, relative wall thickness, posterior wall thickness and interventricular septal thickness (p<0.05 all). Those with an HRE had higher risk of LV hypertrophy (relative risk: 2.6 [1.85-3.70]), increased LV mass (47±7g), LV mass index (7±2g/m
2 ), relative wall thickness (0.02±0.005), posterior wall thickness (0.78±0.20mm), interventricular septal thickness (0.78±0.17mm) and left atrial diameter (2±0.52mm) vs. those without an HRE (p<0.05 all). Results were broadly similar between studies with different population characteristics., Conclusions: Exercise systolic BP is associated with cardiac structure, and those with an HRE show evidence towards adverse remodelling. Results were similar across different study populations, highlighting the hypertension-related cardiovascular risk associated with an HRE., (Copyright © 2021 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.)- Published
- 2021
- Full Text
- View/download PDF
6. Lack of Strategic Funding and Long-Term Job Security Threaten to Have Profound Effects on Cardiovascular Researcher Retention in Australia.
- Author
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Climie RE, Wu JHY, Calkin AC, Chapman N, Inglis SC, Mirabito Colafella KM, Picone DS, Tan JTM, Thomas E, Viola HM, Wise SG, Murphy AJ, Nelson MR, Nicholls SJ, Hool LC, Doyle K, Figtree GA, and Marques FZ
- Subjects
- Adult, Australia, Betacoronavirus, COVID-19, Employment economics, Employment psychology, Female, Financing, Government, Humans, Male, Organizational Culture, Pandemics, Planning Techniques, SARS-CoV-2, Surveys and Questionnaires, Biomedical Research economics, Biomedical Research organization & administration, Biomedical Research trends, Cardiovascular Diseases, Coronavirus Infections epidemiology, Financial Management methods, Financial Management organization & administration, Financial Management statistics & numerical data, Pneumonia, Viral epidemiology, Research Personnel economics, Research Personnel psychology, Research Personnel statistics & numerical data, Research Support as Topic organization & administration, Research Support as Topic trends, Workforce statistics & numerical data
- Abstract
Background: Cardiovascular disease is the leading cause of death in Australia. Investment in research solutions has been demonstrated to yield health and a 9.8-fold return economic benefit. The sector, however, is severely challenged with success rates of traditional peer-reviewed funding in decline. Here, we aimed to understand the perceived challenges faced by the cardiovascular workforce in Australia prior to the COVID-19 pandemic., Methods: We used an online survey distributed across Australian cardiovascular societies/councils, universities and research institutes over a period of 6 months during 2019, with 548 completed responses. Inclusion criteria included being an Australian resident or an Australian citizen who lived overseas, and a current or past student or employee in the field of cardiovascular research., Results: The mean age of respondents was 42±13 years, 47% were male, 85% had a full-time position, and 40% were a group leader or laboratory head. Twenty-three per cent (23%) had permanent employment, and 82% of full-time workers regularly worked >40 hours/week. Sixty-eight per cent (68%) said they had previously considered leaving the cardiovascular research sector. If their position could not be funded in the next few years, a staggering 91% of respondents would leave the sector. Compared to PhD- and age-matched men, women were less likely to be a laboratory head and to feel they had a long-term career path as a cardiovascular researcher, while more women were unsure about future employment and had considered leaving the sector (all p<0.05). Greater job security (76%) and government and philanthropic investment in cardiovascular research (72%) were highlighted by responders as the main changes to current practices that would encourage them to stay., Conclusion: Strategic solutions, such as diversification of career pathways and funding sources, and moving from a competitive to a collaborative culture, need to be a priority to decrease reliance on government funding and allow cardiovascular researchers to thrive., (Copyright © 2020 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved.)
- Published
- 2020
- Full Text
- View/download PDF
7. Building an Academic-Industry Partnership to Tackle Australia's Biggest Health Burden.
- Author
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Climie RE, Kingwell BA, and Figtree GA
- Subjects
- Australia epidemiology, Humans, Cardiovascular Diseases epidemiology, Cardiovascular Diseases therapy, Global Health, Health Policy
- Abstract
Cardiovascular disease (CVD) poses a highly significant health and economic burden in Australia and worldwide, with the latest global burden of disease study identifying cardiovascular disease as an "expanding threat to global health" [1]. Australian cardiovascular researchers are recognised internationally for their broad expertise spanning from fundamental molecular and cellular biology, through innovative bioengineering approaches, patient-focussed clinical trials, and impactful community interventions for improved public health. However, funding challenges have resulted in a fragmented research sector struggling to survive, let alone work together as an effective national team with strategic leadership and collaboration. The Australian Cardiovascular Alliance have successfully advocated for a federally supported Mission for Cardiovascular Helath ($220 Million). A key element of success in their goal of enhancing the CV health of Austrlaians, is partnering with industry., (Copyright © 2019. Published by Elsevier B.V.)
- Published
- 2019
- Full Text
- View/download PDF
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