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2. Contributors

Author

Abbas, Anzar, primary, Ahuja, Shalini, additional, Van Ameringen, Michael, additional, Andersson, Gerhard, additional, Andreassen, Ole A., additional, Bantjes, Jason, additional, Billieux, Joël, additional, B. Clark, Sydney, additional, Bőthe, Beáta, additional, Brand, Matthias, additional, Caricasole, Valentina, additional, Carmi, Lior, additional, Chamberlain, Samuel R., additional, Connolly, Samantha L., additional, Crawford, Allison, additional, Curcin, Vasa, additional, Day, Giselle, additional, Delespaul, Philippe, additional, Delfabbro, Paul H., additional, Ecker, Anthony H., additional, Fernández-Aranda, Fernando, additional, Fernando, Luwishennadige M.N., additional, Fineberg, Naomi A., additional, Flessner, Christopher A., additional, Frei, Oleksandr, additional, Fuss, Johannes, additional, Galatzer-Levy, Isaac R., additional, Gladstone, Theresa R., additional, Gloston, Gabrielle F., additional, Gonsalves, Pattie P., additional, Grant, Jon E., additional, Hartford, Anna, additional, Hilty, Donald, additional, Hindley, Guy, additional, Hogan, Julianna B., additional, Ing, Kevin, additional, Insel, Thomas R., additional, Ioannidis, Konstantinos, additional, Jarrett, Madeleine L., additional, Jiménez-Murcia, Susana, additional, Jorm, Anthony, additional, King, Daniel L., additional, Kishimoto, Taishiro, additional, Lahoud, Ashley A., additional, Lindsay, Jan A., additional, Lochner, Christine, additional, Luo, John, additional, Mestre-Bach, Gemma, additional, Mueller, Kai, additional, Naslund, John A., additional, van Os, Jim, additional, Patterson, Beth, additional, Potenza, Marc N., additional, Reavley, Nicola, additional, Schultebraucks, Katharina, additional, Shore, Jay H., additional, Siddiqui, Saher, additional, Slabbert, Philip, additional, Smeland, Olav B., additional, Stein, Dan J., additional, Strauss, John, additional, Torous, John, additional, Vadillo, Miguel A., additional, Varinelli, Alberto, additional, Verhagen, Simone, additional, Vismara, Matteo, additional, Wegmann, Elisa, additional, Wongkoblap, Akkapon, additional, and Zhang, Jasmine, additional

Published
2022
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3. Exploring the interplay between psychotic experiences, functional somatic symptoms and health anxiety in childhood and adolescence - A longitudinal cohort study

Author

Hersenen-Medisch 1, Brain, Rimvall, Martin Køster, Rask, Charlotte Ulrikka, Jensen, Jens Søndergaard, Olsen, Else Marie, Clemmensen, Lars, Skovgaard, Anne Mette, Verhulst, Frank, van Os, Jim, Jeppesen, Pia, Hersenen-Medisch 1, Brain, Rimvall, Martin Køster, Rask, Charlotte Ulrikka, Jensen, Jens Søndergaard, Olsen, Else Marie, Clemmensen, Lars, Skovgaard, Anne Mette, Verhulst, Frank, van Os, Jim, and Jeppesen, Pia

Published
2024

4. Validation of the Collaborative Outcomes study on Health and Functioning during Infection Times (COH-FIT) questionnaire for adults

Author

Solmi, Marco, Thompson, Trevor, Estrade, Andres, Agorastos, Agorastos, Radua, Joaquim, Cortese, Samuele, Dragioti, Elena, Leisch, Friedrich, Vancampfort, Davy, Thygesen, Lau Caspar, Aschauer, Harald, Schloegelhofer, Monika, Aschauer, Elena, Schneeberger, Andres, Huber, Christian G., Hasler, Gregor, Conus, Philippe, Do Cuenod, Kim Q., von Kaenel, Roland, Arrondo, Gonzalo, Fusar-Poli, Paolo, Gorwood, Philip, Llorca, Pierre-Michel, Krebs, Marie-Odile, Scanferla, Elisabetta, Kishimoto, Taishiro, Rabbani, Golam, Skonieczna-Zydecka, Karolina, Brambilla, Paolo, Favaro, Angela, Takamiya, Akihiro, Zoccante, Leonardo, Colizzi, Marco, Bourgin, Julie, Kaminski, Karol, Moghadasin, Maryam, Seedat, Soraya, Matthews, Evan, Wells, John, Vassilopoulou, Emilia, Gadelha, Ary, Su, Kuan-Pin, Kwon, Jun Soo, Kim, Minah, Lee, Tae Young, Papsuev, Oleg, Mankova, Denisa, Boscutti, Andrea, Gerunda, Cristiano, Saccon, Diego, Righi, Elena, Monaco, Francesco, Croatto, Giovanni, Cereda, Guido, Demurtas, Jacopo, Brondino, Natascia, Veronese, Nicola, Enrico, Paolo, Politi, Pierluigi, Ciappolino, Valentina, Pfennig, Andrea, Bechdolf, Andreas, Meyer-Lindenberg, Andreas, Kahl, Kai G., Domschke, Katharina, Bauer, Michael, Koutsouleris, Nikolaos, Winter, Sibylle, Borgwardt, Stefan, Bitter, Istvan, Balazs, Judit, Czobor, Pal, Unoka, Zsolt, Mavridis, Dimitris, Tsamakis, Konstantinos, Bozikas, Vasilios P., Tunvirachaisakul, Chavit, Maes, Michael, Rungnirundorn, Teerayuth, Supasitthumrong, Thitiporn, Haque, Ariful, Brunoni, Andre R., Costardi, Carlos Gustavo, Schuch, Felipe Barreto, Polanczyk, Guilherme, Luiz, Jhoanne Merlyn, Fonseca, Lais, Aparicio, Luana V., Valvassori, Samira S., Nordentoft, Merete, Vendsborg, Per, Hoffmann, Sofie Have, Sehli, Jihed, Sartorius, Norman, Heuss, Sabina, Guinart, Daniel, Hamilton, Jane, Kane, John, Rubio, Jose, Sand, Michael, Koyanagi, Ai, Solanes, Aleix, Andreu-Bernabeu, Alvaro, Jose Caceres, Antonia San, Arango, Celso, Diaz-Caneja, Covadonga M., Hidalgo-Mazzei, Diego, Vieta, Eduard, Gonzalez-Penas, Javier, Fortea, Lydia, Parellada, Mara, Fullana, Miquel A., Verdolini, Norma, Andrlikova, Eva, Janku, Karolina, Millan, Mark John, Honciuc, Mihaela, Moniuszko-Malinowska, Anna, Loniewski, Igor, Samochowiec, Jerzy, Kiszkiel, Lukasz, Marlicz, Maria, Sowa, Pawel, Marlicz, Wojciech, Spies, Georgina, Stubbs, Brendon, Firth, Joseph, Sullivan, Sarah, Darcin, Asli Enez, Aksu, Hatice, Dilbaz, Nesrin, Noyan, Onur, Kitazawa, Momoko, Kurokawa, Shunya, Tazawa, Yuki, Anselmi, Alejandro, Cracco, Cecilia, Ines Machado, Ana, Estrade, Natalia, De Leo, Diego, Curtis, Jackie, Berk, Michael, Ward, Philip, Teasdale, Scott, Rosenbaum, Simon, Marx, Wolfgang, Horodnic, Adrian Vasile, Oprea, Liviu, Alexinschi, Ovidiu, Ifteni, Petru, Turliuc, Serban, Ciuhodaru, Tudor, Bolos, Alexandra, Matei, Valentin, Nieman, Dorien H., Sommer, Iris, van Os, Jim, van Amelsvoort, Therese, Sun, Ching-Fang, Guu, Ta-wei, Jiao, Can, Zhang, Jieting, Fan, Jialin, Zou, Liye, Yu, Xin, Chi, Xinli, de Timary, Philippe, van Winkel, Ruud, Ng, Bernardo, Pena, Edilberto, Arellano, Ramon, Roman, Raquel, Sanchez, Thelma, Movina, Larisa, Morgado, Pedro, Brissos, Sofia, Aizberg, Oleg, Mosina, Anna, Krinitski, Damir, Mugisha, James, Sadeghi-Bahmani, Dena, Sheybani, Farshad, Sadeghi, Masoud, Hadi, Samira, Brand, Serge, Errazuriz, Antonia, Crossley, Nicolas, Ristic, Dragana Ignjatovic, Lopez-Jaramillo, Carlos, Efthymiou, Dimitris, Kuttichira, Praveenlal, Kallivayalil, Roy Abraham, Javed, Afzal, Afridi, Muhammad Iqbal, James, Bawo, Seb-Akahomen, Omonefe Joy, Fiedorowicz, Jess, Carvalho, Andre F., Daskalakis, Jeff, Yatham, Lakshmi N., Yang, Lin, Okasha, Tarek, Dahdouh, Aicha, Gerdle, Bjoern, Tiihonen, Jari, Il Shin, Jae, Lee, Jinhee, Mhalla, Ahmed, Gaha, Lotfi, Brahim, Takoua, Altynbekov, Kuanysh, Negay, Nikolay, Nurmagambetova, Saltanat, Abu Jamei, Yasser, Weiser, Mark, Correll, Christoph U., Solmi, Marco, Thompson, Trevor, Estrade, Andres, Agorastos, Agorastos, Radua, Joaquim, Cortese, Samuele, Dragioti, Elena, Leisch, Friedrich, Vancampfort, Davy, Thygesen, Lau Caspar, Aschauer, Harald, Schloegelhofer, Monika, Aschauer, Elena, Schneeberger, Andres, Huber, Christian G., Hasler, Gregor, Conus, Philippe, Do Cuenod, Kim Q., von Kaenel, Roland, Arrondo, Gonzalo, Fusar-Poli, Paolo, Gorwood, Philip, Llorca, Pierre-Michel, Krebs, Marie-Odile, Scanferla, Elisabetta, Kishimoto, Taishiro, Rabbani, Golam, Skonieczna-Zydecka, Karolina, Brambilla, Paolo, Favaro, Angela, Takamiya, Akihiro, Zoccante, Leonardo, Colizzi, Marco, Bourgin, Julie, Kaminski, Karol, Moghadasin, Maryam, Seedat, Soraya, Matthews, Evan, Wells, John, Vassilopoulou, Emilia, Gadelha, Ary, Su, Kuan-Pin, Kwon, Jun Soo, Kim, Minah, Lee, Tae Young, Papsuev, Oleg, Mankova, Denisa, Boscutti, Andrea, Gerunda, Cristiano, Saccon, Diego, Righi, Elena, Monaco, Francesco, Croatto, Giovanni, Cereda, Guido, Demurtas, Jacopo, Brondino, Natascia, Veronese, Nicola, Enrico, Paolo, Politi, Pierluigi, Ciappolino, Valentina, Pfennig, Andrea, Bechdolf, Andreas, Meyer-Lindenberg, Andreas, Kahl, Kai G., Domschke, Katharina, Bauer, Michael, Koutsouleris, Nikolaos, Winter, Sibylle, Borgwardt, Stefan, Bitter, Istvan, Balazs, Judit, Czobor, Pal, Unoka, Zsolt, Mavridis, Dimitris, Tsamakis, Konstantinos, Bozikas, Vasilios P., Tunvirachaisakul, Chavit, Maes, Michael, Rungnirundorn, Teerayuth, Supasitthumrong, Thitiporn, Haque, Ariful, Brunoni, Andre R., Costardi, Carlos Gustavo, Schuch, Felipe Barreto, Polanczyk, Guilherme, Luiz, Jhoanne Merlyn, Fonseca, Lais, Aparicio, Luana V., Valvassori, Samira S., Nordentoft, Merete, Vendsborg, Per, Hoffmann, Sofie Have, Sehli, Jihed, Sartorius, Norman, Heuss, Sabina, Guinart, Daniel, Hamilton, Jane, Kane, John, Rubio, Jose, Sand, Michael, Koyanagi, Ai, Solanes, Aleix, Andreu-Bernabeu, Alvaro, Jose Caceres, Antonia San, Arango, Celso, Diaz-Caneja, Covadonga M., Hidalgo-Mazzei, Diego, Vieta, Eduard, Gonzalez-Penas, Javier, Fortea, Lydia, Parellada, Mara, Fullana, Miquel A., Verdolini, Norma, Andrlikova, Eva, Janku, Karolina, Millan, Mark John, Honciuc, Mihaela, Moniuszko-Malinowska, Anna, Loniewski, Igor, Samochowiec, Jerzy, Kiszkiel, Lukasz, Marlicz, Maria, Sowa, Pawel, Marlicz, Wojciech, Spies, Georgina, Stubbs, Brendon, Firth, Joseph, Sullivan, Sarah, Darcin, Asli Enez, Aksu, Hatice, Dilbaz, Nesrin, Noyan, Onur, Kitazawa, Momoko, Kurokawa, Shunya, Tazawa, Yuki, Anselmi, Alejandro, Cracco, Cecilia, Ines Machado, Ana, Estrade, Natalia, De Leo, Diego, Curtis, Jackie, Berk, Michael, Ward, Philip, Teasdale, Scott, Rosenbaum, Simon, Marx, Wolfgang, Horodnic, Adrian Vasile, Oprea, Liviu, Alexinschi, Ovidiu, Ifteni, Petru, Turliuc, Serban, Ciuhodaru, Tudor, Bolos, Alexandra, Matei, Valentin, Nieman, Dorien H., Sommer, Iris, van Os, Jim, van Amelsvoort, Therese, Sun, Ching-Fang, Guu, Ta-wei, Jiao, Can, Zhang, Jieting, Fan, Jialin, Zou, Liye, Yu, Xin, Chi, Xinli, de Timary, Philippe, van Winkel, Ruud, Ng, Bernardo, Pena, Edilberto, Arellano, Ramon, Roman, Raquel, Sanchez, Thelma, Movina, Larisa, Morgado, Pedro, Brissos, Sofia, Aizberg, Oleg, Mosina, Anna, Krinitski, Damir, Mugisha, James, Sadeghi-Bahmani, Dena, Sheybani, Farshad, Sadeghi, Masoud, Hadi, Samira, Brand, Serge, Errazuriz, Antonia, Crossley, Nicolas, Ristic, Dragana Ignjatovic, Lopez-Jaramillo, Carlos, Efthymiou, Dimitris, Kuttichira, Praveenlal, Kallivayalil, Roy Abraham, Javed, Afzal, Afridi, Muhammad Iqbal, James, Bawo, Seb-Akahomen, Omonefe Joy, Fiedorowicz, Jess, Carvalho, Andre F., Daskalakis, Jeff, Yatham, Lakshmi N., Yang, Lin, Okasha, Tarek, Dahdouh, Aicha, Gerdle, Bjoern, Tiihonen, Jari, Il Shin, Jae, Lee, Jinhee, Mhalla, Ahmed, Gaha, Lotfi, Brahim, Takoua, Altynbekov, Kuanysh, Negay, Nikolay, Nurmagambetova, Saltanat, Abu Jamei, Yasser, Weiser, Mark, and Correll, Christoph U.

