1. Volatile oil from striped African pepper (Xylopia parviflora, Annonaceae) possesses notable chemopreventive, anti-inflammatory and antimicrobial potential.
- Author
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Woguem V, Fogang HP, Maggi F, Tapondjou LA, Womeni HM, Quassinti L, Bramucci M, Vitali LA, Petrelli D, Lupidi G, Papa F, Vittori S, and Barboni L
- Subjects
- Animals, Anti-Infective Agents chemistry, Anti-Inflammatory Agents chemistry, Antioxidants chemistry, Antioxidants pharmacology, Bacteria drug effects, Bacteria growth & development, Cell Line, Tumor, Cell Proliferation drug effects, Fungi drug effects, Fungi growth & development, Humans, Macrophages drug effects, Macrophages immunology, Mice, Neoplasms drug therapy, Oils, Volatile chemistry, Protective Agents chemistry, Anti-Infective Agents pharmacology, Anti-Inflammatory Agents pharmacology, Neoplasms prevention & control, Oils, Volatile pharmacology, Protective Agents pharmacology, Xylopia chemistry
- Abstract
Fruits of Xylopia parviflora, well known as striped African pepper, are sold in the Cameroonian markets as a flavouring ingredient to make traditional soups. The essential oil hydrodistilled from fruits was analysed for in vitro biological activities, namely cytotoxic, anti-inflammatory, antimicrobial and antioxidant, by MTT, nitric oxide inhibitory assay, agar disc diffusion method, and DPPH and ABTS assays. The essential oil composition, analysed by GC and GC-MS, was dominated by monoterpene hydrocarbons (50.0%) responsible for the pepper odour, such as β-pinene (34.0%) and α-pinene (10.3%). The oil induced a strong inhibitory effect on tumour cells MDA-MB 231 and HCT116, with inhibition values close to those of cisplatin. A dose-dependent decrease in NO production was noted in RAW 264.7 macrophages treated with the oil, revealing a promising anti-inflammatory potential. The essential oil showed a measurable antimicrobial activity against all the species tested, while the radical scavenging activity was low., (Copyright © 2013 Elsevier Ltd. All rights reserved.)
- Published
- 2014
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