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The review highlights significant advances in delivery systems, with an emphasis on the use of cashew gum (CG), a natural polysaccharide extracted from Anacardium occidentale L., recognized for its remarkable biodegradability and versatility. CG has a wide range of applications spanning sectors such as food, pharmaceuticals, agriculture, and biotechnology. This study examines research focused on the extraction, purification, and chemical modifications of CG, as well as its combination with other biopolymers to enhance physicochemical and mechanical properties. These strategies aim to optimize the gum's characteristics, allowing for the creation of innovative materials with improved performance, expanding its potential applications. This review aims to provide a comprehensive overview of recent research trends, focusing on the utilization of CG as a polymeric component in the development of biomaterials with diverse applications., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024. Published by Elsevier Ltd.)

Efavirenz (EFZ) is one of the most used drugs in the treatment of AIDS and is the first antiretroviral choice. However, since it has low solubility, it does not exhibit suitable bioavailability, which interferes with its therapeutic action and is classified as a class II drug according Biopharmaceutical Classification System (low solubility and high permeability). Among several drug delivery systems, the multicomponent systems with cyclodextrins and hydrophilic polymers are a promising alternative for increasing the aqueous solubility of the drug. The present study aimed to develop and characterize in a ternary system of EFZ, MβCD and PVP K30. The results showed that the solid ternary system provided a large increase in the dissolution rate which was greater than 80% and was characterized by DSC, TG, XRD, FT-IR and SEM. The use of the ternary system (EFZ, MβCD and PVP K30 1%) proved to be a viable, effective and safe delivery of the drug. The addition of the hydrophilic polymer appeared to be suitable for the development of a solid oral pharmaceutical product, with possible industrial scale-up and with low concentration of CDs (cyclodextrins)., (Copyright © 2015 Elsevier Ltd. All rights reserved.)