Abstract

Background: The Collaborative Outcome study on Health and Functioning during Infection Times (COH-FIT; www.coh-fit.com) is an anonymous and global online survey measuring health and functioning during the COVID-19 pandemic. The aim of this study was to test concurrently the validity of COH-FIT items and the in-ternal validity of the co-primary outcome, a composite psychopathology "P-score". Methods: The COH-FIT survey has been translated into 30 languages (two blind forward-translations, consensus, one independent English back-translation, final harmonization). To measure mental health, 1-4 items ("COH-FIT items") were extracted from validated questionnaires (e.g. Patient Health Questionnaire 9). COH-FIT items measured anxiety, depressive, post-traumatic, obsessive-compulsive, bipolar and psychotic symptoms, as well as stress, sleep and concentration. COH-FIT Items which correlated r >= 0.5 with validated companion question-naires, were initially retained. A P-score factor structure was then identified from these items using exploratory factor analysis (EFA) and confirmatory factor analyses (CFA) on data split into training and validation sets. Consistency of results across languages, gender and age was assessed. Results: From >150,000 adult responses by May 6th, 2022, a subset of 22,456 completed both COH-FIT items and validated questionnaires. Concurrent validity was consistently demonstrated across different languages for COH-FIT items. CFA confirmed EFA results of five first-order factors (anxiety, depression, post-traumatic, psychotic, psychophysiologic symptoms) and revealed a single second-order factor P-score, with high internal reliability (omega = 0.95). Factor structure was consistent across age and sex. Conclusions: COH-FIT is a valid instrument to globally measure mental health during infection times. The P-score is a valid measure of multidimensional mental health.

Published
2023
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5. Prevalence, time trends, and correlates of major depressive episode and other psychiatric conditions among young people amid major social unrest and COVID-19 in Hong Kong: a representative epidemiological study from 2019 to 2022

Author

Hersenen-Medisch 1, Brain, Wong, Stephanie M.Y., Chen, Eric Y.H., Suen, Y. N., Wong, Corine S.M., Chang, W. C., Chan, Sherry K.W., McGorry, Patrick D., Morgan, Craig, van Os, Jim, McDaid, David, Jones, Peter B., Lam, T. H., Lam, Linda C.W., Lee, Edwin H.M., Tang, Eric Y.H., Ip, Charlie H., Ho, Winky W.K., McGhee, Sarah M., Sham, P. C., Hui, Christy L.M., Hersenen-Medisch 1, Brain, Wong, Stephanie M.Y., Chen, Eric Y.H., Suen, Y. N., Wong, Corine S.M., Chang, W. C., Chan, Sherry K.W., McGorry, Patrick D., Morgan, Craig, van Os, Jim, McDaid, David, Jones, Peter B., Lam, T. H., Lam, Linda C.W., Lee, Edwin H.M., Tang, Eric Y.H., Ip, Charlie H., Ho, Winky W.K., McGhee, Sarah M., Sham, P. C., and Hui, Christy L.M.

Published
2023

7. Longitudinal invariance of psychotic experiences in children and adolescents: What do the data tell us?

Author

Hersenen-Medisch 1, Brain, Barbosa, Matheus Ghossain, Machado, Viviane, Ziebold, Carolina, Moriyama, Tais, Bressan, Rodrigo A, Pan, Pedro, Rohde, Luis Augusto, Miguel, Euripedes Constantino, Fonseca, Lais, Van Os, Jim, Gadelha, Ary, Hersenen-Medisch 1, Brain, Barbosa, Matheus Ghossain, Machado, Viviane, Ziebold, Carolina, Moriyama, Tais, Bressan, Rodrigo A, Pan, Pedro, Rohde, Luis Augusto, Miguel, Euripedes Constantino, Fonseca, Lais, Van Os, Jim, and Gadelha, Ary

Published
2023

8. Personal recovery suits us all: A study in patients with non-affective psychosis, unaffected siblings and healthy controls

Author

Onderzoek, Brain, Hersenen-Medisch 1, Van Eck, Robin Michael, van Velden, Judith, Vellinga, Astrid, van der Krieke, Lian, Castelein, Stynke, de Haan, Lieuwe, Schirmbeck, Frederike, van Amelsvoort, Therese, Bartels-Velthuis, Agna A, Bruggeman, Richard, Cahn, Wiepke, Simons, Claudia J P, van Os, Jim, Onderzoek, Brain, Hersenen-Medisch 1, Van Eck, Robin Michael, van Velden, Judith, Vellinga, Astrid, van der Krieke, Lian, Castelein, Stynke, de Haan, Lieuwe, Schirmbeck, Frederike, van Amelsvoort, Therese, Bartels-Velthuis, Agna A, Bruggeman, Richard, Cahn, Wiepke, Simons, Claudia J P, and van Os, Jim

Published
2023

9. The collaborative outcomes study on health and functioning during infection times in adults (COH-FIT-Adults): Design and methods of an international online survey targeting physical and mental health effects of the COVID-19 pandemic

Author

Solmi, Marco, Estrade, Andres, Thompson, Trevor, Agorastos, Agorastos, Radua, Joaquim, Cortese, Samuele, Dragioti, Elena, Leisch, Friedrich, Vancampfort, Davy, Thygesen, Lau Caspar, Aschauer, Harald, Schloegelhofer, Monika, Akimova, Elena, Schneeberger, Andres, Huber, Christian G., Hasler, Gregor, Conus, Philippe, Do Cuenod, Kim Q., von Kanel, Roland, Arrondo, Gonzalo, Fusar-Poli, Paolo, Gorwood, Philip, Llorca, Pierre-Michel, Krebs, Marie-Odile, Scanferla, Elisabetta, Kishimoto, Taishiro, Rabbani, Golam, Skonieczna-Zydecka, Karolina, Brambilla, Paolo, Favaro, Angela, Takamiya, Akihiro, Zoccante, Leonardo, Colizzi, Marco, Bourgin, Julie, Kaminski, Karol, Moghadasin, Maryam, Seedat, Soraya, Matthews, Evan, Wells, John, Vassilopoulou, Emilia, Gadelha, Ary, Su, Kuan-Pin, Kwon, Jun Soo, Kim, Minah, Lee, Tae Young, Papsuev, Oleg, Mankova, Denisa, Boscutti, Andrea, Gerunda, Cristiano, Saccon, Diego, Righi, Elena, Monaco, Francesco, Croatto, Giovanni, Cereda, Guido, Demurtas, Jacopo, Brondino, Natascia, Veronese, Nicola, Enrico, Paolo, Politi, Pierluigi, Ciappolino, Valentina, Pfennig, Andrea, Bechdolf, Andreas, Meyer-Lindenberg, Andreas, Kahl, Kai G., Domschke, Katharina, Bauer, Michael, Koutsouleris, Nikolaos, Winter, Sibylle, Borgwardt, Stefan, Bitter, Istvan, Balazs, Judit, Czobor, Pal, Unoka, Zsolt, Mavridis, Dimitris, Tsamakis, Konstantinos, Bozikas, Vasilios P., Tunvirachaisakul, Chavit, Maes, Michael, Rungnirundorn, Teerayuth, Supasitthumrong, Thitiporn, Haque, Ariful, Brunoni, Andre R., Costardi, Carlos Gustavo, Schuch, Felipe Barreto, Polanczyk, Guilherme, Luiz, Jhoanne Merlyn, Fonseca, Lais, Aparicio, Luana, V, Valvassori, Samira S., Nordentoft, Merete, Vendsborg, Per, Hoffmann, Sofie Have, Sehli, Jihed, Sartorius, Norman, Heuss, Sabina, Guinart, Daniel, Hamilton, Jane, Kane, John, Rubio, Jose, Sand, Michael, Koyanagi, Ai, Solanes, Aleix, Andreu-Bernabeu, Alvaro, San Jose Caceres, Antonia, Arango, Celso, Diaz-Caneja, Covadonga M., Hidalgo-Mazzei, Diego, Vieta, Eduard, Gonzalez-Penas, Javier, Fortea, Lydia, Parellada, Mara, Fullana, Miquel A., Verdolini, Norma, Farkova, Eva, Janku, Karolina, Millan, Mark, Honciuc, Mihaela, Moniuszko-Malinowska, Anna, Loniewski, Igor, Samochowiec, Jerzy, Kiszkiel, Lukasz, Marlicz, Maria, Sowa, Pawel, Marlicz, Wojciech, Spies, Georgina, Stubbs, Brendon, Firth, Joseph, Sullivan, Sarah, Darcin, Asli Enez, Aksu, Hatice, Dilbaz, Nesrin, Noyan, Onur, Kitazawa, Momoko, Kurokawa, Shunya, Tazawa, Yuki, Anselmi, Alejandro, Cracco, Cecilia, Ines Machado, Ana, Estrade, Natalia, De Leo, Diego, Curtis, Jackie, Berk, Michael, Ward, Philip, Teasdale, Scott, Rosenbaum, Simon, Marx, Wolfgang, Horodnic, Adrian Vasile, Oprea, Liviu, Alexinschi, Ovidiu, Ifteni, Petru, Turliuc, Serban, Ciuhodaru, Tudor, Bolos, Alexandra, Matei, Valentin, Nieman, Dorien H., Sommer, Iris, van Os, Jim, van Amelsvoort, Therese, Sun, Ching-Fang, Guu, Ta-wei, Jiao, Can, Zhang, Jieting, Fan, Jialin, Zou, Liye, Yu, Xin, Chi, Xinli, de Timary, Philippe, van Winke, Ruud, Ng, Bernardo, Pena, Edilberto, Arellano, Ramon, Roman, Raquel, Sanchez, Thelma, Movina, Larisa, Morgado, Pedro, Brissos, Sofia, Aizberg, Oleg, Mosina, Anna, Krinitski, Damir, Mugisha, James, Sadeghi-Bahmani, Dena, Sadeghi, Masoud, Hadi, Samira, Brand, Serge, Errazuriz, Antonia, Crossley, Nicolas, Ristic, Dragana Ignjatovic, Lopez-Jaramillo, Carlos, Efthymiou, Dimitris, Kuttichira, Praveenlal, Kallivayalil, Roy Abraham, Javed, Afzal, Afridi, Muhammad Iqbal, James, Bawo, Seb-Akahomen, Omonefe Joy, Fiedorowicz, Jess, Carvalho, Andre F., Daskalakis, Jeff, Yatham, Lakshmi N., Yang, Lin, Okasha, Tarek, Dahdouh, Aicha, Gerdle, Bjorn, Tiihonen, Jari, Shin, Jae Il, Lee, Jinhee, Mhalla, Ahmed, Gaha, Lotfi, Brahim, Takoua, Altynbekov, Kuanysh, Negay, Nikolay, Nurmagambetova, Saltanat, Abu Jamei, Yasser, Weiser, Mark, Correll, Christoph U., Solmi, Marco, Estrade, Andres, Thompson, Trevor, Agorastos, Agorastos, Radua, Joaquim, Cortese, Samuele, Dragioti, Elena, Leisch, Friedrich, Vancampfort, Davy, Thygesen, Lau Caspar, Aschauer, Harald, Schloegelhofer, Monika, Akimova, Elena, Schneeberger, Andres, Huber, Christian G., Hasler, Gregor, Conus, Philippe, Do Cuenod, Kim Q., von Kanel, Roland, Arrondo, Gonzalo, Fusar-Poli, Paolo, Gorwood, Philip, Llorca, Pierre-Michel, Krebs, Marie-Odile, Scanferla, Elisabetta, Kishimoto, Taishiro, Rabbani, Golam, Skonieczna-Zydecka, Karolina, Brambilla, Paolo, Favaro, Angela, Takamiya, Akihiro, Zoccante, Leonardo, Colizzi, Marco, Bourgin, Julie, Kaminski, Karol, Moghadasin, Maryam, Seedat, Soraya, Matthews, Evan, Wells, John, Vassilopoulou, Emilia, Gadelha, Ary, Su, Kuan-Pin, Kwon, Jun Soo, Kim, Minah, Lee, Tae Young, Papsuev, Oleg, Mankova, Denisa, Boscutti, Andrea, Gerunda, Cristiano, Saccon, Diego, Righi, Elena, Monaco, Francesco, Croatto, Giovanni, Cereda, Guido, Demurtas, Jacopo, Brondino, Natascia, Veronese, Nicola, Enrico, Paolo, Politi, Pierluigi, Ciappolino, Valentina, Pfennig, Andrea, Bechdolf, Andreas, Meyer-Lindenberg, Andreas, Kahl, Kai G., Domschke, Katharina, Bauer, Michael, Koutsouleris, Nikolaos, Winter, Sibylle, Borgwardt, Stefan, Bitter, Istvan, Balazs, Judit, Czobor, Pal, Unoka, Zsolt, Mavridis, Dimitris, Tsamakis, Konstantinos, Bozikas, Vasilios P., Tunvirachaisakul, Chavit, Maes, Michael, Rungnirundorn, Teerayuth, Supasitthumrong, Thitiporn, Haque, Ariful, Brunoni, Andre R., Costardi, Carlos Gustavo, Schuch, Felipe Barreto, Polanczyk, Guilherme, Luiz, Jhoanne Merlyn, Fonseca, Lais, Aparicio, Luana, V, Valvassori, Samira S., Nordentoft, Merete, Vendsborg, Per, Hoffmann, Sofie Have, Sehli, Jihed, Sartorius, Norman, Heuss, Sabina, Guinart, Daniel, Hamilton, Jane, Kane, John, Rubio, Jose, Sand, Michael, Koyanagi, Ai, Solanes, Aleix, Andreu-Bernabeu, Alvaro, San Jose Caceres, Antonia, Arango, Celso, Diaz-Caneja, Covadonga M., Hidalgo-Mazzei, Diego, Vieta, Eduard, Gonzalez-Penas, Javier, Fortea, Lydia, Parellada, Mara, Fullana, Miquel A., Verdolini, Norma, Farkova, Eva, Janku, Karolina, Millan, Mark, Honciuc, Mihaela, Moniuszko-Malinowska, Anna, Loniewski, Igor, Samochowiec, Jerzy, Kiszkiel, Lukasz, Marlicz, Maria, Sowa, Pawel, Marlicz, Wojciech, Spies, Georgina, Stubbs, Brendon, Firth, Joseph, Sullivan, Sarah, Darcin, Asli Enez, Aksu, Hatice, Dilbaz, Nesrin, Noyan, Onur, Kitazawa, Momoko, Kurokawa, Shunya, Tazawa, Yuki, Anselmi, Alejandro, Cracco, Cecilia, Ines Machado, Ana, Estrade, Natalia, De Leo, Diego, Curtis, Jackie, Berk, Michael, Ward, Philip, Teasdale, Scott, Rosenbaum, Simon, Marx, Wolfgang, Horodnic, Adrian Vasile, Oprea, Liviu, Alexinschi, Ovidiu, Ifteni, Petru, Turliuc, Serban, Ciuhodaru, Tudor, Bolos, Alexandra, Matei, Valentin, Nieman, Dorien H., Sommer, Iris, van Os, Jim, van Amelsvoort, Therese, Sun, Ching-Fang, Guu, Ta-wei, Jiao, Can, Zhang, Jieting, Fan, Jialin, Zou, Liye, Yu, Xin, Chi, Xinli, de Timary, Philippe, van Winke, Ruud, Ng, Bernardo, Pena, Edilberto, Arellano, Ramon, Roman, Raquel, Sanchez, Thelma, Movina, Larisa, Morgado, Pedro, Brissos, Sofia, Aizberg, Oleg, Mosina, Anna, Krinitski, Damir, Mugisha, James, Sadeghi-Bahmani, Dena, Sadeghi, Masoud, Hadi, Samira, Brand, Serge, Errazuriz, Antonia, Crossley, Nicolas, Ristic, Dragana Ignjatovic, Lopez-Jaramillo, Carlos, Efthymiou, Dimitris, Kuttichira, Praveenlal, Kallivayalil, Roy Abraham, Javed, Afzal, Afridi, Muhammad Iqbal, James, Bawo, Seb-Akahomen, Omonefe Joy, Fiedorowicz, Jess, Carvalho, Andre F., Daskalakis, Jeff, Yatham, Lakshmi N., Yang, Lin, Okasha, Tarek, Dahdouh, Aicha, Gerdle, Bjorn, Tiihonen, Jari, Shin, Jae Il, Lee, Jinhee, Mhalla, Ahmed, Gaha, Lotfi, Brahim, Takoua, Altynbekov, Kuanysh, Negay, Nikolay, Nurmagambetova, Saltanat, Abu Jamei, Yasser, Weiser, Mark, and Correll, Christoph U.

