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Your search keyword '"de Mello Silva, Breno"' showing total 4 results
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4 results on '"de Mello Silva, Breno"'

1. Contributors

Author

Aboellail, Tawfik, primary, Abrahão, Jônatas Santos, additional, Adelino, Talita, additional, Akkina, Ramesh, additional, Alboudi, Ayman, additional, Alcantara, Luiz Carlos Junior, additional, Andersen, Henning, additional, Andrade, Teresinha De Jesus Aguiar Dos Santos, additional, Arakawa, Masashi, additional, de Araújo, Josélio Maria Galvão, additional, Azevedo, Pamella Nunes, additional, Bagasra, Omar, additional, Bailey, Mark J., additional, Baraklı, Serdar, additional, Basile, Alison Jane, additional, Bátiz, Luis Federico, additional, Bayrakci, Benan, additional, Bentes, Aline Almeida, additional, Bernatchez, Jean A., additional, Blázquez, A.B., additional, Borchardt-Lohölter, Viola, additional, Borges, Ana Luiza Vilela, additional, Burali, Maria Sole, additional, Bustamante-Barrientos, Felipe A., additional, Cabral Filho, Paulo E., additional, Cañas, Steven Vargas, additional, Castro, Talita, additional, Chang, Gwong-Jen J., additional, Chao, Day-Yu, additional, Chaudhari, Ameya, additional, Chaverra-Rodriguez, Duverney, additional, Christoff, Raissa R., additional, Coelho, Luiz Felipe Leomil, additional, Corrêa, Diogo Goulart, additional, Coste, Michael, additional, Coutinho, Raquel Zanatta, additional, da Costa Júnior, Joaquim Soares, additional, da Cunha Pereira, Anna Carolina Toledo, additional, da Matta Guedes, Paulo Marcos, additional, da Silva, Guilherme Liberato, additional, DaCosta, Jaderson Costa, additional, Dandekar, Prajakta, additional, Danielli, Amos, additional, das Dores Alves de Oliveira, Maria, additional, Deniz, Orhan, additional, Desprès, Philippe, additional, Drumond, Betânia Paiva, additional, Duque, Jonny, additional, e Silva Alves, Patrícia, additional, El Kalamouni, Chaker, additional, Fernandes, José Veríssimo, additional, Ferreira, Gustavo Portela, additional, Foiadelli, T., additional, Fonseca, Vagner, additional, Fontes, Adriana, additional, Frenkel, Lawrence, additional, Gadea, Gilles, additional, Garcez, Patricia P., additional, Giovanetti, Marta, additional, Gomez, Fernando, additional, Gulas-Wroblewski, Bonnie E., additional, Gümüşyayla, Şadiye, additional, Gurung, Sunam, additional, Haddad, Juliano G., additional, Harbo, Thomas, additional, Hedin-Pereira, Cecília, additional, Henzi, Roberto, additional, Hughes, Holly R., additional, Hygino da Cruz Júnior, Luiz Celso, additional, Jameson, Andrew, additional, Jordan, Rachel, additional, Kairis, Rebecca B., additional, Kaura, Taruna, additional, Kesici, Selman, additional, Khazali, Ahmad Suhail, additional, Klemens, Julia Maria, additional, Kroon, Erna Geessien, additional, Lam, Walter Sze Tung, additional, Lattwein, Erik, additional, Lazarev, Vladimir V., additional, Leite, Túlio César Rodrigues, additional, Li, Cui, additional, Lima, Nerilson Marques, additional, Lopes Moreira, Maria Elizabeth, additional, Loza, Karina Carrillo, additional, Machado, Denise Cantarelli, additional, Majolo, Fernanda, additional, Malaquias, Luiz Cosme Cotta, additional, Manfroni, Giuseppe, additional, Marinowic, Daniel Rodrigo, additional, Marques Abramov, Dimitri, additional, Marseglia, G.L., additional, McLean, Ewen, additional, de Mello Silva, Breno, additional, Mendez-Sanchez, Stelia, additional, Mewara, Abhishek, additional, Morita, Eiji, additional, Murray, Kristy O., additional, Myers, Dean, additional, Nascimento, Manuela Sales Lima, additional, Nascimento, Osvaldo J.M., additional, Paes, Marciano Viana, additional, Papin, James, additional, Pereira, Giovannia A.L., additional, Pereira, Goreti, additional, Pereira, Maria I.A., additional, Pervaiz, Naveed, additional, Purse, Byron W., additional, Rabelo, Kíssila, additional, Ribeiro, Jéssika F.F., additional, Ronca, Shannon E., additional, Roth, Shira, additional, Saad Salles, Tania Regina, additional, Sacchetto, Lívia, additional, Saiz, J.C., additional, Salomão, Natália Gedeão, additional, Santos, Beate S., additional, Saschenbrecker, Sandra, additional, Savasta, S., additional, Schlumberger, Wolfgang, additional, Schmitt, Kimberly, additional, Siqueira-Neto, Jair L., additional, Soon, Derek Tuck Loong, additional, Soto-Hernández, José Luis, additional, de Souza, Gabriel Augusto Pires, additional, Steinhagen, Katja, additional, Stiba, Konstanze, additional, Tambyah, Paul Ananth, additional, Tan, Gene S., additional, Tosta, Stephane, additional, Trabatti, C., additional, Vural, Gönül, additional, Werner, Heron, additional, Xavier, Joilson, additional, Xu, Zhiheng, additional, Xuan, Tay Wei, additional, and Yusof, Rohana, additional

Published
2022
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2. Nanotechnology applied in the control and diagnosis of Zika virus and its vectors

Author

de Souza, Gabriel Augusto Pires, primary, Sacchetto, Lívia, additional, Drumond, Betânia Paiva, additional, Abrahão, Jônatas Santos, additional, Leite, Túlio César Rodrigues, additional, de Mello Silva, Breno, additional, da Cunha Pereira, Anna Carolina Toledo, additional, Ferreira, Gustavo Portela, additional, Malaquias, Luiz Cosme Cotta, additional, and Coelho, Luiz Felipe Leomil, additional

Published
2021
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3. Hepatoprotective, antioxidant, anti-inflammatory, and antiviral activities of silymarin against mayaro virus infection.

