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Your search keyword '"de la Luna, Susana"' showing total 5 results
Start Over Author "de la Luna, Susana" Publisher elsevier
5 results on '"de la Luna, Susana"'

1. List of Contributors

Author

ALLEN, MARIE, primary, ALTING-MEES, MICHELLE A., additional, JOSÉ AYALA, FRANCISCO, additional, BÄHRING, SILVIA, additional, BANKIER, ALAN T., additional, BARRELL, BARCLAY G., additional, BAUER, STEVEN R., additional, BECK, STEPHAN, additional, BECKER-ANDRÉ, MICHAEL, additional, BEHR, JEAN-PAUL, additional, BHAGWAT, ASHOK S., additional, BHARUCHA, ADI D., additional, BIRNBOIM, H.C., additional, BOTTEMA, CYNTHIA D.K., additional, BOTTERMAN, JOHAN, additional, BRONSTEIN, IRENA, additional, BROWN, CAROL M., additional, BULL, MICHAEL, additional, CAI, ZELING, additional, CASSADY, JOSLYN D., additional, CATE, RICHARD L., additional, CHAI, KARL X., additional, CHAO, JULIE, additional, CHAO, LEE, additional, CHEE, MARK S., additional, CHEN, LIN, additional, COLECLOUGH, CHRISTOPHER, additional, CRAXTON, MOLLY, additional, DE BLOCK, MARC, additional, DE LA LUNA, SUSANA, additional, DE WET, JEFFREY R., additional, DENECKE, JÜRGEN, additional, D'HALLUIN, KATHLEEN, additional, DU, ZIJIN, additional, DUTTON, CHARYL M., additional, DWARKI, V.J., additional, EBERWINE, JAMES, additional, ECKELS, DAVID D., additional, EHRENFELS, CHRISTIAN W., additional, ERLICH, HENRY, additional, EVANS, GLEN A., additional, FERRO-LUZZI AMES, GIOVANNA, additional, FINNELL, RICHARD, additional, FROHMAN, MICHAEL A., additional, FULLER, CARL W., additional, GABRIELSEN, ODD S., additional, GARCIA, J. VICTOR, additional, GEE, MELISSA A., additional, JANE GEIGER, MARY, additional, GORSKI, JACK, additional, GUILFOYLE, TOM J., additional, GYLLENSTEN, ULF B., additional, HAGEN, GRETCHEN, additional, HANAFEY, MICHAEL K., additional, HARTL, DANIEL L., additional, HERMANSON, GARY G., additional, HO, STEFFAN N., additional, HOOD, LEROY, additional, HORTON, ROBERT M., additional, HRUBY, DENNIS E., additional, HUET, JANINE, additional, HUFFAKER, TIM C., additional, HUNT, HENRY D., additional, II, SETSUKO, additional, JANSSENS, JAN, additional, JONES, MICHAEL D., additional, JUNG, VINCENT, additional, KAWASAKI, ERNEST, additional, KREITMAN, MARTIN, additional, LANDWEBER, LAURA F., additional, LEEMANS, JAN, additional, LELONG, JEAN-CLAUDE, additional, LÉVESQUE, GEORGES, additional, LIEBER, ANDRE, additional, LOEFFLER, JEAN-PHILIPPE, additional, LUEHRSEN, KENNETH R., additional, LYNCH, CARMEL M., additional, MACFERRIN, KURTIS D., additional, MACKLER, SCOTT, additional, MAEDA, KAYO, additional, MALONE, ROBERT W., additional, MCCLURE, BRUCE A., additional, MILLER, A. DUSTY, additional, MILLER, DANIEL G., additional, MIYASHIRO, KEVIN, additional, MURPHY, OWEN J., additional, OCHMAN, HOWARD, additional, ORTÍU, JUAN, additional, PADDOCK, GARY V., additional, PADMANABHAN, R., additional, PEASE, LARRY R., additional, PESTKA, SIDNEY, additional, PESTKA, STEVEN B., additional, POTTER, HUNTINGTON, additional, POUSTKA, ANNEMARIE, additional, PULLEN, JEFFREY K., additional, RAFALSKI, J. ANTONI, additional, RAWLINSON, WILLIAM D., additional, REYNAERTS, ARLETTE, additional, RUSSELL, J.A., additional, SAIKI, RANDALL, additional, SANDIG, VOLKER, additional, SANFORD, J.C., additional, SARKAR, GOBINDA, additional, SCHEUERMANN, RICHARD H., additional, SCHREIBER, STUART L., additional, SCOTT, JAMIE K., additional, SCZAKIEL, GEORG, additional, SHORT, J.M., additional, SHYAMALA, VENKATAKRISHNA, additional, SINGH, HARINDER, additional, SMITH, F.D., additional, SMITH, GEORGE P., additional, SMITH, VICTORIA, additional, SNIDER, KEN, additional, SOH, JAEMOG, additional, SOMMER, WOLFGANG, additional, SOMMER, STEVE S., additional, SONG, YAH-RU, additional, SORGE, J.A., additional, SPENCER, CORINNE, additional, STRAUSS, MICHAEL, additional, TARTOF, KENNETH D., additional, TERRANOVA, MICHAEL P., additional, TINGEY, SCOTT V., additional, TIZARD, RICHARD, additional, VARNER, JOSEPH E., additional, VEN MURTHY, M.R., additional, VERDINE, GREGORY L., additional, VERMA, INDER M., additional, VOYTA, JOHN C., additional, WALBOT, VIRGINIA, additional, WHITTAKER, PAUL A., additional, WILLIAMS, JOHN G.K., additional, WILSON, ELIZABETH M., additional, WILSON, RICHARD K., additional, YE, ZHENG-HUA, additional, ZELENETZ, ANDREW D., additional, ZHANG, Q.X., additional, and ZHAO, L.-J., additional