Abstract

Background: . High-quality comprehensive data on short-/long-term physical/mental health effects of the COVID-19 pandemic are needed. Methods: . The Collaborative Outcomes study on Health and Functioning during Infection Times (COH-FIT) is an international, multi-language (n=30) project involving >230 investigators from 49 countries/territories/regions, endorsed by national/international professional associations. COH-FIT is a multi-wave, on-line anonymous, cross-sectional survey [wave 1: 04/2020 until the end of the pandemic, 12 months waves 2/3 starting 6/24 months threreafter] for adults, adolescents (14-17), and children (6-13), utilizing non-probability/snowball and representative sampling. COH-FIT aims to identify non-modifiable/modifiable risk factors/treatment targets to inform prevention/intervention programs to improve social/health outcomes in the general population/vulnerable subgrous during/after COVID-19. In adults, co-primary outcomes are change from pre-COVID-19 to intra-COVID-19 in well-being (WHO-5) and a composite psychopathology P-Score. Key secondary outcomes are a P-extended score, global mental and physical health. Secondary outcomes include health-service utilization/ functioning, treatment adherence, functioning, symptoms/behaviors/emotions, substance use, violence, among others. Results: . Starting 04/26/2020, up to 14/07/2021 >151,000 people from 155 countries/territories/regions and six continents have participated. Representative samples of >= 1,000 adults have been collected in 15 countries. Overall, 43.0% had prior physical disorders, 16.3% had prior mental disorders, 26.5% were health care workers, 8.2% were aged >= 65 years, 19.3% were exposed to someone infected with COVID-19, 76.1% had been in quarantine, and 2.1% had been COVID 19-positive. Limitations: . Cross-sectional survey, preponderance of non-representative participants. Conclusions: . Results from COH-FIT will comprehensively quantify the impact of COVID-19, seeking to ide

Published
2022

10. Physical and mental health impact of COVID-19 on children, adolescents, and their families: The Collaborative Outcomes study on Health and Functioning during Infection Times-Children and Adolescents (COH-FIT-C&A)

Author

Solmi, Marco, Estrade, Andres, Thompson, Trevor, Agorastos, Agorastos, Radua, Joaquim, Cortese, Samuele, Dragioti, Elena, Leisch, Friedrich, Vancampfort, Davy, Thygesen, Lau Caspar, Aschauer, Harald, Schloegelhofer, Monika, Akimova, Elena, Schneeberger, Andres, Huber, Christian G., Hasler, Gregor, Conus, Philippe, Do Cuenod, Kim Q., von Kanel, Roland, Arrondo, Gonzalo, Fusar-Poli, Paolo, Gorwood, Philip, Llorca, Pierre-Michel, Krebs, Marie-Odile, Scanferla, Elisabetta, Kishimoto, Taishiro, Rabbani, Golam, Skonieczna-Zydecka, Karolina, Brambilla, Paolo, Favaro, Angela, Takamiya, Akihiro, Zoccante, Leonardo, Colizzi, Marco, Bourgin, Julie, Kaminski, Karol, Moghadasin, Maryam, Seedat, Soraya, Matthews, Evan, Wells, John, Vassilopoulou, Emilia, Gadelha, Ary, Su, Kuan-Pin, Kwon, Jun Soo, Kim, Minah, Lee, Tae Young, Papsuev, Oleg, Mankova, Denisa, Boscutti, Andrea, Gerunda, Cristiano, Saccon, Diego, Righi, Elena, Monaco, Francesco, Croatto, Giovanni, Cereda, Guido, Demurtas, Jacopo, Brondino, Natascia, Veronese, Nicola, Enrico, Paolo, Politi, Pierluigi, Ciappolino, Valentina, Pfennig, Andrea, Bechdolf, Andreas, Meyer-Lindenberg, Andreas, Kahl, Kai G., Domschke, Katharina, Bauer, Michael, Koutsouleris, Nikolaos, Winter, Sibylle, Borgwardt, Stefan, Bitter, Istvan, Balazs, Judit, Czobor, Pal, Unoka, Zsolt, Mavridis, Dimitris, Tsamakis, Konstantinos, Bozikas, Vasilios P., Tunvirachaisakul, Chavit, Maes, Michael, Rungnirundorn, Teerayuth, Supasitthumrong, Thitiporn, Haque, Ariful, Brunoni, Andre R., Costardi, Carlos Gustavo, Schuch, Felipe Barreto, Polanczyk, Guilherme, Luiz, Jhoanne Merlyn, Fonseca, Lais, Aparicio, Luana, V, Valvassori, Samira S., Nordentoft, Merete, Vendsborg, Per, Hoffmann, Sofie Have, Sehli, Jihed, Sartorius, Norman, Heuss, Sabina, Guinart, Daniel, Hamilton, Jane, Kane, John, Rubio, Jose, Sand, Michael, Koyanagi, Ai, Solanes, Aleix, Andreu-Bernabeu, Alvaro, Caceres, Antonia San Jose, Arango, Celso, Diaz-Caneja, Covadonga M., Hidalgo-Mazzei, Diego, Vieta, Eduard, Gonzalez-Penas, Javier, Fortea, Lydia, Parellada, Mara, Fullana, Miquel A., Verdolini, Norma, Farkova, Eva, Janku, Karolina, Millan, Mark, Honciuc, Mihaela, Moniuszko-Malinowska, Anna, Loniewski, Igor, Samochowiec, Jerzy, Kiszkiel, Lukasz, Marlicz, Maria, Sowa, Pawel, Marlicz, Wojciech, Spies, Georgina, Stubbs, Brendon, Firth, Joseph, Sullivan, Sarah, Darcin, Asli Enez, Aksu, Hatice, Dilbaz, Nesrin, Noyan, Onur, Kitazawa, Momoko, Kurokawa, Shunya, Tazawa, Yuki, Anselmi, Alejandro, Cracco, Cecilia, Machado, Ana Ines, Estrade, Natalia, De Leo, Diego, Curtis, Jackie, Berk, Michael, Ward, Philip, Teasdale, Scott, Rosenbaum, Simon, Marx, Wolfgang, Horodnic, Adrian Vasile, Oprea, Liviu, Alexinschi, Ovidiu, Ifteni, Petru, Turliuc, Serban, Ciuhodaru, Tudor, Bolos, Alexandra, Matei, Valentin, Nieman, Dorien H., Sommer, Iris, van Os, Jim, van Amelsvoort, Therese, Sun, Ching-Fang, Guu, Ta-Wei, Jiao, Can, Zhang, Jieting, Fan, Jialin, Zou, Liye, Yu, Xin, Chi, Xinli, de Timary, Philippe, van Winke, Ruud, Ng, Bernardo, Pena, Edilberto, Arellano, Ramon, Roman, Raquel, Sanchez, Thelma, Movina, Larisa, Morgado, Pedro, Brissos, Sofia, Aizberg, Oleg, Mosina, Anna, Krinitski, Damir, Mugisha, James, Sadeghi-Bahmani, Dena, Sadeghi, Masoud, Hadi, Samira, Brand, Serge, Errazuriz, Antonia, Crossley, Nicolas, Ristic, Dragana Ignjatovic, Lopez-Jaramillo, Carlos, Efthymiou, Dimitris, Kuttichira, Praveenlal, Kallivayalil, Roy Abraham, Javed, Afzal, Afridi, Muhammad Iqbal, James, Bawo, Seb-Akahomen, Omonefe Joy, Fiedorowicz, Jess, Carvalho, Andre F., Daskalakis, Jeff, Yatham, Lakshmi N., Yang, Lin, Okasha, Tarek, Dahdouh, Aicha, Gerdle, Bjorn, Tiihonen, Jari, Shin, Jae Il, Lee, Jinhee, Mhalla, Ahmed, Gaha, Lotfi, Brahim, Takoua, Altynbekov, Kuanysh, Negay, Nikolay, Nurmagambetova, Saltanat, Abu Jamei, Yasser, Weiser, Mark, Correll, Christoph U., Solmi, Marco, Estrade, Andres, Thompson, Trevor, Agorastos, Agorastos, Radua, Joaquim, Cortese, Samuele, Dragioti, Elena, Leisch, Friedrich, Vancampfort, Davy, Thygesen, Lau Caspar, Aschauer, Harald, Schloegelhofer, Monika, Akimova, Elena, Schneeberger, Andres, Huber, Christian G., Hasler, Gregor, Conus, Philippe, Do Cuenod, Kim Q., von Kanel, Roland, Arrondo, Gonzalo, Fusar-Poli, Paolo, Gorwood, Philip, Llorca, Pierre-Michel, Krebs, Marie-Odile, Scanferla, Elisabetta, Kishimoto, Taishiro, Rabbani, Golam, Skonieczna-Zydecka, Karolina, Brambilla, Paolo, Favaro, Angela, Takamiya, Akihiro, Zoccante, Leonardo, Colizzi, Marco, Bourgin, Julie, Kaminski, Karol, Moghadasin, Maryam, Seedat, Soraya, Matthews, Evan, Wells, John, Vassilopoulou, Emilia, Gadelha, Ary, Su, Kuan-Pin, Kwon, Jun Soo, Kim, Minah, Lee, Tae Young, Papsuev, Oleg, Mankova, Denisa, Boscutti, Andrea, Gerunda, Cristiano, Saccon, Diego, Righi, Elena, Monaco, Francesco, Croatto, Giovanni, Cereda, Guido, Demurtas, Jacopo, Brondino, Natascia, Veronese, Nicola, Enrico, Paolo, Politi, Pierluigi, Ciappolino, Valentina, Pfennig, Andrea, Bechdolf, Andreas, Meyer-Lindenberg, Andreas, Kahl, Kai G., Domschke, Katharina, Bauer, Michael, Koutsouleris, Nikolaos, Winter, Sibylle, Borgwardt, Stefan, Bitter, Istvan, Balazs, Judit, Czobor, Pal, Unoka, Zsolt, Mavridis, Dimitris, Tsamakis, Konstantinos, Bozikas, Vasilios P., Tunvirachaisakul, Chavit, Maes, Michael, Rungnirundorn, Teerayuth, Supasitthumrong, Thitiporn, Haque, Ariful, Brunoni, Andre R., Costardi, Carlos Gustavo, Schuch, Felipe Barreto, Polanczyk, Guilherme, Luiz, Jhoanne Merlyn, Fonseca, Lais, Aparicio, Luana, V, Valvassori, Samira S., Nordentoft, Merete, Vendsborg, Per, Hoffmann, Sofie Have, Sehli, Jihed, Sartorius, Norman, Heuss, Sabina, Guinart, Daniel, Hamilton, Jane, Kane, John, Rubio, Jose, Sand, Michael, Koyanagi, Ai, Solanes, Aleix, Andreu-Bernabeu, Alvaro, Caceres, Antonia San Jose, Arango, Celso, Diaz-Caneja, Covadonga M., Hidalgo-Mazzei, Diego, Vieta, Eduard, Gonzalez-Penas, Javier, Fortea, Lydia, Parellada, Mara, Fullana, Miquel A., Verdolini, Norma, Farkova, Eva, Janku, Karolina, Millan, Mark, Honciuc, Mihaela, Moniuszko-Malinowska, Anna, Loniewski, Igor, Samochowiec, Jerzy, Kiszkiel, Lukasz, Marlicz, Maria, Sowa, Pawel, Marlicz, Wojciech, Spies, Georgina, Stubbs, Brendon, Firth, Joseph, Sullivan, Sarah, Darcin, Asli Enez, Aksu, Hatice, Dilbaz, Nesrin, Noyan, Onur, Kitazawa, Momoko, Kurokawa, Shunya, Tazawa, Yuki, Anselmi, Alejandro, Cracco, Cecilia, Machado, Ana Ines, Estrade, Natalia, De Leo, Diego, Curtis, Jackie, Berk, Michael, Ward, Philip, Teasdale, Scott, Rosenbaum, Simon, Marx, Wolfgang, Horodnic, Adrian Vasile, Oprea, Liviu, Alexinschi, Ovidiu, Ifteni, Petru, Turliuc, Serban, Ciuhodaru, Tudor, Bolos, Alexandra, Matei, Valentin, Nieman, Dorien H., Sommer, Iris, van Os, Jim, van Amelsvoort, Therese, Sun, Ching-Fang, Guu, Ta-Wei, Jiao, Can, Zhang, Jieting, Fan, Jialin, Zou, Liye, Yu, Xin, Chi, Xinli, de Timary, Philippe, van Winke, Ruud, Ng, Bernardo, Pena, Edilberto, Arellano, Ramon, Roman, Raquel, Sanchez, Thelma, Movina, Larisa, Morgado, Pedro, Brissos, Sofia, Aizberg, Oleg, Mosina, Anna, Krinitski, Damir, Mugisha, James, Sadeghi-Bahmani, Dena, Sadeghi, Masoud, Hadi, Samira, Brand, Serge, Errazuriz, Antonia, Crossley, Nicolas, Ristic, Dragana Ignjatovic, Lopez-Jaramillo, Carlos, Efthymiou, Dimitris, Kuttichira, Praveenlal, Kallivayalil, Roy Abraham, Javed, Afzal, Afridi, Muhammad Iqbal, James, Bawo, Seb-Akahomen, Omonefe Joy, Fiedorowicz, Jess, Carvalho, Andre F., Daskalakis, Jeff, Yatham, Lakshmi N., Yang, Lin, Okasha, Tarek, Dahdouh, Aicha, Gerdle, Bjorn, Tiihonen, Jari, Shin, Jae Il, Lee, Jinhee, Mhalla, Ahmed, Gaha, Lotfi, Brahim, Takoua, Altynbekov, Kuanysh, Negay, Nikolay, Nurmagambetova, Saltanat, Abu Jamei, Yasser, Weiser, Mark, and Correll, Christoph U.

