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Your search keyword '"Praphairaksit N"' showing total 2 results
Start Over Author "Praphairaksit N" Publisher elsevier applied science publishers
2 results on '"Praphairaksit N"'

1. Mucoadhesive 4-carboxybenzenesulfonamide-chitosan with antibacterial properties.

Author

Suvannasara P, Juntapram K, Praphairaksit N, Siralertmukul K, and Muangsin N

Subjects
Acetylation, Administration, Mucosal, Adsorption, Animals, Anti-Bacterial Agents chemistry, Anti-Bacterial Agents pharmacology, Cell Survival drug effects, Chitosan chemical synthesis, Chitosan chemistry, Chitosan pharmacology, Chlorocebus aethiops, Delayed-Action Preparations chemistry, Delayed-Action Preparations pharmacology, Disk Diffusion Antimicrobial Tests, Escherichia coli drug effects, Humans, Intestinal Mucosa metabolism, MCF-7 Cells, Staphylococcus aureus drug effects, Sulfonamides chemistry, Sulfonamides pharmacology, Vero Cells, Viscosity, Anti-Bacterial Agents chemical synthesis, Chitosan analogs & derivatives, Delayed-Action Preparations chemical synthesis, Sulfonamides chemical synthesis
Abstract

The mucoadhesive property of chitosan, especially in an acidic (

Published
2013
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2. Electrosprayed polyelectrolyte complexes between mucoadhesive N,N,N,-trimethylchitosan-homocysteine thiolactone and alginate/carrageenan for camptothecin delivery.

Author

Juntapram K, Praphairaksit N, Siraleartmukul K, and Muangsin N

Subjects
Antineoplastic Agents, Phytogenic administration & dosage, Drug Carriers, Electrochemical Techniques methods, Glucuronic Acid chemistry, Hexuronic Acids chemistry, Homocysteine chemistry, Microscopy, Electron, Scanning, Mucins metabolism, Spectroscopy, Fourier Transform Infrared, Tissue Adhesives, Alginates chemistry, Camptothecin administration & dosage, Carrageenan chemistry, Chitosan chemistry, Drug Delivery Systems, Homocysteine analogs & derivatives, Mucins drug effects, Polymers chemistry
Abstract

Novel hydrogel polyelectrolyte complexes (PECs) between the N,N,N,-trimethylchitosan-homocysteine thiolactone (TM-HT-chitosan) and two anionic polymers were investigated. The particles of pure thiolated chitosan and its PECs with alginate and carrageenan were fabricated using the electrospray ionization technique. The hydrogel PEC particles were characterized by scanning electron microscopy, dynamic light scattering, Fourier transform infrared microscopy, thermogravimetric analysis, encapsulation efficiency (EE), mucoadhesive property and in vitro drug release behavior. TM-HT-chitosan/alginate particles could be loaded with camptothecin (CPT), employed as a model anti-cancer drug, at an over 70% EE, and revealed both a reduced burst effect and a prolonged release of CPT over 3 days. The resultant TM-HT-chitosan/alginate PEC particles displayed a 5.60-, 1.86- and 1.55-fold stronger mucoadhesive property compared to that of the unmodified chitosan/alginate PEC at pH 1.2, 4.0 and 6.4, respectively, and this was not affected by the CPT loading level., (Copyright © 2012 Elsevier Ltd. All rights reserved.)

Published
2012
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