Search

Your search keyword '"de Haan, Judith J"' showing total 3 results
Start Over Author "de Haan, Judith J" Publisher elsevier
3 results on '"de Haan, Judith J"'

1. The therapeutic potential of targeting CD40-TRAF6 pathway in cardiovascular Diseases.

Author

Bosch L, de Haan JJ, Seijkens TTP, van Tiel CM, Brans MAD, Pasterkamp G, Lutgens E, and de Jager SCA

Subjects
Animals, CD40 Antigens metabolism, Cardiovascular Diseases metabolism, Humans, Intracellular Signaling Peptides and Proteins metabolism, Nanoparticles administration & dosage, Signal Transduction physiology, CD40 Antigens antagonists & inhibitors, Cardiovascular Diseases drug therapy, Drug Delivery Systems methods, Intracellular Signaling Peptides and Proteins antagonists & inhibitors, Signal Transduction drug effects
Published
2020
Full Text
View/download PDF

3. Platelets enter atherosclerotic plaque via intraplaque microvascular leakage and intraplaque hemorrhage: a histopathological study in carotid plaques.

Author

van Lammeren GW, Pasterkamp G, de Vries JP, Bosch L, de Haan JJ, de Kleijn DP, Moll FL, and Vink A

Subjects
Aged, Biomarkers analysis, Blood Platelets immunology, Carotid Arteries immunology, Carotid Artery Diseases blood, Carotid Artery Diseases complications, Carotid Artery Diseases immunology, Disease Progression, Female, Hemorrhage blood, Hemorrhage etiology, Hemorrhage immunology, Humans, Immunohistochemistry, Interleukin-8 analysis, Male, Microvessels immunology, Microvessels metabolism, Middle Aged, Plaque, Atherosclerotic, Platelet Glycoprotein GPIb-IX Complex analysis, Rupture, Spontaneous, Blood Platelets pathology, Capillary Permeability, Carotid Arteries pathology, Carotid Artery Diseases pathology, Hemorrhage pathology, Microvessels pathology
Abstract

Background: Platelets foster an inflammatory environment that influences atherosclerotic lesion progression and facilitates plaque rupture, in addition to their role in acute thrombus formation. The route of entry of platelets into the atherosclerotic plaque and their exact location inside the plaque are however not completely understood., Methods and Results: 188 carotid plaques were examined for the presence of platelets using immunohistochemistry (CD42b), and 76/188 (40.4%) were platelet positive. Platelets were observed in intraplaque hemorrhages, around plaque microvessels, mostly without leakage of erythrocytes; and in mural thrombi. Platelet positive staining was associated with a higher plaque microvessel density, and elevated plaque-levels of interleukin-8., Conclusion: Due to their short life span, platelets reflect recent bleeding. It can be hypothesized that platelets might serve as a marker for leaky microvessels inside atherosclerotic plaques that are at risk for development, or progression of plaque hemorrhage., (Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.)

Published
2012
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results