Abstract

Background: The COVID-19 pandemic has altered daily routines and family functioning, led to closing schools, and dramatically limited social interactions worldwide. Measuring its impact on mental health of vulnerable children and adolescents is crucial. Methods: The Collaborative Outcomes study on Health and Functioning during Infection Times (COH-FIT - www. coh-fit.com) is an on-line anonymous survey, available in 30 languages, involving >230 investigators from 49 countries supported by national/international professional associations. COH-FIT has thee waves (until the pandemic is declared over by the WHO, and 6-18 months plus 24-36 months after its end). In addition to adults, COH-FIT also includes adolescents (age 14-17 years), and children (age 6-13 years), recruited via nonprobability/snowball and representative sampling and assessed via self-rating and parental rating. Nonmodifiable/modifiable risk factors/treatment targets to inform prevention/intervention programs to promote health and prevent mental and physical illness in children and adolescents will be generated by COH-FIT. Co primary outcomes are changes in well-being (WHO-5) and a composite psychopathology P-Score. Multiple behavioral, family, coping strategy and service utilization factors are also assessed, including functioning and quality of life. Results: Up to June 2021, over 13,000 children and adolescents from 59 countries have participated in the COHFIT project, with representative samples from eleven countries. Limitations: Cross-sectional and anonymous design. Conclusions: Evidence generated by COH-FIT will provide an international estimate of the COVID-19 effect on children's, adolescents' and families', mental and physical health, well-being, functioning and quality of life, informing the formulation of present and future evidence-based interventions and policies to minimize adverse effects of the present and future pandemics on youth.

Published
2022

11. Verbal memory performance predicts remission and functional outcome in people at clinical high-risk for psychosis

Author

Hedges, Emily P., Dickson, Hannah, Tognin, Stefania, Modinos, Gemma, Antoniades, Mathilde, van der Gaag, Mark, de Haan, Lieuwe, McGorry, Patrick, Pantelis, Christos, Riecher-Rossler, Anita, Bressan, Rodrigo, Barrantes-Vidal, Neus, Krebs, Marie-Odile, Nordentoft, Merete, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P., van Os, Jim, Valmaggia, Lucia R., McGuire, Philip, Kempton, Matthew J., Hedges, Emily P., Dickson, Hannah, Tognin, Stefania, Modinos, Gemma, Antoniades, Mathilde, van der Gaag, Mark, de Haan, Lieuwe, McGorry, Patrick, Pantelis, Christos, Riecher-Rossler, Anita, Bressan, Rodrigo, Barrantes-Vidal, Neus, Krebs, Marie-Odile, Nordentoft, Merete, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P., van Os, Jim, Valmaggia, Lucia R., McGuire, Philip, and Kempton, Matthew J.

Abstract

Robust deficits in cognitive functioning are present in people with psychosis and are evident in the early stages of the disorder. Impairments in verbal memory and verbal fluency are reliably seen in individuals at clinical high risk for psychosis (CHR) compared to healthy populations. As previous studies have shown a relationship between cognition and longer-term outcomes in schizophrenia, the aim of this paper was to explore whether verbal memory and verbal fluency performance predicted outcomes in a large CHR sample recruited as part of the EUGEI High Risk Study. Participants included 316 CHR individuals, 90.8% of whom were not currently on anti psychotic medication, and 60 healthy controls. Verbal memory and verbal fluency performance were measured at baseline. At two-year follow-up, CHR individuals were assessed by three different outcome measures, those who did and did not (1) transition to psychosis, (2) experience burdening impairment or disabilities, or (3) remit clinically from CHR status. Individuals with CHR displayed significant verbal memory and verbal fluency deficits at baseline compared to healthy controls (Hedges' g effect size = 0.24 to 0.66). There were no significant dif-ferences in cognitive performance of those who did , did not transition to psychosis. However, impaired immediate verbal recall predicted both functional disability and non-remission from the CHR state. Results remained significant when analyses were restricted to only include antipsychotic-free CHR participants. These findings may inform the development of early interventions designed to improve cognitive deficits in the early stages of psychosis.

Published
2022

12. Exposome and Trans-syndromal Developmental Trajectories Toward Psychosis

Author

Hersenen-Medisch 1, Brain, Barzilay, Ran, Pries, Lotta-Katrin, Moore, Tyler M, Gur, Raquel E, van Os, Jim, Rutten, Bart P F, Guloksuz, Sinan, Hersenen-Medisch 1, Brain, Barzilay, Ran, Pries, Lotta-Katrin, Moore, Tyler M, Gur, Raquel E, van Os, Jim, Rutten, Bart P F, and Guloksuz, Sinan

Published
2022

13. Gender differences in the association between environment and psychosis

Author

Hersenen-Medisch 1, Brain, Pence, Aysegul Yay, Pries, Lotta Katrin, Ferrara, Maria, Rutten, Bart P.F., van Os, Jim, Guloksuz, Sinan, Hersenen-Medisch 1, Brain, Pence, Aysegul Yay, Pries, Lotta Katrin, Ferrara, Maria, Rutten, Bart P.F., van Os, Jim, and Guloksuz, Sinan

Published
2022

14. General psychopathology and its social correlates in the daily lives of youth

Author

Hersenen-Medisch 1, Brain, Achterhof, Robin, Kirtley, Olivia J., Schneider, Maude, Hagemann, Noëmi, Hermans, Karlijn S.F.M., Hiekkaranta, Anu P., Lecei, Aleksandra, Decoster, Jeroen, Derom, Catherine, De Hert, Marc, Gülöksüz, Sinan, Jacobs, Nele, Menne-Lothmann, Claudia, Rutten, Bart P.F., Thiery, Evert, van Os, Jim, van Winkel, Ruud, Wichers, Marieke, Myin-Germeys, Inez, Hersenen-Medisch 1, Brain, Achterhof, Robin, Kirtley, Olivia J., Schneider, Maude, Hagemann, Noëmi, Hermans, Karlijn S.F.M., Hiekkaranta, Anu P., Lecei, Aleksandra, Decoster, Jeroen, Derom, Catherine, De Hert, Marc, Gülöksüz, Sinan, Jacobs, Nele, Menne-Lothmann, Claudia, Rutten, Bart P.F., Thiery, Evert, van Os, Jim, van Winkel, Ruud, Wichers, Marieke, and Myin-Germeys, Inez

Published
2022

16. Pre-training inter-rater reliability of clinical instruments in an international psychosis research project

Author

Berendsen, Steven, Kapitein, Pim, Schirmbeck, Frederike, van Tricht, Mirjam J., McGuire, Philip, Morgan, Craig, Gayer-Anderson, Charlotte, Kempton, Matthew J., Valmaggia, Lucia, Quattrone, Diego, di Forti, Marta, van der Gaag, Mark, Kirkbride, James B., Jongsma, Hannah E., Jones, Peter B., Parellada, Maria, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Sanjuan, Julio, Santos, Jose Luis, Szoke, Andrei, Tortelli, Andrea, Llorca, Pierre-Michel, Tarricone, Ilaria, Tripoli, Giada, Ferraro, Laura, La Cascia, Caterina, Lasalvia, Antonio, Tosato, Sarah, Menezes, Paulo Rossi, Del-Ben, Cristina Marta, Nelson, Barnaby, Riecher-Rossler, Anita, Bressan, Rodrigo, Barrantes-Vidal, Neus, Krebs, Marie-Odile, Nordentoft, Merete, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P. F., van Os, Jim, Velthorst, Eva, de Haan, Lieuwe, Berendsen, Steven, Kapitein, Pim, Schirmbeck, Frederike, van Tricht, Mirjam J., McGuire, Philip, Morgan, Craig, Gayer-Anderson, Charlotte, Kempton, Matthew J., Valmaggia, Lucia, Quattrone, Diego, di Forti, Marta, van der Gaag, Mark, Kirkbride, James B., Jongsma, Hannah E., Jones, Peter B., Parellada, Maria, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Sanjuan, Julio, Santos, Jose Luis, Szoke, Andrei, Tortelli, Andrea, Llorca, Pierre-Michel, Tarricone, Ilaria, Tripoli, Giada, Ferraro, Laura, La Cascia, Caterina, Lasalvia, Antonio, Tosato, Sarah, Menezes, Paulo Rossi, Del-Ben, Cristina Marta, Nelson, Barnaby, Riecher-Rossler, Anita, Bressan, Rodrigo, Barrantes-Vidal, Neus, Krebs, Marie-Odile, Nordentoft, Merete, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P. F., van Os, Jim, Velthorst, Eva, and de Haan, Lieuwe