Author

Ferraz AC, Almeida LT, da Silva Caetano CC, da Silva Menegatto MB, Souza Lima RL, de Senna JPN, de Oliveira Cardoso JM, Perucci LO, Talvani A, Geraldo de Lima W, de Mello Silva B, Barbosa Reis A, de Magalhães JC, and Lopes de Brito Magalhães C

Subjects
Animals, Cell Line, Female, Male, Mice, Mice, Inbred BALB C, Oxidative Stress drug effects, Phytotherapy methods, Alphavirus drug effects, Alphavirus Infections drug therapy, Anti-Inflammatory Agents pharmacology, Antioxidants pharmacology, Antiviral Agents pharmacology, Silymarin pharmacology, Virus Replication drug effects
Abstract

Infection caused by Mayaro virus (MAYV) is responsible for causing acute nonspecific fever, in which the majority of patients develop incapacitating and persistent arthritis/arthralgia. Mayaro fever is a neglected and underreported disease without treatment or vaccine, which has gained attention in recent years after the competence of Aedes aegypti to transmit MAYV was observed in the laboratory, coupled with the fact that cases are being increasingly reported outside of endemic forest areas, calling attention to the potential of an urban cycle arising in the near future. Thus, to mitigate the lack of information about the pathological aspects of MAYV, we previously described the involvement of oxidative stress in MAYV infection in cultured cells and in a non-lethal mouse model. Additionally, we showed that silymarin, a natural compound, attenuated MAYV-induced oxidative stress and inhibited MAYV replication in cells. The antioxidant and anti-MAYV effects prompted us to determine whether silymarin could also reduce oxidative stress and MAYV replication after infection in an immunocompetent animal model. We show that infected mice exhibited reduced weight gain, hepatomegaly, splenomegaly, anaemia, thrombocytopenia, leukopenia, increased liver transaminases, increased pro-inflammatory cytokines and liver inflammation, increased oxidative damage biomarkers, and reduced antioxidant enzyme activity. However, in animals infected and treated with silymarin, all these parameters were reversed or significantly improved, and the detection of viral load in the liver, spleen, brain, thigh muscle, and footpad was significantly reduced. This work reinforces the potent hepatoprotective, antioxidant, anti-inflammatory, and antiviral effects of silymarin against MAYV infection, demonstrating its potential against Mayaro fever disease., (Copyright © 2021 Elsevier B.V. All rights reserved.)

Published
2021
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4. Antiviral activity of silymarin against Mayaro virus and protective effect in virus-induced oxidative stress.

Author

Camini FC, da Silva TF, da Silva Caetano CC, Almeida LT, Ferraz AC, Alves Vitoreti VM, de Mello Silva B, de Queiroz Silva S, de Magalhães JC, and de Brito Magalhães CL

Subjects
Alphavirus Infections drug therapy, Antioxidants pharmacology, Chikungunya virus drug effects, Hep G2 Cells, Humans, Silybum marianum chemistry, Reactive Oxygen Species, Silybin pharmacology, Virus Replication drug effects, Alphavirus drug effects, Antiviral Agents pharmacology, Oxidative Stress drug effects, Silymarin pharmacology
Abstract

Mayaro virus (MAYV) is a neglected arbovirus belonging to the family Togaviridae. Its infection leads to Mayaro fever, with clinical manifestations such as fever, myalgia, headache, rash, arthralgia, vomiting, and diarrhea. The most prominent complaint from infected person is the long-lasting arthritis/arthralgia. The treatment for Mayaro fever is mainly symptom-based and there are no vaccines or antiviral drugs currently available, thus, natural products with anti-MAYV activity may provide a potential alternative. Recent evidences suggest that oxidative stress plays an important role in MAYV infection and compounds capable of modulating oxidative stress could represent a novel therapeutic approach in modulating MAYV-associated oxidative cellular damage. Silymarin is a complex extracted of Silybum marianum, or milk thistle, and its major active compound is silybin, which has a remarkable biological effect. Its antioxidant and antiviral effects, including its antiviral activity against the Chikungunya virus (CHIKV), prompted us to think whether silymarin could also reduce the replication of the MAYV and restore the pro-oxidant/antioxidant balance in the context of MAYV infection, leading to reduced cellular oxidative stress. We assessed the antiviral activity and protective effect of silymarin against oxidative stress in MAYV-infected HepG2 cells. Cytopathic effect inhibition, viral replication, and plaque reduction assays were used to determine the anti-MAYV activity of silymarin. Additionally, we determined whether silymarin could reduce MAYV-induced oxidative cell damage. Briefly, silymarin exhibited potent antiviral activity against MAYV and reduced MAYV-induced ROS formation and levels of malondialdehyde (MDA) and carbonyl protein, which are biomarkers of oxidative stress. In conclusion, the ability of silymarin to inhibit MAYV replication and attenuate MAYV-induce oxidative stress warrants further investigation of this compound as a novel therapeutic approach to Mayaro fever disease., (Copyright © 2018. Published by Elsevier B.V.)

Published
2018
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