Published
1995
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4. Epitope mapping of cross-reactive monoclonal antibodies specific for the influenza A virus PA and PB2 polypeptides

Author

Comisión Interministerial de Ciencia y Tecnología, CICYT (España), Ministerio de Educación y Ciencia (España), Bárcena, Juan [0000-0001-6050-0654], de la Luna, Susana [0000-0001-7765-916X], Melero, José A. [0000-0001-8148-6521], Ortín, Juan [0000-0002-6200-4678], Ochoa, M., Bárcena, Juan, de la Luna, Susana, Melero, José A., Douglas, A.R., Nieto, A., Ortín, Juan, Skehel, J.J., Portela, Agustín, Comisión Interministerial de Ciencia y Tecnología, CICYT (España), Ministerio de Educación y Ciencia (España), Bárcena, Juan [0000-0001-6050-0654], de la Luna, Susana [0000-0001-7765-916X], Melero, José A. [0000-0001-8148-6521], Ortín, Juan [0000-0002-6200-4678], Ochoa, M., Bárcena, Juan, de la Luna, Susana, Melero, José A., Douglas, A.R., Nieto, A., Ortín, Juan, Skehel, J.J., and Portela, Agustín

Abstract

Characterization of the epitopes recognized by 21 monoclonal antibodies (MAbs) specific for the influenza A virus PA (13 MAbs) and PB2 (8 MAbs) polypeptides (Bárcena et al. (1994) J. Virol. 68, 6900-6909) raised against denatured polypeptides produced in E. coli is described. MAbs were characterized by: (1) competitive binding ELISAs; (2) mapping of the protein regions that specify their binding sites; and (3) analyses of their ability to recognize the corresponding viral protein in a number of viral isolates. Five and three non-overlapping antigenic areas were defined by the anti-PA and anti-PB2 MAbs, respectively. Five of the anti-PA MAbs recognized antigenic determinants located within the amino-terminal 157 amino acids of the PA protein, and 6 others reacted strongly with a PA fragment comprising the first 236 amino acids. All 8 anti-PB2 antibodies reacted strongly with a polypeptide fragment containing amino acids 1-113 of the PB2 protein. Analyses of the reactivities of 4 anti-P antibodies with 23 influenza A virus reference strains isolated over a period of 61 years and recovered from humans, pigs, birds and horses, showed that the epitopes were conserved among all viral isolates. The application of these antibodies as research and diagnostic tools is discussed.

Published
1995

5. Nuclear transport of influenza virus polymerase PA protein

Author

Comisión Interministerial de Ciencia y Tecnología, CICYT (España), Fundación Ramón Areces, Nieto, Amelia [0000-0002-0911-0439], de la Luna, Susana [0000-0001-7765-916X], Bárcena, Juan [0000-0001-6050-0654], Valcárcel, Juan [0000-0001-5398-3571], Melero, José A. [0000-0001-8148-6521], Ortín, Juan [0000-0002-6200-4678], Nieto, Amelia, de la Luna, Susana, Bárcena, Juan, Portela, Agustín, Valcárcel, Juan, Melero, José A., Ortín, Juan, Comisión Interministerial de Ciencia y Tecnología, CICYT (España), Fundación Ramón Areces, Nieto, Amelia [0000-0002-0911-0439], de la Luna, Susana [0000-0001-7765-916X], Bárcena, Juan [0000-0001-6050-0654], Valcárcel, Juan [0000-0001-5398-3571], Melero, José A. [0000-0001-8148-6521], Ortín, Juan [0000-0002-6200-4678], Nieto, Amelia, de la Luna, Susana, Bárcena, Juan, Portela, Agustín, Valcárcel, Juan, Melero, José A., and Ortín, Juan

Abstract

The subcellular distribution of influenza polymerase PA subunit has been studied using a SV40-recombinant virus (SVPA76), which allows the expression and accumulation of this protein in COS-1 cells. In contrast to the complete nuclear localization observed for the PA subunit several hours after influenza virus infection, when COS-1 cells were infected with the SVPA76 recombinant, the PA protein accumulated either in the nucleus, in the cytoplasm or was distributed throughout the cell. When cells were infected with the SVPA76 recombinant and superinfected with influenza virus, a clear increase in the proportion of cells showing nuclear localization of the PA protein was observed, suggesting that some trans-factor may be required to allow complete nuclear accumulation of the protein. Double infections using SVPA76 recombinant and either SVPB1 or SVNS recombinant viruses showed a complete correlation between expression of polymerase PB1 subunit or NS1 protein and nuclear localization of polymerase PA subunit. However, no such correlation was observed in the double infections of SVPA76 and SVNP recombinants. These results suggest that polymerase PB1 subunit and the non-structural proteins could be involved in the nuclear targeting or nuclear retention of influenza polymerase PA protein.

Published
1992

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