Published
2021

17. The relationship of symptom dimensions with premorbid adjustment and cognitive characteristics at first episode psychosis: Findings from the EU-GEI study

Author

Hersenen-Medisch 1, Brain, Ferraro, Laura, La Cascia, Caterina, La Barbera, Daniele, Sanchez-Gutierrez, Teresa, Tripoli, Giada, Seminerio, Fabio, Sartorio, Crocettarachele, Marrazzo, Giovanna, Sideli, Lucia, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Bobes, Julio, Del-Ben, Cristina Marta, Gayer-Anderson, Charlotte, Jongsma, Hannah E., Kirkbride, James B., Lasalvia, Antonio, Tosato, Sarah, Llorca, Pierre Michel, Menezes, Paulo Rossi, Rutten, Bart P., Santos, Jose Luis, Sanjuán, Julio, Selten, Jean Paul, Szöke, Andrei, Tarricone, Ilaria, Muratori, Roberto, Tortelli, Andrea, Velthorst, Eva, Rodriguez, Victoria, Quattrone, Andrea, Jones, Peter B., Van Os, Jim, Vassos, Evangelos, Morgan, Craig, de Haan, Lieuwe, Reininghaus, Ulrich, Cardno, Alastair G., Di Forti, Marta, Murray, Robin M., Quattrone, Diego, Hersenen-Medisch 1, Brain, Ferraro, Laura, La Cascia, Caterina, La Barbera, Daniele, Sanchez-Gutierrez, Teresa, Tripoli, Giada, Seminerio, Fabio, Sartorio, Crocettarachele, Marrazzo, Giovanna, Sideli, Lucia, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Bobes, Julio, Del-Ben, Cristina Marta, Gayer-Anderson, Charlotte, Jongsma, Hannah E., Kirkbride, James B., Lasalvia, Antonio, Tosato, Sarah, Llorca, Pierre Michel, Menezes, Paulo Rossi, Rutten, Bart P., Santos, Jose Luis, Sanjuán, Julio, Selten, Jean Paul, Szöke, Andrei, Tarricone, Ilaria, Muratori, Roberto, Tortelli, Andrea, Velthorst, Eva, Rodriguez, Victoria, Quattrone, Andrea, Jones, Peter B., Van Os, Jim, Vassos, Evangelos, Morgan, Craig, de Haan, Lieuwe, Reininghaus, Ulrich, Cardno, Alastair G., Di Forti, Marta, Murray, Robin M., and Quattrone, Diego

Published
2021

18. Relationship between social cognition, general cognition, and risk for suicide in individuals with a psychotic disorder

Author

Onderzoek, Brain, Hersenen-Medisch 1, Dickhoff, Justine, Opmeer, Esther Marije, Heering, Henriette Dorotheé, Bruggeman, Richard, van Amelsvoort, Therese, Bartels-Velthuis, Agna A., Cahn, Wiepke, de Haan, Lieuwe, Schirmbeck, Frederike, Simons, Claudia J.P., van Os, Jim, Aleman, André, van Tol, Marie José, Onderzoek, Brain, Hersenen-Medisch 1, Dickhoff, Justine, Opmeer, Esther Marije, Heering, Henriette Dorotheé, Bruggeman, Richard, van Amelsvoort, Therese, Bartels-Velthuis, Agna A., Cahn, Wiepke, de Haan, Lieuwe, Schirmbeck, Frederike, Simons, Claudia J.P., van Os, Jim, Aleman, André, and van Tol, Marie José

Published
2021

19. Symptom-network dynamics in irritable bowel syndrome with comorbid panic disorder using electronic momentary assessment: A randomized controlled trial of escitalopram vs. placebo

Author

Hersenen-Medisch 1, Brain, Kreiter, Daniël, Drukker, Marjan, Mujagic, Zlatan, Vork, Lisa, Rutten, Bart P F, van Os, Jim, Masclee, Ad A M, Kruimel, Joanna W, Leue, Carsten, Hersenen-Medisch 1, Brain, Kreiter, Daniël, Drukker, Marjan, Mujagic, Zlatan, Vork, Lisa, Rutten, Bart P F, van Os, Jim, Masclee, Ad A M, Kruimel, Joanna W, and Leue, Carsten

Published
2021

20. IS THE ERA OF CANDIDATE GENES X CANNABIS USE REALLY DEAD?

Author

Quattrone, Diego, Lewis, Cathryn, Richards, Alexander, Vassos, Evangelos, Gayer-Anderson, Charlotte, Ferraro, Laura, Tripoli, Giada, Rutten, Bart, O'Donovan, Michael, Morgan, Craig, Van Os, Jim, Sham, Pak, Reininghaus, Ulrich, Murray, Robin, Forti, Marta Di, Quattrone, Diego, Lewis, Cathryn, Richards, Alexander, Vassos, Evangelo, Gayer-Anderson, Charlotte, Ferraro, Laura, Tripoli, Giada, Rutten, Bart, O'Donovan, Michael, Morgan, Craig, Van Os, Jim, Sham, Pak, Reininghaus, Ulrich, Murray, Robin, and Forti, Marta Di

Subjects
DRD2, psychosis, genes, Settore MED/25 - Psichiatria
Abstract

Background: Historically, gene X environment examinations in psychotic disorders have employed candidate gene methods and environmental determinants impacting on similar biological mechanisms. However, genome wide association studies (GWAS) show that many variants associated with schizophrenia have a modest effect size on risk. In this respect, it is unclear whether the effect of cannabis on psychosis phenotypes is modified by a few genes, e.g. those involved in dopamine signalling, or by the overall genetic susceptibility to schizophrenia. Indeed, candidate gene approaches might be complementary to GWAS to test gene X cannabis interaction. We aimed to investigate the interactive effects of cannabis use on variants in DRD2 gene on: 1) the risk of developing first episode psychosis (FEP); and 2) the frequency of positive symptoms at FEP. We undertook a replication study of previous Gene X Cannabis interactions for DRD2 (rs1076560); further, we tested interactions between cannabis use and any SNP associated with schizophrenia within DRD2 gene in the last Psychiatric Genomics Consortium (PGC) GWAS. Methods: We genotyped ∼830 FEP patients and ∼1200 controls recruited across six countries as part of the large EUGEI study. OPerational CRITeria system and Cannabis Experience Questionnaire were used for evaluating psychopathology and patterns of cannabis use. Dimensions of psychopathology, which included a specific dimension of positive symptoms, were estimated using multidimensional item response modelling in Mplus. We tested for an interaction between risk allele count and daily cannabis use on: 1) the risk of psychotic disorder in the case-control study; 2) the positive symptom dimension in the case-only sample. Only one SNP in DRD2 was significantly associated with schizophrenia in the PGC study, so we tested for interaction with rs2514218, in addition to rs1076560. These regression models, conducted in STATA 14, were adjusted for age, gender, ethnicity, 10 principal components (PC) for population stratification and SNP-environment and SNP-PC interaction terms. Results were corrected for multiple testing of four SNPs (p

Published
2019

21. Microstructural white matter network-connectivity in individuals with psychotic disorder, unaffected siblings and controls

Author

Michielse, Stijn, Rakijo, Kimberley, Peeters, Sanne, Viechtbauer, Wolfgang, van Os, Jim, Marcelis, Machteld, Bruggeman, Richard, Cahn, Wiepke, de Haan, Lieuwe, Kahn, Rene S, Meijer, Carin, Myin-Germeys, Inez, Wiersma, Durk, Section Lifespan Psychology, RS-Research Line Lifespan psychology (part of IIESB program), Neurochirurgie, RS: MHeNs - R3 - Neuroscience, Psychiatrie & Neuropsychologie, RS: MHeNs School for Mental Health and Neuroscience, RS: MHeNs - R2 - Mental Health, and MUMC+: Hersen en Zenuw Centrum (3)

Subjects
Male, CIDI, Composite International Diagnostic Interview, ROI, region of interest, Efficiency, lcsh:RC346-429, 0302 clinical medicine, STRUCTURAL BRAIN NETWORKS, AAL, anatomical atlas labeling, SCHIZOPHRENIA, SIS-r, Structured Interview for Schizotypy –revised, Longitudinal Studies, Connectivity, Positive and Negative Syndrome Scale, 05 social sciences, White matter, Regular Article, Network connectivity, Multilevel regression, medicine.anatomical_structure, Diffusion Tensor Imaging, Neurology, Schizophrenia, Radiology Nuclear Medicine and imaging, lcsh:R858-859.7, Female, Life Sciences & Biomedicine, Psychopathology, Adult, medicine.medical_specialty, Psychosis, CC, clustering coefficient, Cognitive Neuroscience, Clinical Neurology, AP, antipsychotic medication, Neuroimaging, lcsh:Computer applications to medicine. Medical informatics, 050105 experimental psychology, Clustering, 03 medical and health sciences, Young Adult, GE, global efficiency, Internal medicine, medicine, Journal Article, Humans, 0501 psychology and cognitive sciences, Radiology, Nuclear Medicine and imaging, Sibling, PANSS, Positive and Negative Syndrome Scale, lcsh:Neurology. Diseases of the nervous system, Science & Technology, business.industry, Siblings, DWI, diffusion weighted imaging, TRACTOGRAPHY, medicine.disease, INTERVIEW, MODEL, RICH-CLUB ORGANIZATION, Psychotic Disorders, LE, local efficiency, Neurology (clinical), Neurosciences & Neurology, Nerve Net, business, 030217 neurology & neurosurgery, NEGATIVE-SYNDROME-SCALE
Abstract

Background Altered structural network-connectivity has been reported in psychotic disorder but whether these alterations are associated with genetic vulnerability, and/or with phenotypic variation, has been less well examined. This study examined i) whether differences in network-connectivity exist between patients with psychotic disorder, siblings of patients with psychotic disorder and controls, and ii) whether network-connectivity alterations vary with (subclinical) symptomatology. Methods Network-connectivity measures (global efficiency (GE), density, local efficiency (LE), clustering coefficient (CC)) were derived from diffusion weighted imaging (DWI) and were compared between 85 patients with psychotic disorder, 93 siblings without psychotic disorder and 80 healthy comparison subjects using multilevel regression models. In patients, associations between Positive and Negative Syndrome Scale (PANSS) symptoms and topological measures were examined. In addition, interactions between subclinical psychopathology and sibling/healthy comparison subject status were examined in models of topological measures. Results While there was no main effect of group with respect to GE, density, LE and CC, siblings had a significantly higher CC compared to patients (B = 0.0039, p = .002). In patients, none of the PANSS symptom domains were significantly associated with any of the four network-connectivity measures. The two-way interaction between group and SIR-r positive score in the model of LE was significant (χ2 = 6.24, p = .01, df = 1). In the model of CC, the interactions between group and respectively SIS-r positive (χ2 = 5.59, p = .02, df = 1) and negative symptom scores (χ2 = 4.71, p = .03, df = 1) were significant. Stratified analysis showed that, in siblings, decreased LE and CC was significantly associated with increased SIS-r positive scores (LE: B = −0.0049, p = .003, CC: B = −0.0066, p = .01) and that decreased CC was significantly associated with increased SIS-r negative scores (B = −0.012, p = .003). There were no significant interactions between group and SIS-r scores in the models of GE and density. Conclusion The findings indicate absence of structural network-connectivity alterations in individuals with psychotic disorder and in individuals at higher than average genetic risk for psychotic disorder, in comparison with healthy subjects. The differential subclinical symptom-network connectivity associations in siblings with respect to controls may be a sign of psychosis vulnerability in the siblings., Highlights • Patients with psychotic disorder had unchanged network efficiency and clustering. • Siblings of patients had higher clustering coefficient compared to patients. • Lower clustering/efficiency was associated with higher positive symptoms in siblings. • Decreased clustering was associated with increased negative symptoms in siblings.

