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Your search keyword '"di Girolamo, F. G."' showing total 2 results
Start Over Author "di Girolamo, F. G." Publisher elsevier
2 results on '"di Girolamo, F. G."'

1. First international meeting of early career investigators

Author

Joop Jonckheer, Tim Friede, Albert Albay, Sebastián Pablo Chapela, Mette M. Berger, Robert G. Martindale, Maria Eloisa Garcia Velasquez, Robert van Gassel, Christian Stoppe, Sanit Wichansawakun, Filippo Giorgio Di Girolamo, Faculty of Medicine and Pharmacy, Intensive Care, Surgery, RS: NUTRIM - R2 - Liver and digestive health, Stoppe, C., van Gassel, R., Jonckheer, J., Garcia Velasquez, M. E., Di Girolamo, F. G., Chapela, S. P., Wichansawakum, S., Albay, A., Friede, T., Martindale, R., and Berger, M. M.

Subjects
0301 basic medicine, RANDOMIZED CONTROLLED-TRIALS, ILL PATIENTS, Critical Illness, Endocrinology, Diabetes and Metabolism, Care nutrition, Nutritional Status, nutritional support, parenteral nutrition, 030209 endocrinology & metabolism, 03 medical and health sciences, Enteral Nutrition, 0302 clinical medicine, LONG-TERM OUTCOMES, Nursing, Intervention (counseling), Intensive care, EARLY ENTERAL NUTRITION, INDIRECT CALORIMETRY, SUPPORT, Humans, enteral nutrition, Medicine, Early career, 2. Zero hunger, 030109 nutrition & dietetics, Nutrition and Dietetics, Critical care, Enteral nutrition, Nutritional support, Parenteral nutrition, Nutritional Support, Critical Care, business.industry, BODY PROTEIN-TURNOVER, medicine.disease, 3. Good health, critical care, Clinical trial, Nutritional Statu, Malnutrition, Clinical research, SUPPLEMENTAL PARENTERAL-NUTRITION, 13. Climate action, ICU, Critical Illne, ENERGY-BALANCE, business, Human
Abstract

Background: Appropriate nutritional support is a key component of care for critically ill patients. While malnutrition increases complications, impacting long term outcomes and healthcare-related costs, uncertainties persist regarding optimal provision of nutritional support in this setting.Methods: An international group of healthcare providers (HCPs) from critical care specialties and nutrition researchers convened to identify knowledge gaps and learnings from studies in critical care nutrition. Clinical research needs were identified in order to better inform future nutrition practices.Results: Challenges in critical care nutrition arise, in part, from inconsistent outcomes in several large-scale studies regarding the optimal amount of calories and protein to prescribe, the optimal time to initiate nutritional support and the role of parental nutrition to support critically ill patients. Furthermore, there is uncertainty on how best to identify patients at nutritional risk, and the appropriate outcome measures for ICU nutrition studies. Given HCPs have a suboptimal evidence base to inform the nutritional management of critically ill patients, further well-designed clinical trials capturing clinically relevant endpoints are needed to address these knowledge gaps.Conclusions: The identified aspects for future research could be addressed in studies designed and conducted in collaboration with an international team of interdisciplinary nutrition experts. The aim of this collaboration is to address the unmet need for robust clinical data needed to develop high-quality evidence-based nutritional intervention recommendations to better inform the future management of critically ill patients. (C) 2020 The Authors. Published by Elsevier Ltd on behalf of European Society for Clinical Nutrition and Metabolism. This is an open access article under the CC BY license.

Published
2020
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2. Amino acid supplementation in l-dopa treated Parkinson's disease patients.

Author

Cucca A, Mazzucco S, Bursomanno A, Antonutti L, Di Girolamo FG, Pizzolato G, Koscica N, Gigli GL, Catalan M, and Biolo G

Subjects
Aged, Aged, 80 and over, Blood Glucose metabolism, C-Reactive Protein metabolism, Cholesterol, HDL blood, Cholesterol, LDL blood, Double-Blind Method, Female, Glutathione metabolism, Humans, Insulin blood, Insulin Resistance, Male, Middle Aged, Nutrition Assessment, Oxidative Stress, Pilot Projects, Prospective Studies, Treatment Outcome, Triglycerides blood, Amino Acids administration & dosage, Diet, Protein-Restricted, Dietary Supplements, Levodopa administration & dosage, Parkinson Disease drug therapy
Abstract

Background: The correlation between Parkinson disease and malnutrition is well established, however a protein-restricted diet is usually prescribed because of potentially negative interactions between dietary amino acids and l-dopa pharmacokinetics. This strategy could increase the risk of further nutritional deficits., Methods: A monocentric, prospective, randomized, double-blind pilot study was performed on two groups of Parkinson-affected, protein-restricted, patients: Intervention (n = 7; amino acid supplementation twice daily) and Placebo (n = 7; placebo supplementation twice daily). At enrolment, after 3- and 6-month supplementation, neurological evaluations (UPDRS III, Hoenh-Yahr scale, l-dopa equivalent dose assessment) were performed and blood sample was collected to define insulin sensitivity (QUICKI index) and oxidative stress (oxidized and reduced glutathione). Repeated measure ANCOVA was applied to define time effect and time × treatment interaction., Results: Participants were comparable at baseline for all assessed parameters. Neurological outcomes and l-dopa requirement were comparable in both group after 6-month of supplementation, without time × treatment interaction. The decrease in insulin sensitivity, as assessed by QUICKI index, observed after 6 months in both groups, was greater in Placebo than in Intervention (time effect p < 0.001; time × treatment interaction p = 0.01). Moreover, despite no changes in total erythrocyte glutathione concentrations, oxidized glutathione levels decreased by 28 ± 17% in the Intervention while increased by 55 ± 38% in Placebo (time effect p = 0.05; time × treatment interaction p = 0.05), after 6-month supplementation., Conclusions: Amino acid supplementation, assumed with shrewd temporal distribution, did not show detrimental effects on neurological and pharmacological control in protein-restricted Parkinson-affected patients, chronically treated with l-dopa. Furthermore, daily amino acid supplementation partially counteracted insulin resistance development and the loss in antioxidant availability., (Copyright © 2015 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.)

Published
2015
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