Published
2019
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22. Network approach of mood and functional gastrointestinal symptom dynamics in relation to childhood trauma in patients with irritable bowel syndrome and comorbid panic disorder

Author

MGGZ, Hersenen-Medisch 1, Brain, Drukker, Marjan, Peters, Jill C H, Vork, Lisa, Mujagic, Zlatan, Rutten, Bart P F, van Os, Jim, Masclee, Ad A M, Kruimel, Joanna W, Leue, Carsten, MGGZ, Hersenen-Medisch 1, Brain, Drukker, Marjan, Peters, Jill C H, Vork, Lisa, Mujagic, Zlatan, Rutten, Bart P F, van Os, Jim, Masclee, Ad A M, Kruimel, Joanna W, and Leue, Carsten

Published
2020

23. Longitudinal evidence for a relation between depressive symptoms and quality of life in schizophrenia using structural equation modeling

Author

van Rooijen, Geeske, van Rooijen, Maaike, Maat, Arija, Vermeulen, Jentien M., Meijer, Carin J., Ruhe, Henricus G., de Haan, Lieuwe, Alizadeh, Behrooz Z., Bartels-Velthuis, Agna A., van Beveren, Nico J., Bruggeman, Richard, Cahn, Wiepke, Delespaul, Philippe, Myin-Germeys, Inez, Kahn, Rene S., Schirmbeck, Frederike, Simons, Claudia J. P., van Amelsvoort, Therese, van Haren, Neeltje E., van Os, Jim, van Winkel, Ruud, Genetic Risk and Outcome of Psychosis (GROUP) Investigators, van Rooijen, Geeske, van Rooijen, Maaike, Maat, Arija, Vermeulen, Jentien M., Meijer, Carin J., Ruhe, Henricus G., de Haan, Lieuwe, Alizadeh, Behrooz Z., Bartels-Velthuis, Agna A., van Beveren, Nico J., Bruggeman, Richard, Cahn, Wiepke, Delespaul, Philippe, Myin-Germeys, Inez, Kahn, Rene S., Schirmbeck, Frederike, Simons, Claudia J. P., van Amelsvoort, Therese, van Haren, Neeltje E., van Os, Jim, van Winkel, Ruud, and Genetic Risk and Outcome of Psychosis (GROUP) Investigators

Published
2019

26. Evidence that self-reported psychotic experiences in children are clinically relevant

Author

Rimvall, Martin K., Gundersen, Steffie, Clemmensen, Lars, Munkholm, Anja, Larsen, Janne Tidselbak, Skovgaard, Anne Mette, Rask, Charlotte Ulrikka, Verhulst, Frank, van Os, Jim, Jeppesen, Pia, Rimvall, Martin K., Gundersen, Steffie, Clemmensen, Lars, Munkholm, Anja, Larsen, Janne Tidselbak, Skovgaard, Anne Mette, Rask, Charlotte Ulrikka, Verhulst, Frank, van Os, Jim, and Jeppesen, Pia

Published
2019

27. Evidence that the association of childhood trauma with psychosis and related psychopathology is not explained by gene-environment correlation : A monozygotic twin differences approach

Author

Lecei, Aleksandra, Decoster, Jeroen, De Hert, Marc, Derom, Catherine, Jacobs, Nele, Menne-Lothmann, Claudia, van Os, Jim, Thiery, Evert, Rutten, Bait P. F., Wichers, Marieke, van Winkel, Ruud, Lecei, Aleksandra, Decoster, Jeroen, De Hert, Marc, Derom, Catherine, Jacobs, Nele, Menne-Lothmann, Claudia, van Os, Jim, Thiery, Evert, Rutten, Bait P. F., Wichers, Marieke, and van Winkel, Ruud

Published
2019

28. Corrigendum to “Long-term course of negative symptom subdomains and relationship with outcome in patients with a psychotic disorder” (Schizophrenia Research (2018) 193 (173–181), (S0920996417303638) (10.1016/j.schres.2017.06.024))

Author

Stiekema, Annemarie P M, Islam, Md Atiqul, Liemburg, Edith J, Castelein, Stynke, van den Heuvel, Edwin R, van Weeghel, Jaap, Aleman, André, Bruggeman, Richard, van der Meer, Lisette, Alizadeh, Behrooz Z, Bartels-Velthuis, Agna A, van Beveren, Nico J, Cahn, Wiepke, de Haan, Lieuwe, Delespaul, Philippe, Meijer, Carin J, Myin-Germeys, Inez, Kahn, Rene S, Schirmbeck, Frederike, Simons, Claudia J P, van Haren, Neeltje E M, van Os, Jim, van Winkel, Ruud, GROUP Investigators, Stiekema, Annemarie P M, Islam, Md Atiqul, Liemburg, Edith J, Castelein, Stynke, van den Heuvel, Edwin R, van Weeghel, Jaap, Aleman, André, Bruggeman, Richard, van der Meer, Lisette, Alizadeh, Behrooz Z, Bartels-Velthuis, Agna A, van Beveren, Nico J, Cahn, Wiepke, de Haan, Lieuwe, Delespaul, Philippe, Meijer, Carin J, Myin-Germeys, Inez, Kahn, Rene S, Schirmbeck, Frederike, Simons, Claudia J P, van Haren, Neeltje E M, van Os, Jim, van Winkel, Ruud, and GROUP Investigators

Published
2019

29. Reward anticipation in individuals with subclinical psychotic experience : A functional MRI approach

Author

Michielse, Stijn, Lange, Iris, Bakker, Jindra, Goossens, Liesbet, Verhagen, Simone, Papalini, Silvia, Wichers, Marieke, Lieverse, Ritsaert, Schruers, Koen, van Amelsvoort, Therese, van Os, Jim, Murray, Graham K., Marcelis, Machteld, Michielse, Stijn, Lange, Iris, Bakker, Jindra, Goossens, Liesbet, Verhagen, Simone, Papalini, Silvia, Wichers, Marieke, Lieverse, Ritsaert, Schruers, Koen, van Amelsvoort, Therese, van Os, Jim, Murray, Graham K., and Marcelis, Machteld

Published
2019

30. European mental health research resources: Picture and recommendations of the ROAMER project

Author

Hazo, Jean-Baptiste, Brunn, Matthias, Wykes, Til, McDaid, David, Dorsey, Maya, Demotes-Mainard, Jacques, van der Feltz-Cornelis, Christina M., Wahlbeck, Kristian, Knappe, Susanne, Meyer-Lindenberg, Andreas, Obradors-Tarrago, Carla, Haro, Josep Maria, Leboyer, Marion, Chevreul, Karine, Robbins, Trevor W., Lewis, Shon, Evans-Lacko, Sara, Belli, Stefano, Bitter, Istvan, Wittchen, Hans-Ulrich, Fiorillo, Andrea, Luciano, Mario, Van Os, Jim, Hazo, Jean-Baptiste, Brunn, Matthias, Wykes, Til, McDaid, David, Dorsey, Maya, Demotes-Mainard, Jacques, van der Feltz-Cornelis, Christina M., Wahlbeck, Kristian, Knappe, Susanne, Meyer-Lindenberg, Andreas, Obradors-Tarrago, Carla, Haro, Josep Maria, Leboyer, Marion, Chevreul, Karine, Robbins, Trevor W., Lewis, Shon, Evans-Lacko, Sara, Belli, Stefano, Bitter, Istvan, Wittchen, Hans-Ulrich, Fiorillo, Andrea, Luciano, Mario, and Van Os, Jim

Published
2019

31. Reward anticipation in individuals with subclinical psychotic experience: A functional MRI approach

Author

Hersenen-Medisch 1, Brain, Michielse, Stijn, Lange, Iris, Bakker, Jindra, Goossens, Liesbet, Verhagen, Simone, Papalini, Silvia, Wichers, Marieke, Lieverse, Ritsaert, Schruers, Koen, van Amelsvoort, Therese, van Os, Jim, Murray, Graham K., Marcelis, Machteld, Hersenen-Medisch 1, Brain, Michielse, Stijn, Lange, Iris, Bakker, Jindra, Goossens, Liesbet, Verhagen, Simone, Papalini, Silvia, Wichers, Marieke, Lieverse, Ritsaert, Schruers, Koen, van Amelsvoort, Therese, van Os, Jim, Murray, Graham K., and Marcelis, Machteld

Published
2019

32. European mental health research resources: Picture and recommendations of the ROAMER project

Author

Hersenen-Medisch 1, Brain, Hazo, Jean-Baptiste, Brunn, Matthias, Wykes, Til, McDaid, David, Dorsey, Maya, Demotes-Mainard, Jacques, van der Feltz-Cornelis, Christina M., Wahlbeck, Kristian, Knappe, Susanne, Meyer-Lindenberg, Andreas, Obradors-Tarrago, Carla, Haro, Josep Maria, Leboyer, Marion, Chevreul, Karine, Robbins, Trevor W., Lewis, Shon, Evans-Lacko, Sara, Belli, Stefano, Bitter, Istvan, Wittchen, Hans-Ulrich, Fiorillo, Andrea, Luciano, Mario, Van Os, Jim, Hersenen-Medisch 1, Brain, Hazo, Jean-Baptiste, Brunn, Matthias, Wykes, Til, McDaid, David, Dorsey, Maya, Demotes-Mainard, Jacques, van der Feltz-Cornelis, Christina M., Wahlbeck, Kristian, Knappe, Susanne, Meyer-Lindenberg, Andreas, Obradors-Tarrago, Carla, Haro, Josep Maria, Leboyer, Marion, Chevreul, Karine, Robbins, Trevor W., Lewis, Shon, Evans-Lacko, Sara, Belli, Stefano, Bitter, Istvan, Wittchen, Hans-Ulrich, Fiorillo, Andrea, Luciano, Mario, and Van Os, Jim

Published
2019

35. Evidence that self-reported psychotic experiences in children are clinically relevant

Author

Hersenen-Medisch 1, Brain, Rimvall, Martin K., Gundersen, Steffie, Clemmensen, Lars, Munkholm, Anja, Larsen, Janne Tidselbak, Skovgaard, Anne Mette, Rask, Charlotte Ulrikka, Verhulst, Frank, van Os, Jim, Jeppesen, Pia, Hersenen-Medisch 1, Brain, Rimvall, Martin K., Gundersen, Steffie, Clemmensen, Lars, Munkholm, Anja, Larsen, Janne Tidselbak, Skovgaard, Anne Mette, Rask, Charlotte Ulrikka, Verhulst, Frank, van Os, Jim, and Jeppesen, Pia

Published
2019

36. Longitudinal evidence for a relation between depressive symptoms and quality of life in schizophrenia using structural equation modeling

Author

Diagnostiek & Vroege Psychose Medisch, Genetica, Onderzoek, Brain, Onderzoeksgroep 11, Onderzoeksgroep 1, Hersenen-Medisch 1, van Rooijen, Geeske, van Rooijen, Maaike, Maat, Arija, Vermeulen, Jentien M., Meijer, Carin J., Ruhe, Henricus G., de Haan, Lieuwe, Alizadeh, Behrooz Z., Bartels-Velthuis, Agna A., van Beveren, Nico J., Bruggeman, Richard, Cahn, Wiepke, Delespaul, Philippe, Myin-Germeys, Inez, Kahn, Rene S., Schirmbeck, Frederike, Simons, Claudia J. P., van Amelsvoort, Therese, van Haren, Neeltje E., van Os, Jim, van Winkel, Ruud, Genetic Risk and Outcome of Psychosis (GROUP) Investigators, Diagnostiek & Vroege Psychose Medisch, Genetica, Onderzoek, Brain, Onderzoeksgroep 11, Onderzoeksgroep 1, Hersenen-Medisch 1, van Rooijen, Geeske, van Rooijen, Maaike, Maat, Arija, Vermeulen, Jentien M., Meijer, Carin J., Ruhe, Henricus G., de Haan, Lieuwe, Alizadeh, Behrooz Z., Bartels-Velthuis, Agna A., van Beveren, Nico J., Bruggeman, Richard, Cahn, Wiepke, Delespaul, Philippe, Myin-Germeys, Inez, Kahn, Rene S., Schirmbeck, Frederike, Simons, Claudia J. P., van Amelsvoort, Therese, van Haren, Neeltje E., van Os, Jim, van Winkel, Ruud, and Genetic Risk and Outcome of Psychosis (GROUP) Investigators

Published
2019

37. Corrigendum to “Long-term course of negative symptom subdomains and relationship with outcome in patients with a psychotic disorder” (Schizophrenia Research (2018) 193 (173–181), (S0920996417303638) (10.1016/j.schres.2017.06.024))

Author

Affectieve & Psychotische Med., Onderzoek, Brain, Onderzoeksgroep 11, Onderzoeksgroep 1, Onderzoeksgroep 4, Hersenen-Medisch 1, Stiekema, Annemarie P M, Islam, Md Atiqul, Liemburg, Edith J, Castelein, Stynke, van den Heuvel, Edwin R, van Weeghel, Jaap, Aleman, André, Bruggeman, Richard, van der Meer, Lisette, Alizadeh, Behrooz Z, Bartels-Velthuis, Agna A, van Beveren, Nico J, Cahn, Wiepke, de Haan, Lieuwe, Delespaul, Philippe, Meijer, Carin J, Myin-Germeys, Inez, Kahn, Rene S, Schirmbeck, Frederike, Simons, Claudia J P, van Haren, Neeltje E M, van Os, Jim, van Winkel, Ruud, GROUP Investigators, Affectieve & Psychotische Med., Onderzoek, Brain, Onderzoeksgroep 11, Onderzoeksgroep 1, Onderzoeksgroep 4, Hersenen-Medisch 1, Stiekema, Annemarie P M, Islam, Md Atiqul, Liemburg, Edith J, Castelein, Stynke, van den Heuvel, Edwin R, van Weeghel, Jaap, Aleman, André, Bruggeman, Richard, van der Meer, Lisette, Alizadeh, Behrooz Z, Bartels-Velthuis, Agna A, van Beveren, Nico J, Cahn, Wiepke, de Haan, Lieuwe, Delespaul, Philippe, Meijer, Carin J, Myin-Germeys, Inez, Kahn, Rene S, Schirmbeck, Frederike, Simons, Claudia J P, van Haren, Neeltje E M, van Os, Jim, van Winkel, Ruud, and GROUP Investigators

Published
2019

38. Evidence that the association of childhood trauma with psychosis and related psychopathology is not explained by gene-environment correlation: A monozygotic twin differences approach

Author

Hersenen-Medisch 1, Brain, Lecei, Aleksandra, Decoster, Jeroen, De Hert, Marc, Derom, Catherine, Jacobs, Nele, Menne-Lothmann, Claudia, van Os, Jim, Thiery, Evert, Rutten, Bart P.F., Wichers, Marieke, van Winkel, Ruud, Hersenen-Medisch 1, Brain, Lecei, Aleksandra, Decoster, Jeroen, De Hert, Marc, Derom, Catherine, Jacobs, Nele, Menne-Lothmann, Claudia, van Os, Jim, Thiery, Evert, Rutten, Bart P.F., Wichers, Marieke, and van Winkel, Ruud

Published
2019

39. A state-independent network of depressive, negative and positive symptoms in male patients with schizophrenia spectrum disorders

Author

van Rooijen, Geeske, Isvoranu, Adela Maria, Kruijt, Olle H., van Borkulo, Claudia D., Meijer, Carin, Wigman, Johanna T.W., Ruhé, Henricus G., de Haan, Lieuwe, Bruggeman, Richard, Cahn, Wiepke, Kahn, René S., Myin-Germeys, Inez, van Os, Jim, Bartels-Velthuis, Agna A., Genetic Risk and Outcome of Psychosis investigators, GROUP investigators, van Rooijen, Geeske, Isvoranu, Adela Maria, Kruijt, Olle H., van Borkulo, Claudia D., Meijer, Carin, Wigman, Johanna T.W., Ruhé, Henricus G., de Haan, Lieuwe, Bruggeman, Richard, Cahn, Wiepke, Kahn, René S., Myin-Germeys, Inez, van Os, Jim, Bartels-Velthuis, Agna A., Genetic Risk and Outcome of Psychosis investigators, and GROUP investigators

Published
2018

40. A state-independent network of depressive, negative and positive symptoms in male patients with schizophrenia spectrum disorders

Author

Affectieve & Psychotische Med., Onderzoek, Brain, Onderzoeksgroep 11, van Rooijen, Geeske, Isvoranu, Adela Maria, Kruijt, Olle H., van Borkulo, Claudia D., Meijer, Carin, Wigman, Johanna T.W., Ruhé, Henricus G., de Haan, Lieuwe, Bruggeman, Richard, Cahn, Wiepke, Kahn, René S., Myin-Germeys, Inez, van Os, Jim, Bartels-Velthuis, Agna A., Genetic Risk and OUtcome of Psychosis investigators, GROUP Investigators, Affectieve & Psychotische Med., Onderzoek, Brain, Onderzoeksgroep 11, van Rooijen, Geeske, Isvoranu, Adela Maria, Kruijt, Olle H., van Borkulo, Claudia D., Meijer, Carin, Wigman, Johanna T.W., Ruhé, Henricus G., de Haan, Lieuwe, Bruggeman, Richard, Cahn, Wiepke, Kahn, René S., Myin-Germeys, Inez, van Os, Jim, Bartels-Velthuis, Agna A., Genetic Risk and OUtcome of Psychosis investigators, and GROUP Investigators

Published
2018

41. Association between schizophrenia and common variation in neurocan (NCAN), a genetic risk factor for bipolar disorder

Author

Mühleisen, Thomas W, Mattheisen, Manuel, Rivandeneira, Fernando, Hofman, Albert, Uitterlinden, André G, Moebus, Susanne, Gieger, Christian, Emeny, Rebecca, Ladwig, Karl-Heinz, Wichmann, H-Erich, Schwarz, Markus, Kammerer-Ciernioch, Jutta, Strohmaier, Jana, Schlösser, Ralf G M, Nenadic, Igor, Sauer, Heinrich, Mössner, Rainald, Maier, Wolfgang, Rujescu, Dan, Lange, Christoph, Ophoff, Roel A, Schulze, Thomas G, Rietschel, Marcella, Degenhardt, Franziska, Nöthen, Markus M, Priebe, Lutz, Schultz, C Christoph, Kahn, René S, Linszen, Don H, van Os, Jim, Wiersma, Durk, Bruggeman, Richard, Cahn, Wiepke, de Haan, Lieuwe, Krabbendam, Lydia, Myin-Germeys, Inez, Breuer, René, Wichmann, H -Erich, Breuer, Rene, Meier, Sandra, Hoffmann, Per, Cichon, Sven, Investigators, GROUP, Psychiatrie & Neuropsychologie, RS: MHeNs School for Mental Health and Neuroscience, Adult Psychiatry, Amsterdam Neuroscience, Epidemiology, and Internal Medicine

Subjects
Oncology, NCAN protein, human, medicine.medical_specialty, Bipolar Disorder, Genotype, Psychotic disorder, Medizin, Genetic overlap, Genome-wide association study, Nerve Tissue Proteins, Polymorphism, Single Nucleotide, Hippocampus, Association, 03 medical and health sciences, 0302 clinical medicine, Gene Frequency, Neurocan, Internal medicine, Genetic variation, mental disorders, medicine, Humans, genetics [Schizophrenia], Genetic Predisposition to Disease, Lectins, C-Type, ddc:610, Bipolar disorder, Risk factor, genetics [Nerve Tissue Proteins], Biological Psychiatry, genetics [Lectins, C-Type], 030304 developmental biology, Genetics, genetics [Chondroitin Sulfate Proteoglycans], 0303 health sciences, Case-control study, Odds ratio, medicine.disease, Psychiatry and Mental health, Manic depression, Chondroitin Sulfate Proteoglycans, Schizophrenia, Case-Control Studies, Cortex, Psychology, genetics [Bipolar Disorder], 030217 neurology & neurosurgery
Abstract

A recent study found genome-wide significant association between common variation in the gene neurocan (NCAN, rs1064395) and bipolar disorder (BD). In view of accumulating evidence that BD and schizophrenia partly share genetic risk factors, we tested this single-nucleotide polymorphism for association with schizophrenia in three independent patient-control samples of European ancestry, totaling 5061 patients and 9655 controls. The rs1064395 A-allele, which confers risk for BD, was significantly over-represented in schizophrenia patients compared to controls (p=2.28x10(-3); odds ratio=1.11). Follow-up in non-overlapping samples from the Schizophrenia Psychiatric GWAS Consortium (5537 patients, 8043 controls) provided further support for our finding (p=0.0239, odds ratio=1.07). Our data suggest that genetic variation in NCAN is a common risk factor for BD and schizophrenia. (C) 2012 Elsevier B.V. All rights reserved.

Published
2012
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42. Developmental course of subclinical positive and negative psychotic symptoms and their associations with genetic risk status and impairment

Author

Janssens, Mayke, Boyette, Lindy Lou, Heering, Henriëtte D., Bartels-Velthuis, Agna A., Lataster, Tineke, Kahn, René S., de Haan, Lieuwe, van Os, Jim, Wiersma, Durk, Bruggeman, Richard, Cahn, Wiepke, Meijer, Carin, Myin-Germeys, Inez, Janssens, Mayke, Boyette, Lindy Lou, Heering, Henriëtte D., Bartels-Velthuis, Agna A., Lataster, Tineke, Kahn, René S., de Haan, Lieuwe, van Os, Jim, Wiersma, Durk, Bruggeman, Richard, Cahn, Wiepke, Meijer, Carin, and Myin-Germeys, Inez

Published
2016

43. Prevalence and classification of hallucinations in multiple sensory modalities in schizophrenia spectrum disorders

Author

Lim, Anastasia, Hoek, Hans W., Deen, Mathijs L., Blom, Jan Dirk, Bruggeman, Richard, Cahn, Wiepke, de Haan, Lieuwe, Kahn, René S., Meijer, Carin J., Myin-Germeys, Inez, van Os, Jim, Wiersma, Durk, Lim, Anastasia, Hoek, Hans W., Deen, Mathijs L., Blom, Jan Dirk, Bruggeman, Richard, Cahn, Wiepke, de Haan, Lieuwe, Kahn, René S., Meijer, Carin J., Myin-Germeys, Inez, van Os, Jim, and Wiersma, Durk

Published
2016

44. Developmental course of subclinical positive and negative psychotic symptoms and their associations with genetic risk status and impairment

Author

UMC Utrecht, Brain, Affectieve & Psychotische Med., Janssens, Mayke, Boyette, Lindy Lou, Heering, Henriëtte D., Bartels-Velthuis, Agna A., Lataster, Tineke, Kahn, René S., de Haan, Lieuwe, van Os, Jim, Wiersma, Durk, Bruggeman, Richard, Cahn, Wiepke, Meijer, Carin, Myin-Germeys, Inez, UMC Utrecht, Brain, Affectieve & Psychotische Med., Janssens, Mayke, Boyette, Lindy Lou, Heering, Henriëtte D., Bartels-Velthuis, Agna A., Lataster, Tineke, Kahn, René S., de Haan, Lieuwe, van Os, Jim, Wiersma, Durk, Bruggeman, Richard, Cahn, Wiepke, Meijer, Carin, and Myin-Germeys, Inez

Published
2016

45. Prevalence and classification of hallucinations in multiple sensory modalities in schizophrenia spectrum disorders

Author

UMC Utrecht, Affectieve & Psychotische Med., Brain, Lim, Anastasia, Hoek, Hans W., Deen, Mathijs L., Blom, Jan Dirk, Bruggeman, Richard, Cahn, Wiepke, de Haan, Lieuwe, Kahn, René S., Meijer, Carin J., Myin-Germeys, Inez, van Os, Jim, Wiersma, Durk, UMC Utrecht, Affectieve & Psychotische Med., Brain, Lim, Anastasia, Hoek, Hans W., Deen, Mathijs L., Blom, Jan Dirk, Bruggeman, Richard, Cahn, Wiepke, de Haan, Lieuwe, Kahn, René S., Meijer, Carin J., Myin-Germeys, Inez, van Os, Jim, and Wiersma, Durk

Published
2016

46. Emotion processing in schizophrenia is state and trait dependent

Author

Maat, Arija, van Montfort, Simone J T, de Nijs, Jessica, Derks, Eske M, Kahn, René S, Linszen, Don H, van Os, Jim, Wiersma, Durk, Bruggeman, Richard, Cahn, Wiepke, de Haan, Lieuwe, Krabbendam, Lydia, Myin-Germeys, Inez, Maat, Arija, van Montfort, Simone J T, de Nijs, Jessica, Derks, Eske M, Kahn, René S, Linszen, Don H, van Os, Jim, Wiersma, Durk, Bruggeman, Richard, Cahn, Wiepke, de Haan, Lieuwe, Krabbendam, Lydia, and Myin-Germeys, Inez

Published
2015

47. Emotion processing in schizophrenia is state and trait dependent

Author

Affectieve & Psychotische Med., Brain, Onderzoek Brain at Risk, Onderzoek, Maat, Arija, van Montfort, Simone J T, de Nijs, Jessica, Derks, Eske M, Kahn, René S, Linszen, Don H, van Os, Jim, Wiersma, Durk, Bruggeman, Richard, Cahn, Wiepke, de Haan, Lieuwe, Krabbendam, Lydia, Myin-Germeys, Inez, Affectieve & Psychotische Med., Brain, Onderzoek Brain at Risk, Onderzoek, Maat, Arija, van Montfort, Simone J T, de Nijs, Jessica, Derks, Eske M, Kahn, René S, Linszen, Don H, van Os, Jim, Wiersma, Durk, Bruggeman, Richard, Cahn, Wiepke, de Haan, Lieuwe, Krabbendam, Lydia, and Myin-Germeys, Inez

Published
2015

48. National funding for mental health research in Finland, France, Spain and the United Kingdom

Author

Hazo, Jean-Baptiste, Gandré, Coralie, Leboyer, Marion, Obradors-Tarragó, Carla, Belli, Stefano, McDaid, David, Park, A-La, Maliandi, Maria, Wahlbeck, Kristian, Wykes, Til, van Os, Jim, Haro, Josep Maria, Chevreul, Karine, Hazo, Jean-Baptiste, Gandré, Coralie, Leboyer, Marion, Obradors-Tarragó, Carla, Belli, Stefano, McDaid, David, Park, A-La, Maliandi, Maria, Wahlbeck, Kristian, Wykes, Til, van Os, Jim, Haro, Josep Maria, and Chevreul, Karine

Abstract

As part of the Roamer project, we aimed at revealing the share of health research budgets dedicated to mental health, as well as on the amounts allocated to such research for four European countries. Finland, France, Spain and the United Kingdom national public and non-profit funding allocated to mental health research in 2011 were investigated using, when possible, bottom-up approaches. Specifics of the data collection varied from country to country. The total amount of public and private not for profit mental health research funding for Finland, France, Spain and the UK was €10·2, €84·8, €16·8, and €127·6 million, respectively. Charities accounted for a quarter of the funding in the UK and less than six per cent elsewhere. The share of health research dedicated to mental health ranged from 4·0% in the UK to 9·7% in Finland. When compared to the DALY attributable to mental disorders, Spain, France, Finland, and the UK invested respectively €12·5, €31·2, €39·5, and €48·7 per DALY. Among these European countries, there is an important gap between the level of mental health research funding and the economic and epidemiologic burden of mental disorders.

49. Collaborative outcomes study on health and functioning during infection times (COH-FIT): Insights on modifiable and non-modifiable risk and protective factors for wellbeing and mental health during the COVID-19 pandemic from multivariable and network analyses.

Author

Solmi M, Thompson T, Cortese S, Estradé A, Agorastos A, Radua J, Dragioti E, Vancampfort D, Thygesen LC, Aschauer H, Schlögelhofer M, Aschauer E, Schneeberger A, Huber CG, Hasler G, Conus P, Cuénod KQD, von Känel R, Arrondo G, Fusar-Poli P, Gorwood P, Llorca PM, Krebs MO, Scanferla E, Kishimoto T, Rabbani G, Skonieczna-Żydecka K, Brambilla P, Favaro A, Takamiya A, Zoccante L, Colizzi M, Bourgin J, Kamiński K, Moghadasin M, Seedat S, Matthews E, Wells J, Vassilopoulou E, Gadelha A, Su KP, Kwon JS, Kim M, Lee TY, Papsuev O, Manková D, Boscutti A, Gerunda C, Saccon D, Righi E, Monaco F, Croatto G, Cereda G, Demurtas J, Brondino N, Veronese N, Enrico P, Politi P, Ciappolino V, Pfennig A, Bechdolf A, Meyer-Lindenberg A, Kahl KG, Domschke K, Bauer M, Koutsouleris N, Winter S, Borgwardt S, Bitter I, Balazs J, Czobor P, Unoka Z, Mavridis D, Tsamakis K, Bozikas VP, Tunvirachaisakul C, Maes M, Rungnirundorn T, Supasitthumrong T, Haque A, Brunoni AR, Costardi CG, Schuch FB, Polanczyk G, Luiz JM, Fonseca L, Aparicio LV, Valvassori SS, Nordentoft M, Vendsborg P, Hoffmann SH, Sehli J, Sartorius N, Heuss S, Guinart D, Hamilton J, Kane J, Rubio J, Sand M, Koyanagi A, Solanes A, Andreu-Bernabeu A, Cáceres ASJ, Arango C, Díaz-Caneja CM, Hidalgo-Mazzei D, Vieta E, Gonzalez-Peñas J, Fortea L, Parellada M, Fullana MA, Verdolini N, Andrlíková E, Janků K, Millan MJ, Honciuc M, Moniuszko-Malinowska A, Łoniewski I, Samochowiec J, Kiszkiel Ł, Marlicz M, Sowa P, Marlicz W, Spies G, Stubbs B, Firth J, Sullivan S, Darcin AE, Aksu H, Dilbaz N, Noyan O, Kitazawa M, Kurokawa S, Tazawa Y, Anselmi A, Cracco C, Machado AI, Estrade N, De Leo D, Curtis J, Berk M, Carvalho AF, Ward P, Teasdale S, Rosenbaum S, Marx W, Horodnic AV, Oprea L, Alexinschi O, Ifteni P, Turliuc S, Ciuhodaru T, Bolos A, Matei V, Nieman DH, Sommer I, van Os J, van Amelsvoort T, Sun CF, Guu TW, Jiao C, Zhang J, Fan J, Zou L, Yu X, Chi X, de Timary P, van Winkel R, Ng B, Peña de León E, Arellano R, Roman R, Sanchez T, Movina L, Morgado P, Brissos S, Aizberg O, Mosina A, Krinitski D, Mugisha J, Sadeghi-Bahmani D, Sheybani F, Sadeghi M, Hadi S, Brand S, Errazuriz A, Crossley N, Ristic DI, López-Jaramillo C, Efthymiou D, Kuttichira P, Kallivayalil RA, Javed A, Afridi MI, James B, Seb-Akahomen OJ, Fiedorowicz J, Daskalakis J, Yatham LN, Yang L, Okasha T, Dahdouh A, Tiihonen J, Shin JI, Lee J, Mhalla A, Gaha L, Brahim T, Altynbekov K, Negay N, Nurmagambetova S, Jamei YA, Weiser M, and Correll CU

Subjects
Humans, Female, Male, Adult, Middle Aged, Risk Factors, Young Adult, Aged, Pandemics, Multivariate Analysis, COVID-19 epidemiology, COVID-19 psychology, COVID-19 prevention & control, Mental Health, Protective Factors
Abstract

There is no multi-country/multi-language study testing a-priori multivariable associations between non-modifiable/modifiable factors and validated wellbeing/multidimensional mental health outcomes before/during the COVID-19 pandemic. Moreover, studies during COVID-19 pandemic generally do not report on representative/weighted non-probability samples. The Collaborative Outcomes study on Health and Functioning during Infection Times (COH-FIT) is a multi-country/multi-language survey conducting multivariable/LASSO-regularized regression models and network analyses to identify modifiable/non-modifiable factors associated with wellbeing (WHO-5)/composite psychopathology (P-score) change. It enrolled general population-representative/weighted-non-probability samples (26/04/2020-19/06/2022). Participants included 121,066 adults (age=42±15.9 years, females=64 %, representative sample=29 %) WHO-5/P-score worsened (SMD=0.53/SMD=0.74), especially initially during the pandemic. We identified 15 modifiable/nine non-modifiable risk and 13 modifiable/three non-modifiable protective factors for WHO-5, 16 modifiable/11 non-modifiable risk and 10 modifiable/six non-modifiable protective factors for P-score. The 12 shared risk/protective factors with highest centrality (network-analysis) were, for non-modifiable factors, country income, ethnicity, age, gender, education, mental disorder history, COVID-19-related restrictions, urbanicity, physical disorder history, household room numbers and green space, and socioeconomic status. For modifiable factors, we identified medications, learning, internet, pet-ownership, working and religion as coping strategies, plus pre-pandemic levels of stress, fear, TV, social media or reading time, and COVID-19 information. In multivariable models, for WHO-5, additional non-modifiable factors with |B|>1 were income loss, COVID-19 deaths. For modifiable factors we identified pre-pandemic levels of social functioning, hobbies, frustration and loneliness, and social interactions as coping strategy. For P-scores, additional non-modifiable/modifiable factors were income loss, pre-pandemic infection fear, and social interactions as coping strategy. COH-FIT identified vulnerable sub-populations and actionable individual/environmental factors to protect well-being/mental health during crisis times. Results inform public health policies, and clinical practice., Competing Interests: Conflict of interest Conflict of interest statements of all authors are detailed in eTable 12., (Copyright © 2024. Published by Elsevier B.V.)

Published
2025
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50. Collaborative Outcomes Study on Health and Functioning During Infection Times (COH-FIT): Global and Risk-Group Stratified Course of Well-Being and Mental Health During the COVID-19 Pandemic in Adolescents.

Author

Solmi M, Thompson T, Cortese S, Estradé A, Agorastos A, Radua J, Dragioti E, Vancampfort D, Thygesen LC, Aschauer H, Schlögelhofer M, Aschauer E, Schneeberger AA, Huber CG, Hasler G, Conus P, Do Cuénod KQ, von Känel R, Arrondo G, Fusar-Poli P, Gorwood P, Llorca PM, Krebs MO, Scanferla E, Kishimoto T, Rabbani G, Skonieczna-Żydecka K, Brambilla P, Favaro A, Takamiya A, Zoccante L, Colizzi M, Bourgin J, Kamiński K, Moghadasin M, Seedat S, Matthews E, Wells J, Vassilopoulou E, Gadelha A, Su KP, Kwon JS, Kim M, Lee TY, Papsuev O, Manková D, Boscutti A, Gerunda C, Saccon D, Righi E, Monaco F, Croatto G, Cereda G, Demurtas J, Brondino N, Veronese N, Enrico P, Politi P, Ciappolino V, Pfennig A, Bechdolf A, Meyer-Lindenberg A, Kahl KG, Domschke K, Bauer M, Koutsouleris N, Winter S, Borgwardt S, Bitter I, Balazs J, Czobor P, Unoka Z, Mavridis D, Tsamakis K, Bozikas VP, Tunvirachaisakul C, Maes M, Rungnirundorn T, Supasitthumrong T, Haque A, Brunoni AR, Costardi CG, Schuch FB, Polanczyk G, Luiz JM, Fonseca L, Aparicio LV, Valvassori SS, Nordentoft M, Vendsborg P, Hoffmann SH, Sehli J, Sartorius N, Heuss S, Guinart D, Hamilton J, Kane J, Rubio J, Sand M, Koyanagi A, Solanes A, Andreu-Bernabeu A, San José Cáceres A, Arango C, Díaz-Caneja CM, Hidalgo-Mazzei D, Vieta E, Gonzalez-Peñas J, Fortea L, Parellada M, Fullana MA, Verdolini N, Andrlíková E, Janků K, Millan MJ, Honciuc M, Moniuszko-Malinowska A, Łoniewski I, Samochowiec J, Kiszkiel Ł, Marlicz M, Sowa P, Marlicz W, Spies G, Stubbs B, Firth J, Sullivan S, Darcin AE, Aksu H, Dilbaz N, Noyan O, Kitazawa M, Kurokawa S, Tazawa Y, Anselmi A, Cracco C, Machado AI, Estrade N, De Leo D, Curtis J, Berk M, Carvalho AF, Ward P, Teasdale S, Rosenbaum S, Marx W, Horodnic AV, Oprea L, Alexinschi O, Ifteni P, Turliuc S, Ciuhodaru T, Bolos A, Matei V, Nieman DH, Sommer I, van Os J, van Amelsvoort T, Sun CF, Guu TW, Jiao C, Zhang J, Fan J, Zou L, Yu X, Chi X, de Timary P, van Winkel R, Ng B, Pena E, Arellano R, Roman R, Sanchez T, Movina L, Morgado P, Brissos S, Aizberg O, Mosina A, Krinitski D, Mugisha J, Sadeghi-Bahmani D, Sheybani F, Sadeghi M, Hadi S, Brand S, Errazuriz A, Crossley N, Ristic DI, López-Jaramillo C, Efthymiou D, Kuttichira P, Kallivayalil RA, Javed A, Afridi MI, James B, Seb-Akahomen OJ, Fiedorowicz J, Daskalakis J, Yatham LN, Yang L, Okasha T, Dahdouh A, Tiihonen J, Shin JI, Lee J, Mhalla A, Gaha L, Brahim T, Altynbekov K, Negay N, Nurmagambetova S, Jamei YA, Weiser M, and Correll CU

Abstract

Objective: To identify the COVID-19 pandemic impact on well-being/mental health, coping strategies, and risk factors in adolescents worldwide., Method: This study was based on an anonymous online multi-national/multi-language survey in the general population (representative/weighted non-representative samples, 14-17 years of age), measuring change in well-being (World Health Organization-Five Well-Being Index [WHO-5]/range = 0-100) and psychopathology (validated composite P-score/range = 0-100), WHO-5 <50 and <29, pre- vs during COVID-19 pandemic (April 26, 2020-June 26, 2022). Coping strategies and 9 a priori- defined individual/cumulative risk factors were measured. A χ 2 , penalized cubic splines, linear regression, and correlation analyses were conducted., Results: Analyzing 8,115 of 8,762 initiated surveys (representative = 75.1%), the pre-pandemic WHO-5 and P-score remained stable during the study (excluding relevant recall bias/drift), but worsened during the pandemic by 5.55 ± 17.13 (SD) and 6.74 ± 16.06 points, respectively (effect size d = 0.27 and d = 0.28). The proportion of adolescents with WHO-5 scores suggesting depression screening (<50) and major depression (<29) increased from 9% to 17% and 2% to 6%. WHO-5 worsened (descending magnitude, with cumulative effect) in adolescents with a mental or physical disorder, female gender, and with school closure. Results were similar for the P-score, with the exception of school closure (not significant) and living in a low-income country, as well as not living in a large city (significant). Changes were significantly but minimally related to COVID-19 deaths/restrictions, returning to near-pre-pandemic values after >2 years. The 3 most subjectively effective coping strategies were Internet use, exercise/walking, and social contacts., Conclusion: Overall, well-being/mental health worsened (small effect sizes) during the early stages of the COVID-19 pandemic, especially in vulnerable subpopulations. Identified at-risk groups, association with pandemic-related measures, and coping strategies can inform individual behaviors and global public health strategies., Study Preregistration Information: Physical and mental health impact of COVID-19 on children, adolescents, and their families: The Collaborative Outcomes study on Health and Functioning during Infection Times - Children and Adolescents (COH-FIT-C&A); https://doi.org/10.1016/j.jad.2021.09.090 DIVERSITY & INCLUSION STATEMENT: We worked to ensure sex and gender balance in the recruitment of human participants. We worked to ensure race, ethnic, and/or other types of diversity in the recruitment of human participants. We worked to ensure that the study questionnaires were prepared in an inclusive way. The author list of this paper includes contributors from the location and/or community where the research was conducted who participated in the data collection, design, analysis, and/or interpretation of the work. We actively worked to promote inclusion of historically underrepresented racial and/or ethnic groups in science in our author group. We actively worked to promote sex and gender balance in our author group. One or more of the authors of this paper self-identifies as a member of one or more historically underrepresented racial and/or ethnic groups in science., (Copyright © 2024 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved.)

Published
2024
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